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  1. Jul 2021
  2. onlinelibrary.wiley.com onlinelibrary.wiley.com
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      DOI: 10.1002/jcp.26115

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    ncbi.nlm.nih.gov/pmc/articles/PMC6331351/
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    sciencedirect.com/science/article/pii/S2211124719300968
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    ANGPTL2 Promotes Inflammation via Integrin α5β1 in Chondrocytes - Mami Takano, Naoto Hirose, Chikako Sumi, Makoto Yanoshita, Sayuri Nishiyama, Azusa Onishi, Yuki Asakawa, Kotaro Tanimoto,
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      anti–total ERK1/2

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    sciencedirect.com/science/article/pii/S2211124718317649
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    Prolonged Exposure to Insulin Inactivates Akt and Erk1/2 and Increases Pancreatic Islet and INS1E β-Cell Apoptosis
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    Nuclear PGK1 Alleviates ADP-Dependent Inhibition of CDC7 to Promote DNA Replication
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    academic.oup.com/endo/article/159/11/3860/5110610
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    DIRAS3 (ARHI) Blocks RAS/MAPK Signaling by Binding Directly to RAS and Disrupting RAS Clusters
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    sciencedirect.com/science/article/pii/S221112471931527X
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    Effects of the presence and absence of amino acids on translation, signaling and long‐term depression in hippocampal slices from Fmr1 knockout mice
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    Exogenous C-type natriuretic peptide therapy for impaired skeletal growth in a murine model of glucocorticoid treatment
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    Amino alkynylisoquinoline and alkynylnaphthyridine compounds potently inhibit acute myeloid leukemia proliferation in mice
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    Protective role of GPR120 in the maintenance of pregnancy by promoting decidualization via regulation of glucose metabolism
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    Sprouty1 regulates neuritogenesis and survival of cortical neurons
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    Tinagl1 Suppresses Triple-Negative Breast Cancer Progression and Metastasis by Simultaneously Inhibiting Integrin/FAK and EGFR Signaling
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    Neuroplasticity and inflammatory alterations in the nucleus accumbens are corrected after risperidone treatment in a schizophrenia-related developmental model in rats
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    1. scibot 22 Jul 2021
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    Microscopic image-based covariation network analysis for actin scaffold-modified insulin signaling
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  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Extracellular domain shedding of the ALK receptor mediates neuroblastoma cell migration
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    1. scibot 14 Jul 2021
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  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dual targeting of salt inducible kinases and CSF1R uncouples bone formation and bone resorption
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    1. scibot 03 Jul 2021
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      DOI: 10.7554/eLife.67772

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    Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer
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    cell.com/molecular-cell/fulltext/S1097-2765(21)00493-7
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    Uncoupling of IL-6 signaling and LC3-associated phagocytosis drives immunoparalysis during sepsis
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    Doxorubicin induces dysregulation of AMPA receptor and impairs hippocampal synaptic plasticity leading to learning and memory deficits
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    Kinome-wide RNAi screening for mediators of ABT-199 resistance in breast cancer cells identifies Wee1 as a novel therapeutic target
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  28. Jun 2021
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    FGF21 promotes thermogenic gene expression as an autocrine factor in adipocytes
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    TNAP is a novel regulator of cardiac fibrosis after myocardial infarction by mediating TGF-β/Smads and ERK1/2 signaling pathways
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      r

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    RAL GTPases mediate EGFR-driven intestinal stem cell proliferation and tumourigenesis
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    OTULIN allies with LUBAC to govern angiogenesis by editing ALK1 linear polyubiquitin
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    Promotion of Bone Lesions Through the Myeloma Integrin α6-Mediated Osteolytic Signaling
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    Protective effects of Da-cheng-qi decoction in rats with intracerebral hemorrhage
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    Tripartite motif 16 ameliorates nonalcoholic steatohepatitis by promoting the degradation of phospho-TAK1
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  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Flightless I is a catabolic factor of chondrocytes that promotes hypertrophy and cartilage degeneration in osteoarthritis
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    The glutathione peroxidase Gpx4 prevents lipid peroxidation and ferroptosis to sustain Treg cell activation and suppression of antitumor immunity
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    Transmembrane adaptor protein PAG is a mediator of PD-1 inhibitory signaling in human T cells
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    The CD44/COL17A1 pathway promotes the formation of multilayered, transformed epithelia
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  40. May 2021
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Neurotensin is an anti-thermogenic peptide produced by lymphatic endothelial cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC8266750/
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    PD-L1 recruits phospholipase C and enhances tumorigenicity of lung tumors harboring mutant forms of EGFR
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  43. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Cyclooxygenase inhibition attenuates brain angiogenesis and independently decreases mouse survival under hypoxia
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      DOI: 10.1111/jnc.15291

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    Dynamic subcellular localization and transcription activity of the SRF cofactor MKL2 in the striatum are regulated by MAPK
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      DOI: 10.1111/jnc.15303

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    A novel oncotherapy strategy: Direct thrombin inhibitors suppress progression, dissemination and spontaneous metastasis in non-small cell lung cancer
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    Thymoquinone administration ameliorates Alzheimer's disease-like phenotype by promoting cell survival in the hippocampus of amyloid beta1-42 infused rat model
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    Hydroxychloroquine Inhibits Macrophage Activation and Attenuates Renal Fibrosis After Ischemia-Reperfusion Injury
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    TNFα-Erk1/2 signaling pathway-regulated SerpinE1 and SerpinB2 are involved in lipopolysaccharide-induced porcine granulosa cell proliferation
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    An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells
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    A hotspot mutation in transcription factor IKZF3 drives B cell neoplasia via transcriptional dysregulation
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    SETD5-Coordinated Chromatin Reprogramming Regulates Adaptive Resistance to Targeted Pancreatic Cancer Therapy
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    Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling
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    Human MC4R variants affect endocytosis, trafficking and dimerization revealing multiple cellular mechanisms involved in weight regulation
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    Pin1 Promotes NLRP3 Inflammasome Activation by Phosphorylation of p38 MAPK Pathway in Septic Shock
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    Acetyl-CoA Synthetase 2: A Critical Linkage in Obesity-Induced Tumorigenesis in Myeloma
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    The Antipsychotic D2AAK1 as a Memory Enhancer for Treatment of Mental and Neurodegenerative Diseases
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    Hematopoietic Progenitor Kinase1 (HPK1) Mediates T Cell Dysfunction and Is a Druggable Target for T Cell-Based Immunotherapies
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    Matrix Rigidity Controls Epithelial-Mesenchymal Plasticity and Tumor Metastasis via a Mechanoresponsive EPHA2/LYN Complex
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    Cocaine-Induced Synaptic Redistribution of NMDARs in Striatal Neurons Alters NMDAR-Dependent Signal Transduction
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    A Gatekeeping Role of ESR2 to Maintain the Primordial Follicle Reserve
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    Gangliosides in the differentiation process of primary neurons: the specific role of GM1-oligosaccharide
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    IGFBP-1 in cardiometabolic pathophysiology – insights from loss-of-function and gain-of-function studies in male mice
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    Cdc42 is involved in NC1 peptide–regulated BTB dynamics through actin and microtubule cytoskeletal reorganization
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    MiR-3121-3p promotes tumor invasion and metastasis by suppressing Rap1GAP in papillary thyroid cancer in vitro
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    Tyrosine kinase inhibitors protect the salivary gland from radiation damage by increasing DNA double strand break repair
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    Prenatal correction of IGF2 to rescue the growth phenotypes in mouse models of Beckwith-Wiedemann and Silver-Russell syndromes
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    Gαo is a major determinant of cAMP signaling in the pathophysiology of movement disorders
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  89. Jan 2021
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    DL-3n-Butylphthalide Improves Blood–Brain Barrier Integrity in Rat After Middle Cerebral Artery Occlusion
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  91. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    Post-transcriptional Gene Regulation by MicroRNA-194 Promotes Neuroendocrine Transdifferentiation in Prostate Cancer
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  93. Dec 2020
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    Gain-of-function hot spot mutant p53R248Q regulation of integrin/FAK/ERK signaling in esophageal squamous cell carcinoma
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    Weak acids induce PGE 2 production in human oesophageal cells: novel mechanisms underlying GERD symptoms
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  96. link.springer.com link.springer.com
    Potential role of TrkB agonist in neuronal survival by promoting CREB/BDNF and PI3K/Akt signaling in vitro and in vivo model of 3-nitropropionic acid (3-NP)-induced neuronal death
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      p44/42 MAPK (Erk1/2) (137F5)

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  97. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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  98. Nov 2020
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    Overcoming Adaptive Resistance to KRAS and MEK Inhibitors by Co-targeting mTORC1/2 Complexes in Pancreatic Cancer
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  100. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
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  101. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cdc42 is involved in NC1 peptide–regulated BTB dynamics through actin and microtubule cytoskeletal reorganization
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    A Broad Response to Intracellular Long-Chain Polyphosphate in Human Cells
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  103. www.frontiersin.org www.frontiersin.org
    Polyunsaturated Fatty Acids Influence LPS-Induced Inflammation of Fish Macrophages Through Differential Modulation of Pathogen Recognition and p38 MAPK/NF-κB Signaling
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      DOI: 10.3389/fimmu.2020.559332

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  104. Oct 2020
  105. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Non-Transcriptional and Translational Function of Canonical NF-κB Signaling in Activating ERK1/2 in IL-1β-Induced COX-2 Expression in Synovial Fibroblasts
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  106. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Schwannoma development is mediated by Hippo pathway dysregulation and modified by RAS/MAPK signaling
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  107. www.cell.com www.cell.com
    Matrix Rigidity Controls Epithelial-Mesenchymal Plasticity and Tumor Metastasis via a Mechanoresponsive EPHA2/LYN Complex
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  108. elifesciences.org elifesciences.org
    Homeostatic plasticity in the retina is associated with maintenance of night vision during retinal degenerative disease
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      DOI: 10.7554/eLife.59422

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  109. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    AMPK promotes SPOP-mediated NANOG degradation to regulate prostate cancer cell stemness
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      DOI: 10.1016/j.devcel.2018.11.033

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  110. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    The p38 signaling pathway mediates the TGF‐β1‐induced increase in type I collagen deposition in human granulosa cells
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      DOI: 10.1096/fj.202001377R

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  111. Sep 2020
  112. onlinelibrary.wiley.com onlinelibrary.wiley.com
    ADAM10 mediates ectopic proximal tubule development and renal fibrosis through Notch signalling
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  113. www.sciencedirect.com www.sciencedirect.com
    Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers
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    Vcp Overexpression and Leucine Supplementation Increase Protein Synthesis and Improve Fear Memory and Social Interaction of Nf1 Mutant Mice
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      DOI: 10.1016/j.celrep.2020.107835

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  115. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide kinetic properties of transcriptional bursting in mouse embryonic stem cells
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      DOI: 10.1126/sciadv.aaz6699

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    Lactate Dehydrogenase A Governs Cardiac Hypertrophic Growth in Response to Hemodynamic Stress
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    Zonisamide Ameliorates Cognitive Impairment by Inhibiting ER Stress in a Mouse Model of Type 2 Diabetes Mellitus
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      DOI: 10.3389/fnagi.2020.00192

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    ADORA1 Inhibition Promotes Tumor Immune Evasion by Regulating the ATF3-PD-L1 Axis
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    Secreted Pyruvate Kinase M2 Promotes Lung Cancer Metastasis through Activating the Integrin Beta1/FAK Signaling Pathway
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    Formation of Human Neuroblastoma in Mouse-Human Neural Crest Chimeras
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    Mitofusin 2 in Macrophages Links Mitochondrial ROS Production, Cytokine Release, Phagocytosis, Autophagy, and Bactericidal Activity
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    Mechanical Stress Regulates Epithelial Tissue Integrity and Stiffness through the FGFR/Erk2 Signaling Pathway during Embryogenesis
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  123. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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  124. journals.plos.org journals.plos.org
    Early effect of laser irradiation in signaling pathways of diabetic rat submandibular salivary glands
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    SpiCee: A Genetic Tool for Subcellular and Cell-Specific Calcium Manipulation
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      DOI: 10.1016/j.celrep.2020.107934

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    Regulatory T Cells Condition Lymphatic Endothelia for Enhanced Transendothelial Migration
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      DOI: 10.1016/j.celrep.2019.12.083

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    Pbrm1 Steers Mesenchymal Stromal Cell Osteolineage Differentiation by Integrating PBAF-Dependent Chromatin Remodeling and BMP/TGF-β Signaling
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  128. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Functional Analysis of KIT Gene Structural Mutations Causing the Porcine Dominant White Phenotype Using Genome Edited Mouse Models
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      DOI: 10.3389/fgene.2020.00138

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  129. academic.oup.com academic.oup.com
    Chaperone-mediated autophagy governs progression of papillary thyroid carcinoma via PPARγ-SDF1/CXCR4 signaling
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    Injectable PLGA-coated ropivacaine produces a long-lasting analgesic effect on incisional pain and neuropathic pain
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  131. www.nature.com www.nature.com
    Organotypic culture assays for murine and human primary and metastatic-site tumors
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  132. www.jneurosci.org www.jneurosci.org
    Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer's Disease Risk
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    Prolactin enhances the proliferation of proliferative endometrial glandular cells and endometrial cancer cells
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    Developmental and Tumor Angiogenesis Requires the Mitochondria-Shaping Protein Opa1
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    Glioblastoma Cell Resistance to EGFR and MET Inhibition Can Be Overcome via Blockade of FGFR-SPRY2 Bypass Signaling
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    TNFAIP3 Interacting Protein 3 Overexpression Suppresses Nonalcoholic Steatohepatitis by Blocking TAK1 Activation
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    Competition for Space Induces Cell Elimination through Compaction-Driven ERK Downregulation
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    Kinetic Heterogeneity of Cancer Cell Fractional Killing
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    Exome Sequencing Identifies Genes and Gene Sets Contributing to Severe Childhood Obesity, Linking PHIP Variants to Repressed POMC Transcription
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    Three-dimensional growth of breast cancer cells potentiates the anti-tumor effects of unacylated ghrelin and AZP-531
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    GM1 Oligosaccharide Crosses the Human Blood–Brain Barrier In Vitro by a Paracellular Route
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    Molecular Stressors Engender Protein Connectivity Dysfunction through Aberrant N-Glycosylation of a Chaperone
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    Proteome Instability Is a Therapeutic Vulnerability in Mismatch Repair-Deficient Cancer
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    Pyruvate Kinase M2 Promotes the Activation of Dendritic Cells by Enhancing IL-12p35 Expression
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    H1N1 Influenza Virus Cross-Activates Gli1 to Disrupt the Intercellular Junctions of Alveolar Epithelial Cells
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    Effect of angiotensin II and angiotensin‐(1–7) on proliferation of stem cells from human dental apical papilla
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    Inhibition of Tumor VEGFR2 Induces Serine 897 EphA2-Dependent Tumor Cell Invasion and Metastasis in NSCLC
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    Low-Dose Sorafenib Acts as a Mitochondrial Uncoupler and Ameliorates Nonalcoholic Steatohepatitis
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    OVA66 promotes tumour angiogenesis and progression through enhancing autocrine VEGF-VEGFR2 signalling
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    Toxicity of Carlina Oxide—A Natural Polyacetylene from the Carlina acaulis Roots—In Vitro and In Vivo Study
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    Novel role for CRK adaptor proteins as essential components of SRC/FAK signaling for epithelial‐mesenchymal transition and colorectal cancer aggressiveness
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    Lysophosphatidic Acid-Mediated GPR35 Signaling in CX3CR1+ Macrophages Regulates Intestinal Homeostasis
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    Blocking EGFR palmitoylation suppresses PI3K signaling and mutant KRAS lung tumorigenesis
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    Rheb1-Independent Activation of mTORC1 in Mammary Tumors Occurs through Activating Mutations in mTOR
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  156. Jan 2020
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    Immune Sensing of Cell Death through Recognition of Histone Sequences by C-Type Lectin-Receptor-2d Causes Inflammation and Tissue Injury
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    A novel 2‐aminobenzimidazole‐based compound Jzu 17 exhibits anti‐ angiogenesis effects via targeting VEGFR‐2 signaling
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    ZIC3 Controls the Transition from Naive to Primed Pluripotency
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    TRIM32/USP11 Balances ARID1A Stability and the Oncogenic/Tumor-Suppressive Status of Squamous Cell Carcinoma
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    EGFR-Pak Signaling Selectively Regulates Glutamine Deprivation-Induced Macropinocytosis
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    Sphingosine 1‐phosphate but not Fingolimod protects neurons against excitotoxic cell death by inducing neurotrophic gene expression in astrocytes
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    Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands
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    CD36-Mediated Metabolic Rewiring of Breast Cancer Cells Promotes Resistance to HER2-Targeted Therapies
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    Pan-Cancer Landscape and Analysis of ERBB2 Mutations Identifies Poziotinib as a Clinically Active Inhibitor and Enhancer of T-DM1 Activity
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    TRPML1 Promotes Protein Homeostasis in Melanoma Cells by Negatively Regulating MAPK and mTORC1 Signaling
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    Landscape of Intercellular Crosstalk in Healthy and NASH Liver Revealed by Single-Cell Secretome Gene Analysis
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    Contrasting patterns of ERK activation in the tail of the striatum in response to aversive and rewarding signals
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    Histamine H1 and H3 receptor activation increases the expression of Glucose Transporter 1 (GLUT-1) in rat cerebro-cortical astrocytes in primary culture
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    GPD1 Specifically Marks Dormant Glioma Stem Cells with a Distinct Metabolic Profile
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    Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors
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    Insulin Potentiates JAK/STAT Signaling to Broadly Inhibit Flavivirus Replication in Insect Vectors
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    Signal Integration and Transcriptional Regulation of the Inflammatory Response Mediated by the GM-/M-CSF Signaling Axis in Human Monocytes
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    CCN1 interlinks integrin and Hippo pathway to autoregulate tip cell activity
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    GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis
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    TAZ Is a Negative Regulator of PPARγ Activity in Adipocytes and TAZ Deletion Improves Insulin Sensitivity and Glucose Tolerance
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    Positive Feedback Defines the Timing, Magnitude, and Robustness of Angiogenesis
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    Risperidone ameliorates prefrontal cortex neural atrophy and oxidative/nitrosative stress in brain and peripheral blood of rats with neonatal ventral hippocampus lesion
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    Phosphorylation of Npas4 by MAPK Regulates Reward-Related Gene Expression and Behaviors
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    Oncogenic Mutations Rewire Signaling Pathways by Switching Protein Recruitment to Phosphotyrosine Sites
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    YAP/TAZ Activation Drives Uveal Melanoma Initiation and Progression
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    A Novel Allosteric Inhibitor of Phosphoglycerate Mutase 1 Suppresses Growth and Metastasis of Non-Small-Cell Lung Cancer
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    GDNF and GFRα1 Are Required for Proper Integration of Adult-Born Hippocampal Neurons
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    Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers
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    Natural molecules induce and synergize to boost expression of the human antimicrobial peptide β-defensin-3
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    NMDAR-Activated PP1 Dephosphorylates GluN2B to Modulate NMDAR Synaptic Content
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    O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3
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    Glutathione transferase P silencing promotes neuronal differentiation of retinal R28 cells
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    CRISPR-induced RASGAP deficiencies in colorectal cancer organoids reveal that only loss of NF1 promotes resistance to EGFR inhibition
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    Human Pluripotency Is Initiated and Preserved by a Unique Subset of Founder Cells
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    GM1 promotes TrkA‐mediated neuroblastoma cell differentiation by occupying a plasma membrane domain different from TrkA
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    Conditional BDNF Delivery from Astrocytes Rescues Memory Deficits, Spine Density, and Synaptic Properties in the 5xFAD Mouse Model of Alzheimer Disease
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    Low expression of CRISP3 predicts a favorable prognosis in patients with mammary carcinoma
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    Protein inhibitor of activated STAT1 Ser503 phosphorylation‐mediated Elk‐1 SUMOylation promotes neuronal survival in APP/PS1 mice
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    Prolonged Exposure to Insulin Inactivates Akt and Erk1/2 and Increases Pancreatic Islet and INS1E β-Cell Apoptosis
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