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  1. Dec 2024
  2. www.sciencedirect.com www.sciencedirect.com
    A commonly inherited human PCSK9 germline variant drives breast cancer metastasis via LRP1 receptor
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    sciencedirect.com/science/article/pii/S0092867424013266
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    Biased signaling by mutant EGFR underlies dependence on PKCα in lung adenocarcinoma
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    sciencedirect.com/science/article/pii/S2211124724013779
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    Generation of iPSC-derived human venous endothelial cells for the modeling of vascular malformations and drug discovery
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    sciencedirect.com/science/article/pii/S1934590924003771
  5. Nov 2024
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    AMPK regulates Bcl2-L-13-mediated mitophagy induction for cardioprotection
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    sciencedirect.com/science/article/pii/S2211124724013524
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    HucMSCs can alleviate abnormal vasculogenesis induced by high glucose through the MAPK signaling pathway
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    sciencedirect.com/science/article/pii/S2589004224025793
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    ACSS2 acts as a lactyl-CoA synthetase and couples KAT2A to function as a lactyltransferase for histone lactylation and tumor immune evasion
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    sciencedirect.com/science/article/pii/S155041312400411X
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Microglia-derived ADAM9 promote GHRH neurons pyroptosis by Mad2L2-JNK-caspase-1 pathway in subarachnoid hemorrhage
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    1. scibot 21 Nov 2024
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    pmc.ncbi.nlm.nih.gov/articles/PMC11575213/
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Bilateral regulation of EGFR activity and local PI(4,5)P2 dynamics in mammalian cells observed with superresolution microscopy
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      DOI: 10.7554/eLife.101652

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    USP7 deubiquitinates KRAS and promotes non-small cell lung cancer
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    sciencedirect.com/science/article/pii/S2211124724012683
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    Insulin Mediates Lipopolysaccharide-Induced Inflammatory Responses and Oxidative Stress in BV2 Microglia
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  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Bidirectional signals generated by Siglec-7 and its crucial ligand tri-sialylated T to escape of cancer cells from immune surveillance
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  15. Oct 2024
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Neuregulin 1 signaling attenuates tumor necrosis factor-α induced female rat luteal cell death
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      DOI: 10.1210/endocr/bqae129

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    ncbi.nlm.nih.gov/pmc/articles/PMC11456883/
  17. aacrjournals.org aacrjournals.org
    NK Receptor Signaling Lowers TCR Activation Threshold, Enhancing Selective Recognition of Cancer Cells by TAA-Specific CTLs
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    1. scibot 08 Oct 2024
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    aacrjournals.org/cancerimmunolres/article/12/10/1421/748722/NK-Receptor-Signaling-Lowers-TCR-Activation
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Combination of JAKi and HDACi Exerts Antiangiogenic Potential in Cutaneous T-Cell Lymphoma
    1
    1. scibot 02 Oct 2024
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      DOI: 10.3390/cancers16183176

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    ncbi.nlm.nih.gov/pmc/articles/PMC11430229/
  19. Sep 2024
  20. link.springer.com link.springer.com
    TRPV4 Blockage Inhibits the Neurogenesis in the Adult Hippocampal Dentate Gyrus Following Pilocarpine‑Induced Status Epilepticus
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    1. scibot 27 Sep 2024
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    link.springer.com/article/10.1007/s12035-024-04504-x
  21. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    A novel inhibitor of class IIa histone deacetylases attenuates collagen-induced arthritis
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      DOI: 10.1111/bph.17306

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.17306
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IKKɛ induces STING non-IFN immune responses via a mechanism analogous to TBK1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11387596/
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    Customised design of antisense oligonucleotides targeting EGFR driver mutants for personalised treatment of non-small cell lung cancer
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    sciencedirect.com/science/article/pii/S235239642400392X
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Atypical cellular responses mediated by intracellular constitutive active TrkB (NTRK2) kinase domains and a solely intracellular NTRK2-fusion oncogene
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    1. scibot 25 Sep 2024
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  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FNIP1 suppresses colorectal cancer progression through inhibiting STAT3 phosphorylation and nuclear translocation
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    1. scibot 25 Sep 2024
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    Zdhhc1- and Zdhhc2-mediated Gpm6a palmitoylation is essential for maintenance of mammary stem cell activity
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    Sphingosine-1-Phosphate Receptor 1 Activity Promotes Tumor Growth by Amplifying VEGF-VEGFR2 Angiogenic Signaling
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  28. www.sciencedirect.com www.sciencedirect.com
    Cancer cell – fibroblast crosstalk via HB-EGF/EGFR/MEK signaling promotes expression of macrophage chemo-attractants in squamous cell carcinoma
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    sciencedirect.com/science/article/pii/S2589004224018601
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    Aged fibroblast-derived extracellular vesicles promote angiogenesis in melanoma
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  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phosphodiesterase 4 is overexpressed in keloid epidermal scars and its inhibition reduces keratinocyte fibrotic alterations
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      DOI: 10.1186/s10020-024-00906-8

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    A bispecific antibody targeting EGFR and AXL delays resistance to osimertinib
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    H3K9 lactylation in malignant cells facilitates CD8+ T cell dysfunction and poor immunotherapy response
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  33. Aug 2024
  34. www.sciencedirect.com www.sciencedirect.com
    FRA1 controls acinar cell plasticity during murine KrasG12D-induced pancreatic acinar to ductal metaplasia
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  35. www.nature.com www.nature.com
    LIFR regulates cholesterol-driven bidirectional hepatocyte–neutrophil cross-talk to promote liver regeneration
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      DOI: 10.1038/s42255-024-01110-y

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  36. www.sciencedirect.com www.sciencedirect.com
    Multiplex Spatial Omics Reveals Changes in Immune-Epithelial Crosstalk During Inflammation and Dysplasia Development in Chronic IBD Patients
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    Integrative plasma and fecal metabolomics identify functional metabolites in adenoma-colorectal cancer progression and as early diagnostic biomarkers
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  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Neuropeptide Y receptor activation preserves inner retinal integrity through PI3K/Akt signaling in a glaucoma mouse model
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      DOI: 10.1093/pnasnexus/pgae299

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    ncbi.nlm.nih.gov/pmc/articles/PMC11305140/
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    Regulation of MYC by CARD14 in human epithelium is a determinant of epidermal homeostasis and disease
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  40. www.researchsquare.com www.researchsquare.com
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      DOI: 10.21203/rs.3.rs-1945681/v1

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  41. www.mdpi.com www.mdpi.com
    Andrographolide Attenuates Established Pulmonary Hypertension via Rescue of Vascular Remodeling
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  42. cancerci.biomedcentral.com cancerci.biomedcentral.com
    Quantitative phosphoproteomic analysis reveals chemoresistance-related proteins and signaling pathways induced by rhIL-6 in human osteosarcoma cells
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  43. Jul 2024
  44. www.cell.com www.cell.com
    Peptostreptococcus stomatis promotes colonic tumorigenesis and receptor tyrosine kinase inhibitor resistance by activating ERBB2-MAPK
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    cell.com/cell-host-microbe/abstract/S1931-3128(24)00254-3
  45. www.sciencedirect.com www.sciencedirect.com
    Human MC4R variants affect endocytosis, trafficking and dimerization revealing multiple cellular mechanisms involved in weight regulation
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      DOI: 10.1016/j.celrep.2021.108862

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  46. 52.53.155.43 52.53.155.43
    Cancer-associated endocrine cells participate in pancreatic carcinogenesis
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  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    Altered GM1 catabolism affects NMDAR-mediated Ca2+ signaling at ER-PM junctions and increases synaptic spine formation in a GM1-gangliosidosis model
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    Acquired NF2 mutation confers resistance to TRK inhibition in an ex vivo LMNA::NTRK1-rearranged soft-tissue sarcoma cell model
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    Overexpression of α-Klotho isoforms promotes distinct Effects on BDNF-Induced Alterations in Dendritic Morphology
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    CircTMEM165 facilitates endothelial repair by modulating mitochondrial fission via miR-192/SCP2 in vitro and in vivo
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    Initiation of a ZAKα-dependent ribotoxic stress response by the innate immunity endoribonuclease RNase L
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  104. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  129. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CHTOP Alleviates Cerebral Ischemia/Reperfusion-Induced Injury by Regulating RNA Alternative Splicing
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  130. Dec 2023
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    Casein kinase-2 inhibition promotes retinal ganglion cell survival after acute intraocular pressure elevation
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    A reversible epigenetic memory of inflammatory injury controls lineage plasticity and tumor initiation in the mouse pancreas
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    Econazole selectively induces cell death in NF1-homozygous mutant tumor cells
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    pERK-mediated IL8 secretion can enhance the migration, invasion, and cisplatin resistance of CD10-positive oral cancer cells
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    ALK inhibitors increase ALK expression and sensitize neuroblastoma cells to ALK.CAR-T cells
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  137. Nov 2023
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    Targeting GPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-κB pathways
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    Functional and spatial proteomics profiling reveals intra- and intercellular signaling crosstalk in colorectal cancer
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    The expression profile and tumorigenic mechanisms of CD97 (ADGRE5) in glioblastoma render it a targetable vulnerability
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    Blockade of CCR5 suppresses paclitaxel-induced peripheral neuropathic pain caused by increased deoxycholic acid
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    A combinatorial therapeutic approach to enhance FLT3-ITD AML treatment
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    Adipo-glial signaling mediates metabolic adaptation in peripheral nerve regeneration
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    HOXC6 drives a therapeutically targetable pancreatic cancer growth and metastasis pathway by regulating MSK1 and PPP2R2B
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    Repositioning of Montelukast to inhibit proliferation of mutated KRAS pancreatic cancer through a novel mechanism that interfere the binding between KRAS and GTP/GDP
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    ANKRD49 promotes the metastasis of NSCLC via activating JNK-ATF2/c-Jun-MMP-2/9 axis
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    Large-scale production of human blastoids amenable to modeling blastocyst development and maternal-fetal cross talk
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    Exploring the role of SWI/SNF complex subunit BAF60c in lipid metabolism and inflammation in fish
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    Targeting cuproptosis by zinc pyrithione in triple-negative breast cancer
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    A Novel ASCT2 Inhibitor, C118P, Blocks Glutamine Transport and Exhibits Antitumour Efficacy in Breast Cancer
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    Skull progenitor cell-driven meningeal lymphatic restoration improves neurocognitive functions in craniosynostosis
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    Peroxisomal ERK mediates Akh/glucagon action and glycemic control
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    Inhibition of a lower potency target drives the anticancer activity of a clinical p38 inhibitor
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    Activation of the JNK/COX-2/HIF-1α axis promotes M1 macrophage via glycolytic shift in HIV-1 infection
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    Irisin reduces amyloid-β by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling
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    Methylation of KRAS by SETD7 promotes KRAS degradation in non-small cell lung cancer
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    CDKL5 deficiency in adult glutamatergic neurons alters synaptic activity and causes spontaneous seizures via TrkB signaling
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    ONC201/TIC10 enhances durability of mTOR inhibitor everolimus in metastatic ER+ breast cancer
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    Metformin Improves the Prerequisites for FGF21 Signaling in Patients with Type 2 Diabetes
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    Tyrosine hydroxylase phosphorylation is under the control of serine 40
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    ERK1-mediated immunomodulation of mesenchymal stem cells ameliorates inflammatory disorders
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    Neutrophil extracellular traps enhance S. aureus skin colonization by oxidative stress induction and downregulation of epidermal barrier genes
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    MAPK-ERK-CREB signaling pathway upregulates Nav1.6 in oxaliplatin-induced neuropathic pain in the rat
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    Tff2 defines transit-amplifying pancreatic acinar progenitors that lack regenerative potential and are protective against Kras-driven carcinogenesis
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    URAT1 is expressed in cardiomyocytes and dotinurad attenuates the development of diet-induced metabolic heart disease.
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    CGK733 alleviates ovariectomy-induced bone loss through blocking RANKL-mediated Ca2+ oscillations and NF-κB/MAPK signaling pathways
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    The MORC2 p.S87L mutation reduces proliferation of pluripotent stem cells derived from a patient with the spinal muscular atrophy-like phenotype by inhibiting proliferation-related signaling pathways
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    Glucose Transporter-2 Regulation of Male versus Female Hypothalamic Astrocyte MAPK Expression and Activation: Impact of Glucose
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    TMEM127 suppresses tumor development by promoting RET ubiquitination, positioning, and degradation
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    Apical extrusion prevents apoptosis from activating an acute inflammatory program in epithelia
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    ASCL1 is activated downstream of the ROR2/CREB signaling pathway to support lineage plasticity in prostate cancer
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    L858R emerges as a potential biomarker predicting response of lung cancer models to anti-EGFR antibodies: Comparison of osimertinib vs. cetuximab
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    Tumoral P2Y2 receptor modulates tumor growth and host anti-tumor immune responses in a syngeneic murine model of oral cancer
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  181. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genetic ablation of ketohexokinase C isoform impairs pancreatic cancer development
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  183. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Discovery of a pyrrole-pyridinimidazole derivative as novel SIRT6 inhibitor for sensitizing pancreatic cancer to gemcitabine
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    Targeting CD36 determines nicotine derivative NNK-induced lung adenocarcinoma carcinogenesis
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    Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer
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    Unique vulnerability of RAC1-mutant melanoma to combined inhibition of CDK9 and immune checkpoints
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    Activation of GPR44 decreases severity of myeloid leukemia via specific targeting of leukemia initiating stem cells
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    PARP2 downregulation in T cells ameliorates lipopolysaccharide-induced inflammation of the large intestine
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    Co-targeting RANK pathway treats and prevents acquired resistance to CDK4/6 inhibitors in luminal breast cancer
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    Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodeling
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    Efferocytes release extracellular vesicles to resolve inflammation and tissue injury via prosaposin-GPR37 signaling
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    Targeting endometrial inflammation in intrauterine adhesion ameliorates endometrial fibrosis by priming MSCs to secrete C1INH
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    TOPK mediates immune evasion of Renal Cell Carcinoma via upregulating the expression of PD-L1
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    SHP2 participates in decidualization by activating ERK to maintain normal nuclear localization of progesterone receptor
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    The nucleotide receptor STING translocates to the phagosomes to negatively regulate anti-fungal immunity
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    Mitigation of non-alcoholic steatohepatitis via recombinant Orosomucoid 2, an acute phase protein modulating the Erk1/2-PPARγ-Cd36 pathway
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    Identification of an IL-1 receptor mutation driving autoinflammation directs IL-1-targeted drug design
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    MEK inhibitor and anti-EGFR antibody overcome sotorasib resistance signals and enhance its antitumor effect in colorectal cancer cells
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    UBE2M-mediated neddylation of TRIM21 regulates obesity-induced inflammation and metabolic disorders
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    How aberrant N-glycosylation can alter protein functionality and ligand binding: An atomistic view
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    HPIP is an essential scaffolding protein running through the EGFR-RAS-ERK pathway and drives tumorigenesis
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    Discovery of a Selective and Orally Bioavailable FGFR2 Degrader for Treating Gastric Cancer
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  206. aacrjournals.org aacrjournals.org
    USP10 regulates ZEB1 ubiquitination and protein stability to inhibit ZEB1-mediated colorectal cancer metastasis
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