2,383 Matching Annotations
  1. Aug 2024
  2. www.sciencedirect.com www.sciencedirect.com
    Protocol for establishing inducible CRISPRd system for blocking transcription factor-binding sites in human pluripotent stem cells
    1
    1. scibot 21 Aug 2024
      Addgene_12260

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    sciencedirect.com/science/article/pii/S2666166724003988
  3. www.sciencedirect.com www.sciencedirect.com
    The SW480 cell line as a model of resident and migrating colon cancer stem cells
    1
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    sciencedirect.com/science/article/pii/S2589004224018832
  4. www.biorxiv.org www.biorxiv.org
    ZFAND6 is a subunit of a TRAF2-cIAP E3 ubiquitin ligase complex essential for mitophagy
    1
    1. scibot 21 Aug 2024
      RRID:Addgene_12260

      DOI: 10.1101/2024.03.27.586763

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    biorxiv.org/content/10.1101/2024.03.27.586763v1
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SFTSV nucleoprotein mediates DNA sensor cGAS degradation to suppress cGAS-dependent antiviral responses
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    1. scibot 21 Aug 2024
      RRID:Addgene_12260

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    ncbi.nlm.nih.gov/pmc/articles/PMC11237745/
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    Oxysterole-binding protein targeted by SARS-CoV-2 viral proteins regulates coronavirus replication
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      RRID:Addgene_12260

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    ncbi.nlm.nih.gov/pmc/articles/PMC11306179/
  7. www.biorxiv.org www.biorxiv.org
    An enhanced Eco1 retron editor enables precision genome engineering in human cells from a single-copy integrated lentivirus
    1
    1. scibot 20 Aug 2024
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    biorxiv.org/content/10.1101/2024.08.05.606586v2
  8. www.cell.com www.cell.com
    SYNGAP1 deficiency disrupts synaptic neoteny in xenotransplanted human cortical neurons in vivo
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      RRID:Addgene_12260

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    cell.com/neuron/abstract/S0896-6273(24)00529-4
  9. www.sciencedirect.com www.sciencedirect.com
    Sugar-mediated non-canonical ubiquitination impairs Nrf1/NFE2L1 activation
    2
    1. scibot 20 Aug 2024
      RRID:Addgene_12260

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    sciencedirect.com/science/article/pii/S1097276524005896
  10. www.sciencedirect.com www.sciencedirect.com
    Protocol for establishing inducible CRISPR interference system for multiple-gene silencing in human pluripotent stem cells
    1
    1. scibot 19 Aug 2024
      Addgene_12260

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    sciencedirect.com/science/article/pii/S2666166724003861
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    Dopaminylation of endothelial TPI1 suppresses ferroptotic angiocrine signals to promote lung regeneration over fibrosis
    1
    1. scibot 19 Aug 2024
      Plasmid_12260

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    sciencedirect.com/science/article/pii/S1550413124002808
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    Purinosomes spatially co-localize with mitochondrial transporters
    1
    1. scibot 19 Aug 2024
      RRID:Addgene_12260

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    sciencedirect.com/science/article/pii/S0021925824021215
  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Construction of an IFNAR1 knockout MDBK cell line using CRISPR/Cas9 and its effect on bovine virus replication
    1
    1. scibot 18 Aug 2024
      psPAX2

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    ncbi.nlm.nih.gov/pmc/articles/PMC11294105/
  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Optimized reporters for multiplexed detection of transcription factor activity
    1
    1. scibot 18 Aug 2024
      12260

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    ncbi.nlm.nih.gov/pmc/articles/PMC11291157/
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting fatty acid oxidation enhances response to HER2-targeted therapy
    1
    1. scibot 18 Aug 2024
      12260

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    ncbi.nlm.nih.gov/pmc/articles/PMC11297952/
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TERT upstream promoter methylation regulates TERT expression and acts as a therapeutic target in TERT promoter mutation-negative thyroid cancer
    1
    1. scibot 18 Aug 2024
      12260

      DOI: 10.1186/s12935-024-03459-2

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    ncbi.nlm.nih.gov/pmc/articles/PMC11297792/
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    UM171 suppresses breast cancer progression by inducing KLF2
    1
    1. scibot 18 Aug 2024
      12260

      DOI: 10.1007/s10549-024-07372-0

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  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Systematic transcriptome profiling of hPSC-derived osteoblasts unveils CORIN's mastery in governing osteogenesis through CEBPD modulation
    1
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      12260

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  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Programmable Protein Stabilization with Language Model-Derived Peptide Guides
    1
    1. scibot 18 Aug 2024
      12260

      DOI: 10.21203/rs.3.rs-4670386/v1

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    ncbi.nlm.nih.gov/pmc/articles/PMC11302690/
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Colchicine-mediated selective autophagic degradation of HBV core proteins inhibits HBV replication and HBV-related hepatocellular carcinoma progression
    1
    1. scibot 18 Aug 2024
      psPAX2

      DOI: 10.1038/s41420-024-02122-z

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    ncbi.nlm.nih.gov/pmc/articles/PMC11303544/
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Oncogenic transcription factors instruct promoter-enhancer hubs in individual triple negative breast cancer cells
    1
    1. scibot 18 Aug 2024
      12260

      DOI: 10.1126/sciadv.adl4043

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    ncbi.nlm.nih.gov/pmc/articles/PMC11305386/
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SNORD88B-mediated WRN nucleolar trafficking drives self-renewal in liver cancer initiating cells and hepatocarcinogenesis
    1
    1. scibot 18 Aug 2024
      12,260

      DOI: 10.1038/s41467-024-50987-6

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    ncbi.nlm.nih.gov/pmc/articles/PMC11306581/
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Protocol for transducing human primary epithelial prostate cells and patient-derived organoids with high efficiency
    1
    1. scibot 18 Aug 2024
      Addgene_12260

      DOI: 10.1016/j.xpro.2024.103200

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    ncbi.nlm.nih.gov/pmc/articles/PMC11315182/
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In vivo single-cell CRISPR uncovers distinct TNF programmes in tumour evolution
    1
    1. scibot 18 Aug 2024
      12260

      DOI: 10.1038/s41586-024-07663-y

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    ncbi.nlm.nih.gov/pmc/articles/PMC11306103/
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Histone-methyltransferase KMT2D deficiency impairs the Fanconi anemia/BRCA pathway upon glycolytic inhibition in squamous cell carcinoma
    1
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      12260

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    ncbi.nlm.nih.gov/pmc/articles/PMC11310337/
  26. www.cell.com www.cell.com
    SETDB1 suppresses NK cell-mediated immunosurveillance in acute myeloid leukemia with granulo-monocytic differentiation
    1
    1. scibot 18 Aug 2024
      RRID:Addgene_12260

      DOI: 10.1016/j.celrep.2024.114536

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    cell.com/cell-reports/fulltext/S2211-1247(24)00865-9
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Latrophilin-2 mediates fluid shear stress mechanotransduction at endothelial junctions
    1
    1. scibot 18 Aug 2024
      RRID:Addgene_12260

      DOI: 10.1038/s44318-024-00142-0

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    ncbi.nlm.nih.gov/pmc/articles/PMC11294477/
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Harnessing DNA replication stress to target RBM10 deficiency in lung adenocarcinoma
    1
    1. scibot 18 Aug 2024
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  29. 52.53.155.43 52.53.155.43
    Modeling of Intracellular Taurine Levels Associated with Ovarian Cancer Reveals Activation of p53, ERK, mTOR and DNA-Damage-Sensing-Dependent Cell Protection
    1
    1. scibot 18 Aug 2024
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    52.53.155.43/95ce582542c39d657f4a12addf8d7529172231d1/2526088VOR-html.html
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Enhancing homology-directed repair efficiency with HDR-boosting modular ssDNA donor
    1
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      12260

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    ncbi.nlm.nih.gov/pmc/articles/PMC11315919/
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Proximity analysis of native proteomes reveals phenotypic modifiers in a mouse model of autism and related neurodevelopmental conditions
    1
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      12260

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    ncbi.nlm.nih.gov/pmc/articles/PMC11316102/
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CD177 is a novel IgG Fc receptor and CD177 genetic variants affect IgG-mediated function
    1
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      psPAX2

      DOI: 10.3389/fimmu.2024.1418539

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    ncbi.nlm.nih.gov/pmc/articles/PMC11316256/
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CHD4 R975H mutant activates tumorigenic pathways and promotes stemness and M2-like macrophage polarization in endometrial cancer
    1
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      12260

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    ncbi.nlm.nih.gov/pmc/articles/PMC11316823/
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Derlin-1-Stat5b axis maintains homeostasis of adult hippocampal neurogenesis
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  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Strong capacity of differentiated PD-L1 CAR-modified UCB-CD34+ cells and PD-L1 CAR-modified UCB-CD34+-derived NK cells in killing target cells and restoration of the anti-tumor function of PD-1-high exhausted T Cells
    1
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      pSPAX2

      DOI: 10.1186/s13287-024-03871-5

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  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Metastatic breast cancer cells are metabolically reprogrammed to maintain redox homeostasis during metastasis
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  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    LACTB suppresses liver cancer progression through regulation of ferroptosis
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      DOI: 10.1016/j.redox.2024.103270

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  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NS1-mediated enhancement of MVC transcription and replication promoted by KAT5/H4K12ac
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      psPAX2

      DOI: 10.1128/jvi.01695-23

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  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Library‐Assisted Evolution in Eukaryotic Cells Yield Adenine Base Editors with Enhanced Editing Specificity
    1
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  40. www.biorxiv.org www.biorxiv.org
    Replicative senescence is ATM driven, reversible, and accelerated by hyperactivation of ATM at normoxia
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    1. scibot 16 Aug 2024
      pPAX2

      DOI: 10.1101/2024.06.24.600514

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    biorxiv.org/content/10.1101/2024.06.24.600514v1
  41. www.sciencedirect.com www.sciencedirect.com
    A primate-specific endogenous retroviral envelope protein sequesters SFRP2 to regulate human cardiomyocyte development
    1
    1. scibot 15 Aug 2024
      Cat# 12260

      DOI: 10.1016/j.stem.2024.07.006

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    sciencedirect.com/science/article/pii/S193459092400256X
  42. www.sciencedirect.com www.sciencedirect.com
    OPA1 promotes ferroptosis by augmenting mitochondrial ROS and suppressing an integrated stress response
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      Cat# 12260

      DOI: 10.1016/j.molcel.2024.07.020

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  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HLTF resolves G4s and promotes G4-induced replication fork slowing to maintain genome stability
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      Cat# 12260

      DOI: 10.1016/j.molcel.2024.07.018

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  44. www.sciencedirect.com www.sciencedirect.com
    The divergent effects of G3BP orthologs on human stress granule assembly imply a centric role for the core protein interaction network
    1
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  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mitophagy defect mediates the aging‐associated hallmarks in Hutchinson–Gilford progeria syndrome
    1
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  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Activating Point Mutations in the MET Kinase Domain Represent a Unique Molecular Subset of Lung Cancer and Other Malignancies Targetable with MET Inhibitors
    1
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      DOI: 10.1158/2159-8290.CD-23-1217

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  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The BET PROTAC inhibitor GNE-987 displays anti-tumor effects by targeting super-enhancers regulated gene in osteosarcoma
    1
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      RRID: Addgene_12260

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  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting RBM39 through indisulam induced mis-splicing of mRNA to exert anti-cancer effects in T-cell acute lymphoblastic leukemia
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      12260

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  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cytidine triphosphate synthase 1-mediated metabolic reprogramming promotes proliferation and drug resistance in multiple myeloma
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  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    β-catenin mediates endodermal commitment of human ES cells via distinct transactivation functions
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  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Olanzapine suppresses mPFC activity-norepinephrine releasing to alleviate CLOCK-enhanced cancer stemness under chronic stress
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  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cathepsin L induces cellular senescence by upregulating CUX1 and p16INK4a
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  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SARS-CoV-2 Accessory Protein ORF8 Targets the Dimeric IgA Receptor pIgR
    1
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      12260

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  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    USP9X inhibits metastasis in pulmonary sarcomatoid carcinoma by regulating epithelial-mesenchymal transition, angiogenesis and immune infiltration
    1
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      pSPAX2

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  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Reduced adipocyte glutaminase activity promotes energy expenditure and metabolic health
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  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Modulations of the mTORC2–GATA3 axis by an isorhamnetin activated endosomal–lysosomal system of the J774.1 macrophage-like cell line
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  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Altered ribosomal profile in acquired resistance and reversal associates with pathological response to chemotherapy in inflammatory breast cancer
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  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Original research: ZFYVE19 deficiency: a ciliopathy involving failure of cell division, with cell death
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  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SMARCA4 controls state plasticity in small cell lung cancer through regulation of neuroendocrine transcription factors and REST splicing
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      12260

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  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Chemoproteomic development of SLC15A4 inhibitors with anti-inflammatory activity
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      12260

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  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Neuronal MAPT expression is mediated by long-range interactions with cis-regulatory elements
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      12260

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  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In vitro assessment of thyroid peroxidase inhibition by chemical exposure: comparison of cell models and detection methods
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  63. www.cell.com www.cell.com
    Epigenomic signatures of sarcomatoid differentiation to guide the treatment of renal cell carcinoma
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      Addgene: 12260

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  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Nuclear rupture induced by capillary constriction forces promotes differential effects on metastatic and normal breast cells
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  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Conserved role of hnRNPL in alternative splicing of epigenetic modifiers enables B cell activation
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      12260

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  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Exogenous Metabolic Modulators Improve Response to Carboplatin in Triple-Negative Breast Cancer
    1
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      psPAX2

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  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Regulation of TSC2 lysosome translocation and mitochondrial turnover by TSC2 acetylation status
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      12260

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  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CLEC4D as a Novel Prognostic Marker Boosts the Proliferation and Migration of Gastric Cancer via the NF-κB/AKT Signaling Pathway
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  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CD38 restrains the activity of extracellular cGAMP in a model of multiple myeloma
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      12260

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  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PAX6 promotes neuroendocrine phenotypes of prostate cancer via enhancing MET/STAT5A-mediated chromatin accessibility
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  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phospholipase PLA2G7 is complementary to GPX4 in mitigating punicic acid induced ferroptosis in prostate cancer cells
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  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    2024.04.26.591029v1.full-html.html
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  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Morphological basis of the lung adenocarcinoma subtypes
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  74. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ERK Activation by BRAFV600E suppresses mesenchymal migration and tumorigenesis by inhibiting RAC1
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  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    METTL17 is an Fe-S cluster checkpoint for mitochondrial translation
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  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrative high-throughput enhancer surveying and functional verification divulges a YY2-condensed regulatory axis conferring risk for osteoporosis
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      psPAX2

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  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Advanced glycation end products promote meniscal calcification by activating the mTOR-ATF4 positive feedback loop
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  78. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Epstein-Barr virus miR-BARTs 7 and 9 modulate viral cycle, cell proliferation, and proteomic profiles in Burkitt lymphoma
    1
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      (Addgene #12260)

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  79. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CBX7C•PHC2 interaction facilitates PRC1 assembly and modulates its phase separation properties
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  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    iNOS is necessary for GBP-mediated T. gondii clearance in murine macrophages via vacuole nitration and intravacuolar network collapse
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      12260

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  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Deletion of Sarcolemmal Membrane-Associated Protein Isoform 3 (SLMAP3) in Cardiac Progenitors Delays Embryonic Growth of Myocardium without Affecting Hippo Pathway
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      https://www.addgene.org/12260/

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  82. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Shaping immune landscape of colorectal cancer by cholesterol metabolites
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  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PTBP3/IGF2BP3/HMGA1 axis promotes renal cancer growth and metastasis
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      12260

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  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Epigenetic Targeting to Overcome Radioresistance in Head and Neck Cancer
    1
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      DOI: 10.3390/cancers16040730

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  85. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TDP-43 chronic deficiency leads to dysregulation of transposable elements and gene expression by affecting R-loop and 5hmC crosstalk
    1
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      12260

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  86. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Akt activation ameliorates deficits in hippocampal-dependent memory and activity-dependent synaptic protein synthesis in an Alzheimer’s disease mouse model
    1
    1. scibot 02 Aug 2024
      12260

      DOI: 10.1016/j.jbc.2023.105619

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  87. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Direct interrogation of context-dependent GPCR activity with a universal biosensor platform
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  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transcription Factor SATB2 Regulates Skeletal Muscle Cell Proliferation and Migration via HDAC4 in Pigs
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  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TGFβ and Hippo Signaling Pathways Coordinate to Promote Acinar to Ductal Metaplasia in Human Pancreas
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      Addgene, Watertown, MA, USA, #12260

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  90. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Opa1 and Drp1 reciprocally regulate cristae morphology, ETC function, and NAD+ regeneration in KRas-mutant lung adenocarcinoma
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  91. www.embopress.org www.embopress.org
    A method for benchmarking genetic screens reveals a predominant mitochondrial bias
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  92. www.cell.com www.cell.com
    Membrane Damage during Ferroptosis Is Caused by Oxidation of Phospholipids Catalyzed by the Oxidoreductases POR and CYB5R1
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  93. journals.lww.com journals.lww.com
    Pan-cancer Genomic Analysis of AXL Mutations Reveals a... : The American Journal of Surgical Pathology
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  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Decoding RNA Metabolism by RNA-linked CRISPR Screening in Human Cells
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  95. www.biorxiv.org www.biorxiv.org
    Multi-species genome-wide CRISPR screens identify GPX4 as a conserved suppressor of cold-induced cell death
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  96. www.nature.com www.nature.com
    Deubiquitinase USP9x regulates the proline biosynthesis pathway in non-small cell lung cancer
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  97. Jul 2024
  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Initial Characterization of WDR5B Reveals a Role in the Proliferation of Retinal Pigment Epithelial Cells
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  99. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Glucocorticoid receptor controls atopic dermatitis inflammation via functional interactions with P63 and autocrine signaling in epidermal keratinocytes
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  100. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Modeling and therapeutic targeting of t(8;21) AML with/without TP53 deficiency
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  101. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  102. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  103. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ZNF397 Deficiency Triggers TET2-Driven Lineage Plasticity and AR-Targeted Therapy Resistance in Prostate Cancer
    2
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  104. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A genome-wide CRISPR/Cas9 screen identifies calreticulin as a selective repressor of ATF6α
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  105. www.biorxiv.org www.biorxiv.org
    Resistance of estrogen receptor function to BET bromodomain inhibition is mediated by transcriptional coactivator cooperativity
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  106. www.mdpi.com www.mdpi.com
    The Leukemic Isocitrate Dehydrogenase (IDH) 1/2 Mutations Impair Myeloid and Erythroid Cell Differentiation of Primary Human Hematopoietic Stem and Progenitor Cells (HSPCs)
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  107. www.sciencedirect.com www.sciencedirect.com
    On the role of p53 in the cellular response to aneuploidy
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  108. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DCAF16-Based Covalent Handle for the Rational Design of Monovalent Degraders
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  109. www.sciencedirect.com www.sciencedirect.com
    Polysome collapse and RNA condensation fluidize the cytoplasm
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  110. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    VHL loss enhances antitumor immunity by activating the anti-viral DNA-sensing pathway
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  111. www.sciencedirect.com www.sciencedirect.com
    Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer
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    Myeloid cells coordinately induce glioma cell-intrinsic and cell-extrinsic pathways for chemoresistance via GP130 signaling
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    IRF4 requires ARID1A to establish plasma cell identity in multiple myeloma
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  114. www.sciencedirect.com www.sciencedirect.com
    PELI2 is a negative regulator of STING signaling that is dynamically repressed during viral infection
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    Efficient, specific, and combinatorial control of endogenous exon splicing with dCasRx-RBM25
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    Renal protection after hemorrhagic shock in rats: Possible involvement of SUMOylation
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    Harnessing the CD44-targeted delivery of self-assembled hyaluronan nanogel to reverse the antagonism between Cisplatin and Gefitinib in NSCLC cancer therapy
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  118. www.sciencedirect.com www.sciencedirect.com
    pLxIS-containing domains are biochemically flexible regulators of interferons and metabolism
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  119. www.cell.com www.cell.com
    Genome-scale exon perturbation screens uncover exons critical for cell fitness
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  120. www.sciencedirect.com www.sciencedirect.com
    Translocational attenuation mediated by the PERK-SRP14 axis is a protective mechanism of unfolded protein response
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  121. www.sciencedirect.com www.sciencedirect.com
    BACH1 inhibits senescence, obesity, and short lifespan by ferroptotic FGF21 secretion
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  122. www.sciencedirect.com www.sciencedirect.com
    The centrosomal protein FGFR1OP controls myosin function in murine intestinal epithelial cells
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  123. www.cell.com www.cell.com
    The splicing factor CCAR1 regulates the Fanconi anemia/BRCA pathway
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  124. www.biorxiv.org www.biorxiv.org
    An Adipo-Pulmonary Axis Mediated by FABP4 Hormone Defines a Therapeutic Target Against Obesity-Induced Airway Disease
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  125. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hsp47 promotes biogenesis of multi-subunit neuroreceptors in the endoplasmic reticulum
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  126. www.sciencedirect.com www.sciencedirect.com
    Sterol-like drugs potentiate statin-triggered prostate cancer cell death by inhibiting SREBP2 nuclear translocation
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  127. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Protocol to identify defined reprogramming factor expression using a factor-indexing single-nuclei multiome sequencing approach
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  128. www.cell.com www.cell.com
    Regulation of the DLC3 tumor suppressor by a novel phosphoswitch
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  129. www.embopress.org www.embopress.org
    DUSP6 inhibition overcomes neuregulin/HER3-driven therapy tolerance in HER2+ breast cancer
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      plasmid_12260

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  130. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DUSP6 inhibition overcomes neuregulin/HER3-driven therapy tolerance in HER2+ breast cancer
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      plasmid_12260

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  131. www.nature.com www.nature.com
    CREB1 promotes expression of immune checkpoint HLA-E leading to immune escape in multiple myeloma
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  132. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Activation of Hippo Pathway Damages Slit Diaphragm by Deprivation of Ajuba Proteins
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      plasmid_12260

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  133. 52.53.155.43 52.53.155.43
    1-s2.0-S2211124724007770-mmc1-html.html
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  134. www.sciencedirect.com www.sciencedirect.com
    Mutation-induced LZTR1 polymerization provokes cardiac pathology in recessive Noonan syndrome
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  135. www.biorxiv.org www.biorxiv.org
    Co-option of mitochondrial nucleic acid sensing pathways by HSV-1 UL12.5 for reactivation from latent Infection
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    biorxiv.org/content/10.1101/2024.07.06.601241v2
  136. www.cell.com www.cell.com
    SART3 reads methylarginine-marked glycine- and arginine-rich motifs
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    cell.com/cell-reports/abstract/S2211-1247(24)00788-5
  137. www.biorxiv.org www.biorxiv.org
    BRAT1 - a new therapeutic target for glioblastoma
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    Acute BRCAness Induction and AR Signaling Blockage through CDK12/7/9 Degradation Enhances PARP Inhibitor Sensitivity in Prostate Cancer
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  139. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cross-species analysis of viral nucleic acid interacting proteins identifies TAOKs as innate immune regulators
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  140. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Alpha-defensin binding expands human adenovirus tropism
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  141. www.sciencedirect.com www.sciencedirect.com
    Synthetic lethal CRISPR screen identifies a cancer cell-intrinsic role of PD-L1 in regulation of vulnerability to ferroptosis
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  142. www.biorxiv.org www.biorxiv.org
    Regulation of cell–nanoparticle interactions through mechanobiology
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      Addgene #12260

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  143. www.cell.com www.cell.com
    Elevating PLK1 overcomes BETi resistance in prostate cancer via triggering BRD4 phosphorylation-dependent degradation in mitosis
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  144. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Plakophilin 4 controls the spatio-temporal activity of RhoA at adherens junctions to promote cortical actin ring formation and tissue tension
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      plasmid_12260

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  145. www.sciencedirect.com www.sciencedirect.com
    The hydrophobicity of the CARD8 N-terminus tunes inflammasome activation
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  146. www.cell.com www.cell.com
    A non-canonical role for a small nucleolar RNA in ribosome biogenesis and senescence
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    cell.com/cell/fulltext/S0092-8674(24)00693-7
  147. www.cell.com www.cell.com
    Crosstalk between epitranscriptomic and epigenomic modifications and its implication in human diseases
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      Plasmid_12260

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  148. 52.53.155.43 52.53.155.43
    ACKR3 Proximity Labeling Identifies Novel G protein- and β-arrestin-independent GPCR Interacting Proteins
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      RRID:Addgene_12260

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  149. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The two-faced role of RNA methyltransferase METTL3 on cellular response to cisplatin in head and neck squamous cell carcinoma in vitro model
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      Addgene_12260

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    ncbi.nlm.nih.gov/pmc/articles/PMC11223524/
  150. www.sciencedirect.com www.sciencedirect.com
    Local vascular Klotho mediates diabetes-induced atherosclerosis via ERK1/2 and PI3-kinase-dependent signaling pathways.
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      AddGene 12260

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  151. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Original research: IFNγ mediates the resistance of tumor cells to distinct NK cell subsets
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    ncbi.nlm.nih.gov/pmc/articles/PMC11218003/
  152. www.medrxiv.org www.medrxiv.org
    The MFN2 Q367H variant from a patient with late-onset distal myopathy reveals a novel pathomechanism connected to mtDNA-mediated inflammation
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    medrxiv.org/content/10.1101/2024.06.20.24309123v1
  153. www.biorxiv.org www.biorxiv.org
    Nuclear receptor E75/NR1D2 drives tumor malignant transformation by integrating Hippo and Notch pathways
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      RRID:Addgene_12260

      DOI: 10.1101/2024.06.27.600913

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    biorxiv.org/content/10.1101/2024.06.27.600913v1
  154. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    γ-secretase facilitates retromer-mediated retrograde transport
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      psPAX2

      DOI: 10.1101/2024.06.07.597932

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    ncbi.nlm.nih.gov/pmc/articles/PMC11185792/
  155. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Therapy-induced secretion of spliceosomal components mediates pro-survival crosstalk between ovarian cancer cells
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  156. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DUSP4 enhances therapeutic sensitivity in HER2-positive breast cancer by inhibiting the G6PD pathway and ROS metabolism by interacting with ALDOB
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      psPAX2

      DOI: 10.1016/j.tranon.2024.102016

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  157. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RNASeq highlights ATF6 pathway regulators for CHO cell engineering with different impacts of ATF6β and WFS1 knockdown on fed-batch production of IgG1
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      Addgene_12260

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  158. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Testis-specific serine kinase 6 (TSSK6) is abnormally expressed in colorectal cancer and promotes oncogenic behaviors
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      Plasmid_12260

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  159. Jun 2024
  160. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Metallothionein 3 Potentiates Pulmonary Artery Smooth Muscle Cell Proliferation by Promoting Zinc-MTF1-ATG5 Axis-mediated Autophagosome Formation
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    1. scibot 30 Jun 2024
      12260

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  161. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PCDH17 restricts dendritic spine morphogenesis by regulating ROCK2-dependent control of the actin cytoskeleton, modulating emotional behavior
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      12260

      DOI: 10.24272/j.issn.2095-8137.2024.055

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  162. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Widespread chromatin context-dependencies of DNA double-strand break repair proteins
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      12260

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  163. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SMAD4 depletion contributes to endocrine resistance by integrating ER and ERBB signaling in HR + HER2− breast cancer
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      12260

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  164. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cytoprotective Role of Autophagy in CDIP1 Expression-Induced Apoptosis in MCF-7 Breast Cancer Cells
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    1. scibot 30 Jun 2024
      12260

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  165. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transcription Factor-Mediated Generation of Dopaminergic Neurons from Human iPSCs—A Comparison of Methods
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  166. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Novel markers of MCL1 inhibitor sensitivity in triple-negative breast cancer cells
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      12260

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  167. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Declining Levels of Neutralizing Antibodies to SARS-CoV-2 Omicron Variants Are Enhanced by Hybrid Immunity and Original/Omicron Bivalent Vaccination
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    1. scibot 30 Jun 2024
      12260

      DOI: 10.3390/vaccines12060564

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  168. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Unique mRNA Vaccine Elicits Protective Efficacy against the SARS-CoV-2 Omicron Variant and SARS-CoV
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    1. scibot 30 Jun 2024
      PS-PAX2

      DOI: 10.3390/vaccines12060605

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  169. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    S2 Peptide-Conjugated SARS-CoV-2 Virus-like Particles Provide Broad Protection against SARS-CoV-2 Variants of Concern
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      12260

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  170. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting cancer-associated fibroblast autophagy renders pancreatic cancer eradicable with immunochemotherapy by inhibiting adaptive immune resistance
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      12,260

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  171. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Streptococcus pneumoniae extracellular vesicles aggravate alveolar epithelial barrier disruption via autophagic degradation of OCLN (occludin)
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      12,260

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  172. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Chemo‐small extracellular vesicles released in cisplatin‐resistance ovarian cancer cells are regulated by the lysosomal function
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    1. scibot 30 Jun 2024
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  173. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Somatic structural variants drive distinct modes of oncogenesis in melanoma
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    1. scibot 30 Jun 2024
      PAX2

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    ncbi.nlm.nih.gov/pmc/articles/PMC11213511/
  174. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Acetyl-NPKY of Integrin-beta 1 binds KINDLIN2 to control endothelial cell proliferation and junctional integrity.
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    1. scibot 30 Jun 2024
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      DOI: 10.1016/j.isci.2024.110129

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    ncbi.nlm.nih.gov/pmc/articles/PMC11187247/
  175. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Continuous evolution of compact protein degradation tags regulated by selective molecular glues
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    1. scibot 30 Jun 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11203266/
  176. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Use of FRET-Sensor ‘Mermaid’ to Detect Subtle Changes in Membrane Potential of Primary Mouse PASMCs
    1
    1. scibot 30 Jun 2024
      Plasmid_12260

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    ncbi.nlm.nih.gov/pmc/articles/PMC11202191/
  177. 52.53.155.43 52.53.155.43
    Modeling of Intracellular Taurine Levels Associated with Ovarian Cancer Reveals Activation of p53, ERK, mTOR and DNA-Damage-Sensing-Dependent Cell Protection
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    1. scibot 30 Jun 2024
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  178. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    METTL3-mediated chromatin contacts promote stress granule phase separation through metabolic reprogramming during senescence
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    1. scibot 30 Jun 2024
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  179. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tripartite Motif-Containing Protein 65 (TRIM65) Inhibits Hepatitis B Virus Transcription
    1
    1. scibot 30 Jun 2024
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  180. www.cell.com www.cell.com
    An HIV-1 CRISPR-Cas9 membrane trafficking screen reveals a role for PICALM intersecting endolysosomes and immunity
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    1. scibot 30 Jun 2024
      Plasmid_12260

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    cell.com/iscience/abstract/S2589-0042(24)01356-7
  181. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    1. scibot 28 Jun 2024
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13672
  182. onlinelibrary.wiley.com onlinelibrary.wiley.com
    A Novel AMPK Inhibitor Sensitizes Pancreatic Cancer Cells to Ferroptosis Induction
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    1. scibot 28 Jun 2024
      RRID:Addgene_12260

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    onlinelibrary.wiley.com/doi/10.1002/advs.202307695
  183. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The increase of long noncoding RNA Fendrr in hepatocytes contributes to liver fibrosis by promoting IL-6 production
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    1. scibot 25 Jun 2024
      psPAX2

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  184. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Direct reprogramming of fibroblasts into functional hepatocytes via CRISPRa activation of endogenous Gata4 and Foxa3
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    1. scibot 25 Jun 2024
      12260

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  185. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A highly effective ferritin-based divalent nanoparticle vaccine shields Syrian hamsters against lethal Nipah virus
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    1. scibot 25 Jun 2024
      Addgene_12260

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  186. www.biorxiv.org www.biorxiv.org
    Characterization of β-Hydroxybutyrate as a Cell Autonomous Fuel for Active Excitatory and Inhibitory Neurons
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    1. scibot 22 Jun 2024
      Addgene_12260

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    biorxiv.org/content/10.1101/2024.06.08.598077v1
  187. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibitors of dermatan sulfate epimerase 1 decreased accumulation of glycosaminoglycans in mucopolysaccharidosis type I fibroblasts
    1
    1. scibot 21 Jun 2024
      12260

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  188. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A genome-scale screen identifies sulfated glycosaminoglycans as pivotal in epithelial cell damage by Candida albicans
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      12260

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  189. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Absence of c-Maf and IL-10 enables Type I IFN enhancement of innate responses to low-dose LPS in alveolar macrophages
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    1. scibot 21 Jun 2024
      12260

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  190. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Crosstalk between Regnase-1 and -3 shapes mast cell survival and cytokine expression
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    1. scibot 21 Jun 2024
      12260

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  191. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Decreased Tiam1‐mediated Rac1 activation is responsible for impaired directional persistence of chondrocyte migration in microtia
    1
    1. scibot 21 Jun 2024
      psPAX2

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  192. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Engineered Self-Regulating Macrophages for Targeted Anti-inflammatory Drug Delivery
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      12260

      DOI: 10.21203/rs.3.rs-4385938/v1

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  193. www.sciencedirect.com www.sciencedirect.com
    Electron transport chain inhibition increases cellular dependence on purine transport and salvage
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    sciencedirect.com/science/article/pii/S1550413124001906
  194. www.sciencedirect.com www.sciencedirect.com
    TNF-NF-κB-p53 axis restricts in vivo survival of hPSC-derived dopamine neurons
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    1. scibot 21 Jun 2024
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    sciencedirect.com/science/article/pii/S0092867424005750
  195. www.sciencedirect.com www.sciencedirect.com
    MTFP1 controls mitochondrial fusion to regulate inner membrane quality control and maintain mtDNA levels
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    sciencedirect.com/science/article/pii/S0092867424005269
  196. www.sciencedirect.com www.sciencedirect.com
    An autoinhibitory switch of the LSD1 disordered region controls enhancer silencing
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    sciencedirect.com/science/article/pii/S1097276524004404
  197. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In Vivo Genome-Wide CRISPR Screening Identifies CITED2 as a Driver of Prostate Cancer Bone Metastasis
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    1. scibot 21 Jun 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11101692/
  198. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Daily glucocorticoids promote glioblastoma growth and circadian synchrony to the host
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      RRID:Addgene_12260

      DOI: 10.1101/2024.05.03.592418

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    ncbi.nlm.nih.gov/pmc/articles/PMC11100585/
  199. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Post-translation digital data encoding into the genomes of mammalian cell populations
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    1. scibot 21 Jun 2024
      Plasmid_12260

      DOI: 10.1101/2024.05.12.591851

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    ncbi.nlm.nih.gov/pmc/articles/PMC11100781/
  200. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PPIA dictates NRF2 stability to promote lung cancer progression
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    1. scibot 21 Jun 2024
      plasmid_12260

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    ncbi.nlm.nih.gov/pmc/articles/PMC11148020/
  201. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide CRISPR/Cas9 screen reveals JunB downmodulation of HIV co-receptor CXCR4
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    1. scibot 21 Jun 2024
      Addgene_12260

      DOI: 10.3389/fmicb.2024.1342444

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