706 Matching Annotations
  1. Nov 2022
  2. www.sciencedirect.com www.sciencedirect.com
    IL-17-induced dimerization of IL-17RA drives the formation of the IL-17 signalosome to potentiate signaling
    1
    1. scibot 05 Nov 2022
      plasmid_48138

      DOI: 10.1016/j.celrep.2022.111489

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    sciencedirect.com/science/article/pii/S2211124722013390
  3. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Docking of Syk to FcεRI is enhanced by Lyn but limited in duration by SHIP1
    1
    1. scibot 04 Nov 2022
      plasmid_48138

      DOI: 10.1091/mbc.E21-12-0603

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    ncbi.nlm.nih.gov/pmc/articles/PMC9582627/
  4. Oct 2022
  5. www.sciencedirect.com www.sciencedirect.com
    Circadian lncRNA ADIRF-AS1 binds PBAF and regulates renal clear cell tumorigenesis
    1
    1. scibot 20 Oct 2022
      plasmid_48138

      DOI: 10.1016/j.celrep.2022.111514

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    sciencedirect.com/science/article/pii/S221112472201364X
  6. academic.oup.com academic.oup.com
    Two type I topoisomerases maintain DNA topology in human mitochondria
    1
    1. scibot 15 Oct 2022
      RRID:Addgene_48138

      DOI: 10.1093/nar/gkac857

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    academic.oup.com/nar/advance-article/doi/10.1093/nar/gkac857/6754920
  7. www.sciencedirect.com www.sciencedirect.com
    Generation of a human embryonic stem cell line targeted homozygous deletion of BMP10 (WAe007-A-2) by CRISPR/Cas9-dgRNA
    1
    1. scibot 14 Oct 2022
      Addgene_48138

      DOI: 10.1016/j.scr.2022.102942

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    sciencedirect.com/science/article/pii/S1873506122002914
  8. www.nature.com www.nature.com
    Caldesmon controls stress fiber force-balance through dynamic cross-linking of myosin II and actin-tropomyosin filaments
    1
    1. scibot 14 Oct 2022
      plasmid_48138

      DOI: 10.1038/s41467-022-33688-w

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    nature.com/articles/s41467-022-33688-w
  9. www.sciencedirect.com www.sciencedirect.com
    Long-term potentiation reconstituted with an artificial TARP/PSD-95 complex
    1
    1. scibot 12 Oct 2022
      Addgene_48138

      DOI: 10.1016/j.celrep.2022.111483

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    sciencedirect.com/science/article/pii/S221112472201333X
  10. www.sciencedirect.com www.sciencedirect.com
    Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas
    1
    1. scibot 07 Oct 2022
      Cat#48138

      DOI: 10.1016/j.molcel.2022.09.007

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    sciencedirect.com/science/article/pii/S1097276522008966
  11. www.sciencedirect.com www.sciencedirect.com
    Two independent respiratory chains adapt OXPHOS performance to glycolytic switch
    1
    1. scibot 05 Oct 2022
      Addgene_48138

      DOI: 10.1016/j.cmet.2022.09.005

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    sciencedirect.com/science/article/pii/S1550413122003953
  12. Sep 2022
  13. www.embopress.org www.embopress.org
    Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair
    1
    1. scibot 29 Sep 2022
      plasmid_48138

      DOI: 10.15252/embr.202154136

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    embopress.org/doi/10.15252/embr.202154136
  14. www.sciencedirect.com www.sciencedirect.com
    Systems analysis of de novo mutations in congenital heart diseases identified a protein network in the hypoplastic left heart syndrome
    1
    1. scibot 27 Sep 2022
      plasmid_48138

      DOI: 10.1016/j.cels.2022.09.001

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    sciencedirect.com/science/article/pii/S2405471222003532
  15. www.sciencedirect.com www.sciencedirect.com
    Use of CRISPR/Cas9-edited HEK293 cells reveals that both conventional and novel protein kinase C isozymes are involved in mGlu5a receptor internalization
    1
    1. scibot 14 Sep 2022
      RRID:Addgene_48138

      DOI: 10.1016/j.jbc.2022.102466

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    sciencedirect.com/science/article/pii/S0021925822009097
  16. www.sciencedirect.com www.sciencedirect.com
    Sublethal cytochrome c release generates drug-tolerant persister cells
    1
    1. scibot 03 Sep 2022
      Addgene 48138

      DOI: 10.1016/j.cell.2022.07.025

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    sciencedirect.com/science/article/pii/S0092867422009783
  17. Aug 2022
  18. 52.53.155.43 52.53.155.43
    mcr-21-0058-html.html
    1
    1. scibot 27 Aug 2022
      RRID:Addgene_48138

      DOI: 10.1158/1541-7786.MCR-21-0058

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    52.53.155.43/b2945508dd72ea968b40713e7d1d3d2b4a0923f9/mcr-21-0058-html.html
  19. www.sciencedirect.com www.sciencedirect.com
    SOX transcription factors direct TCF-independent WNT/β-catenin responsive transcription to govern cell fate in human pluripotent stem cells
    1
    1. scibot 26 Aug 2022
      RRID:Addgene_48138

      DOI: 10.1016/j.celrep.2022.111247

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    sciencedirect.com/science/article/pii/S2211124722010658
  20. www.sciencedirect.com www.sciencedirect.com
    Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IκBα
    1
    1. scibot 25 Aug 2022
      Plasmid_48138

      DOI: 10.1016/j.cmet.2022.08.002

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    sciencedirect.com/science/article/pii/S155041312200345X
  21. www.sciencedirect.com www.sciencedirect.com
    Glycosphingolipids are mediators of cancer plasticity through independent signaling pathways
    1
    1. scibot 17 Aug 2022
      addgene_48138

      DOI: 10.1016/j.celrep.2022.111181

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    sciencedirect.com/science/article/pii/S2211124722009949
  22. www.sciencedirect.com www.sciencedirect.com
    Targeting the mRNA endonuclease CPSF73 inhibits breast cancer cell migration, invasion, and self-renewal
    1
    1. scibot 10 Aug 2022
      Plasmid_48138

      DOI: 10.1016/j.isci.2022.104804

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    sciencedirect.com/science/article/pii/S2589004222010768
  23. www.nature.com www.nature.com
    A multimodal iPSC platform for cystic fibrosis drug testing
    1
    1. scibot 02 Aug 2022
      RRID:Addgene_48138

      DOI: 10.1038/s41467-022-31854-8

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    nature.com/articles/s41467-022-31854-8
  24. Jul 2022
  25. www.sciencedirect.com www.sciencedirect.com
    Mapping subcellular localizations of unannotated microproteins and alternative proteins with MicroID
    1
    1. scibot 30 Jul 2022
      Plasmid_48138

      DOI: 10.1016/j.molcel.2022.06.035

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    sciencedirect.com/science/article/pii/S1097276522006530
  26. www.sciencedirect.com www.sciencedirect.com
    “Stripe” transcription factors provide accessibility to co-binding partners in mammalian genomes
    1
    1. scibot 27 Jul 2022
      Addgene_48138

      DOI: 10.1016/j.molcel.2022.06.029

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    sciencedirect.com/science/article/pii/S1097276522006128
  27. www.sciencedirect.com www.sciencedirect.com
    The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de novo nucleotide synthesis
    1
    1. scibot 02 Jul 2022
      Plasmid_48138

      DOI: 10.1016/j.molcel.2022.06.008

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    sciencedirect.com/science/article/pii/S1097276522005445
  28. Jun 2022
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Domain fusion TLR2-4 enhances the autophagy-dependent clearance of Staphylococcus aureus in the genetic engineering goat
    1
    1. scibot 30 Jun 2022
      RRID:Addgene_48138

      DOI: 10.7554/eLife.78044

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    ncbi.nlm.nih.gov/pmc/articles/PMC9239677/
  30. elifesciences.org elifesciences.org
    GSK3 inhibition rescues growth and telomere dysfunction in dyskeratosis congenita iPSC-derived type II alveolar epithelial cells
    1
    1. scibot 17 Jun 2022
      Addgene_48138

      DOI: 10.7554/eLife.64430

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    elifesciences.org/articles/64430
  31. www.sciencedirect.com www.sciencedirect.com
    Interplay between symmetric arginine dimethylation and ubiquitylation regulates TDP1 proteostasis for the repair of topoisomerase I-DNA adducts
    1
    1. scibot 15 Jun 2022
      AddgeneCat#48138

      DOI: 10.1016/j.celrep.2022.110940

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    sciencedirect.com/science/article/pii/S2211124722007227
  32. rupress.org rupress.org
    ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling
    1
    1. scibot 09 Jun 2022
      RRID:Addgene_48138

      DOI: 10.1083/jcb.202106046

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    rupress.org/jcb/article/221/7/e202106046/213259/ER-lysosome-lipid-transfer-protein-VPS13C-PARK23
  33. www.sciencedirect.com www.sciencedirect.com
    A TRIM66/DAX1/Dux axis suppresses the totipotent 2-cell-like state in murine embryonic stem cells
    2
    1. scibot 03 Jun 2022
      Addgene # 48138

      DOI: 10.1016/j.stem.2022.05.004

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    2. scibot 03 Jun 2022
      Addgene_48138

      DOI: 10.1016/j.stem.2022.05.004

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    sciencedirect.com/science/article/pii/S1934590922002041
  34. May 2022
  35. www.nature.com www.nature.com
    Gene-specific nonsense-mediated mRNA decay targeting for cystic fibrosis therapy
    1
    1. scibot 28 May 2022
      plasmid_48138

      DOI: 10.1038/s41467-022-30668-y

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    nature.com/articles/s41467-022-30668-y
  36. www.sciencedirect.com www.sciencedirect.com
    Lymph node colonization induces tumor-immune tolerance to promote distant metastasis
    1
    1. scibot 12 May 2022
      plasmid_48138

      DOI: 10.1016/j.cell.2022.04.019

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    sciencedirect.com/science/article/pii/S0092867422004664
  37. www.mdpi.com www.mdpi.com
    First Characterization of Human Dermal Fibroblasts Showing a Decreased Xylosyltransferase-I Expression Induced by the CRISPR/Cas9 System
    1
    1. scibot 10 May 2022
      RRID:Addgene_48138

      DOI: 10.3390/ijms23095045

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    mdpi.com/1422-0067/23/9/5045
  38. www.sciencedirect.com www.sciencedirect.com
    Generation of a MIR5004 knockout cell line from human induced Pluripotent Stem Cells by CRISPR/Cas9 gene editing
    1
    1. scibot 05 May 2022
      RRID:Addgene_48138

      DOI: 10.1016/j.scr.2022.102805

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    sciencedirect.com/science/article/pii/S1873506122001544
  39. www.sciencedirect.com www.sciencedirect.com
    The Mettl3 epitranscriptomic writer amplifies p53 stress responses
    1
    1. scibot 05 May 2022
      Plasmid_48138

      DOI: 10.1016/j.molcel.2022.04.010

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    sciencedirect.com/science/article/pii/S1097276522003215
  40. Apr 2022
  41. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Identification of a Crosstalk among TGR5, GLIS2, and TP53 Signaling Pathways in the Control of Undifferentiated Germ Cell Homeostasis and Chemoresistance
    1
    1. scibot 30 Apr 2022
      Plasmid_48138

      DOI: 10.1002/advs.202200626

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    onlinelibrary.wiley.com/doi/10.1002/advs.202200626
  42. academic.oup.com academic.oup.com
    A rationalized definition of general tumor suppressor microRNAs excludes miR-34a
    1
    1. scibot 30 Apr 2022
      RRID:Addgene_48138

      DOI: 10.1093/nar/gkac277

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    academic.oup.com/nar/advance-article/doi/10.1093/nar/gkac277/6574673
  43. www.sciencedirect.com www.sciencedirect.com
    The cargo adaptor protein CLINT1 is phosphorylated by the Numb-associated kinase BIKE and mediates dengue virus infection
    1
    1. scibot 29 Apr 2022
      plasmid_48138

      DOI: 10.1016/j.jbc.2022.101956

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    sciencedirect.com/science/article/pii/S0021925822003969
  44. www.sciencedirect.com www.sciencedirect.com
    RBPMS is an RNA-binding protein that mediates cardiomyocyte binucleation and cardiovascular development
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    1. scibot 28 Apr 2022
      RRID:Addgene_48138

      DOI: 10.1016/j.devcel.2022.03.017

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    sciencedirect.com/science/article/pii/S1534580722002118
  45. www.biorxiv.org www.biorxiv.org
    ANKLE1 cleaves mitochondrial DNA and contributes to cancer risk by driving the Warburg effect and apoptosis resistance
    1
    1. scibot 27 Apr 2022
      Plasmid_48138

      DOI: 10.1101/2021.10.27.466184

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    biorxiv.org/content/10.1101/2021.10.27.466184v1
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Plet1 is an epigenetically regulated cell surface protein that provides essential cues to direct trophoblast stem cell differentiation
    1
    1. scibot 13 Apr 2022
      Plasmid_48138

      DOI: 10.1038/srep25112

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    ncbi.nlm.nih.gov/pmc/articles/PMC4848516/
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    GFPT2/GFAT2 and AMDHD2 act in tandem to control the hexosamine pathway
    1
    1. scibot 02 Apr 2022
      RRID:Addgene_48138

      DOI: 10.7554/eLife.69223

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    ncbi.nlm.nih.gov/pmc/articles/PMC8970586/
  48. Mar 2022
  49. www.sciencedirect.com www.sciencedirect.com
    Genome-wide analysis of haploinsufficiency in human embryonic stem cells
    1
    1. scibot 30 Mar 2022
      Addgene Cat. # 48138

      DOI: 10.1016/j.celrep.2022.110573

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    sciencedirect.com/science/article/pii/S2211124722003175
  50. www.sciencedirect.com www.sciencedirect.com
    Rif1 and Hmgn3 regulate the conversion of murine trophoblast stem cells
    1
    1. scibot 30 Mar 2022
      Plasmid_48138

      DOI: 10.1016/j.celrep.2022.110570

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    sciencedirect.com/science/article/pii/S221112472200314X
  51. www.sciencedirect.com www.sciencedirect.com
    Parallel kinase pathways stimulate actin polymerization at depolarized mitochondria
    1
    1. scibot 26 Mar 2022
      plasmid_48138

      DOI: 10.1016/j.cub.2022.02.058

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  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR-Cas9-mediated induction of large chromosomal inversions in human bronchial epithelial cells
    1
    1. scibot 26 Mar 2022
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  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Insights From Long-term Follow-up of a Girl With Adrenal Insufficiency and Sphingosine-1-Phosphate Lyase Deficiency
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  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The E3 ligase TRIM1 ubiquitinates LRRK2 and controls its localization, degradation, and toxicity
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  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Applying Sodium Carbonate Extraction Mass Spectrometry to Investigate Defects in the Mitochondrial Respiratory Chain
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  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The m6A(m)-independent role of FTO in regulating WNT signaling pathways
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  57. www.sciencedirect.com www.sciencedirect.com
    A hotspot mutation targeting the R-RAS2 GTPase acts as a potent oncogenic driver in a wide spectrum of tumors
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  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of SHP-1 activity by PKC-θ regulates NK cell activation threshold and cytotoxicity
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  59. www.nature.com www.nature.com
    Rap1 prevents colitogenic Th17 cell expansion and facilitates Treg cell differentiation and distal TCR signaling
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  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A ciliopathy complex builds distal appendages to initiate ciliogenesis
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    A simple protocol to isolate a single human cell PRDX1 knockout generated by CRISPR-Cas9 system
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    Fumarate inhibits PTEN to promote tumorigenesis and therapeutic resistance of type2 papillary renal cell carcinoma
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  63. www.sciencedirect.com www.sciencedirect.com
    Diacylglycerol kinase η regulates cell proliferation and its levels are elevated by glucocorticoids in undifferentiated neuroblastoma cells
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    An HNF1α truncation associated with maturity-onset diabetes of the young impairs pancreatic progenitor differentiation by antagonizing HNF1β function
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  65. www.sciencedirect.com www.sciencedirect.com
    BMP gradient along the intestinal villus axis controls zonated enterocyte and goblet cell states
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  66. Feb 2022
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    Gene architecture directs splicing outcome in separate nuclear spatial regions
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  68. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    TP53 promotes lineage commitment of human embryonic stem cells through ciliogenesis and sonic hedgehog signaling
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  69. www.nature.com www.nature.com
    The BCL-2 family member BOK promotes KRAS-driven lung cancer progression in a p53-dependent manner
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  70. Jan 2022
  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Heparan Sulfate Proteoglycans (HSPGs) Serve as the Mediator Between Monomeric Tau and Its Subsequent Intracellular ERK1/2 Pathway Activation
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  72. link.springer.com link.springer.com
    Plasmolipin regulates basolateral-to-apical transcytosis of ICAM-1 and leukocyte adhesion in polarized hepatic epithelial cells
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  73. www.sciencedirect.com www.sciencedirect.com
    Robust genome editing in adult vascular endothelium by nanoparticle delivery of CRISPR-Cas9 plasmid DNA
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    sciencedirect.com/science/article/pii/S2211124721017009
  74. www.mdpi.com www.mdpi.com
    Disc Large Homolog 1 Is Critical for Early T Cell Receptor Micro Cluster Formation and Activation in Human T Cells
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      plasmid_183

      DOI: 10.3390/vaccines9121446

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  75. Dec 2021
  76. www.sciencedirect.com www.sciencedirect.com
    Dichotomous Effects of Cellular Expression of STAT3 on Tumor Growth of HNSCC
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  77. www.mdpi.com www.mdpi.com
    Disc Large Homolog 1 Is Critical for Early T Cell Receptor Micro Cluster Formation and Activation in Human T Cells
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  78. link.springer.com link.springer.com
    Loss of hexokinase 1 sensitizes ovarian cancer to high-dose metformin
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  79. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A novel live-cell imaging assay reveals regulation of endosome maturation
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  80. www.sciencedirect.com www.sciencedirect.com
    Anti-recombination function of MutSα restricts telomere extension by ALT-associated homology-directed repair
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    Jpx RNA regulates CTCF anchor site selection and formation of chromosome loops
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  82. academic.oup.com academic.oup.com
    Evidence for nutrient-dependent regulation of the COPII coat by O-GlcNAcylation
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      plasmid_48138

      DOI: 10.1093/glycob/cwab055

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    academic.oup.com/glycob/article/31/9/1102/6299516
  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dynamic Analysis of 4E-BP1 Phosphorylation in Neurons with Tsc2 or Depdc5 Knockout
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      DOI: 10.1016/j.expneurol.2020.113432

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  84. academic.oup.com academic.oup.com
    Detection of Neanderthal Adaptively Introgressed Genetic Variants that Modulate Reporter Gene Expression in Human Immune Cells
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      DOI: 10.1093/molbev/msab304

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    academic.oup.com/mbe/advance-article/doi/10.1093/molbev/msab304/6400258
  85. Nov 2021
  86. www.sciencedirect.com www.sciencedirect.com
    Generation of auxin inducible degron (AID) knock-in cell lines for targeted protein degradation in mammalian cells
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  87. www.sciencedirect.com www.sciencedirect.com
    A recurrent chromosomal inversion suffices for driving escape from oncogene-induced senescence via subTAD reorganization
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  88. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13115
  89. www.sciencedirect.com www.sciencedirect.com
    Gene regulatory networks controlling temporal patterning, neurogenesis, and cell-fate specification in mammalian retina
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  90. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    New Hybrid Compounds Combining Fragments of Usnic Acid and Thioether Are Inhibitors of Human Enzymes TDP1, TDP2 and PARP1
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      DOI: 10.3390/ijms222111336

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  91. www.sciencedirect.com www.sciencedirect.com
    Distinct regulation of tonic GABAergic inhibition by NMDA receptor subtypes
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      Cat# 48138

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  92. www.sciencedirect.com www.sciencedirect.com
    Mitochondrial respiration restricts Listeria monocytogenes infection by slowing down host cell receptor recycling
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      plasmid_48138

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  93. link.springer.com link.springer.com
    Loss of SORCS2 is Associated with Neuronal DNA Double-Strand Breaks
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      RRID:Addgene_48138

      DOI: 10.1007/s10571-021-01163-7

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  94. www.sciencedirect.com www.sciencedirect.com
    Crystal structure of the Tspan15 LEL domain reveals a conserved ADAM10 binding site
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      Addgene Cat # 48138

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  95. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy
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      DOI: 10.7554/eLife.65759

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    ncbi.nlm.nih.gov/pmc/articles/PMC8550759/
  96. Oct 2021
  97. www.sciencedirect.com www.sciencedirect.com
    A bipartite element with allele-specific functions safeguards DNA methylation imprints at the Dlk1-Dio3 locus
    1
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      Plasmid_48138

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  98. www.sciencedirect.com www.sciencedirect.com
    Loss of FBXO31-mediated degradation of DUSP6 dysregulates ERK and PI3K-AKT signaling and promotes prostate tumorigenesis
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      Cat. No. 48138

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    Syndromic RNA Polymerase II insufficiency: Generation of a human induced pluripotent stem cell line (UUIGPi002A-5) with a heterozygous disruption of POLR2A
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    MultiEditR: The first tool for detection and quantification of multiple RNA editing sites from Sanger sequencing demonstrates comparable fidelity to RNA-seq
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    Mechanism of noncoding RNA-associated N6-methyladenosine recognition by an RNA processing complex during IgH DNA recombination
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    Sequential inverse dysregulation of the RNA helicases DDX3X and DDX3Y facilitates MYC-driven lymphomagenesis
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    Formation of Lipofuscin-Like Autofluorescent Granules in the Retinal Pigment Epithelium Requires Lysosome Dysfunction
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    Overlapping roles of JIP3 and JIP4 in promoting axonal transport of lysosomes in human iPSC-derived neurons
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    Integration of T helper and BCR signals governs enhanced plasma cell differentiation of memory B cells by regulation of CD45 phosphatase activity
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    The ALPK1 pathway drives the inflammatory response to Campylobacter jejuni in human intestinal epithelial cells
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    Overlapping Role of SCYL1 and SCYL3 in Maintaining Motor Neuron Viability
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    Generation of GLA-Knockout Human Embryonic Stem Cell Lines to Model Autophagic Dysfunction and Exosome Secretion in Fabry Disease-Associated Hypertrophic Cardiomyopathy
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    In vivo proximity proteomics of nascent synapses reveals a novel regulator of cytoskeleton-mediated synaptic maturation.
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    A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family
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    ASCL1 Reorganizes Chromatin to Direct Neuronal Fate and Suppress Tumorigenicity of Glioblastoma Stem Cells
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    Exosome RNA Unshielding Couples Stromal Activation to Pattern Recognition Receptor Signaling in Cancer
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    Exosome-mediated delivery of CRISPR/Cas9 for targeting of oncogenic KrasG12D in pancreatic cancer
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    Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD
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    The E3 ubiquitin ligase RNF10 modifies 40S ribosomal subunits of ribosomes compromised in translation
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    Innate immune response orchestrates phosphoribosyl pyrophosphate synthetases to support DNA repair
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    Disruption of Coronin 1 Signaling in T Cells Promotes Allograft Tolerance while Maintaining Anti-Pathogen Immunity
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  141. elifesciences.org elifesciences.org
    Identification of TMEM206 proteins as pore of PAORAC/ASOR acid-sensitive chloride channels
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    CRISPR-READI: Efficient Generation of Knockin Mice by CRISPR RNP Electroporation and AAV Donor Infection
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  143. Jul 2021
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    The TIA1 RNA-Binding Protein Family Regulates EIF2AK2-Mediated Stress Response and Cell Cycle Progression
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      DOI: 10.1371/journal.ppat.1007694

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    journals.plos.org/plospathogens/article
  146. www.sciencedirect.com www.sciencedirect.com
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    1. scibot 31 Jul 2021
      plasmid_48138

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    sciencedirect.com/science/article/pii/S2211124719301044
  147. www.sciencedirect.com www.sciencedirect.com
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      RRID:Addgene_48138

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    sciencedirect.com/science/article/pii/S2211124719300610
  148. www.sciencedirect.com www.sciencedirect.com
    Structural Basis of Teneurin-Latrophilin Interaction in Repulsive Guidance of Migrating Neurons
    1
    1. scibot 30 Jul 2021
      RRID:Addgene_48138

      DOI: 10.1016/j.cell.2019.12.014

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    sciencedirect.com/science/article/pii/S0092867419313765
  149. www.sciencedirect.com www.sciencedirect.com
    Dectin-1 Binding to Annexins on Apoptotic Cells Induces Peripheral Immune Tolerance via NADPH Oxidase-2
    1
    1. scibot 30 Jul 2021
      Addgene_48138

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    sciencedirect.com/science/article/pii/S2211124719315773
  150. www.sciencedirect.com www.sciencedirect.com
    Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR
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    1. scibot 30 Jul 2021
      plasmid_48138

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  151. www.sciencedirect.com www.sciencedirect.com
    Translational Control through Differential Ribosome Pausing during Amino Acid Limitation in Mammalian Cells
    1
    1. scibot 30 Jul 2021
      Addgene_48138

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    sciencedirect.com/science/article/pii/S1097276518305161
  152. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Are Small Nucleolar RNAs “CRISPRable”? A Report on Box C/D Small Nucleolar RNA Editing in Human Cells
    1
    1. scibot 29 Jul 2021
      Addgene, #48138

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    ncbi.nlm.nih.gov/pmc/articles/PMC6856654/
  153. mcr.aacrjournals.org mcr.aacrjournals.org
    Intron 1-Mediated Regulation of EGFR Expression In EGFR-Dependent Malignancies is Mediated by AP-1 and BET Proteins
    1
    1. scibot 29 Jul 2021
      Addgene, plasmid #48138

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    mcr.aacrjournals.org/content/17/11/2208
  154. www.sciencedirect.com www.sciencedirect.com
    The Leukemogenic TCF3-HLF Complex Rewires Enhancers Driving Cellular Identity and Self-Renewal Conferring EP300 Vulnerability
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      Addgene: Cat#48138

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    sciencedirect.com/science/article/pii/S1535610819304787
  155. link.springer.com link.springer.com
    Restore natural fertility of <Emphasis Type="Italic">Kit</Emphasis><Superscript><Emphasis Type="Italic">w</Emphasis></Superscript><Emphasis Type="Italic">/Kit</Emphasis><Superscript><Emphasis Type="Italic">wv</Emphasis></Superscript> mouse with nonobstructive azoospermia through gene editing on SSCs mediated by CRISPR-Cas9
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      Addgene plasmid 48138

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  156. www.sciencedirect.com www.sciencedirect.com
    A Pliable Mediator Acts as a Functional Rather Than an Architectural Bridge between Promoters and Enhancers
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      Addgene, 48138

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    sciencedirect.com/science/article/pii/S0092867419307767
  157. bmcbiol.biomedcentral.com bmcbiol.biomedcentral.com
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    bmcbiol.biomedcentral.com/articles/10.1186/s12915-017-0453-8
  158. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Lamina-Associated Domain Border Governs Nuclear Lamina Interactions, Transcription, and Recombination of the Tcrb Locus
    1
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      plasmid_48138

      DOI: 10.1016/j.celrep.2018.10.052

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    ncbi.nlm.nih.gov/pmc/articles/PMC6287930/
  159. www.sciencedirect.com www.sciencedirect.com
    A Dock-and-Lock Mechanism Clusters ADAM10 at Cell-Cell Junctions to Promote α-Toxin Cytotoxicity
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    1. scibot 27 Jul 2021
      48138

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    sciencedirect.com/science/article/pii/S2211124718316929
  160. www.cell.com www.cell.com
    Transcription-mediated supercoiling regulates genome folding and loop formation
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      RRID:Addgene_48138

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    cell.com/molecular-cell/fulltext/S1097-2765(21)00456-1
  161. www.sciencedirect.com www.sciencedirect.com
    Targeted protein degradation reveals a direct role of SPT6 in RNAPII elongation and termination
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      Addgene_48138

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  162. www.mdpi.com www.mdpi.com
    New Hybrid Compounds Combining Fragments of Usnic Acid and Monoterpenoids for Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibition
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    1. scibot 09 Jul 2021
      RRID:Addgene_48138

      DOI: 10.3390/biom11070973

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  163. www.sciencedirect.com www.sciencedirect.com
    The RAS GTPase RIT1 compromises mitotic fidelity through spindle assembly checkpoint suppression
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    1. scibot 09 Jul 2021
      plasmid_48138

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    sciencedirect.com/science/article/pii/S0960982221008253
  164. elifesciences.org elifesciences.org
    BAP1/ASXL complex modulation regulates epithelial-mesenchymal transition during trophoblast differentiation and invasion
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      RRID:Addgene_48138

      DOI: 10.7554/eLife.63254

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    elifesciences.org/articles/63254
  165. www.sciencedirect.com www.sciencedirect.com
    Derivation of induced pluripotent stem cells line (RCPCMi007-A-1) with inactivation of the beta-2-microblogulin gene by CRISPR/Cas9 genome editing
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    1. scibot 01 Jul 2021
      RRID:Addgene_48138

      DOI: 10.1016/j.scr.2021.102451

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    sciencedirect.com/science/article/pii/S1873506121002981
  166. Jun 2021
  167. www.sciencedirect.com www.sciencedirect.com
    Revealing molecular pathways for cancer cell fitness through a genetic screen of the cancer translatome
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    1. scibot 30 Jun 2021
      Addgene_48138

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    sciencedirect.com/science/article/pii/S2211124721006975
  168. www.sciencedirect.com www.sciencedirect.com
    BAP1 enhances Polycomb repression by counteracting widespread H2AK119ub1 deposition and chromatin condensation
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    1. scibot 30 Jun 2021
      plasmid_48138

      DOI: 10.1016/j.molcel.2021.06.020

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    sciencedirect.com/science/article/pii/S1097276521005001
  169. www.embopress.org www.embopress.org
    Cysteamine–bicalutamide combination therapy corrects proximal tubule phenotype in cystinosis
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      Addgene_48138

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    embopress.org/doi/full/10.15252/emmm.202013067
  170. link.springer.com link.springer.com
    Validating TDP1 as an Inhibition Target for the Development of Chemosensitizers for Camptothecin-Based Chemotherapy Drugs
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      RRID:Addgene_48138

      DOI: 10.1007/s40487-021-00158-0

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  171. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HNRNP A1 Promotes Lung Cancer Cell Proliferation by Modulating VRK1 Translation
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    1. scibot 17 Jun 2021
      RRID:Addgene_48138

      DOI: 10.3390/ijms22115506

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    ncbi.nlm.nih.gov/pmc/articles/PMC8197126/
  172. www.cell.com www.cell.com
    STAG2 loss rewires oncogenic and developmental programs to promote metastasis in Ewing sarcoma
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      RRID:Addgene_48138

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    cell.com/cancer-cell/fulltext/S1535-6108(21)00273-7
  173. www.sciencedirect.com www.sciencedirect.com
    A role for the Cockayne Syndrome B (CSB)-Elongin ubiquitin ligase complex in signal-dependent RNA polymerase II transcription
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      DOI: 10.1016/j.jbc.2021.100862

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    sciencedirect.com/science/article/pii/S0021925821006621
  174. elifesciences.org elifesciences.org
    Wnt- and glutamate-receptors orchestrate stem cell dynamics and asymmetric cell division
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    1. scibot 11 Jun 2021
      RRID:Addgene_48138

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    elifesciences.org/articles/59791
  175. elifesciences.org elifesciences.org
    Distinct expression requirements and rescue strategies for BEST1 loss- and gain-of-function mutations
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    1. scibot 05 Jun 2021
      RRID :Addgene_48138

      DOI: 10.7554/eLife.67622

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    elifesciences.org/articles/67622
  176. elifesciences.org elifesciences.org
    PHAROH lncRNA regulates Myc translation in hepatocellular carcinoma via sequestering TIAR
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    elifesciences.org/articles/68263
  177. www.sciencedirect.com www.sciencedirect.com
    Choline kinase alpha 2 acts as a protein kinase to promote lipolysis of lipid droplets
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    1. scibot 02 Jun 2021
      Plasmid_48138

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    sciencedirect.com/science/article/pii/S1097276521003622
  178. May 2021
  179. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SAM homeostasis is regulated by CFIm-mediated splicing of MAT2A
    1
    1. scibot 27 May 2021
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    ncbi.nlm.nih.gov/pmc/articles/PMC8139829/
  180. www.sciencedirect.com www.sciencedirect.com
    Adhesion-mediated mechanosignaling forces mitohormesis
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    1. scibot 21 May 2021
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  181. www.sciencedirect.com www.sciencedirect.com
    Transcriptional co-activator regulates melanocyte differentiation and oncogenesis by integrating cAMP and MAPK/ERK pathways
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    1. scibot 19 May 2021
      plasmid_48138

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  182. link.springer.com link.springer.com
    An Intronic Variant of CHD7 Identified in Autism Patients Interferes with Neuronal Differentiation and Development
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      Addgene_48138

      DOI: 10.1007/s12264-021-00685-w

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  183. www.sciencedirect.com www.sciencedirect.com
    Chromatin accessibility governs the differential response of cancer and T cells to arginine starvation
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      RRID:Addgene_48138

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  184. www.nature.com www.nature.com
    Multiple interactions of the oncoprotein transcription factor MYC with the SWI/SNF chromatin remodeler
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    1. scibot 10 May 2021
      RRID:Addgene_48138

      DOI: 10.1038/s41388-021-01804-7

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    nature.com/articles/s41388-021-01804-7
  185. www.sciencedirect.com www.sciencedirect.com
    ATG4 family proteins drive phagophore growth independently of the LC3/GABARAP lipidation system
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    1. scibot 08 May 2021
      plasmid_48138

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    sciencedirect.com/science/article/pii/S1097276521001696
  186. www.sciencedirect.com www.sciencedirect.com
    Paradoxical Mitophagy Regulation by PINK1 and TUFm
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    1. scibot 07 May 2021
      Addgene_48138

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  187. www.sciencedirect.com www.sciencedirect.com
    GIGYF2 and 4EHP Inhibit Translation Initiation of Defective Messenger RNAs to Assist Ribosome-Associated Quality Control
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    1. scibot 07 May 2021
      plasmid_48138

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    sciencedirect.com/science/article/pii/S1097276520304731
  188. www.sciencedirect.com www.sciencedirect.com
    ERK2 Phosphorylates PFAS to Mediate Posttranslational Control of De Novo Purine Synthesis
    1
    1. scibot 07 May 2021
      Plasmid_48138

      DOI: 10.1016/j.molcel.2020.05.001

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  189. www.sciencedirect.com www.sciencedirect.com
    SH3BP4 promotes neuropilin-1 and α5-integrin endocytosis and is inhibited by Akt
    1
    1. scibot 06 May 2021
      Addgene_48138

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    sciencedirect.com/science/article/pii/S1534580721002069
  190. www.sciencedirect.com www.sciencedirect.com
    Cell-Cycle-Dependent ERK Signaling Dynamics Direct Fate Specification in the Mammalian Preimplantation Embryo
    2
    1. scibot 05 May 2021
      Addgene Repository #48138

      DOI: 10.1016/j.devcel.2020.09.013

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      plasmid_48138

      DOI: 10.1016/j.devcel.2020.09.013

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    sciencedirect.com/science/article/pii/S1534580720307152
  191. www.sciencedirect.com www.sciencedirect.com
    Inositol Polyphosphate Multikinase Inhibits Liquid-Liquid Phase Separation of TFEB to Negatively Regulate Autophagy Activity
    1
    1. scibot 05 May 2021
      Plasmid_48138

      DOI: 10.1016/j.devcel.2020.10.010

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    sciencedirect.com/science/article/pii/S1534580720308005
  192. www.sciencedirect.com www.sciencedirect.com
    A Membrane-Tethered Ubiquitination Pathway Regulates Hedgehog Signaling and Heart Development
    1
    1. scibot 05 May 2021
      Addgene_48138

      DOI: 10.1016/j.devcel.2020.08.012

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    sciencedirect.com/science/article/pii/S1534580720306705
  193. www.sciencedirect.com www.sciencedirect.com
    Endogenous Retrovirus-Derived lncRNA BANCR Promotes Cardiomyocyte Migration in Humans and Non-human Primates
    1
    1. scibot 05 May 2021
      Addgene_48138

      DOI: 10.1016/j.devcel.2020.07.006

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    sciencedirect.com/science/article/pii/S1534580720305803
  194. www.sciencedirect.com www.sciencedirect.com
    Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth
    1
    1. scibot 01 May 2021
      plasmid_48138

      DOI: 10.1016/j.cmet.2021.02.001

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    sciencedirect.com/science/article/pii/S1550413121000577
  195. Apr 2021
  196. www.sciencedirect.com www.sciencedirect.com
    Convergence of mammalian RQC and C-end rule proteolytic pathways via alanine tailing
    1
    1. scibot 28 Apr 2021
      plasmid_48138

      DOI: 10.1016/j.molcel.2021.03.004

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    sciencedirect.com/science/article/pii/S1097276521001726
  197. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cross-Comparison of Human iPSC Motor Neuron Models of Familial and Sporadic ALS Reveals Early and Convergent Transcriptomic Disease Signatures
    1
    1. scibot 27 Apr 2021
      RRID:Addgene_48138

      DOI: 10.1016/j.cels.2020.10.010

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    ncbi.nlm.nih.gov/pmc/articles/PMC7897311/
  198. www.sciencedirect.com www.sciencedirect.com
    iPSC modeling of stage-specific leukemogenesis reveals BAALC as a key oncogene in severe congenital neutropenia
    1
    1. scibot 24 Apr 2021
      Plasmid_48138

      DOI: 10.1016/j.stem.2021.03.023

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    sciencedirect.com/science/article/pii/S1934590921001569
  199. www.sciencedirect.com www.sciencedirect.com
    Generation of disease-specific and CRISPR/Cas9-mediated gene-corrected iPS cells from a patient with adult progeria Werner syndrome
    1
    1. scibot 24 Apr 2021
      plasmid_48138

      DOI: 10.1016/j.scr.2021.102360

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    sciencedirect.com/science/article/pii/S1873506121002063
  200. www.sciencedirect.com www.sciencedirect.com
    Generation of a FTO gene knockout human embryonic stem cell line using CRISPR/Cas9 editing
    1
    1. scibot 23 Apr 2021
      48138, Addgene

      DOI: 10.1016/j.scr.2021.102362

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    sciencedirect.com/science/article/pii/S1873506121002087
  201. www.sciencedirect.com www.sciencedirect.com
    High-Resolution mRNA and Secretome Atlas of Human Enteroendocrine Cells
    1
    1. scibot 23 Apr 2021
      plasmid_48138

      DOI: 10.1016/j.cell.2020.04.036

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    sciencedirect.com/science/article/pii/S0092867420305018
  202. www.sciencedirect.com www.sciencedirect.com
    MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway
    1
    1. scibot 22 Apr 2021
      Plasmid Cat #48138

      DOI: 10.1016/j.ccell.2020.11.004

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    sciencedirect.com/science/article/pii/S1535610820305961
  203. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Elevated CXorf67 Expression in PFA Ependymomas Suppresses DNA Repair and Sensitizes to PARP Inhibitors
    1
    1. scibot 22 Apr 2021
      RRID:Addgene_48138

      DOI: 10.1016/j.ccell.2020.10.009

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    ncbi.nlm.nih.gov/pmc/articles/PMC8455074/
  204. www.nature.com www.nature.com
    CRL4 AMBRA1 is a master regulator of D-type cyclins
    1
    1. scibot 22 Apr 2021
      plasmid_48138

      DOI: 10.1038/s41586-021-03445-y

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    nature.com/articles/s41586-021-03445-y
  205. www.cell.com www.cell.com
    IL6/STAT3 Signaling Hijacks Estrogen Receptor α Enhancers to Drive Breast Cancer Metastasis
    1
    1. scibot 20 Apr 2021
      Addgene_48138

      DOI: 10.1016/j.ccell.2020.06.007

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    cell.com/cancer-cell/fulltext/S1535-6108(20)30311-1
  206. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The deubiquitinase Usp9x regulates PRC2-mediated chromatin reprogramming during mouse development
    1
    1. scibot 20 Apr 2021
      RRID:Addgene_48138

      DOI: 10.1038/s41467-021-21910-0

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    ncbi.nlm.nih.gov/pmc/articles/PMC7994559/
  207. www.sciencedirect.com www.sciencedirect.com
    Tau aggregates are RNA-protein assemblies that mislocalize multiple nuclear speckle components
    1
    1. scibot 13 Apr 2021
      RRID:Addgene_48138

      DOI: 10.1016/j.neuron.2021.03.026

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    sciencedirect.com/science/article/pii/S0896627321001963
  208. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Evaluation of AXIN1 and AXIN2 as targets of tankyrase inhibition in hepatocellular carcinoma cell lines
    1
    1. scibot 10 Apr 2021
      plasmid_48138

      DOI: 10.1038/s41598-021-87091-4

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    ncbi.nlm.nih.gov/pmc/articles/PMC8018973/
  209. www.sciencedirect.com www.sciencedirect.com
    mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis
    1
    1. scibot 02 Apr 2021
      Plasmid_48138

      DOI: 10.1016/j.molcel.2021.03.009

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    sciencedirect.com/science/article/pii/S1097276521001775
  210. Mar 2021
  211. www.sciencedirect.com www.sciencedirect.com
    An early cell shape transition drives evolutionary expansion of the human forebrain
    1
    1. scibot 26 Mar 2021
      RRID:Addgene_48138

      DOI: 10.1016/j.cell.2021.02.050

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    sciencedirect.com/science/article/pii/S0092867421002397
  212. link.springer.com link.springer.com
    Deletion of the XIST promoter from the human inactive X chromosome compromises polycomb heterochromatin maintenance
    1
    1. scibot 26 Mar 2021
      RRID:Addgene_48138

      DOI: 10.1007/s00412-021-00754-z

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    link.springer.com/article/10.1007/s00412-021-00754-z
  213. elifesciences.org elifesciences.org
    TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation
    1
    1. scibot 20 Mar 2021
      plasmid_48138

      DOI: 10.7554/eLife.62873

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    elifesciences.org/articles/62873
  214. www.sciencedirect.com www.sciencedirect.com
    A genome-wide CRISPR screen identifies UFMylation and TRAMP-like complexes as host factors required for hepatitis A virus infection
    1
    1. scibot 17 Mar 2021
      Plasmid_48138

      DOI: 10.1016/j.celrep.2021.108859

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    sciencedirect.com/science/article/pii/S221112472100173X
  215. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Reversal of the Inflammatory Responses in Fabry Patient iPSC-Derived Cardiovascular Endothelial Cells by CRISPR/Cas9-Corrected Mutation
    1
    1. scibot 17 Mar 2021
      RRID:Addgene_48138

      DOI: 10.3390/ijms22052381

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    ncbi.nlm.nih.gov/pmc/articles/PMC7956852/
  216. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrative identification of the pathogenic role of a novel G6PD missense mutation c.697G>C
    1
    1. scibot 13 Mar 2021
      RRID:Addgene_48138

      DOI: 10.21037/atm-20-3941

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    ncbi.nlm.nih.gov/pmc/articles/PMC7940930/
  217. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    LAP2alpha maintains a mobile and low assembly state of A-type lamins in the nuclear interior
    1
    1. scibot 13 Mar 2021
      RRID:Addgene_48138

      DOI: 10.7554/eLife.63476

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    ncbi.nlm.nih.gov/pmc/articles/PMC7939549/
  218. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Follistatin is a novel therapeutic target and biomarker in FLT3/ITD acute myeloid leukemia
    1
    1. scibot 09 Mar 2021
      Addgene_48138

      DOI: 10.15252/emmm.201910895

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    ncbi.nlm.nih.gov/pmc/articles/PMC7136967/
  219. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NAD+ enhances ribitol and ribose rescue of α-dystroglycan functional glycosylation in human FKRP-mutant myotubes
    1
    1. scibot 09 Mar 2021
      plasmid_48138

      DOI: 10.7554/eLife.65443

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    ncbi.nlm.nih.gov/pmc/articles/PMC7924940/