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  1. May 2023
  2. www.mdpi.com www.mdpi.com
    Comparative Analysis of Six IRF Family Members in Alveolar Epithelial Cell-Intrinsic Antiviral Responses
    1
    1. scibot 06 May 2023
      52961

      DOI: 10.3390/cells10102600

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    mdpi.com/2073-4409/10/10/2600/htm
  3. www.nature.com www.nature.com
    Methionine consumption by cancer cells drives a progressive upregulation of PD-1 expression in CD4 T cells
    2
    1. scibot 06 May 2023
      plasmid_52961

      DOI: 10.1038/s41467-023-38316-9

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    2. scibot 06 May 2023
      RRID:Addgene_5296153

      DOI: 10.1038/s41467-023-38316-9

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    nature.com/articles/s41467-023-38316-9
  4. www.sciencedirect.com www.sciencedirect.com
    Stress-induced perturbations in intracellular amino acids reprogram mRNA translation in osmoadaptation independently of the ISR
    1
    1. scibot 05 May 2023
      Plasmid_52961

      DOI: 10.1016/j.celrep.2022.111092

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    sciencedirect.com/science/article/pii/S2211124722008944
  5. journals.asm.org journals.asm.org
    Membrane-Tethered Mucin 1 Is Stimulated by Interferon and Virus Infection in Multiple Cell Types and Inhibits Influenza A Virus Infection in Human Airway Epithelium
    1
    1. scibot 05 May 2023
      RRID:Addgene_52961

      DOI: 10.1128/mbio.01055-22

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    journals.asm.org/doi/10.1128/mbio.01055-22
  6. www.mdpi.com www.mdpi.com
    Neuropilin-1 Knockout and Rescue Confirms Its Role to Promote Metastasis in MDA-MB-231 Breast Cancer Cells
    1
    1. scibot 04 May 2023
      plasmid_52961

      DOI: 10.3390/ijms24097792

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    mdpi.com/1422-0067/24/9/7792
  7. journals.asm.org journals.asm.org
    Interplay between Furin and Sialoglycans in Modulating Adeno-Associated Viral Cell Entry
    1
    1. scibot 04 May 2023
      RRID:Addgene_52961

      DOI: 10.1128/jvi.00093-23

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    journals.asm.org/doi/10.1128/jvi.00093-23
  8. Apr 2023
  9. www.nature.com www.nature.com
    Development of anti-feline PD-1 antibody and its functional analysis
    1
    1. scibot 25 Apr 2023
      RRID:Addgene_52961

      DOI: 10.1038/s41598-023-31543-6

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    nature.com/articles/s41598-023-31543-6
  10. aacrjournals.org aacrjournals.org
    Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity
    1
    1. scibot 21 Apr 2023
      RRID:Addgene_52961

      DOI: 10.1158/2326-6066.CIR-22-0056

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    aacrjournals.org/cancerimmunolres/article/11/3/381/716712/Cancer-Cell-Resistance-to-IFN-Can-Occur-via
  11. www.sciencedirect.com www.sciencedirect.com
    A genome-wide CRISPR screen maps endogenous regulators of PPARG gene expression in bladder cancer
    1
    1. scibot 21 Apr 2023
      Addgene_52961

      DOI: 10.1016/j.isci.2023.106525

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    sciencedirect.com/science/article/pii/S2589004223006028
  12. www.sciencedirect.com www.sciencedirect.com
    VMP1 affects endoplasmic reticulum stress sensitivity via differential modulation of the three unfolded protein response arms
    1
    1. scibot 20 Apr 2023
      plasmid_52961

      DOI: 10.1016/j.celrep.2023.112209

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    sciencedirect.com/science/article/pii/S2211124723002206
  13. www.biorxiv.org www.biorxiv.org
    Distinct roles of Bdnf I and Bdnf IV transcript variant expression in hippocampal neurons
    1
    1. scibot 20 Apr 2023
      Addgene_52961

      DOI: 10.1101/2023.04.05.535694

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    biorxiv.org/content/10.1101/2023.04.05.535694v1
  14. www.sciencedirect.com www.sciencedirect.com
    Targeting the mevalonate pathway suppresses ARID1A-inactivated cancers by promoting pyroptosis
    1
    1. scibot 19 Apr 2023
      RRID:Addgene_52961

      DOI: 10.1016/j.ccell.2023.03.002

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    sciencedirect.com/science/article/pii/S1535610823000508
  15. www.nature.com www.nature.com
    Ether phospholipids are required for mitochondrial reactive oxygen species homeostasis
    1
    1. scibot 18 Apr 2023
      Plasmid_52961

      DOI: 10.1038/s41467-023-37924-9

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    nature.com/articles/s41467-023-37924-9
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR-suppressor scanning for systematic discovery of drug resistance mutations
    1
    1. scibot 12 Apr 2023
      Addgene_52961

      DOI: 10.1002/cpz1.614

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    ncbi.nlm.nih.gov/pmc/articles/PMC10073897/
  17. www.sciencedirect.com www.sciencedirect.com
    The orphan receptor Nur77 binds cytoplasmic LPS to activate the non-canonical NLRP3 inflammasome
    1
    1. scibot 06 Apr 2023
      Plasmid_52961

      DOI: 10.1016/j.immuni.2023.03.003

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    sciencedirect.com/science/article/pii/S1074761323001231
  18. Mar 2023
  19. www.biorxiv.org www.biorxiv.org
    Alternative splicing of its 5’ untranslated region controls CD20 mRNA translation and enables resistance to CD20-directed immunotherapies
    1
    1. scibot 31 Mar 2023
      plasmid_52961

      DOI: 10.1101/2023.02.19.529123

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    biorxiv.org/content/10.1101/2023.02.19.529123v2
  20. www.biorxiv.org www.biorxiv.org
    Primate TRIM34 is a broadly-acting, TRIM5-dependent lentiviral restriction factor
    1
    1. scibot 31 Mar 2023
      Addgene_52961

      DOI: 10.1101/2023.03.24.534139

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    biorxiv.org/content/10.1101/2023.03.24.534139v1
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Loss of the Volume-regulated Anion Channel Components LRRC8A and LRRC8D Limits Platinum Drug Efficacy
    1
    1. scibot 29 Mar 2023
      RRID:Addgene_52961

      DOI: 10.1158/2767-9764.CRC-22-0208

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    ncbi.nlm.nih.gov/pmc/articles/PMC7613873/
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Checkpoint kinase 1/2 inhibition potentiates anti-tumoral immune response and sensitizes gliomas to immune checkpoint blockade
    1
    1. scibot 26 Mar 2023
      RRID:Addgene_52961

      DOI: 10.1038/s41467-023-36878-2

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    ncbi.nlm.nih.gov/pmc/articles/PMC10033639/
  23. www.sciencedirect.com www.sciencedirect.com
    Tumor PD-L1 engages myeloid PD-1 to suppress type I interferon to impair cytotoxic T lymphocyte recruitment
    1
    1. scibot 16 Mar 2023
      RRID:Addgene_52961

      DOI: 10.1016/j.ccell.2023.02.005

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    sciencedirect.com/science/article/pii/S1535610823000338
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    VCP/p97, a pleiotropic protein regulator of the DNA damage response and proteostasis, is a potential therapeutic target in KRAS-mutant pancreatic cancer
    1
    1. scibot 16 Mar 2023
      Addgene_52961

      DOI: 10.18632/genesandcancer.231

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    ncbi.nlm.nih.gov/pmc/articles/PMC10010283/
  25. www.sciencedirect.com www.sciencedirect.com
    IFNγ is a central node of cancer immune equilibrium
    1
    1. scibot 09 Mar 2023
      plasmid_52961

      DOI: 10.1016/j.celrep.2023.112219

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    sciencedirect.com/science/article/pii/S2211124723002309
  26. www.biorxiv.org www.biorxiv.org
    KIF16B mediates anterograde transport and modulates lysosomal degradation of the HIV-1 envelope glycoprotein
    1
    1. scibot 09 Mar 2023
      RRID:Addgene_52961

      DOI: 10.1101/2023.03.01.530732

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    biorxiv.org/content/10.1101/2023.03.01.530732v1
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    LRP6 Is a Functional Receptor for Attenuated Canine Distemper Virus
    1
    1. scibot 05 Mar 2023
      RRID:Addgene_52961

      DOI: 10.1128/mbio.03114-22

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    ncbi.nlm.nih.gov/pmc/articles/PMC9973313/
  28. www.biorxiv.org www.biorxiv.org
    LCP1 Regulates Cell Motility in Chondrosarcoma and Correlates with Metastatic Potential and Poor Patient Outcomes
    1
    1. scibot 03 Mar 2023
      RRID:Addgene_52961

      DOI: 10.1101/2023.01.31.526513

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    biorxiv.org/content/10.1101/2023.01.31.526513v1
  29. www.biorxiv.org www.biorxiv.org
    SYNGAP1 deficiency disrupts neoteny in human cortical neurons in vivo
    1
    1. scibot 03 Mar 2023
      RRID:Addgene_52961

      DOI: 10.1101/2023.01.14.524054

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    biorxiv.org/content/10.1101/2023.01.14.524054v1
  30. www.sciencedirect.com www.sciencedirect.com
    NF-κB activation enhances STING signaling by altering microtubule-mediated STING trafficking
    1
    1. scibot 02 Mar 2023
      RRID:Addgene_52961

      DOI: 10.1016/j.celrep.2023.112185

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    sciencedirect.com/science/article/pii/S2211124723001961
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Activity-based CRISPR scanning uncovers allostery in DNA methylation maintenance machinery
    1
    1. scibot 02 Mar 2023
      Addgene_52961

      DOI: 10.7554/eLife.80640

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    ncbi.nlm.nih.gov/pmc/articles/PMC9946446/
  32. Feb 2023
  33. www.sciencedirect.com www.sciencedirect.com
    An adverse tumor-protective effect of IDO1 inhibition
    1
    1. scibot 23 Feb 2023
      RRID: Addgene_52961

      DOI: 10.1016/j.xcrm.2023.100941

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    sciencedirect.com/science/article/pii/S2666379123000332
  34. www.sciencedirect.com www.sciencedirect.com
    Huntingtin S421 phosphorylation increases kinesin and dynein engagement on early endosomes and lysosomes
    1
    1. scibot 23 Feb 2023
      RRID:Addgene_52961

      DOI: 10.1016/j.bpj.2023.02.006

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    sciencedirect.com/science/article/pii/S000634952300098X
  35. www.nature.com www.nature.com
    ERdj5 protects goblet cells from endoplasmic reticulum stress-mediated apoptosis under inflammatory conditions
    1
    1. scibot 11 Feb 2023
      RRID:Addgene_52961

      DOI: 10.1038/s12276-023-00945-x

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    nature.com/articles/s12276-023-00945-x
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A modular CRISPR screen identifies individual and combination pathways contributing to HIV-1 latency
    1
    1. scibot 11 Feb 2023
      Addgene_52961

      DOI: 10.1371/journal.ppat.1011101

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    ncbi.nlm.nih.gov/pmc/articles/PMC9907829/
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR screening reveals a dependency on ribosome recycling for efficient SARS-CoV-2 programmed ribosomal frameshifting and viral replication
    1
    1. scibot 08 Feb 2023
      RRID:Addgene_52961

      DOI: 10.1016/j.celrep.2023.112076

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    ncbi.nlm.nih.gov/pmc/articles/PMC9884621/
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    KDM5A Inhibits Antitumor Immune Responses Through Downregulation of the Antigen-Presentation Pathway in Ovarian Cancer
    1
    1. scibot 04 Feb 2023
      RRID:Addgene_52961

      DOI: 10.1158/2326-6066.CIR-22-0088

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    ncbi.nlm.nih.gov/pmc/articles/PMC9357105/
  39. biosignaling.biomedcentral.com biosignaling.biomedcentral.com
    FKBP12 is a major regulator of ALK2 activity in multiple myeloma cells
    1
    1. scibot 02 Feb 2023
      RRID:Addgene_52961

      DOI: 10.1186/s12964-022-01033-9

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    biosignaling.biomedcentral.com/articles/10.1186/s12964-022-01033-9
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The endothelial-enriched lncRNA LINC00607 mediates angiogenic function
    1
    1. scibot 01 Feb 2023
      RRID:Addgene_52961

      DOI: 10.1007/s00395-023-00978-3

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    ncbi.nlm.nih.gov/pmc/articles/PMC9879848/
  41. Jan 2023
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ADAR RNA editing on antisense RNAs results in apparent U-to-C base changes on overlapping sense transcripts
    1
    1. scibot 25 Jan 2023
      RRID:Addgene_52961

      DOI: 10.3389/fcell.2022.1080626

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    ncbi.nlm.nih.gov/pmc/articles/PMC9852825/
  43. www.nature.com www.nature.com
    Smarcd3 is an epigenetic modulator of the metabolic landscape in pancreatic ductal adenocarcinoma
    1
    1. scibot 21 Jan 2023
      plasmid_52961

      DOI: 10.1038/s41467-023-35796-7

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    nature.com/articles/s41467-023-35796-7
  44. www.sciencedirect.com www.sciencedirect.com
    TRIM28 secures skeletal stem cell fate during skeletogenesis by silencing neural gene expression and repressing GREM1/AKT/mTOR signaling axis
    1
    1. scibot 21 Jan 2023
      RRID:Addgene_52961

      DOI: 10.1016/j.celrep.2023.112012

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    sciencedirect.com/science/article/pii/S2211124723000232
  45. journals.asm.org journals.asm.org
    LRP6 Is a Functional Receptor for Attenuated Canine Distemper Virus
    1
    1. scibot 19 Jan 2023
      RRID:Addgene_52961

      DOI: 10.1128/mbio.03114-22

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    journals.asm.org/doi/10.1128/mbio.03114-22
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identifying the Transcriptional Drivers of Metastasis Embedded within Localized Melanoma
    1
    1. scibot 15 Jan 2023
      RRID:Addgene_52961

      DOI: 10.1158/2159-8290.CD-22-0427

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    ncbi.nlm.nih.gov/pmc/articles/PMC9827116/
  47. 52.53.155.43 52.53.155.43
    SSRN-id4265019-html.html
    3
    1. scibot 14 Jan 2023
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      DOI: 10.2139/ssrn.4265019

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  48. link.springer.com link.springer.com
    Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression
    1
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  49. 52.53.155.43 52.53.155.43
    SSRN-id4267401-html.html
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  50. www.mdpi.com www.mdpi.com
    Partial Truncation of the C-Terminal Domain of PTCH1 in Cancer Enhances Autophagy and Metabolic Adaptability
    1
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  51. www.sciencedirect.com www.sciencedirect.com
    DIAPH3 condensates formed by liquid-liquid phase separation act as a regulatory hub for stress-induced actin cytoskeleton remodeling
    1
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  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of β2 microglobulin, the product of B2M gene, as a Host Factor for Vaccinia Virus Infection by Genome-Wide CRISPR genetic screens
    1
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  53. www.sciencedirect.com www.sciencedirect.com
    Immune checkpoint therapy-elicited sialylation of IgG antibodies impairs antitumorigenic type I interferon responses in hepatocellular carcinoma
    1
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  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PRC2 Inactivating Mutations in Cancer Enhance Cytotoxic Response to DNMT1 Targeted Therapy via Enhanced Viral Mimicry
    1
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  55. www.sciencedirect.com www.sciencedirect.com
    Exosomal miR-27b-3p secreted by visceral adipocytes contributes to endothelial inflammation and atherogenesis
    1
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  56. www.sciencedirect.com www.sciencedirect.com
    Ribosomal RNA-based epitranscriptomic regulation of chondrocyte translation and proteome in osteoarthritis
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  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Immortalization of primary marmoset skin fibroblasts by CRISPR-Cas9-mediated gene targeting
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  58. www.sciencedirect.com www.sciencedirect.com
    Metabolic enzyme UAP1 mediates IRF3 pyrophosphorylation to facilitate innate immune response
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  59. www.sciencedirect.com www.sciencedirect.com
    Functional partitioning of transcriptional regulators by patterned charge blocks
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  60. www.sciencedirect.com www.sciencedirect.com
    Palmitoylation prevents sustained inflammation by limiting NLRP3 inflammasome activation through chaperone-mediated autophagy
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  61. www.cell.com www.cell.com
    Genetic and pharmacological modulation of DNA mismatch repair heterogeneous tumors promotes immune surveillance
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    cell.com/cancer-cell/fulltext/S1535-6108(22)00589-X
  62. Dec 2022
  63. www.embopress.org www.embopress.org
    DNA damage repair kinase DNA-PK and cGAS synergize to induce cancer-related inflammation in glioblastoma
    4
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  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Characterizing the metabolic role of STAT3 in canine osteosarcoma
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    1. scibot 30 Dec 2022
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  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Calcium phosphate-based nanomedicine mediated CRISPR/Cas9 delivery for prostate cancer therapy
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  66. www.sciencedirect.com www.sciencedirect.com
    The Golgi-resident protein ACBD3 concentrates STING at ER-Golgi contact sites to drive export from the ER
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    sciencedirect.com/science/article/pii/S2211124722017648
  67. www.sciencedirect.com www.sciencedirect.com
    ΔNp63/p73 drive metastatic colonization by controlling a regenerative epithelial stem cell program in quasi-mesenchymal cancer stem cells
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  68. www.sciencedirect.com www.sciencedirect.com
    Macrophage NFATC2 mediates angiogenic signaling during mycobacterial infection
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  69. www.sciencedirect.com www.sciencedirect.com
    Hyaluronan driven by epithelial aPKC deficiency remodels the microenvironment and creates a vulnerability in mesenchymal colorectal cancer
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  70. www.nature.com www.nature.com
    SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-β signaling
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  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An ER phospholipid hydrolase drives ER-associated mitochondrial constriction for fission and fusion
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  72. www.sciencedirect.com www.sciencedirect.com
    USP32-regulated LAMTOR1 ubiquitination impacts mTORC1 activation and autophagy induction
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  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MUC5B mobilizes and MUC5AC spatially aligns mucociliary transport on human airway epithelium
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  74. www.tandfonline.com www.tandfonline.com
    Immortalization of primary marmoset skin fibroblasts by CRISPR-Cas9-mediated gene targeting
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  75. www.sciencedirect.com www.sciencedirect.com
    Specific and efficient gene knockout and overexpression in mouse interscapular brown adipocytes in vivo
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  76. www.sciencedirect.com www.sciencedirect.com
    BRAFV600E in colorectal cancer reduces sensitivity to oxidative stress and promotes site-specific metastasis by stimulating glutathione synthesis
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  77. Nov 2022
  78. www.sciencedirect.com www.sciencedirect.com
    LPA maintains innate antiviral immunity in a pro-active state via STK38L-mediated IRF3 Ser303 phosphorylation
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  79. www.liebertpub.com www.liebertpub.com
    Human IFNAR2 Mutant Generated by CRISPR/Cas9-Induced Exon Skipping Upregulates a Subset of Tonic-Like Interferon-Stimulated Genes Upon IFNβ Stimulation
    2
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  80. www.sciencedirect.com www.sciencedirect.com
    POLθ processes ssDNA gaps and promotes replication fork progression in BRCA1-deficient cells
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  81. www.nature.com www.nature.com
    Arc controls alcohol cue relapse by a central amygdala mechanism
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  82. www.researchsquare.com www.researchsquare.com
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  83. www.sciencedirect.com www.sciencedirect.com
    Systematic generation and imaging of tandem repeats reveal base-pairing properties that promote RNA aggregation
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  84. www.sciencedirect.com www.sciencedirect.com
    Dissecting the genetic and microenvironmental factors of gastric tumorigenesis in mice
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  85. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Lysosome Docking to WIPI1 Rings and ER-connected Phagophores Occurs During DNAJB12 and GABARAP-Dependent Selective Autophagy of Misfolded P23H-Rhodopsin
    1
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  86. elifesciences.org elifesciences.org
    Genome-wide base editor screen identifies regulators of protein abundance in yeast
    1
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  87. www.sciencedirect.com www.sciencedirect.com
    Multiphase coalescence mediates Hippo pathway activation
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  88. 52.53.155.43 52.53.155.43
    The lysosome membrane protein, Sidt2: A novel insulin granule membrane protein regulates β cell dedifferentiation by a new pathway involving insulin secretion
    1
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      DOI: 10.21203/rs.3.rs-1957968/v1

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  89. 52.53.155.43 52.53.155.43
    Arc controls alcohol cue relapse by a central amygdala mechanism
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  90. www.nature.com www.nature.com
    HIF1α-AS1 is a DNA:DNA:RNA triplex-forming lncRNA interacting with the HUSH complex
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  91. Oct 2022
  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Highly Conserved Interaction Profiles between Clinically Relevant Mutants of the Cytomegalovirus CDK-like Kinase pUL97 and Human Cyclins: Functional Significance of Cyclin H
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  93. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CASK loss of function differentially regulates neuronal maturation and synaptic function in human induced cortical excitatory neurons
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  94. Sep 2022
  95. www.sciencedirect.com www.sciencedirect.com
    De novo sphingolipid biosynthesis necessitates detoxification in cancer cells
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  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Zinc-finger antiviral protein-mediated inhibition of porcine epidemic diarrhea virus growth is antagonized by the coronaviral nucleocapsid protein
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    Meteorin links the bone marrow hypoxic state to hematopoietic stem/progenitor cell mobilization
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    CRISPR-Cas9 screen in human embryonic stem cells to identify genes required for neural differentiation
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    Targeting of MCL-1 in breast cancer-associated fibroblasts reverses their myofibroblastic phenotype and pro-invasive properties
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  100. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NCOA4-mediated ferritinophagy is a pancreatic cancer dependency via maintenance of iron bioavailability for iron-sulfur cluster proteins
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  101. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Sirtuin 6 protects against hepatic fibrogenesis by suppressing the YAP and TAZ function
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    S1-END-seq reveals DNA secondary structures in human cells
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  103. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Membrane-Tethered Mucin 1 Is Stimulated by Interferon and Virus Infection in Multiple Cell Types and Inhibits Influenza A Virus Infection in Human Airway Epithelium
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  104. Aug 2022
  105. www.sciencedirect.com www.sciencedirect.com
    RBM45 is an m6A-binding protein that affects neuronal differentiation and the splicing of a subset of mRNAs
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    Induction of tumor cell autosis by myxoma virus-infected CAR-T and TCR-T cells to overcome primary and acquired resistance
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  107. 52.53.155.43 52.53.155.43
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  108. onlinelibrary.wiley.com onlinelibrary.wiley.com
    BNIP-2 Activation of Cellular Contractility Inactivates YAP for H9c2 Cardiomyoblast Differentiation
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    Glycosphingolipids are mediators of cancer plasticity through independent signaling pathways
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    The redox cycling of STAT2 maintains innate immune homeostasis
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  111. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Relationship of microsatellite instability to mismatch repair deficiency in malignant tumors of dogs
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    Discovery of compounds that reactivate p53 mutants in vitro and in vivo
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  113. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Attenuation of SARS‐CoV‐2 replication and associated inflammation by concomitant targeting of viral and host cap 2'‐O‐ribose methyltransferases
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    Prominin1 and Notch Regulate Ciliary Length and Dynamics in Multiciliated Cells of the Airway Epithelium.
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    Regulation of alternative polyadenylation by the C2H2-zinc-finger protein Sp1
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  116. Jul 2022
  117. 52.53.155.43 52.53.155.43
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  118. www.sciencedirect.com www.sciencedirect.com
    FAM69C, a kinase critical for synaptic function and memory, is defective in neurodegenerative dementia
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    Development of STEAP1 targeting chimeric antigen receptor for adoptive cell therapy against cancer
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  121. Jun 2022
  122. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrating multi-omics data reveals function and therapeutic potential of deubiquitinating enzymes
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    Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence
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    Lenalidomide bypasses CD28 co-stimulation to reinstate PD-1 immunotherapy by activating Notch signaling
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  125. www.sciencedirect.com www.sciencedirect.com
    Targeting EP2 receptor with multifaceted mechanisms for high-risk neuroblastoma
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  126. aacrjournals.org aacrjournals.org
    Vitamin D Receptor activation attenuates Hippo pathway effectors and cell survival in metastatic neuroblastoma
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  127. www.nature.com www.nature.com
    BCL-2 isoform β promotes angiogenesis by TRiC-mediated upregulation of VEGF-A in lymphoma
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  128. ar.iiarjournals.org ar.iiarjournals.org
    LXRβ Activation Inhibits the Proliferation of Small-cell Lung Cancer Cells by Depleting Cellular Cholesterol
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  129. www.sciencedirect.com www.sciencedirect.com
    Metabolic-scale gene activation screens identify SLCO2B1 as a heme transporter that enhances cellular iron availability
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    Oncofusion-driven de novo enhancer assembly promotes malignancy in Ewing sarcoma via aberrant expression of the stereociliary protein LOXHD1
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  131. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Undercarboxylated, but not Carboxylated, Osteocalcin suppresses TNF-α induced inflammatory signaling pathway in Myoblast
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  132. elifesciences.org elifesciences.org
    Cryo-sensitive aggregation triggers NLRP3 inflammasome assembly in cryopyrin-associated periodic syndrome
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  133. www.sciencedirect.com www.sciencedirect.com
    RNF31 inhibition sensitizes tumors to bystander killing by innate and adaptive immune cells
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  134. www.sciencedirect.com www.sciencedirect.com
    Deubiquitinase OTUD3 regulates metabolism homeostasis in response to nutritional stresses
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  135. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HIF1α/HIF2α induces glioma cell dedifferentiation into cancer stem cells through Sox2 under hypoxic conditions
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    1. scibot 07 Jun 2022
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  136. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The SETDB1–TRIM28 complex suppresses antitumor immunity
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  137. www.nature.com www.nature.com
    HER2 G776S mutation promotes oncogenic potential in colorectal cancer cells when accompanied by loss of APC function
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  138. www.sciencedirect.com www.sciencedirect.com
    Intrinsic antiviral immunity of barrier cells revealed by an iPSC-derived blood-brain barrier cellular model
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  139. www.sciencedirect.com www.sciencedirect.com
    LL-37 transports immunoreactive cGAMP to activate STING signaling and enhance interferon-mediated host antiviral immunity
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  140. www.sciencedirect.com www.sciencedirect.com
    Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson’s disease
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  141. May 2022
  142. link.springer.com link.springer.com
    Endocytic trafficking of GAS6–AXL complexes is associated with sustained AKT activation
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  143. www.sciencedirect.com www.sciencedirect.com
    DDX41 is required for cGAS-STING activation against DNA virus infection
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    HIV-1 exploits the Fanconi anemia pathway for viral DNA integration
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  145. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    OGG1 Inhibition Triggers Synthetic Lethality and Enhances The Effect of PARP Inhibitor Olaparib in BRCA1-Deficient TNBC Cells
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  146. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    C/EBPδ-induced epigenetic changes control the dynamic gene transcription of S100a8 and S100a9
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  147. www.sciencedirect.com www.sciencedirect.com
    Human NLRP1 is a sensor of pathogenic coronavirus 3CL proteases in lung epithelial cells
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  148. aacrjournals.org aacrjournals.org
    Melanoma-secreted Amyloid Beta Suppresses Neuroinflammation and Promotes Brain Metastasis
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  149. www.sciencedirect.com www.sciencedirect.com
    Lymph node colonization induces tumor-immune tolerance to promote distant metastasis
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  150. www.sciencedirect.com www.sciencedirect.com
    The lactate-NAD+ axis activates cancer-associated fibroblasts by downregulating p62
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  151. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The immune checkpoint B7-H3 (CD276) regulates adipocyte progenitor metabolism and obesity development
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    1. scibot 11 May 2022
      RRID:Addgene_52961

      DOI: 10.1126/sciadv.abm7012

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  152. www.science.org www.science.org
    The immune checkpoint B7-H3 (CD276) regulates adipocyte progenitor metabolism and obesity development
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    1. scibot 10 May 2022
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  153. www.sciencedirect.com www.sciencedirect.com
    Transmembrane serine protease 2 (TMPRSS2) proteolytically activates the epithelial sodium channel (ENaC) by cleaving the channel’s γ-subunit
    2
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      RRID: Addgene 52961

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  154. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A myosin chaperone, UNC-45A, is a novel regulator of intestinal epithelial barrier integrity and repair
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    1. scibot 05 May 2022
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      DOI: 10.1096/fj.202200154R

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  155. Apr 2022
  156. www.sciencedirect.com www.sciencedirect.com
    Functional genetic screen identifies ITPR3/calcium/RELB axis as a driver of colorectal cancer metastatic liver colonization
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    1. scibot 29 Apr 2022
      RRID:Addgene_52961

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  157. www.nature.com www.nature.com
    Identifying a confused cell identity for esophageal squamous cell carcinoma
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  158. www.sciencedirect.com www.sciencedirect.com
    Establishing transgenic murine esophageal organoids
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    sciencedirect.com/science/article/pii/S2666166722001976
  159. aacrjournals.org aacrjournals.org
    CDK2 Inhibition Enhances Antitumor Immunity by Increasing IFN Response to Endogenous Retroviruses
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  160. www.sciencedirect.com www.sciencedirect.com
    In vitro and in vivo assay of the ER lipid scramblase TMEM41B
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  161. www.sciencedirect.com www.sciencedirect.com
    Multilayered omics reveal sex- and depot-dependent adipose progenitor cell heterogeneity
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  162. www.sciencedirect.com www.sciencedirect.com
    Mitochondrial dynamics regulate genome stability via control of caspase-dependent DNA damage
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  163. www.sciencedirect.com www.sciencedirect.com
    Rapid establishment of human colonic organoid knockout lines
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  164. www.nature.com www.nature.com
    CHMP2A regulates tumor sensitivity to natural killer cell-mediated cytotoxicity
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  165. www.nature.com www.nature.com
    Virally programmed extracellular vesicles sensitize cancer cells to oncolytic virus and small molecule therapy
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  166. www.sciencedirect.com www.sciencedirect.com
    Altered BAF occupancy and transcription factor dynamics in PBAF-deficient melanoma
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  167. www.sciencedirect.com www.sciencedirect.com
    Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis
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  168. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Generation of a CHIP isogenic human iPSC-derived cortical neuron model for functional proteomics
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  169. Mar 2022
  170. academic.oup.com academic.oup.com
    Nuclear receptor activation shapes spatial genome organization essential for gene expression control: lessons learned from the vitamin D receptor
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  171. www.sciencedirect.com www.sciencedirect.com
    A selective PPM1A inhibitor activates autophagy to restrict the survival of Mycobacterium tuberculosis
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  172. www.nature.com www.nature.com
    PLK1 inhibition selectively induces apoptosis in ARID1A deficient cells through uncoupling of oxygen consumption from ATP production
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  173. www.sciencedirect.com www.sciencedirect.com
    Deletion of STAT3 from Foxd1 cell population protects mice from kidney fibrosis by inhibiting pericytes trans-differentiation and migration
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    CRISPR-Cas9 screen identifies oxidative phosphorylation as essential for cancer cell survival at low extracellular pH
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  175. www.nature.com www.nature.com
    Generation of CRISPR–Cas9-mediated genetic knockout human intestinal tissue–derived enteroid lines by lentivirus transduction and single-cell cloning
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  176. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Selective modulation of a pan-essential protein as a therapeutic strategy in cancer
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  177. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of novel HPFH-like mutations by CRISPR base editing that elevate the expression of fetal hemoglobin
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      DOI: 10.7554/eLife.65421

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  178. www.sciencedirect.com www.sciencedirect.com
    Recruitment of DNA to tumor-derived microvesicles
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  179. Feb 2022
  180. www.sciencedirect.com www.sciencedirect.com
    Systematic illumination of druggable genes in cancer genomes
    1
    1. scibot 23 Feb 2022
      Addgene_52961

      DOI: 10.1016/j.celrep.2022.110400

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    sciencedirect.com/science/article/pii/S2211124722001218
  181. www.sciencedirect.com www.sciencedirect.com
    HOTTIP-dependent R-loop formation regulates CTCF boundary activity and TAD integrity in leukemia
    1
    1. scibot 18 Feb 2022
      RRID:Addgene_52961

      DOI: 10.1016/j.molcel.2022.01.014

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    sciencedirect.com/science/article/pii/S1097276522000570
  182. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    TP53 promotes lineage commitment of human embryonic stem cells through ciliogenesis and sonic hedgehog signaling
    1
    1. scibot 16 Feb 2022
      AddgenePlasmid #52961

      DOI: 10.1016/j.celrep.2022.110395

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    pubmed.ncbi.nlm.nih.gov/35172133/
  183. www.sciencedirect.com www.sciencedirect.com
    Characterization of a small molecule inhibitor of disulfide reductases that induces oxidative stress and lethality in lung cancer cells
    2
    1. scibot 11 Feb 2022
      Addgene_52961

      DOI: 10.1016/j.celrep.2022.110343

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    2. scibot 09 Feb 2022
      Addgene_52961

      DOI: 10.1016/j.celrep.2022.110343

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    sciencedirect.com/science/article/pii/S2211124722000596
  184. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Correction of a Factor VIII genomic inversion with designer-recombinases
    1
    1. scibot 08 Feb 2022
      RRID:Addgene_52961

      DOI: 10.1038/s41467-022-28080-7

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    ncbi.nlm.nih.gov/pmc/articles/PMC8776779/
  185. www.sciencedirect.com www.sciencedirect.com
    SPARCLE, a p53-induced lncRNA, controls apoptosis after genotoxic stress by promoting PARP-1 cleavage
    1
    1. scibot 02 Feb 2022
      RRID:Addgene_52961

      DOI: 10.1016/j.molcel.2022.01.001

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    sciencedirect.com/science/article/pii/S1097276522000016
  186. www.sciencedirect.com www.sciencedirect.com
    ICAM-1-mediated adhesion is a prerequisite for exosome-induced T cell suppression
    1
    1. scibot 02 Feb 2022
      Addgene_52961

      DOI: 10.1016/j.devcel.2022.01.002

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    sciencedirect.com/science/article/pii/S1534580722000028
  187. Jan 2022
  188. elifesciences.org elifesciences.org
    Overexpression screen of interferon-stimulated genes identifies RARRES3 as a restrictor of Toxoplasma gondii infection
    1
    1. scibot 29 Jan 2022
      plasmid_52961

      DOI: 10.7554/eLife.73137

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    elifesciences.org/articles/73137
  189. www.sciencedirect.com www.sciencedirect.com
    Histone deacetylase 3 contributes to the antiviral innate immunity of macrophages by interacting with FOXK1 to regulate STAT1/2 transcription
    1
    1. scibot 26 Jan 2022
      AddgeneCat# 52961

      DOI: 10.1016/j.celrep.2022.110302

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    sciencedirect.com/science/article/pii/S2211124722000146
  190. www.sciencedirect.com www.sciencedirect.com
    Lineage-specific silencing of PSAT1 induces serine auxotrophy and sensitivity to dietary serine starvation in luminal breast tumors
    1
    1. scibot 19 Jan 2022
      Addgene52961

      DOI: 10.1016/j.celrep.2021.110278

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    sciencedirect.com/science/article/pii/S2211124721017939
  191. www.sciencedirect.com www.sciencedirect.com
    Reprogramming of nucleotide metabolism by interferon confers dependence on the replication stress response pathway in pancreatic cancer cells
    1
    1. scibot 16 Jan 2022
      AddgeneCat#52961

      DOI: 10.1016/j.celrep.2021.110236

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    sciencedirect.com/science/article/pii/S2211124721017459
  192. www.sciencedirect.com www.sciencedirect.com
    Modeling cell protrusion predicts how Myosin II and actin turnover affect adhesion-based signaling
    1
    1. scibot 12 Jan 2022
      RRID:Addgene_52961

      DOI: 10.1016/j.bpj.2021.11.2889

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    sciencedirect.com/science/article/pii/S0006349521038820
  193. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    https://biorxiv.org/cgi/content/10.1101/2021.12.10.472112
    1
    1. scibot 05 Jan 2022
      RRID:Addgene_52961

      DOI: 10.1101/2021.12.10.472112

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    ncbi.nlm.nih.gov/pmc/articles/PMC8687463/
  194. Dec 2021
  195. www.sciencedirect.com www.sciencedirect.com
    Assessing kinetics and recruitment of DNA repair factors using high content screens
    1
    1. scibot 29 Dec 2021
      Plasmid_52961

      DOI: 10.1016/j.celrep.2021.110176

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    sciencedirect.com/science/article/pii/S2211124721016764
  196. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrated stress response regulates GDF15 secretion from adipocytes, preferentially suppresses appetite for a high-fat diet and improves obesity
    1
    1. scibot 11 Dec 2021
      Plasmid_52961

      DOI: 10.1016/j.isci.2021.103448

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    ncbi.nlm.nih.gov/pmc/articles/PMC8633987/
  197. www.sciencedirect.com www.sciencedirect.com
    Genome-wide fitness gene identification reveals Roquin as a potent suppressor of CD8 T cell expansion and anti-tumor immunity
    1
    1. scibot 08 Dec 2021
      Addgene_52961

      DOI: 10.1016/j.celrep.2021.110083

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    sciencedirect.com/science/article/pii/S2211124721015746
  198. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Beta-Tubulin Isotype TUBB6 Controls Microtubule and Actin Dynamics in Osteoclasts
    1
    1. scibot 04 Dec 2021
      RRID:Addgene_52961

      DOI: 10.3389/fcell.2021.778887

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    ncbi.nlm.nih.gov/pmc/articles/PMC8639228/
  199. Nov 2021
  200. www.sciencedirect.com www.sciencedirect.com
    HRD1-mediated METTL14 degradation regulates m6A mRNA modification to suppress ER proteotoxic liver disease
    1
    1. scibot 30 Nov 2021
      Cat# 52961

      DOI: 10.1016/j.molcel.2021.10.028

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    sciencedirect.com/science/article/pii/S1097276521009485
  201. onlinelibrary.wiley.com onlinelibrary.wiley.com
    β2SP/TET2 complex regulates gene 5hmC modification after cerebral ischemia
    1
    1. scibot 30 Nov 2021
      addgene_52961

      DOI: 10.1111/jcmm.17060

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    onlinelibrary.wiley.com/doi/10.1111/jcmm.17060
  202. www.sciencedirect.com www.sciencedirect.com
    PALP: A rapid imaging technique for stratifying ferroptosis sensitivity in normal and tumor tissues in situ
    1
    1. scibot 23 Nov 2021
      Addgene, Cat# 52961

      DOI: 10.1016/j.chembiol.2021.11.001

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    sciencedirect.com/science/article/pii/S2451945621004785
  203. www.nature.com www.nature.com
    Soluble guanylate cyclase signalling mediates etoposide resistance in progressing small cell lung cancer
    1
    1. scibot 21 Nov 2021
      RRID:Addgene_52961

      DOI: 10.1038/s41467-021-26823-6

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    nature.com/articles/s41467-021-26823-6
  204. www.sciencedirect.com www.sciencedirect.com
    TIAM1-RAC1 promote small-cell lung cancer cell survival through antagonizing Nur77-induced BCL2 conformational change
    1
    1. scibot 10 Nov 2021
      plasmid_52961

      DOI: 10.1016/j.celrep.2021.109979

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    sciencedirect.com/science/article/pii/S2211124721014583
  205. Oct 2021
  206. www.sciencedirect.com www.sciencedirect.com
    MAPK pathway activation selectively inhibits ASCL1-driven small cell lung cancer
    1
    1. scibot 29 Oct 2021
      RRID:Addgene_52961

      DOI: 10.1016/j.isci.2021.103224

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    sciencedirect.com/science/article/pii/S2589004221011925
  207. www.sciencedirect.com www.sciencedirect.com
    GCN2 adapts protein synthesis to scavenging-dependent growth
    1
    1. scibot 27 Oct 2021
      Plasmid_52961

      DOI: 10.1016/j.cels.2021.09.014

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    sciencedirect.com/science/article/pii/S2405471221003823
  208. www.sciencedirect.com www.sciencedirect.com
    Increased ACTL6A occupancy within mSWI/SNF chromatin remodelers drives human squamous cell carcinoma
    1
    1. scibot 23 Oct 2021
      52961

      DOI: 10.1016/j.molcel.2021.10.005

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    sciencedirect.com/science/article/pii/S1097276521008340
  209. www.sciencedirect.com www.sciencedirect.com
    NRF2 promotes urothelial cell response to bacterial infection by regulating reactive oxygen species and RAB27B expression
    1
    1. scibot 21 Oct 2021
      RRID:Addgene_52961

      DOI: 10.1016/j.celrep.2021.109856

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    sciencedirect.com/science/article/pii/S2211124721013231