1,452 Matching Annotations
  1. Dec 2024
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    GO-CRISPR: A highly controlled workflow to discover gene essentiality in loss-of-function screens
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    pmc.ncbi.nlm.nih.gov/articles/PMC11654918/
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Impaired branched-chain amino acid (BCAA) catabolism during adipocyte differentiation decreases glycolytic flux
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    pmc.ncbi.nlm.nih.gov/articles/PMC11667163/
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Identification of α-galactosylceramide as an endogenous mammalian antigen for iNKT cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11660903/
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TGFβ signaling sensitizes MEKi-resistant human melanoma to targeted therapy-induced apoptosis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11663225/
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    MYO1F positions cGAS on the plasma membrane to ensure full and functional signaling
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    sciencedirect.com/science/article/pii/S1097276524009511
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    Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening
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    sciencedirect.com/science/article/pii/S2405471224003375
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    Inhibiting intracellular CD28 in cancer cells enhances antitumor immunity and overcomes anti-PD-1 resistance via targeting PD-L1
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    sciencedirect.com/science/article/pii/S1535610824004434
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    Retargeting target-directed microRNA-decay sites to highly expressed viral or cellular miRNAs
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    pmc.ncbi.nlm.nih.gov/articles/PMC11662681/
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    Genomic and transcriptomic landscape of human gastrointestinal stromal tumors
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    pmc.ncbi.nlm.nih.gov/articles/PMC11532483/
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    Global versus local matrix remodeling drives rotational versus invasive collective migration of epithelial cells
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    sciencedirect.com/science/article/pii/S1534580724007214
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    The Cullin3-Rbx1-KLHL9 E3 ubiquitin ligase complex ubiquitinates Rheb and supports amino acid-induced mTORC1 activation
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    sciencedirect.com/science/article/pii/S2211124724014529
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    Kinome-wide CRISPR-Cas9 screens revealed EXOSC10 as a positive regulator of TGF-β signaling
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    pmc.ncbi.nlm.nih.gov/articles/PMC11605321/
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    PEBP1 amplifies mitochondrial dysfunction induced integrated stress response
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    elifesciences.org/reviewed-preprints/102852
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    Restricting lysine normalizes toxic catabolites associated with ALDH7A1 deficiency in cells and mice
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    sciencedirect.com/science/article/pii/S2211124724014207
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    Defining Splicing Factor Requirements for Androgen Receptor Variant Synthesis in Advanced Prostate Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11612623/
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    Control of cell proliferation by memories of mitosis
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    Mesenchymal GDNF promotes intestinal enterochromaffin cell differentiation
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    A commonly inherited human PCSK9 germline variant drives breast cancer metastasis via LRP1 receptor
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    Specific tRNAs promote mRNA decay by recruiting the CCR4-NOT complex to translating ribosomes
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    science.org/doi/10.1126/science.adq8587
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    Glucose limitation protects cancer cells from apoptosis induced by pyrimidine restriction and replication inhibition
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    nature.com/articles/s42255-024-01166-w
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The ribotoxic stress response drives acute inflammation, cell death, and epidermal thickening in UV-irradiated skin in vivo
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    pmc.ncbi.nlm.nih.gov/articles/PMC11671030/
  23. Nov 2024
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Specific tRNAs promote mRNA decay by recruiting the CCR4-NOT complex to translating ribosomes
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  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Exploitation of the fibrinolytic system by B-cell acute lymphoblastic leukemia and its therapeutic targeting
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    Altered sphingolipid biosynthetic flux and lipoprotein trafficking contribute to trans-fat-induced atherosclerosis
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    sciencedirect.com/science/article/pii/S1550413124004121
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    Profound synthetic lethality between SMARCAL1 and FANCM
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  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ACE2-independent sarbecovirus cell entry can be supported by TMPRSS2-related enzymes and can reduce sensitivity to antibody-mediated neutralization
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  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Breast cancer secretes anti-ferroptotic MUFAs and depends on selenoprotein synthesis for metastasis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11555046/
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Senataxin deficiency disrupts proteostasis through nucleolar ncRNA-driven protein aggregation
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  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting Catechol-O-Methyltransferase Induces Mitochondrial Dysfunction and Enhances the Efficacy of Radiotherapy in Glioma
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  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DYRK1A interacts with the tuberous sclerosis complex and promotes mTORC1 activity
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    Comparative Analysis of Host Cell Entry Efficiency and Neutralization Sensitivity of Emerging SARS-CoV-2 Lineages KP.2, KP.2.3, KP.3, and LB.1
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  34. Oct 2024
  35. www.sciencedirect.com www.sciencedirect.com
    Disruption of cellular plasticity by repeat RNAs in human pancreatic cancer
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  36. www.biorxiv.org www.biorxiv.org
    Metabolic mapping of the human solute carrier superfamily
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    biorxiv.org/content/10.1101/2024.09.23.614124v1
  37. Sep 2024
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Repression of mRNA translation initiation by GIGYF1 via disrupting the eIF3-eIF4G1 interaction
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    ncbi.nlm.nih.gov/pmc/articles/PMC466957/
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    R-loop resolution by ARIP4 helicase promotes androgen-mediated transcription induction
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    ncbi.nlm.nih.gov/pmc/articles/PMC11259169/
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting conserved TIM3+VISTA+ tumor-associated macrophages overcomes resistance to cancer immunotherapy
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    ncbi.nlm.nih.gov/pmc/articles/PMC11259173/
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Daxx mediated histone H3.3 deposition on HSV-1 DNA restricts genome decompaction and the progression of immediate-early transcription
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    ncbi.nlm.nih.gov/pmc/articles/PMC11343217/
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BL-918 activates PINK1/Parkin signaling pathway to ameliorate the progression of Parkinson’s disease
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    ncbi.nlm.nih.gov/pmc/articles/PMC11345547/
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    E-cadherin loss drives diffuse-type gastric tumorigenesis via EZH2-mediated reprogramming
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    ncbi.nlm.nih.gov/pmc/articles/PMC10899090/
  44. academic.oup.com academic.oup.com
    TRMT10A dysfunction perturbs codon translation of initiator methionine and glutamine and impairs brain functions in mice
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    academic.oup.com/nar/article/52/15/9230/7697529
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    P53-dependent hypusination of eIF5A affects mitochondrial translation and senescence immune surveillance
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    ncbi.nlm.nih.gov/pmc/articles/PMC11358140/
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of TOPORS ubiquitin ligase augments the efficacy of DNA hypomethylating agents through DNMT1 stabilization
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    ncbi.nlm.nih.gov/pmc/articles/PMC11358161/
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Novel insights into vancomycin-loaded calcium sulfate and negative pressure wound therapy in preventing infections in open fractures
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    ncbi.nlm.nih.gov/pmc/articles/PMC11360527/
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Chemical genetic screens reveal defective lysosomal trafficking as synthetic lethal with NF1 loss
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    ncbi.nlm.nih.gov/pmc/articles/PMC11361638/
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Role of TIM-1 and CD300a in Zika Virus Infection Investigated with Cell-Based Electrical Impedance
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    ncbi.nlm.nih.gov/pmc/articles/PMC11352571/
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phosphorylation of GCN2 by mTOR confers adaptation to conditions of hyper-mTOR activation under stress
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    ncbi.nlm.nih.gov/pmc/articles/PMC11362803/
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrin α2 is an early marker for osteoclast differentiation that contributes to key steps in osteoclastogenesis
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    ncbi.nlm.nih.gov/pmc/articles/PMC11363192/
  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Notch signaling suppresses neuroendocrine differentiation and alters the immune microenvironment in advanced prostate cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11364388/
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Proteomic analysis of ferroptosis pathways reveals a role of CEPT1 in suppressing ferroptosis
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    ncbi.nlm.nih.gov/pmc/articles/PMC11365556/
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    LINC00894 Regulates Cerebral Ischemia/Reperfusion Injury by Stabilizing EIF5 and Facilitating ATF4-Mediated Induction of FGF21 and ACOD1 Expression
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  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Primate-specific BTN3A2 protects against SARS-CoV-2 infection by interacting with and reducing ACE2
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    ncbi.nlm.nih.gov/pmc/articles/PMC11367481/
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Fluorinated NAD Precursors Enhance FK866 Cytotoxicity by Activating SARM1 in Glioblastoma Cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC11429243/
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HRS Facilitates Newcastle Disease Virus Replication in Tumor Cells by Promoting Viral Budding
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    ncbi.nlm.nih.gov/pmc/articles/PMC11432301/
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structural and Functional Characterization of the Most Frequent Pathogenic PRKN Substitution p.R275W
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    ncbi.nlm.nih.gov/pmc/articles/PMC11430725/
  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dihydrotestosterone Enhances MICA-Mediated Immune Responses to Epstein–Barr Virus-Associated Gastric Carcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC11429822/
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SPRED3 regulates the NF-κB signaling pathway in thyroid cancer and promotes the proliferation
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    ncbi.nlm.nih.gov/pmc/articles/PMC11372091/
  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PRKDC Induces Chemoresistance in Osteosarcoma by Recruiting GDE2 to Stabilize GNAS and Activate AKT
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    ncbi.nlm.nih.gov/pmc/articles/PMC11372366/
  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RUVBL1/2 Blockade Targets YTHDF1 Activity to Suppress m6A-Dependent Oncogenic Translation and Colorectal Tumorigenesis
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    ncbi.nlm.nih.gov/pmc/articles/PMC11372367/
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The V-ATPase complex component RNAseK is required for lysosomal hydrolase delivery and autophagosome degradation
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    ncbi.nlm.nih.gov/pmc/articles/PMC11374810/
  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ubiquitin-specific peptidase 22 controls integrin-dependent cancer cell stemness and metastasis
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    ncbi.nlm.nih.gov/pmc/articles/PMC11378969/
  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    USP26 as a hepatitis B virus-induced deubiquitinase primes hepatocellular carcinogenesis by epigenetic remodeling
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  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    N-glycosylation by Mgat5 imposes a targetable constraint on immune-mediated tumor clearance
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    ncbi.nlm.nih.gov/pmc/articles/PMC11383181/
  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    4EBP1-mediated SLC7A11 protein synthesis restrains ferroptosis triggered by MEK inhibitors in advanced ovarian cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11383183/
  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cyclophilin J limits linear ubiquitin signaling and controls colorectal cancer progression
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    ncbi.nlm.nih.gov/pmc/articles/PMC11386053/
  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DBT is a metabolic switch for maintenance of proteostasis under proteasomal impairment
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  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mitochondrial RNA cytosolic leakage drives the SASP
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  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    KAT6A Condensates Impair PARP1 Trapping of PARP Inhibitors in Ovarian Cancer
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  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Glaesserella parasuis serotype 4 exploits fibronectin via RlpA for tracheal colonization following porcine circovirus type 2 infection
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    ncbi.nlm.nih.gov/pmc/articles/PMC11392263/
  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tumor suppressor BAP1 suppresses disulfidptosis through the regulation of SLC7A11 and NADPH levels
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  74. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DPM1 modulates desmosomal adhesion and epidermal differentiation through SERPINB5
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    ncbi.nlm.nih.gov/pmc/articles/PMC10937187/
  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A heterocyclic compound inhibits viral release by inducing cell surface BST2/Tetherin/CD317/HM1.24
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    ncbi.nlm.nih.gov/pmc/articles/PMC11419809/
  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    EspH utilizes phosphoinositide and Rab binding domains to interact with plasma membrane infection sites and Rab GTPases*
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    ncbi.nlm.nih.gov/pmc/articles/PMC11421376/
  77. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Induction of immortal-like and functional CAR T cells by defined factors
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  78. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HDAC8 Enhances the Function of HIF‐2α by Deacetylating ETS1 to Decrease the Sensitivity of TKIs in ccRCC
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    ncbi.nlm.nih.gov/pmc/articles/PMC11423204/
  79. www.sciencedirect.com www.sciencedirect.com
    Saturation mutagenesis-reinforced functional assays for disease-related genes
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  80. www.biorxiv.org www.biorxiv.org
    PEBP1 amplifies mitochondrial dysfunction induced integrated stress response
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    biorxiv.org/content/10.1101/2024.09.20.614039v1
  81. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13728
  82. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BCL-2 and BOK regulate apoptosis by interaction of their C-terminal transmembrane domains
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  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Retinoic acid-induced protein 14 links mechanical forces to Hippo signaling
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    ncbi.nlm.nih.gov/pmc/articles/PMC11387738/
  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A suite of genome-engineered hepatic cells provides novel insights into the spatiotemporal metabolism of apolipoprotein B and apolipoprotein B–containing lipoprotein secretion
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    ncbi.nlm.nih.gov/pmc/articles/PMC11416059/
  85. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Human tetraspanin CD81 facilitates invasion of Salmonella enterica into human epithelial cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC11423668/
  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    STIM1 promotes acquired resistance to sorafenib by attenuating ferroptosis in hepatocellular carcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC11402164/
  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Knockout of the WD40 domain of ATG16L1 enhances foot and mouth disease virus replication
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    ncbi.nlm.nih.gov/pmc/articles/PMC11342673/
  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Decoding sunitinib resistance in ccRCC: Metabolic-reprogramming-induced ABAT and GABAergic system shifts
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    ncbi.nlm.nih.gov/pmc/articles/PMC11295714/
  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Circumventing resistance within the Ewing sarcoma microenvironment by combinatorial innate immunotherapy
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    ncbi.nlm.nih.gov/pmc/articles/PMC11404285/
  90. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Recruitment of the m6A/m6Am demethylase FTO to target RNAs by the telomeric zinc finger protein ZBTB48
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  180. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  185. Jul 2024
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  187. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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