1,598 Matching Annotations
  1. Apr 2025
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Intrinsic OASL expression licenses interferon induction during influenza A virus infection
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    pmc.ncbi.nlm.nih.gov/articles/PMC11956916/
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    KLF4 promotes a KRT13+ hillock-like state in squamous lung cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11952405/
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Light-induced expression of gRNA allows for optogenetic gene editing of T lymphocytes in vivo
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    pmc.ncbi.nlm.nih.gov/articles/PMC11925727/
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A CRISPR-Cas9 screen reveals genetic determinants of the cellular response to decitabine
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11933316/
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-wide CRISPR screen identifies BUB1 kinase as a druggable vulnerability in malignant pleural mesothelioma
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11968822/
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting PI3K inhibitor resistance in breast cancer with metabolic drugs
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    pmc.ncbi.nlm.nih.gov/articles/PMC11926384/
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Comprehensive Investigation of a Tyrosine Kinase Inhibitor-Resistant Gene Zeste White 10 in Hepatocellular Carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC11954606/
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Retinoic acid enhances γδ T cell cytotoxicity in nasopharyngeal carcinoma by reversing immune exhaustion
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    pmc.ncbi.nlm.nih.gov/articles/PMC11955114/
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Oncogenic activation of SMYD3-SHCBP1 promotes breast cancer development and is coupled with resistance to immune therapy
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11954966/
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Bone Marrow-Targeted Liposomes Loaded with Bortezomib Overcome Multiple Myeloma Resistance
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    pmc.ncbi.nlm.nih.gov/articles/PMC11966756/
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A novel ubiquitin-related genes-based signature demonstrated values in prognostic prediction, immune landscape sculpture and therapeutic options in laryngeal cancer
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11965687/
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The impact of a high fat diet and platelet activation on pre-metastatic niche formation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11965330/
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Colorectal cancer hot spot mutations attenuate the ASXL-MLL4 interaction
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    pmc.ncbi.nlm.nih.gov/articles/PMC11957774/
  15. www.biorxiv.org www.biorxiv.org
    NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT
    1
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    biorxiv.org/content/10.1101/2025.03.29.646096v1
  16. www.sciencedirect.com www.sciencedirect.com
    DSCC1 restrains 53BP1/RIF1 signaling at DNA double-strand breaks to promote homologous recombination repair
    1
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    sciencedirect.com/science/article/pii/S2211124725002232
  17. www.sciencedirect.com www.sciencedirect.com
    Dicer deficiency affects microglial function during demyelination and impairs remyelination
    1
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    sciencedirect.com/science/article/pii/S0969996125000956
  18. www.sciencedirect.com www.sciencedirect.com
    Injured tubular epithelia-derived CCN1 promotes the mobilization of fibroblasts toward injury sites after kidney injury
    1
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    sciencedirect.com/science/article/pii/S2589004225004377
  19. Mar 2025
  20. www.sciencedirect.com www.sciencedirect.com
    ACVR2A attenuation impacts lactate production and hyperglycolytic conditions attracting regulatory T cells in hepatocellular carcinoma
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    sciencedirect.com/science/article/pii/S2666379125001119
  21. www.sciencedirect.com www.sciencedirect.com
    Amplified dosage of the NKX2-1 lineage transcription factor controls its oncogenic role in lung adenocarcinoma
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    sciencedirect.com/science/article/pii/S1097276525001947
  22. www.sciencedirect.com www.sciencedirect.com
    Lipid-metabolism-focused CRISPR screens identify enzymes of the mevalonate pathway as essential for prostate cancer growth
    1
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    sciencedirect.com/science/article/pii/S2211124725002414
  23. www.biorxiv.org www.biorxiv.org
    Knocking out Arl13b completely abolishes primary ciliogenesis
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    biorxiv.org/content/10.1101/2025.03.17.643595v1
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Histone variant H2A.Z deposition and acetylation directs the canonical Notch signaling response
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC6144792/
  25. 52.53.155.43 52.53.155.43
    PDF-html.html
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    52.53.155.43/9f932175def02910028aeef91fa3dbdc5f9789b5/PDF-html.html
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Truncated Mutation of TP53 Promotes Chemoresistance in Tongue Squamous Cell Carcinoma
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11900931/
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Selective 3-MST Inhibitor I3MT-3 Works as a Potent Caspase-1 Inhibitor
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    pmc.ncbi.nlm.nih.gov/articles/PMC11899812/
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Systematic interrogation of functional genes underlying cholesterol and lipid homeostasis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11912599/
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Metformin sensitizes triple-negative breast cancer to histone deacetylase inhibitors by targeting FGFR4
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    pmc.ncbi.nlm.nih.gov/articles/PMC11912690/
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-wide screening in human embryonic stem cells identifies genes and pathways involved in the p53 pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC11907909/
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RNF20 dual regulation of MDA5 signaling to maintain immune homeostasis in chickens
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    pmc.ncbi.nlm.nih.gov/articles/PMC11915864/
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    STT3B promotes porcine epidemic diarrhea virus replication by regulating N-glycosylation of PEDV S protein
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    pmc.ncbi.nlm.nih.gov/articles/PMC11915848/
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Ectopic expression of testis-specific transcription elongation factor in driving cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11908497/
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TRIP13 protects pancreatic cancer cells against intrinsic and therapy-induced DNA replication stress
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11923746/
  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    FABP4 as a therapeutic host target controlling SARS-CoV-2 infection
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    pmc.ncbi.nlm.nih.gov/articles/PMC11904229/
  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Comprehensive genomic dependency landscape of a human colon cancer organoid
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    pmc.ncbi.nlm.nih.gov/articles/PMC11906589/
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A positive feedback loop between SMAD3 and PINK1 in regulation of mitophagy
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    pmc.ncbi.nlm.nih.gov/articles/PMC11894195/
  38. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Therapeutic targeting de novo purine biosynthesis driven by β-catenin-dependent PPAT upregulation in hepatoblastoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC11914223/
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Enhanced therapeutic efficacy of anti-PD-1 blockade by targeting LAMP2A inhibits lysosomal degradation of STING and TBK1
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11898276/
  40. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Single-cell delineation of strain-specific HIV-1 Vif activities using dual reporter sensor cells and live cell imaging
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    pmc.ncbi.nlm.nih.gov/articles/PMC11915839/
  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Succinate dehydrogenase activity supports de novo purine synthesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11888382/
  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Tetraspanin CD9 alters cellular trafficking and endocytosis of tetraspanin CD63, affecting CD63 packaging into small extracellular vesicles
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    pmc.ncbi.nlm.nih.gov/articles/PMC11919600/
  43. www.sciencedirect.com www.sciencedirect.com
    Pyruvate metabolism enzyme DLAT promotes tumorigenesis by suppressing leucine catabolism
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    sciencedirect.com/science/article/pii/S155041312500066X
  44. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    MyoD1 localization at the nuclear periphery is mediated by association of WFS1 with active enhancers
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    pmc.ncbi.nlm.nih.gov/articles/PMC11914251/
  45. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The TCF4 Gene Regulates Apoptosis of Corneal Endothelial Cells in Fuchs Endothelial Corneal Dystrophy
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    pmc.ncbi.nlm.nih.gov/articles/PMC11895853/
  46. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    KSHV hijacks the antiviral kinase IKKε to initiate lytic replication
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11781660/
  47. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A guanidine-based coronavirus replication inhibitor which targets the nsp15 endoribonuclease and selects for interferon-susceptible mutant viruses
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11856660/
  48. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Regulation of CXCR4 function by S1P1 through heteromerization
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    pmc.ncbi.nlm.nih.gov/articles/PMC11863771/
  49. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    MicroRNA profiling identifies VHL/HIF-2α dependent miR-2355-5p as a key modulator of clear cell Renal cell carcinoma tumor growth
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    pmc.ncbi.nlm.nih.gov/articles/PMC11869434/
  50. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Microtubule acetylation is not required for HIV-1 infection or TRIM69-mediated restriction of HIV-1 infection
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    pmc.ncbi.nlm.nih.gov/articles/PMC11852722/
  51. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cell type-specific epigenetic regulatory circuitry of coronary artery disease loci
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    pmc.ncbi.nlm.nih.gov/articles/PMC11870499/
  52. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CD47 prevents Rac-mediated phagocytosis through Vav1 dephosphorylation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11844498/
  53. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Multiplexed CRISPRi Reveals a Transcriptional Switch Between KLF Activators and Repressors in the Maturing Neocortex
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    pmc.ncbi.nlm.nih.gov/articles/PMC11839100/
  54. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Target cell adhesion limits macrophage phagocytosis and promotes trogocytosis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11839035/
  55. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The lncRNA DUBR is regulated by CTCF and coordinates chromatin landscape and gene expression in hematopoietic cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11850227/
  56. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    OTUD6B regulates KIFC1-dependent centrosome clustering and breast cancer cell survival
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    pmc.ncbi.nlm.nih.gov/articles/PMC11850729/
  57. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The proximity-based protein interactome and regulatory logics of the transcription factor p65 NF-κB/RELA
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    pmc.ncbi.nlm.nih.gov/articles/PMC11850942/
  58. www.nature.com www.nature.com
    Targeting aldolase A in hepatocellular carcinoma leads to imbalanced glycolysis and energy stress due to uncontrolled FBP accumulation
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    nature.com/articles/s42255-024-01201-w
  59. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    UM171 glues asymmetric CRL3–HDAC1/2 assembly to degrade CoREST corepressors
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    pmc.ncbi.nlm.nih.gov/articles/PMC11882444/
  60. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Interplay between CTCF-binding and CTCF-lacking regulatory elements in generating an architectural stripe at the Igh locus
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    pmc.ncbi.nlm.nih.gov/articles/PMC11876664/
  61. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    HBV-associated hepatocellular carcinomas inhibit antitumor CD8+ T cell via the long noncoding RNA HDAC2-AS2
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    pmc.ncbi.nlm.nih.gov/articles/PMC11871238/
  62. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Chenodeoxycholic acid modulates cholestatic niche through FXR/Myc/P-selectin axis in liver endothelial cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11873286/
  63. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pluripotency factor Tex10 finetunes Wnt signaling for spermatogenesis and primordial germ cell development
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    pmc.ncbi.nlm.nih.gov/articles/PMC11847947/
  64. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SLC25A38 is required for mitochondrial pyridoxal 5’-phosphate (PLP) accumulation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11760969/
  65. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TMEM41B is an endoplasmic reticulum Ca2+ release channel maintaining naive T cell quiescence and responsiveness
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11880246/
  66. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    FTO deficiency facilitates epithelia dysfunction in oral lichen planus
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    pmc.ncbi.nlm.nih.gov/articles/PMC11847738/
  67. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CHIP protects lysosomes from CLN4 mutant-induced membrane damages
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    pmc.ncbi.nlm.nih.gov/articles/PMC11870535/
  68. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Semaphorin 3F inhibits breast cancer metastasis by regulating the Akt-mTOR and TGFβ signaling pathways via neuropilin-2
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    pmc.ncbi.nlm.nih.gov/articles/PMC11876635/
  69. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mechanisms of NLRP3 activation and inhibition elucidated by functional analysis of disease-associated variants
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    pmc.ncbi.nlm.nih.gov/articles/PMC11876074/
  70. www.sciencedirect.com www.sciencedirect.com
    Transcription-coupled AID deamination damage depends on ELOF1-associated RNA polymerase II
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    sciencedirect.com/science/article/pii/S109727652500111X
  71. www.sciencedirect.com www.sciencedirect.com
    ENKD1 modulates innate immune responses through enhanced geranylgeranyl pyrophosphate synthase activity
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    sciencedirect.com/science/article/pii/S2211124725001688
  72. www.sciencedirect.com www.sciencedirect.com
    Integrated computational analysis identifies therapeutic targets with dual action in cancer cells and T cells
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    sciencedirect.com/science/article/pii/S107476132500072X
  73. Feb 2025
  74. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Host cell lectins ASGR1 and DC-SIGN jointly with TMEM106B confer ACE2 independence and imdevimab resistance to SARS-CoV-2 pseudovirus with spike mutation E484D
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    pmc.ncbi.nlm.nih.gov/articles/PMC11852847/
  75. www.sciencedirect.com www.sciencedirect.com
    Restraint of inflammasome-driven cytokine responses through the mRNA stability protein TTP
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    sciencedirect.com/science/article/pii/S2211124725001111
  76. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Lamin B1 regulates RNA splicing factor expression by modulating the spatial positioning and chromatin interactions of the ETS1 gene locus
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    pmc.ncbi.nlm.nih.gov/articles/PMC11834782/
  77. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting ELOVL6 to disrupt c-MYC driven lipid metabolism in pancreatic cancer enhances chemosensitivity
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11830767/
  78. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PARP7 inhibits type I interferon signaling to prevent autoimmunity and lung disease
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11837972/
  79. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TRIP13 protects pancreatic cancer cells against intrinsic and therapy-induced DNA replication stress
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11838190/
  80. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Non-AUG HIV-1 uORF translation elicits specific T cell immune response and regulates viral transcript expression
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    pmc.ncbi.nlm.nih.gov/articles/PMC11836288/
  81. www.sciencedirect.com www.sciencedirect.com
    A KIF1C-CNBP motor-adaptor complex for trafficking mRNAs to cell protrusions
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    sciencedirect.com/science/article/pii/S2211124725001172
  82. www.sciencedirect.com www.sciencedirect.com
    mTOR-mediated p62/SQSTM1 stabilization confers a robust survival mechanism for ovarian cancer
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    sciencedirect.com/science/article/pii/S0304383525001296
  83. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    FBXO31-mediated ubiquitination of OGT maintains O-GlcNAcylation homeostasis to restrain endometrial malignancy
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    pmc.ncbi.nlm.nih.gov/articles/PMC11788441/
  84. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Brd7 loss reawakens dormant metastasis initiating cells in lung by forging an immunosuppressive niche
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    pmc.ncbi.nlm.nih.gov/articles/PMC11799300/
  85. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Host 3’ flap endonuclease Mus81 plays a critical role in trimming the terminal redundancy of hepatitis B virus relaxed circular DNA during covalently closed circular DNA formation
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11801639/
  86. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Identification of selective SWI/SNF dependencies in enzalutamide-resistant prostate cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11794516/
  87. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The O-glycosyltransferase C1GALT1 promotes EWSR1::FLI1 expression and is a therapeutic target for Ewing sarcoma
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11788431/
  88. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Interleukin-1 prevents SARS-CoV-2-induced membrane fusion to restrict viral transmission via induction of actin bundles
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11820142/
  89. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Aberrant expression of GTPase-activating protein ARAP1 triggers circular dorsal ruffles associated with malignancy in hepatocellular carcinoma Hep3B cells
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  179. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  181. www.mdpi.com www.mdpi.com
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  182. Oct 2024
  183. www.sciencedirect.com www.sciencedirect.com
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  184. www.biorxiv.org www.biorxiv.org
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  185. Sep 2024
  186. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  187. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  188. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  189. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  192. academic.oup.com academic.oup.com
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  194. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  196. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  197. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  199. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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