644 Matching Annotations
  1. Sep 2020
  2. www.sciencedirect.com www.sciencedirect.com
    Cryo-EM Reveals Integrin-Mediated TGF-β Activation without Release from Latent TGF-β
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    1. scibot 17 Sep 2020
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      DOI: 10.1016/j.cell.2019.12.030

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    sciencedirect.com/science/article/pii/S0092867419313923
  3. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Delineating an extracellular redox-sensitive module in T-type Ca2+ channels
    1
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      DOI: 10.1074/jbc.RA120.012668

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    ncbi.nlm.nih.gov/pmc/articles/PMC7196644/
  4. elifesciences.org elifesciences.org
    Molecular principles of assembly, activation, and inhibition in epithelial sodium channel
    1
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      DOI: 10.7554/eLife.59038

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    elifesciences.org/articles/59038
  5. elifesciences.org elifesciences.org
    Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism
    1
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      DOI: 10.7554/eLife.56185

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    elifesciences.org/articles/56185
  6. elifesciences.org elifesciences.org
    Cryo-EM structure of the lysosomal chloride-proton exchanger CLC-7 in complex with OSTM1
    1
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      DOI: 10.7554/eLife.59555

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    elifesciences.org/articles/59555
  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Alternative splice variants of rhomboid proteins: In silico analysis of database entries for select model organisms and validation of functional potential
    1
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      DOI: 10.12688/f1000research.13383.1

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    ncbi.nlm.nih.gov/pmc/articles/PMC7065720/
  8. elifesciences.org elifesciences.org
    Structure of RNA polymerase bound to ribosomal 30S subunit
    1
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      DOI: 10.7554/eLife.28560

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    elifesciences.org/articles/28560
  9. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    β11-12 linker isomerization governs acid-sensing ion channel desensitization and recovery
    1
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      DOI: 10.7554/eLife.51111

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    ncbi.nlm.nih.gov/pmc/articles/PMC7041949/
  10. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Profiling of myristoylation in Toxoplasma gondii reveals an N-myristoylated protein important for host cell penetration
    1
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      DOI: 10.7554/eLife.57861

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    ncbi.nlm.nih.gov/pmc/articles/PMC7373427/
  11. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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      DOI: 10.1111/bph.14912

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.14912
  12. www.cell.com www.cell.com
    Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains
    1
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      DOI: 10.1016/j.molcel.2018.11.006

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    cell.com/molecular-cell/abstract/S1097-2765(18)30948-1
  13. www.sciencedirect.com www.sciencedirect.com
    Identification of a G-Protein-Independent Activator of GIRK Channels
    2
    1. scibot 15 Sep 2020
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      DOI: 10.1016/j.celrep.2020.107770

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      DOI: 10.1016/j.celrep.2020.107770

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    sciencedirect.com/science/article/pii/S2211124720307506
  14. elifesciences.org elifesciences.org
    Casposase structure and the mechanistic link between DNA transposition and spacer acquisition by CRISPR-Cas
    1
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      DOI: 10.7554/eLife.50004

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    elifesciences.org/articles/50004
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate
    1
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      DOI: 10.7554/eLife.52774

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    ncbi.nlm.nih.gov/pmc/articles/PMC7112951/
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Highly regulated, diversifying NTP-dependent biological conflict systems with implications for the emergence of multicellularity
    1
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      DOI: 10.7554/eLife.52696

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    ncbi.nlm.nih.gov/pmc/articles/PMC7159879/
  17. www.frontiersin.org www.frontiersin.org
    Computational Design of a Novel VLP-Based Vaccine for Hepatitis B Virus
    2
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      DOI: 10.3389/fimmu.2020.02074

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      DOI: 10.3389/fimmu.2020.02074

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    frontiersin.org/article/10.3389/fimmu.2020.02074/full
  18. www.cell.com www.cell.com
    Restriction of HIV-1 Escape by a Highly Broad and Potent Neutralizing Antibody
    1
    1. scibot 12 Sep 2020
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      DOI: 10.1016/j.cell.2020.01.010

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    cell.com/cell/abstract/S0092-8674(20)30057-X
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An ultralong CDRH2 in HCV neutralizing antibody demonstrates structural plasticity of antibodies against E2 glycoprotein
    1
    1. scibot 11 Sep 2020
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      DOI: 10.7554/eLife.53169

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    ncbi.nlm.nih.gov/pmc/articles/PMC7064334/
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The architecture of EMC reveals a path for membrane protein insertion
    1
    1. scibot 10 Sep 2020
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      DOI: 10.7554/eLife.57887

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    ncbi.nlm.nih.gov/pmc/articles/PMC7292650/
  21. elifesciences.org elifesciences.org
    Patient-specific mutations impair BESTROPHIN1’s essential role in mediating Ca2+-dependent Cl- currents in human RPE
    1
    1. scibot 09 Sep 2020
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      DOI: 10.7554/eLife.29914

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    elifesciences.org/articles/29914
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    C-mannosylation supports folding and enhances stability of thrombospondin repeats
    1
    1. scibot 09 Sep 2020
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      DOI: 10.7554/eLife.52978

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    ncbi.nlm.nih.gov/pmc/articles/PMC6954052/
  23. elifesciences.org elifesciences.org
    Cryo-EM structures of human ZnT8 in both outward- and inward-facing conformations
    1
    1. scibot 09 Sep 2020
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      DOI: 10.7554/eLife.58823

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    elifesciences.org/articles/58823
  24. elifesciences.org elifesciences.org
    Structure of mouse protocadherin 15 of the stereocilia tip link in complex with LHFPL5
    1
    1. scibot 09 Sep 2020
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      DOI: 10.7554/eLife.38770

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    elifesciences.org/articles/38770
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cryo-EM structure of the potassium-chloride cotransporter KCC4 in lipid nanodiscs
    1
    1. scibot 09 Sep 2020
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      DOI: 10.7554/eLife.52505

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    ncbi.nlm.nih.gov/pmc/articles/PMC7200160/
  26. www.jbc.org www.jbc.org
    Suramin and NF449 are IP5K inhibitors that disrupt inositol hexakisphosphate–mediated regulation of cullin–RING ligase and sensitize cancer cells to MLN4924/pevonedistat
    1
    1. scibot 08 Sep 2020
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      DOI: 10.1074/jbc.RA120.014375

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    jbc.org/content/295/30/10281.full
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Insights into herpesvirus assembly from the structure of the pUL7:pUL51 complex
    1
    1. scibot 08 Sep 2020
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      DOI: 10.7554/eLife.53789

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    ncbi.nlm.nih.gov/pmc/articles/PMC7289601/
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies
    1
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      DOI: 10.1016/j.cell.2020.06.025

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    ncbi.nlm.nih.gov/pmc/articles/PMC7311918/
  29. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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      DOI: 10.1111/bph.14918

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.14918
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A CLC-ec1 mutant reveals global conformational change and suggests a unifying mechanism for the CLC Cl–/H+ transport cycle
    1
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      DOI: 10.7554/eLife.53479

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    ncbi.nlm.nih.gov/pmc/articles/PMC7253180/
  31. elifesciences.org elifesciences.org
    Structure and activation mechanism of the BBSome membrane protein trafficking complex
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      DOI: 10.7554/eLife.53322

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    elifesciences.org/articles/53322
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Kin discrimination in social yeast is mediated by cell surface receptors of the Flo11 adhesin family
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      DOI: 10.7554/eLife.55587

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    ncbi.nlm.nih.gov/pmc/articles/PMC7156268/
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The His-Gly motif of acid-sensing ion channels resides in a reentrant ‘loop’ implicated in gating and ion selectivity
    1
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      DOI: 10.7554/eLife.56527

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    ncbi.nlm.nih.gov/pmc/articles/PMC7308080/
  34. europepmc.org europepmc.org
    Adeno-associated virus-binding antibodies detected in cats living in the Northeastern United States lack neutralizing activity
    1
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      DOI: 10.1038/s41598-020-66596-4

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    europepmc.org/article/MED/32572045
  35. www.sciencedirect.com www.sciencedirect.com
    Salmonella Typhoid Toxin PltB Subunit and Its Non-typhoidal Salmonella Ortholog Confer Differential Host Adaptation and Virulence
    1
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      DOI: 10.1016/j.chom.2020.04.005

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    sciencedirect.com/science/article/pii/S1931312820302328
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Atomic structure of a mitochondrial complex I intermediate from vascular plants
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      DOI: 10.7554/eLife.56664

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    ncbi.nlm.nih.gov/pmc/articles/PMC7447434/
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structures reveal gatekeeping of the mitochondrial Ca2+ uniporter by MICU1-MICU2
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      DOI: 10.7554/eLife.59991

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    ncbi.nlm.nih.gov/pmc/articles/PMC7434445/
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Limited dishevelled/Axin oligomerization determines efficiency of Wnt/β-catenin signal transduction
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      DOI: 10.7554/eLife.55015

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    ncbi.nlm.nih.gov/pmc/articles/PMC7200158/
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Systematic Review of Plant Ribosome Heterogeneity and Specialization
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      DOI: 10.3389/fpls.2020.00948

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    ncbi.nlm.nih.gov/pmc/articles/PMC7332886/
  40. Jan 2020
  41. www.sciencedirect.com www.sciencedirect.com
    Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome
    1
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      DOI: 10.1016/j.ccell.2019.06.007

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    sciencedirect.com/science/article/pii/S1535610819302983
  42. www.sciencedirect.com www.sciencedirect.com
    On-Site Ribosome Remodeling by Locally Synthesized Ribosomal Proteins in Axons
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      DOI: 10.1016/j.celrep.2019.11.025

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    sciencedirect.com/science/article/pii/S2211124719314962
  43. www.sciencedirect.com www.sciencedirect.com
    Rewiring Ancient Residue Interaction Networks Drove the Evolution of Specificity in Steroid Receptors
    1
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    Structural Basis of Protection against H7N9 Influenza Virus by Human Anti-N9 Neuraminidase Antibodies
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    Structure of the gene therapy vector, adeno-associated virus with its cell receptor, AAVR
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    Identification and Characterization of Mutations in Ubiquitin Required for Non-covalent Dimer Formation
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    Two Separation-of-Function Isoforms of Human TPP1 Dictate Telomerase Regulation in Somatic and Germ Cells
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    The Structural Basis for Low Conductance in the Membrane Protein VDAC upon β-NADH Binding and Voltage Gating
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    Discovery of Human Signaling Systems: Pairing Peptides to G Protein-Coupled Receptors
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    Rapid and Focused Maturation of a VRC01-Class HIV Broadly Neutralizing Antibody Lineage Involves Both Binding and Accommodation of the N276-Glycan
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    Conformational Plasticity in the HIV-1 Fusion Peptide Facilitates Recognition by Broadly Neutralizing Antibodies
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    Molecular determinants of α-conotoxin potency for inhibition of human and rat α6β4 nicotinic acetylcholine receptors
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    Osh Proteins Control Nanoscale Lipid Organization Necessary for PI(4,5)P2 Synthesis
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    Near-Complete Structure and Model of Tel1ATM from Chaetomium thermophilum Reveals a Robust Autoinhibited ATP State
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    Structural Basis for the Inhibition of CRISPR-Cas12a by Anti-CRISPR Proteins
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    Human Antibodies that Slow Erythrocyte Invasion Potentiate Malaria-Neutralizing Antibodies
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    Cryo-EM structure of the rhodopsin-Gαi-βγ complex reveals binding of the rhodopsin C-terminal tail to the gβ subunit
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    Qualitative Analyses of Polishing and Precoating FIB Milled Crystals for MicroED
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    Structural basis of phosphatidylcholine recognition by the C2–domain of cytosolic phospholipase A2α
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    Broad and Potent Neutralizing Antibodies Recognize the Silent Face of the HIV Envelope
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    Aneuploidy in Oocytes Is Prevented by Sustained CDK1 Activity through Degron Masking in Cyclin B1
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    Structural and functional characterization of an otopetrin family proton channel
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    O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3
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    Dynamic Regulation of Long-Chain Fatty Acid Oxidation by a Noncanonical Interaction between the MCL-1 BH3 Helix and VLCAD
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    Prp19/Pso4 Is an Autoinhibited Ubiquitin Ligase Activated by Stepwise Assembly of Three Splicing Factors
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    Dual Modifications of α-Galactosylceramide Synergize to Promote Activation of Human Invariant Natural Killer T Cells and Stimulate Anti-tumor Immunity
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    Opposing Effects of CREBBP Mutations Govern the Phenotype of Rubinstein-Taybi Syndrome and Adult SHH Medulloblastoma
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    Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation
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    Completeness of HIV-1 Envelope Glycan Shield at Transmission Determines Neutralization Breadth
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    Structural insights into modulation and selectivity of transsynaptic neurexin–LRRTM interaction
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    The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery
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    Structural Analysis of the Ash2L/Dpy-30 Complex Reveals a Heterogeneity in H3K4 Methylation
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    Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma
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    The Ciliary Machinery Is Repurposed for T Cell Immune Synapse Trafficking of LCK
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    Regulation of the Activity in the p53 Family Depends on the Organization of the Transactivation Domain
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    TMC1 Forms the Pore of Mechanosensory Transduction Channels in Vertebrate Inner Ear Hair Cells
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    Ensemble Properties of Bax Determine Its Function
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    Inhibition of K-RAS4B by a Unique Mechanism of Action: Stabilizing Membrane-Dependent Occlusion of the Effector-Binding Site
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    Crystal Structure of the COMPASS H3K4 Methyltransferase Catalytic Module
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    Multisite Substrate Recognition in Asf1-Dependent Acetylation of Histone H3 K56 by Rtt109
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    Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding
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    Mechanotransduction by PCDH15 Relies on a Novel cis-Dimeric Architecture
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    Precise and Predictable CRISPR Chromosomal Rearrangements Reveal Principles of Cas9-Mediated Nucleotide Insertion
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    A Structure-Based Strategy for Engineering Selective Ubiquitin Variant Inhibitors of Skp1-Cul1-F-Box Ubiquitin Ligases
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    Homologous Lympho-Epithelial Kazal-type Inhibitor Domains Delay Blood Coagulation by Inhibiting Factor X and XI with Differential Specificity
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    Polarity of Neuronal Membrane Traffic Requires Sorting of Kinesin Motor Cargo during Entry into Dendrites by a Microtubule-Associated Septin
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    Structural Basis for Auto-Inhibition of the NDR1 Kinase Domain by an Atypically Long Activation Segment
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    Structural and Dynamics Comparison of Thermostability in Ancient, Modern, and Consensus Elongation Factor Tus
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    Structure of the CLC-1 chloride channel from Homo sapiens
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    Human LINE-1 retrotransposition requires a metastable coiled coil and a positively charged N-terminus in L1ORF1p
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    Structure of the Dnmt1 Reader Module Complexed with a Unique Two-Mono-Ubiquitin Mark on Histone H3 Reveals the Basis for DNA Methylation Maintenance
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    An Alkynyl-Fucose Halts Hepatoma Cell Migration and Invasion by Inhibiting GDP-Fucose-Synthesizing Enzyme FX, TSTA3
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    Allosteric Activation Dictates PRC2 Activity Independent of Its Recruitment to Chromatin
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    Structure and reconstitution of yeast Mpp6-nuclear exosome complexes reveals that Mpp6 stimulates RNA decay and recruits the Mtr4 helicase
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    A Rare Lysozyme Crystal Form Solved Using Highly Redundant Multiple Electron Diffraction Datasets from Micron-Sized Crystals
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    Analysis of Global and Site-Specific Radiation Damage in Cryo-EM
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    The Structure of an Infectious Human Polyomavirus and Its Interactions with Cellular Receptors
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    Discrimination against RNA Backbones by a ssDNA Binding Protein
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    Structure-based membrane dome mechanism for Piezo mechanosensitivity
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    Targeting Phosphopeptide Recognition by the Human BRCA1 Tandem BRCT Domain to Interrupt BRCA1-Dependent Signaling
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    Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability
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    Structural Basis for Draxin-Modulated Axon Guidance and Fasciculation by Netrin-1 through DCC
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    Robo1 Forms a Compact Dimer-of-Dimers Assembly
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    Alternative splice variants of rhomboid proteins: Comparative analysis of database entries for select model organisms and validation of functional potential
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    GroEL Ring Separation and Exchange in the Chaperonin Reaction
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    Repair of UV-Induced DNA Damage Independent of Nucleotide Excision Repair Is Masked by MUTYH
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    A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants
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    Structural Mechanism for Modulation of Synaptic Neuroligin-Neurexin Signaling by MDGA Proteins
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    Immunization-Elicited Broadly Protective Antibody Reveals Ebolavirus Fusion Loop as a Site of Vulnerability
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    Crystal Structure and Regulation of the Citrus Pol III Repressor MAF1 by Auxin and Phosphorylation
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    A Phosphosite within the SH2 Domain of Lck Regulates Its Activation by CD45
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    RADX Promotes Genome Stability and Modulates Chemosensitivity by Regulating RAD51 at Replication Forks
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    Structural and Functional Insights into Human Re-initiation Complexes
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    Structural Insights into Modulation of Neurexin-Neuroligin Trans-synaptic Adhesion by MDGA1/Neuroligin-2 Complex
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