644 Matching Annotations
  1. Dec 2024
  2. www.sciencedirect.com www.sciencedirect.com
    Structural insights into subunit-dependent functional regulation in epithelial sodium channels
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    1. scibot 12 Dec 2024
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    sciencedirect.com/science/article/pii/S0969212624005264
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Tracking fructose 1,6-bisphosphate dynamics in liver cancer cells using a fluorescent biosensor
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    pmc.ncbi.nlm.nih.gov/articles/PMC11617404/
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    Dual BACH1 regulation by complementary SCF-type E3 ligases
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    1. scibot 10 Dec 2024
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    sciencedirect.com/science/article/pii/S0092867424013229
  5. Nov 2024
  6. www.embopress.org www.embopress.org
    Structure of a step II catalytically activated spliceosome from Chlamydomonas reinhardtii
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    1. scibot 28 Nov 2024
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      DOI: 10.1038/s44318-024-00274-3

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    embopress.org/doi/10.1038/s44318-024-00274-3
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cryo‐EM reveals transition states of the Acinetobacter baumannii F1 ‐ATPase rotary subunits γ and ε, unveiling novel compound targets
    1
    1. scibot 26 Nov 2024
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    pmc.ncbi.nlm.nih.gov/articles/PMC11580714/
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Identification of ATP-Competitive Human CMG Helicase Inhibitors for Cancer Intervention that Disrupt CMG-Replisome Function
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    1. scibot 16 Nov 2024
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      DOI: 10.1158/1535-7163.MCT-23-0904

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    pmc.ncbi.nlm.nih.gov/articles/PMC11532780/
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Functional characterization of optic photoreception in Lymnaea stagnalis
    1
    1. scibot 14 Nov 2024
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      DOI: 10.1371/journal.pone.0313407

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    pmc.ncbi.nlm.nih.gov/articles/PMC11556747/
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Structural insights into human zinc transporter ZnT1 mediated Zn2+ efflux
    1
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      DOI: 10.1038/s44319-024-00287-3

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    pmc.ncbi.nlm.nih.gov/articles/PMC11549101/
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Conservation of the cooling agent binding pocket within the TRPM subfamily
    1
    1. scibot 08 Nov 2024
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      DOI: 10.7554/eLife.99643

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    pmc.ncbi.nlm.nih.gov/articles/PMC11530238/
  12. elifesciences.org elifesciences.org
    TRPML1 gating modulation by allosteric mutations and lipids
    1
    1. scibot 07 Nov 2024
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      DOI: 10.7554/eLife.100987

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    elifesciences.org/articles/100987
  13. www.mdpi.com www.mdpi.com
    Stephania tetrandra and Its Active Compound Coclaurine Sensitize NSCLC Cells to Cisplatin through EFHD2 Inhibition
    1
    1. scibot 07 Nov 2024
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      DOI: 10.3390/ph17101356

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    mdpi.com/1424-8247/17/10/1356
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    4’-Ethynyl-2’-Deoxycytidine (EdC) Preferentially Targets Lymphoma and Leukemia Subtypes by Inducing Replicative Stress
    1
    1. scibot 07 Nov 2024
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  15. Sep 2024
  16. www.sciencedirect.com www.sciencedirect.com
    Discovery and characterization of a pan-betacoronavirus S2-binding antibody
    1
    1. scibot 27 Sep 2024
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    sciencedirect.com/science/article/pii/S0969212624003691
  17. www.sciencedirect.com www.sciencedirect.com
    Assessing AF2’s ability to predict structural ensembles of proteins
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    1. scibot 27 Sep 2024
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    sciencedirect.com/science/article/pii/S0969212624003708
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IKKɛ induces STING non-IFN immune responses via a mechanism analogous to TBK1
    1
    1. scibot 26 Sep 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11387596/
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Prominin 1 and Tweety Homology 1 both induce extracellular vesicle formation
    1
    1. scibot 25 Sep 2024
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      DOI: 10.7554/eLife.100061

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    ncbi.nlm.nih.gov/pmc/articles/PMC11405016/
  20. www.sciencedirect.com www.sciencedirect.com
    β-chitosan attenuates hepatic macrophage-driven inflammation and reverses aging-related cognitive impairment
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    1. scibot 25 Sep 2024
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    sciencedirect.com/science/article/pii/S2589004224019916
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Neck linker docking is critical for Kinesin-1 force generation in cells but at a cost to motor speed and processivity
    1
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      DOI: 10.7554/eLife.44146

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    ncbi.nlm.nih.gov/pmc/articles/PMC6533058/
  22. Aug 2024
  23. www.sciencedirect.com www.sciencedirect.com
    Interaction between the TBC1D24 TLDc domain and the KIBRA C2 domain is disrupted by two epilepsy-associated TBC1D24 missense variants
    1
    1. scibot 29 Aug 2024
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      DOI: 10.1016/j.jbc.2024.107725

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    sciencedirect.com/science/article/pii/S0021925824022269
  24. www.cell.com www.cell.com
    Structural insights into the chloroplast protein import in land plants
    1
    1. scibot 28 Aug 2024
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      DOI: 10.1016/j.cell.2024.08.003

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    cell.com/cell/fulltext/S0092-8674(24)00894-8
  25. www.sciencedirect.com www.sciencedirect.com
    Conservation and specialization of the Ycf2-FtsHi chloroplast protein import motor in green algae
    1
    1. scibot 28 Aug 2024
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      DOI: 10.1016/j.cell.2024.08.002

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    sciencedirect.com/science/article/pii/S0092867424008936
  26. www.sciencedirect.com www.sciencedirect.com
    Viral DNA polymerase structures reveal mechanisms of antiviral drug resistance
    1
    1. scibot 28 Aug 2024
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      DOI: 10.1016/j.cell.2024.07.048

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    sciencedirect.com/science/article/pii/S0092867424008420
  27. www.sciencedirect.com www.sciencedirect.com
    Engineering of pH-dependent antigen binding properties for toxin-targeting IgG1 antibodies using light-chain shuffling
    1
    1. scibot 21 Aug 2024
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    sciencedirect.com/science/article/pii/S0969212624002776
  28. www.sciencedirect.com www.sciencedirect.com
    Generation of densely labeled oligonucleotides for the detection of small genomic elements
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      DOI: 10.1016/j.crmeth.2024.100840

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    sciencedirect.com/science/article/pii/S2667237524002133
  29. 52.53.155.43 52.53.155.43
    The Development of an Automated Computational Workflow to Prioritize Potential Resistance Variants.
    1
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      DOI: 10.22541/au.172114480.03196251/v1

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    52.53.155.43/a5f2a18497e8c38643b8230fda89f923d68c20e8/1191591-html.html
  30. europepmc.orghttp europepmc.orghttp
    Structural Basis for a Safety-Belt Mechanism That Anchors Condensin to Chromosomes
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      DOI: 10.1016/j.cell.2017.09.008

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    europepmc.orghttp//europepmc.org/articles/PMC5651216/
  31. pubs.acs.org pubs.acs.org
    Symmetrical Bispyridinium Compounds Act as Open Channel Blockers of Cation-Selective Ion Channels
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    1. scibot 02 Aug 2024
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      DOI: 10.1021/acsptsci.3c00308

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    pubs.acs.org/doi/10.1021/acsptsci.3c00308
  32. 52.53.155.43 52.53.155.43
    Supplemental_Materials (1)-html.html
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      DOI: 10.2337/figshare.21183496

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  33. www.sciencedirect.com www.sciencedirect.com
    The V-ATPase/ATG16L1 axis is controlled by the V1H subunit
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    sciencedirect.com/science/article/pii/S1097276524005793
  34. Jul 2024
  35. www.sciencedirect.com www.sciencedirect.com
    They all rock: A systematic comparison of conformational movements in LeuT-fold transporters
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      DOI: 10.1016/j.str.2024.06.015

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    sciencedirect.com/science/article/pii/S0969212624002338
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The histone demethylase KDM5 is required for synaptic structure and function at the Drosophila neuromuscular junction
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      DOI: 10.1016/j.celrep.2021.108753

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    ncbi.nlm.nih.gov/pmc/articles/PMC7945993/
  37. www.cell.com www.cell.com
    Stress-dependent condensate formation regulated by the ubiquitin-related modifier Urm1
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      DOI: 10.1016/j.cell.2024.06.009

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    cell.com/cell/fulltext/S0092-8674(24)00649-4
  38. 52.53.155.43 52.53.155.43
    The Development of an Automated Computational Workflow to Prioritize Potential Resistance Variants.
    1
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      DOI: 10.22541/au.172114480.03196251/v1

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  39. www.biorxiv.org www.biorxiv.org
    Evolutionary Dynamics of Lineage-Specific Class-A GPCR Subsets Reveal Widespread Chemosensory Roles and Adaptations in Lophotrochozoa
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      DOI: 10.1101/2024.07.14.603414

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    biorxiv.org/content/10.1101/2024.07.14.603414v1
  40. www.sciencedirect.com www.sciencedirect.com
    Crimean-Congo hemorrhagic fever survivors elicit protective non-neutralizing antibodies that target 11 overlapping regions on glycoprotein GP38
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    sciencedirect.com/science/article/pii/S2211124724008313
  41. www.sciencedirect.com www.sciencedirect.com
    Incense-burning smoke ingredient Auramine enhances lincRNA-p21 expression for chemosensitization in p53-mutated non-small cell lung cancer
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      DOI: 10.1016/j.jhazmat.2024.135105

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    sciencedirect.com/science/article/pii/S0304389424016844
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A force-sensitive mutation reveals a non-canonical role for dynein in anaphase progression
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      DOI: 10.1083/jcb.202310022

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    ncbi.nlm.nih.gov/pmc/articles/PMC11215527/
  43. Jun 2024
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR/Cas9 screening reveals a distinct class of MHC-I binders with precise HLA-peptide recognition
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      DOI: 10.1016/j.isci.2024.110120

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    ncbi.nlm.nih.gov/pmc/articles/PMC11209011/
  45. onlinelibrary.wiley.com onlinelibrary.wiley.com
    A Novel AMPK Inhibitor Sensitizes Pancreatic Cancer Cells to Ferroptosis Induction
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      DOI: 10.1002/advs.202307695

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    onlinelibrary.wiley.com/doi/10.1002/advs.202307695
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The clock gene BHLHE40 and atypical CCNG2 control androgen-induced cellular senescence as a novel tumor suppressive pathway in prostate cancer
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      DOI: 10.1186/s13046-024-03097-6

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    ncbi.nlm.nih.gov/pmc/articles/PMC11188219/
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The genomes of Dahlia pinnata, Cosmos bipinnatus, and Bidens alba in tribe Coreopsideae provide insights into polyploid evolution and inulin biosynthesis
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      DOI: 10.1093/gigascience/giae032

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    A metabolomics pipeline highlights microbial metabolism in bloodstream infections
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    Mechanism of heterochromatin remodeling revealed by the DDM1 bound nucleosome structures
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    PredCoffee: A binary classification approach specifically for coffee odor
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    Targeted protein degradation systems to enhance Wnt signaling
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    POT1 recruits and regulates CST-Polα/primase at human telomeres
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  53. May 2024
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    A targeted single mutation in influenza A virus universal epitope transforms immunogenicity and protective immunity via CD4+ T cell activation
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    Two rare variants that affect the same amino acid in CFTR have distinct responses to ivacaftor
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    Designing Combinatorial Multiepitope Vaccine Candidates against Scrub Typus by a Proteome-wide Immunoinfomatics Approach
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    Generation of densely labeled oligonucleotides for the detection of small genomic elements
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    TNFRSF19 within the 13q12.12 risk locus functions as a lung cancer suppressor by binding Wnt3a to inhibit Wnt/β-catenin signaling.
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    The C-terminal disordered loop domain of Apc8 unlocks APC/C mitotic activation
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    Deep mutational scanning of hepatitis B virus reveals a mechanism for cis-preferential reverse transcription
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    Analysis of tumor-associated AXIN1 missense mutations identifies variants that activate β-catenin signaling
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    Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition
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  63. Apr 2024
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    Osteosarcoma cells secrete CXCL14 that activates integrin α11β1 on fibroblasts to form a lung metastatic niche
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    Structural basis of ligand specificity and channel activation in an insect gustatory receptor
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  66. Mar 2024
  67. www.thno.org www.thno.org
    Vitamin D binding protein (VDBP) hijacks twist1 to inhibit vasculogenic mimicry in hepatocellular carcinoma
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    Flexible scaffold-based cheminformatics approach for polypharmacological drug design
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    FAM86A methylation of eEF2 links mRNA translation elongation to tumorigenesis
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    Convergent evolution and targeting of diverse E2 epitopes by human broadly neutralizing antibodies are associated with HCV clearance
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    Abcg2a is the functional homolog of human ABCG2 expressed at the zebrafish blood–brain barrier
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    Anti-apoptotic MCL-1 promotes long-chain fatty acid oxidation through interaction with ACSL1
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    ZP2 cleavage blocks polyspermy by modulating the architecture of the egg coat
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    Epstein-Barr virus gp42 antibodies reveal sites of vulnerability for receptor binding and fusion to B cells
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    Cryo-EM structures of the plant plastid-encoded RNA polymerase
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  76. Feb 2024
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    Integrating Network Pharmacology and Experimental Verification to Explore the Pharmacological Mechanisms of Radix Paeoniae Rubra Against Glioma
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    Origin of eukaryotic-like Vps23 shapes an ancient functional interplay between ESCRT and ubiquitin system in Asgard archaea
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    Repositioning baloxavir marboxil as VISTA agonist that ameliorates experimental asthma
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    Three-step docking by WIPI2, ATG16L1, and ATG3 delivers LC3 to the phagophore
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    Multiple serine transposase dimers assemble the transposon-end synaptic complex during IS607-family transposition
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  83. Jan 2024
  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Engineering paralog-specific PSD-95 recombinant binders as minimally interfering multimodal probes for advanced imaging techniques
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    Structural evidence for protein-protein interaction between the non-canonical methyl-CpG-binding domain of SETDB proteins and C11orf46
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    Cadmium promotes the binding and centrosomal translocation of CCDC85C and PLK4 via ROS-GCLM pathway to trigger centrosome amplification in colon cancer cells
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    Neutralizing antibodies evolve to exploit vulnerable sites in the HCV envelope glycoprotein E2 and mediate spontaneous clearance of infection
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    Reappraisal of the DNA phosphorothioate modification machinery: uncovering neglected functional modalities and identification of new counter-invader defense systems
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  89. Dec 2023
  90. www.sciencedirect.com www.sciencedirect.com
    Epinephrine inhibits PI3Kα via the Hippo kinases
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    Protein semisynthesis underscores the role of a conserved lysine in activation and desensitization of acid-sensing ion channels
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    Assembly-mediated activation of the SIR2-HerA supramolecular complex for anti-phage defense
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  94. Nov 2023
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    Impact of Mutations Defining SARS-CoV-2 Omicron Subvariants BA.2.12.1 and BA.4/5 on Spike Function and Neutralization
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    The evolution and determinants of neutralization of potent head-binding antibodies against Ebola virus
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    STX-478, a Mutant-Selective, Allosteric PI3Kα Inhibitor Spares Metabolic Dysfunction and Improves Therapeutic Response in PI3Kα-Mutant Xenografts
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    Energy coupling and stoichiometry of Zn2+/H+ antiport by the prokaryotic cation diffusion facilitator YiiP
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  101. Oct 2023
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    KANK1 shapes focal adhesions by orchestrating protein binding, mechanical force sensing, and phase separation
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    Destruction of self-derived PAMP via T3SS2 effector VopY to subvert PAMP-triggered immunity mediates Vibrio parahaemolyticus pathogenicity
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    Evolution and functional role prediction of the CYP6DE and CYP6DJ subfamilies in Dendroctonus (Curculionidae: Scolytinae) bark beetles
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    Breast Cancer Cells are Sensitized by Piperine to Radiotherapy through Estrogen Receptor-α mediated modulation of a Key NHEJ repair protein- DNA-PK
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    A combination of two resistance mechanisms is critical for tick-borne encephalitis virus escape from a broadly neutralizing human antibody
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  108. Sep 2023
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  110. Aug 2023
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    Identification of Selective ATP-Competitive CMG Helicase Inhibitors for Cancer Intervention that Disrupt CMG-Replisome Function
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    Structure of the thrombopoietin-MPL receptor complex is a blueprint for biasing hematopoiesis
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    Phage T3 overcomes the BREX defense through SAM cleavage and inhibition of SAM synthesis by SAM lyase
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    The design of functional proteins using tensorized energy calculations
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  116. 52.53.155.43 52.53.155.43
    Structural insights into anion selectivity and activation mechanism of LRRC8 volume-regulated anion channels
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    A tetracationic porphyrin with dual anti-prion activity
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  118. Jul 2023
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    Targeting of multiple tumor-associated antigens by individual T cell receptors during successful cancer immunotherapy
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    Structural definition of HLA class II-presented SARS-CoV-2 epitopes reveals a mechanism to escape pre-existing CD4+ T cell immunity
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    Sterol derivative binding to the orthosteric site causes conformational changes in an invertebrate Cys-loop receptor
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  122. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Biallelic variants in MAD2L1BP (p31comet) cause female infertility characterized by oocyte maturation arrest
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    Bacterial effector restricts liquid-liquid phase separation of ZPR1 to antagonize host UPRER
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  124. Jun 2023
  125. www.biorxiv.org www.biorxiv.org
    Cleaving DNA with DNA: cooperative tuning of structure and reactivity driven by copper ions
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    Type IV-A CRISPR-Csf complex: Assembly, dsDNA targeting, and CasDinG recruitment
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    Belly roll, a GPI-anchored Ly6 protein, regulates Drosophila melanogaster escape behaviors by modulating the excitability of nociceptive peptidergic interneurons
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    HLA-II immunopeptidome profiling and deep learning reveal features of antigenicity to inform antigen discovery
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    Centromere/kinetochore is assembled through CENP-C oligomerization
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  130. aacrjournals.org aacrjournals.org
    3D-informed targeting of the Trop-2 signal-activation site drives selective cancer vulnerability
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  131. May 2023
  132. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The genomic landscape of sensitivity to arsenic trioxide uncovered by genome-wide CRISPR-Cas9 screening
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    Unanticipated broad phylogeny of BEN DNA-binding domains revealed by structural homology searches
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  134. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Human gasdermin D and MLKL disrupt mitochondria, endocytic traffic and TORC1 signalling in budding yeast
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  135. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    High-resolution structures with bound Mn2+ and Cd2+ map the metal import pathway in an Nramp transporter
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  136. www.sciencedirect.com www.sciencedirect.com
    Molecular basis of SARS-CoV-2 Omicron variant evasion from shared neutralizing antibody response
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    cis-B7:CD28 interactions at invaginated synaptic membranes provide CD28 co-stimulation and promote CD8+ T cell function and anti-tumor immunity
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    Bioinformatics and gene expression analysis of the legume F-box/WD40 proteins in NaCl and high temperature stress
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    An ABCC9 Missense Variant Is Associated with Sudden Cardiac Death and Dilated Cardiomyopathy in Juvenile Dogs
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    Examining asymmetric pairwise pre-reaction and transition states in enzymatic catalysis by molecular dynamics simulation and quantum mechanics/molecular mechanics calculation
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    BUB-1-bound PLK-1 directs CDC-20 kinetochore recruitment to ensure timely embryonic mitoses
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  142. Apr 2023
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    Entrectinib a Plausible Inhibitor for Osteopontin (SPP1) in Cervical Cancer—Integrated Bioinformatic Approach
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    Species-specific MARCO-alphavirus interactions dictate chikungunya virus viremia
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    Machine learning predictions of MHC-II specificities reveal alternative binding mode of class II epitopes
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  147. Mar 2023
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    New biochemistry in the Rhodanese-phosphatase superfamily: emerging roles in diverse metabolic processes, nucleic acid modifications, and biological conflicts
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    Structural features of the Notch ankyrin domain-Deltex WWE2 domain heterodimer determined by NMR spectroscopy and functional implications
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    Structures of NF-κB p52 homodimer-DNA complexes rationalize binding mechanisms and transcription activation
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    Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause deadly disease
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    Increased retinoic acid signaling decreases lung metastasis in salivary adenoid cystic carcinoma by inhibiting the noncanonical Notch1 pathway
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  153. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  154. Feb 2023
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    Non-canonical pattern recognition of a pathogen-derived metabolite by a nuclear hormone receptor identifies virulent bacteria in C. elegans
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    DYF-5/MAK–dependent phosphorylation promotes ciliary tubulin unloading
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    Structural basis for ATG9A recruitment to the ULK1 complex in mitophagy initiation
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    Spermine enhances antiviral and anticancer responses by stabilizing DNA binding with the DNA sensor cGAS
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    Cellular mechanism of action of forsythiaside for the treatment of diabetic kidney disease
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  161. Jan 2023
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    The conserved centrosomin motif, γTuNA, forms a dimer that directly activates microtubule nucleation by the γ-tubulin ring complex (γTuRC)
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    Improved ANAP incorporation and VCF analysis reveal details of P2X7 current facilitation and a limited conformational interplay between ATP binding and the intracellular ballast domain
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    Canagliflozin promotes osteoblastic MC3T3-E1 differentiation via AMPK/RUNX2 and improves bone microarchitecture in type 2 diabetic mice
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  166. Dec 2022
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    Structures of drug-specific monoclonal antibodies bound to opioids and nicotine reveal a common mode of binding
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  170. Nov 2022
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    Structure of a TOC-TIC supercomplex spanning two chloroplast envelope membranes
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    Neutralizing monoclonal antibodies elicited by mosaic RBD nanoparticles bind conserved sarbecovirus epitopes
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    IL-17-induced dimerization of IL-17RA drives the formation of the IL-17 signalosome to potentiate signaling
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    Mitoguardin-2–mediated lipid transfer preserves mitochondrial morphology and lipid droplet formation
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  175. Oct 2022
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    Human WDR5 promotes breast cancer growth and metastasis via KMT2-independent translation regulation
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  177. Sep 2022
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  180. Aug 2022
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    Protocol to identify host-viral protein interactions between coagulation-related proteins and their genetic variants with SARS-CoV-2 proteins
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    Protocol to study the oligomeric organization of single-span transmembrane peptides using molecular dynamics simulations
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    Structure of a fully assembled tumor-specific T cell receptor ligated by pMHC
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    Vision-related convergent gene losses reveal SERPINE3’s unknown role in the eye
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    Emergence of immune escape at dominant SARS-CoV-2 killer T-cell epitope
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  186. Jul 2022
  187. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Comprehensive fitness landscape of SARS-CoV-2 Mpro reveals insights into viral resistance mechanisms
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  189. Jun 2022
  190. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dynamics of allosteric regulation of the phospholipase C-γ isozymes upon recruitment to membranes
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  191. journals.plos.org journals.plos.org
    Inhibition of histone H3-H4 chaperone pathways rescues C. elegans sterility by H2B loss
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  192. www.cell.com www.cell.com
    Rational exploration of fold atlas for human solute carrier proteins
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    cell.com/structure/fulltext/S0969-2126(22)00189-7
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    The time-zero HSQC method improves the linear free energy relationship of a polypeptide chain through the accurate measurement of residue-specific equilibrium constants
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  194. www.sciencedirect.com www.sciencedirect.com
    Structural basis for RNA surveillance by the human nuclear exosome targeting (NEXT) complex
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    Mussel-inspired monomer – A new selective protease inhibitor against dentine collagen degradation
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  196. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A basement membrane discovery pipeline uncovers network complexity, regulators, and human disease associations
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  197. www.sciencedirect.com www.sciencedirect.com
    Mediator recruits the cohesin loader Scc2 to RNA Pol II-transcribed genes and promotes sister chromatid cohesion
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  198. May 2022
  199. www.sciencedirect.com www.sciencedirect.com
    Aβ-induced synaptic impairments require CaMKII activity that is stimulated by indirect signaling events
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  200. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Bradycardic Agent Ivabradine Acts as an Atypical Inhibitor of Voltage-Gated Sodium Channels
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  201. www.sciencedirect.com www.sciencedirect.com
    Broad and ultra-potent cross-clade neutralization of HIV-1 by a vaccine-induced CD4 binding site bovine antibody
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  202. Apr 2022
  203. journals.physiology.org journals.physiology.org
    Whole genome sequencing identifies a deletion mutation in the unknown-functional KCNG2 from familial sick sinus syndrome
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  204. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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  205. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    Basis for drug selectivity of plasmepsin IX and X inhibition in Plasmodium falciparum and vivax
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  207. www.sciencedirect.com www.sciencedirect.com
    RPAP2 regulates a transcription initiation checkpoint by inhibiting assembly of pre-initiation complex
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    Structure of the poxvirus decapping enzyme D9 reveals its mechanism of cap recognition and catalysis
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  209. Mar 2022
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    Ligand-independent oligomerization of TACI is controlled by the transmembrane domain and regulates proliferation of activated B cells
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    Asymmetric and non-stoichiometric glycoprotein recognition by two distinct antibodies results in broad protection against ebolaviruses
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  212. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Binding blockade between TLN1 and integrin β1 represses triple-negative breast cancer
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  213. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phosphosite-dependent Presentation of Dual Phosphorylated Peptides by MHC Class I Molecules
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  214. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structural basis for an unprecedented enzymatic alkylation in cylindrocyclophane biosynthesis
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  215. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structural basis of nanobodies neutralizing SARS-CoV-2 variants
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  216. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Crystals of TELSAM–target protein fusions that exhibit minimal crystal contacts and lack direct inter-TELSAM contacts
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  217. www.sciencedirect.com www.sciencedirect.com
    Structural basis for the catalytic activity of filamentous human serine beta-lactamase-like protein LACTB
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  218. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structure and ion-release mechanism of PIB-4-type ATPases
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    Structural insights into DNMT5-mediated ATP-dependent high-fidelity epigenome maintenance
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    Structures of SAS-6 coiled coil hold implications for the polarity of the centriolar cartwheel
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    Receptor tyrosine kinases regulate signal transduction through a liquid-liquid phase separated state
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    Structural basis for catalyzed assembly of the Sonic hedgehog–Patched1 signaling complex
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    sciencedirect.com/science/article/pii/S1534580722000740
  223. Feb 2022
  224. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cdc6 is sequentially regulated by PP2A-Cdc55, Cdc14, and Sic1 for origin licensing in S. cerevisiae
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      DOI: 10.7554/eLife.74437

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    The light chain of the L9 antibody is critical for binding circumsporozoite protein minor repeats and preventing malaria
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    Naegleria’s mitotic spindles are built from unique tubulins and highlight core spindle features
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