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  1. Sep 2024
  2. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Conditioning- and reward-related dendritic and presynaptic plasticity of nucleus accumbens neurons in male and female sign-tracker rats
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    1. scibot 27 Sep 2024
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      DOI: 10.1111/ejn.16513

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    onlinelibrary.wiley.com/doi/10.1111/ejn.16513
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    Misprogramming of glucose metabolism impairs recovery of hippocampal slices from neuronal GLT-1 knockout mice and contributes to excitotoxic injury through mitochondrial superoxide production
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    1. scibot 27 Sep 2024
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      DOI: 10.1111/jnc.16205

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    onlinelibrary.wiley.com/doi/10.1111/jnc.16205
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    Linking activation of synaptic NMDA receptors-induced CREB signaling to brief exposure of cortical neurons to oligomeric amyloid-beta peptide
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    1. scibot 27 Sep 2024
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      DOI: 10.1111/jnc.16222

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    onlinelibrary.wiley.com/doi/10.1111/jnc.16222
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    Tumor-Resident Microbiota-Based Risk Model Predicts Neoadjuvant Therapy Response of Locally Advanced Esophageal Squamous Cell Carcinoma Patients
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    1. scibot 27 Sep 2024
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      DOI: 10.1002/advs.202309742

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    onlinelibrary.wiley.com/doi/10.1002/advs.202309742
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    Sex-dependent differences in the ability of nicotine to modulate discrimination learning and cognitive flexibility in mice
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    1. scibot 27 Sep 2024
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      DOI: 10.1111/jnc.16227

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    onlinelibrary.wiley.com/doi/10.1111/jnc.16227
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    Enteric glial NLRP3 inflammasome contributes to gut mucosal barrier alterations in a mouse model of diet-induced obesity
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    1. scibot 27 Sep 2024
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      DOI: 10.1111/apha.14232

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    onlinelibrary.wiley.com/doi/10.1111/apha.14232
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    A living organoid biobank of patients with Crohn’s disease reveals molecular subtypes for personalized therapeutics
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      DOI: 10.1016/j.xcrm.2024.101748

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    sciencedirect.com/science/article/pii/S2666379124004786
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    A Ctnnb1 enhancer transcriptionally regulates Wnt signaling dosage to balance homeostasis and tumorigenesis of intestinal epithelia
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    1. scibot 27 Sep 2024
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      DOI: 10.7554/eLife.98238

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    ncbi.nlm.nih.gov/pmc/articles/PMC11424096/
  10. www.pnas.org www.pnas.org
    MDGAs perform activity-dependent synapse type-specific suppression via distinct extracellular mechanisms
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    1. scibot 26 Sep 2024
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      DOI: 10.1073/pnas.2322978121

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    UA influences the progression of breast cancer via the AhR/p27Kip1/cyclin E pathway
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    1. scibot 26 Sep 2024
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      DOI: 10.1096/fj.202400938R

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    Protocol for assessing murine cell doublet engagement and subsequent effects using flow cytometry and imaging flow cytometry
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    1. scibot 26 Sep 2024
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      DOI: 10.1016/j.xpro.2024.103152

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    sciencedirect.com/science/article/pii/S2666166724003174
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    A fast and responsive voltage indicator with enhanced sensitivity for unitary synaptic events
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    1. scibot 26 Sep 2024
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      DOI: 10.1016/j.neuron.2024.08.019

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    sciencedirect.com/science/article/pii/S0896627324006433
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    CXCR4 orchestrates the TOX-programmed exhausted phenotype of CD8+ T cells via JAK2/STAT3 pathway
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    1. scibot 26 Sep 2024
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      DOI: 10.1016/j.xgen.2024.100659

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    sciencedirect.com/science/article/pii/S2666979X24002702
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Motor Cortical Neuronal Hyperexcitability Associated with α-Synuclein Aggregation
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    1. scibot 26 Sep 2024
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      DOI: 10.21203/rs.3.rs-4797540/v1

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    ncbi.nlm.nih.gov/pmc/articles/PMC11398582/
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Notch1 Phase Separation Coupled Percolation facilitates target gene expression and enhancer looping
    1
    1. scibot 26 Sep 2024
      RRID:SCR_002798

      DOI: 10.1038/s41598-024-71634-6

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    ncbi.nlm.nih.gov/pmc/articles/PMC11413390/
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IKKɛ induces STING non-IFN immune responses via a mechanism analogous to TBK1
    1
    1. scibot 26 Sep 2024
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      DOI: 10.1016/j.isci.2024.110693

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  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Precision Oncology and Systemic Targeted Therapy in Pseudomyxoma Peritonei
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    1. scibot 26 Sep 2024
      RRID:SCR_002798

      DOI: 10.1158/1078-0432.CCR-23-4072

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    ncbi.nlm.nih.gov/pmc/articles/PMC11393541/
  19. www.science.org www.science.org
    Signal flow in the NMDA receptor–dependent phosphoproteome regulates postsynaptic plasticity for aversive learning
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    1. scibot 26 Sep 2024
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      DOI: 10.1126/scisignal.ado9852

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    science.org/doi/10.1126/scisignal.ado9852
  20. www.frontiersin.org www.frontiersin.org
    Endoplasmic reticulum associated degradation preserves neurons viability by maintaining endoplasmic reticulum homeostasis
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    1. scibot 26 Sep 2024
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      DOI: 10.3389/fnins.2024.1437854

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    frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2024.1437854/full
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Reconstitution of the Multiple Myeloma Microenvironment Following Lymphodepletion with BCMA CAR-T Therapy
    1
    1. scibot 25 Sep 2024
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      DOI: 10.1158/1078-0432.CCR-24-0352

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    ncbi.nlm.nih.gov/pmc/articles/PMC11393544/
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps
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    1. scibot 25 Sep 2024
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      DOI: 10.1158/1078-0432.CCR-23-3860

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    ncbi.nlm.nih.gov/pmc/articles/PMC11393545/
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A benzarone derivative inhibits EYA to suppress tumor growth in SHH medulloblastoma
    1
    1. scibot 25 Sep 2024
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      DOI: 10.1158/0008-5472.CAN-22-3784

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    ncbi.nlm.nih.gov/pmc/articles/PMC10948029/
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MC4R Variants Modulate α-MSH and Setmelanotide Induced Cellular Signaling at Multiple Levels
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    1. scibot 25 Sep 2024
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      DOI: 10.1210/clinem/dgae210

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    ncbi.nlm.nih.gov/pmc/articles/PMC11403317/
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Drug Discovery Pipeline for MAPK/ERK Pathway Inhibitors in Caenorhabditis elegans
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    1. scibot 25 Sep 2024
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      DOI: 10.1158/2767-9764.CRC-24-0221

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  26. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Anabolic deficits and divergent unfolded protein response underlie skeletal and cardiac muscle growth impairments in the Yoshida hepatoma tumor model of cancer cachexia
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    1. scibot 25 Sep 2024
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      DOI: 10.14814/phy2.70044

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  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Fidgetin-like 2 depletion enhances cell migration by regulating GEF-H1, RhoA, and FAK
    1
    1. scibot 25 Sep 2024
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      DOI: 10.1016/j.bpj.2022.12.018

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    ncbi.nlm.nih.gov/pmc/articles/PMC10541466/
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Probing Gag-Env dynamics at HIV-1 assembly sites using live-cell microscopy
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    1. scibot 25 Sep 2024
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      DOI: 10.1128/jvi.00649-24

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    ncbi.nlm.nih.gov/pmc/articles/PMC11406925/
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Simple and highly specific targeting of resident microglia with adeno-associated virus
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    1. scibot 25 Sep 2024
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      DOI: 10.1016/j.isci.2024.110706

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    ncbi.nlm.nih.gov/pmc/articles/PMC11407971/
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Lysosomal TBK1 responds to amino acid availability to relieve Rab7-dependent mTORC1 inhibition
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      DOI: 10.1038/s44318-024-00180-8

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    ncbi.nlm.nih.gov/pmc/articles/PMC11405869/
  31. elifesciences.org elifesciences.org
    Mutant mice lacking alternatively spliced p53 isoforms unveil Ackr4 as a male-specific prognostic factor in Myc-driven B-cell lymphomas
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      DOI: 10.7554/eLife.92774

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    elifesciences.org/articles/92774
  32. www.sciencedirect.com www.sciencedirect.com
    Coagulation factor X promotes resistance to androgen-deprivation therapy in prostate cancer
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      DOI: 10.1016/j.ccell.2024.08.018

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    sciencedirect.com/science/article/pii/S1535610824003179
  33. www.sciencedirect.com www.sciencedirect.com
    A transmitochondrial sodium gradient controls membrane potential in mammalian mitochondria
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      DOI: 10.1016/j.cell.2024.08.045

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    sciencedirect.com/science/article/pii/S0092867424009747
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Atypical cellular responses mediated by intracellular constitutive active TrkB (NTRK2) kinase domains and a solely intracellular NTRK2-fusion oncogene
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      DOI: 10.1038/s41417-024-00809-0

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    ncbi.nlm.nih.gov/pmc/articles/PMC11405271/
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Bisecting GlcNAc modification reverses the chemoresistance via attenuating the function of P-gp
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      DOI: 10.7150/thno.93879

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  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Deletion of the RGD motif from the penton base in oncolytic adenoviruses enhances antitumor efficacy of combined CAR T cell therapy
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      DOI: 10.1016/j.omton.2024.200863

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  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Unlocking the Secrets of Adipose Tissue: How an Obesity-Associated Secretome Promotes Osteoblast Dedifferentiation via TGF-β1 Signaling, Paving the Path to an Adipogenic Phenotype
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      DOI: 10.3390/cells13171418

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    ncbi.nlm.nih.gov/pmc/articles/PMC11394205/
  38. www.sciencedirect.com www.sciencedirect.com
    DDI2 protease controls embryonic development and inflammation via TCF11/NRF1
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      DOI: 10.1016/j.isci.2024.110893

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    sciencedirect.com/science/article/pii/S2589004224021187
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    RNA-modifying enzyme Alkbh8 is involved in mouse embryonic development
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      DOI: 10.1016/j.isci.2024.110777

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    sciencedirect.com/science/article/pii/S2589004224020029
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    IGFBP7 is upregulated in islets from T2D donors and reduces insulin secretion
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      DOI: 10.1016/j.isci.2024.110767

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    sciencedirect.com/science/article/pii/S2589004224019928
  41. www.sciencedirect.com www.sciencedirect.com
    β-chitosan attenuates hepatic macrophage-driven inflammation and reverses aging-related cognitive impairment
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      DOI: 10.1016/j.isci.2024.110766

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    sciencedirect.com/science/article/pii/S2589004224019916
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    Tumour-associated mesenchymal stromal cells modulate macrophage phagocytosis in stromal-rich colorectal cancer via PD-1 signalling.
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      DOI: 10.1016/j.isci.2024.110701

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    Group X phospholipase A2 links colonic lipid homeostasis to systemic metabolism via host-microbiota interaction
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    Natural Linoleic Acid from Marine Fungus Eutypella sp. F0219 Blocks KEAP1/NRF2 Interaction and Ameliorates MASLD by Targeting FABP4
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    Lysosome-related organelle integrity suppresses TIR-1 aggregation to restrain toxic propagation of p38 innate immunity
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    Intestinal immunity in C. elegans is activated by pathogen effector-triggered aggregation of the guard protein TIR-1 on lysosome-related organelles
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    Whole abdominal pencil beam scanned proton FLASH increases acute lethality
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    Fentanyl depression of respiration: Comparison with heroin and morphine
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    Human CST complex protects stalled replication forks by directly blocking MRE11 degradation of nascent‐strand DNA
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    CXCL12-induced rescue of cortical dendritic spines and cognitive flexibility
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    Aberrant Tonic Inhibition of Dopaminergic Neuronal Activity Causes Motor Symptoms in Animal Models of Parkinson’s Disease
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    Transgenic overexpression of polysialyltransferase ST8SiaIV under the control of a neuron-specific promoter does not affect brain development but impairs exploratory behavior
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  55. onlinelibrary.wiley.com onlinelibrary.wiley.com
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    Neuroprotective effects of an engineered commensal bacterium in the 1‐methyl‐4‐phenyl‐1, 2, 3, 6‐tetrahydropyridine Parkinson disease mouse model via producing glucagon‐like peptide‐1
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    A Regulatory Circuit Controlling the Dynamics of NFκB cRel Transitions B Cells from Proliferation to Plasma Cell Differentiation
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      DOI: 10.1016/j.immuni.2019.02.004

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    Pathology of white matter integrity in three major white matter fasciculi: A post‐mortem study of schizophrenia and treatment status
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      DOI: 10.1111/bph.14612

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  59. onlinelibrary.wiley.com onlinelibrary.wiley.com
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      DOI: 10.1002/brb3.1118

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  60. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Physiologically normal 5% O2 supports neuronal differentiation and resistance to inflammatory injury in neural stem cell cultures
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  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Opposing Effects of Membrane-Anchored CX3CL1 on Amyloid and Tau Pathologies via the p38 MAPK Pathway
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      DOI: 10.1523/JNEUROSCI.0853-14.2014

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    Mcam stabilizes a luminal progenitor-like breast cancer cell state via Ck2 control and Src/Akt/Stat3 attenuation
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    Nuclear actin is a critical regulator of Drosophila female germline stem cell maintenance
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    MED12 and CDK8/19 modulate androgen receptor activity and enzalutamide response in prostate cancer
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      DOI: 10.1210/endocr/bqae114

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    Embryonic origins of forebrain oligodendrocytes revisited by combinatorial genetic fate mapping
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      DOI: 10.7554/eLife.95406

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    IL36G-producing neutrophil-like monocytes promote cachexia in cancer
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    Artemisinin attenuates perinatal inflammation and consequent oxidative stress in oligodendrocyte precursor cells by inhibiting IRAK-4 and IRAK-1
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    Rewired glutamate metabolism diminishes cytostatic action of L-asparaginase
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    Protocol to generate two distinct standard-of-care murine glioblastoma models for evaluating novel combination therapies
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    Validation of a PD-1/CD28 chimeric switch receptor to augment CAR-T function in dogs with spontaneous B cell lymphoma
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    Tumor-reactive T cell clonotype dynamics underlying clinical response to TIL therapy in melanoma
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    Systems mapping of bidirectional endosomal transport through the crowded cell
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    Dynamic allostery drives autocrine and paracrine TGF-β signaling
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    Stretch triggers microtubule stabilization and MARCKS-dependent membrane incorporation in the shaft of embryonic axons
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    Neuromedin U Neurons in the Edinger–Westphal Nucleus Respond to Alcohol Without Interfering with the Urocortin 1 Response
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      DOI: 10.1007/s11064-024-04238-1

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    FEBS Press
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    ZG16 enhances the maturation of dendritic cells via induction of CD40 and contributes to the antitumor immunity in pancreatic cancer
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      DOI: 10.1038/s41388-024-03154-6

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    MG53 suppresses tumor growth via transcriptional inhibition of KIF11 in pancreatic cancer
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      DOI: 10.1016/j.tranon.2024.102118

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    Male cuticular pheromones stimulate removal of the mating plug and promote re-mating through pC1 neurons in Drosophila females
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      DOI: 10.7554/eLife.96013

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    Disruption of HSD17B12 in mouse hepatocytes leads to reduced body weight and defect in the lipid droplet expansion associated with microvesicular steatosis
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    Clearing the JUNQ: the molecular machinery for sequestration, localization, and degradation of the JUNQ compartment
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    Pretargeted Radioimmunotherapy with the Novel Anti-oxMIF/HSG Bispecific Antibody ON105 Results in Significant Tumor Regression in Murine Models of Cancer
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    GRP94 Promotes Anoikis Resistance and Peritoneal Metastasis through YAP/TEAD1 pathway in Gastric Cancer
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    Histone demethylase JARID1C/KDM5C regulates Th17 cells by increasing IL-6 expression in diabetic plasmacytoid dendritic cells
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    Eslicarbazepine induces apoptosis and cell cycle arrest in C6 glioma cells in vitro and suppresses tumor growth in an intracranial rat model
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    Inhibition of Aberrantly Overexpressed Polo-like Kinase 4 Is a Potential Effective Treatment for DNA Damage Repair–Deficient Uterine Leiomyosarcoma
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    Interaction between the TBC1D24 TLDc domain and the KIBRA C2 domain is disrupted by two epilepsy-associated TBC1D24 missense variants
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    GSK805 inhibits alpha-smooth muscle expression and modulates liver inflammation without impairing the well-being of mice
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  162. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Chronic Lithium Treatment Alters NMDA and AMPA Receptor Synaptic Availability and Dendritic Spine Organization in the Rat Hippocampus
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    CRISPR screening uncovers a long-range enhancer for ONECUT1 in pancreatic differentiation and links a diabetes risk variant
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    Proteasome resides in and dismantles plant heat stress granules constitutively
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    Multiple guidance mechanisms control axon growth to generate precise T-shaped bifurcation during dorsal funiculus development in the spinal cord
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    Fam49b dampens TCR signal strength to regulate survival of positively selected thymocytes and peripheral T cells
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    The role of DPYD and the effects of DPYD suppressor luteolin combined with 5‐FU in pancreatic cancer
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    Patient-derived tumor organoids mimic treatment-induced DNA damage response in glioblastoma
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    TRIM24 upregulates ORM2 to alleviate abnormal lipid metabolism, inflammation, and oxidative stress in mice with obstructive sleep apnea syndrome & metabolic dysfunction-associated steatotic liver disease
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    Camu-camu decreases hepatic steatosis and liver injury markers in overweight, hypertriglyceridemic individuals: A randomized crossover trial
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    Obesity intensifies sex-specific interferon signaling to selectively worsen central nervous system autoimmunity in females
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    Pyruvate kinase modulates the link between β-cell fructose metabolism and insulin secretion
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    Long non-coding RNAs involved in Drosophila development and regeneration
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    Concurrent RB1 Loss and BRCA Deficiency Predicts Enhanced Immunologic Response and Long-term Survival in Tubo-ovarian High-grade Serous Carcinoma
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    Epithelial organoid supports resident memory CD8 T cell differentiation
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    Negative feedback control of hypothalamic feeding circuits by the taste of food
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    Autism-associated CHD8 controls reactive gliosis and neuroinflammation via remodeling chromatin in astrocytes
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    Protocol for transducing human primary epithelial prostate cells and patient-derived organoids with high efficiency
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  180. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Multiple layers of diversity govern the cell type specificity of GABAergic input received by mouse subicular pyramidal neurons
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    Dysfunctional BTN3A together with deregulated immune checkpoints and type I/II IFN dictate defective interplay between pDCs and γδ T cells in melanoma patients, which impacts clinical outcomes
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    Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies
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    Prospective effect of linkers type on the anticancer activity of pemetrexed-monoclonal antibody (atezolizumab) conjugates
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    Galectin-3 induces pathogenic immunosuppressive macrophages through interaction with TREM2 in lung cancer
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    BRCA Status Dictates Wnt Responsiveness in Epithelial Ovarian Cancer
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    Protocol for in vivo nucleic acid delivery utilizing the rolling microneedle electrode array
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    Different Proteomic Profiles Regarding Antihypertensive Therapy in Preeclampsia Pregnant
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    RET overexpression leads to increased brain metastatic competency in luminal breast cancer
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    "Expression and prognostic relevance of PD-1, PD-L1 and CTLA-4 immune checkpoints in adrenocortical carcinoma"
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    Paired organoids from primary gastric cancer and lymphatic metastasis are useful for personalized medicine
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    Crucial role for sensory nerves and Na/H exchanger inhibition in dapagliflozin and empagliflozin-induced arterial relaxation
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    The C-terminus of Rad is required for membrane localization and L-type calcium channel regulation
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    Taste cells expressing Ionotropic Receptor 94e reciprocally impact feeding and egg laying in Drosophila
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    OPA1 promotes ferroptosis by augmenting mitochondrial ROS and suppressing an integrated stress response
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    Schwann cell-secreted PGE2 promotes sensory neuron excitability during development
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  198. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    p53R172H and p53R245W Hotspot Mutations Drive Distinct Transcriptomes in Mouse Mammary Tumors Through a Convergent Transcriptional Mediator
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