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  1. Jun 2022
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    Gene copy number and negative feedback differentially regulate transcriptional variability of segmentation clock genes
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    sciencedirect.com/science/article/pii/S2589004222008513
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    Methionine oxidation activates pyruvate kinase M2 to promote pancreatic cancer metastasis
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    sciencedirect.com/science/article/pii/S109727652200541X
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    Multiomics identifies the link between intratumor steatosis and the exhausted tumor immune microenvironment in hepatocellular carcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC9970024/
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    Bidirectional regulation of synaptic SUMOylation by Group 1 metabotropic glutamate receptors
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    link.springer.com/article/10.1007/s00018-022-04405-z
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    Potassium Channel Conductance Is Involved in Phenylephrine-Induced Spontaneous Firing of Serotonergic Neurons in the Dorsal Raphe Nucleus
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    ncbi.nlm.nih.gov/pmc/articles/PMC9207280/
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    Imaging the Stability of Chronic Electrical Microstimulation Using Electrodes Coated with PEDOT/CNT and Iridium Oxide
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    YM155 induces DNA damage and cell death in anaplastic thyroid cancer cells by inhibiting DNA topoisomerase IIα at the ATP binding site
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    aacrjournals.org/mct/article/21/6/925/699190/YM155-Induces-DNA-Damage-and-Cell-Death-in
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    Loss of low molecular weight protein tyrosine phosphatase (LMPTP) shows limited improvement in glucose tolerance but causes mild cardiac hypertrophy in mice
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    Loss of low-molecular-weight protein tyrosine phosphatase shows limited improvement in glucose tolerance but causes mild cardiac hypertrophy in mice
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    journals.physiology.org/doi/10.1152/ajpendo.00161.2021
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    Extraoral expression and characterization of bitter taste receptors in Astyanax mexicanus (Mexican Tetra Fish)
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    52.53.155.43/480d9c5a9e0c93ffd25acfa85d5333fab4616ac7/FASEB BioAdvances - 2022 - Bhatia - Extraoral expression and characterization of bitter taste receptors in Astyanax-html.html
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    Astrocytic urea cycle detoxifies Aβ-derived ammonia while impairing memory in Alzheimer’s disease
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    Very-low-density lipoprotein receptor-enhanced lipid metabolism in pancreatic stellate cells promotes pancreatic fibrosis
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    The cephalic phase of insulin release is modulated by IL-1β
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    Cholesterol and matrisome pathways dysregulated in astrocytes and microglia
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    Effect of ferroptosis inhibitors oxindole-curcumin hybrid compound and N,N-dimethylaniline derivatives on rotenone-induced oxidative stress
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    Glypican-3 targeted thorium-227 alpha therapy reduces tumor burden in an orthotopic xenograft murine model of hepatocellular carcinoma
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    Ym1+ macrophages orchestrate fibrosis, lesion growth and progression during development of murine pancreatic cancer
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    F1000Research Article: Insulin and insulin-like growth factor-I receptors in astrocytes exert different effects on behavior and Alzheimer´s-like pathology.
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    Fat body-derived Spz5 remotely facilitates tumor-suppressive cell competition through Toll-6-α-Spectrin axis-mediated Hippo activation
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    BCL-2 isoform β promotes angiogenesis by TRiC-mediated upregulation of VEGF-A in lymphoma
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    Fibroblast-Induced Paradoxical PI3K Pathway Activation in PTEN-Competent Colorectal Cancer: Implications for Therapeutic PI3K/mTOR Inhibition
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    Estrogen May Enhance Toll-Like Receptor 4-Induced Inflammatory Pathways in People With HIV: Implications for Transgender Women on Hormone Therapy
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    Deletion of the Sodium-Dependent Glutamate Transporter GLT-1 in Maturing Oligodendrocytes Attenuates Myelination of Callosal Axons During a Postnatal Phase of Central Nervous System Development
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    Neuroplastic changes in c-Fos, ΔFosB, BDNF, trkB, and Arc expression in the hippocampus of male Roman rats: differential effects of sexual activity
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    Sex-specific cannabinoid 1 receptors on GABAergic neurons in the ventrolateral periaqueductal gray mediate analgesia in mice
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    Combinatorial ASO-mediated therapy with low dose SMN and the protective modifier Chp1 is not sufficient to ameliorate SMA pathology hallmarks
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    Mitochondrial cyclophilin D promotes disease tolerance by licensing NK cell development and IL-22 production against influenza virus
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    NR2F1 is a barrier to dissemination of early stage breast cancer cells.
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    Phosphorylation of SHP2 at Tyr62 enables acquired resistance to SHP2 allosteric inhibitors in FLT3-ITD-driven AML
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    Tanycytes control hypothalamic liraglutide uptake and its anti-obesity actions
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    Neoadjuvant FOLFIRINOX therapy is associated with increased effector T cells and reduced suppressor cells in pancreatic cancer patients
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    A Simple and Robust Single-Step Method for CAR-Vδ1 γδT Cell Expansion and Transduction for Cancer Immunotherapy
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    Modelling the structure of Short Gastrulation and generation of a toolkit for studying its function in Drosophila
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    Metabolic-scale gene activation screens identify SLCO2B1 as a heme transporter that enhances cellular iron availability
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    Neuropilin-1 cooperates with PD-1 in CD8+ T-cells predicting outcomes in melanoma patients treated with anti-PD1
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    Cancer Stem Cells, not Bulk Tumor Cells, Determine Mechanisms of Resistance to SMO Inhibitors
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    GluN3A excitatory glycine receptors control adult cortical and amygdalar circuits
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    Absence of microglia promotes diverse pathologies and early lethality in Alzheimer’s disease mice
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    A brainstem circuit for nausea suppression
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    MASTL is enriched in cancerous and pluripotent stem cells and influences OCT1/OCT4 levels
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    Poroptosis: a form of cell death depending on plasma membrane nanopores formation
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    Interplay between symmetric arginine dimethylation and ubiquitylation regulates TDP1 proteostasis for the repair of topoisomerase I-DNA adducts
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    Iloprost requires the Frizzled 9 receptor to prevent lung cancer
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    Porcupine inhibition disrupts mitochondrial function and homeostasis in WNT ligand-addicted pancreatic cancer
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    GPC1-targeted immunotoxins inhibit pancreatic tumor growth in mice via depletion of short-lived GPC1 and downregulation of Wnt signaling
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    A Comprehensive Guide for Assessing Covalent Inhibition in Enzymatic Assays Illustrated with Kinetic Simulations
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    Integrative metabolomics and transcriptomics analysis reveals novel therapeutic vulnerabilities in lung cancer
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  57. elifesciences.org elifesciences.org
    Magnetic stimulation allows focal activation of the mouse cochlea
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    elifesciences.org/articles/76682
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    Cryo-sensitive aggregation triggers NLRP3 inflammasome assembly in cryopyrin-associated periodic syndrome
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    Histological quantification of cerebral cavernous malformations in the murine brain
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    The focal adhesion protein β-parvin controls cardiomyocyte shape and sarcomere assembly in response to mechanical load
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    Structural basis for RNA surveillance by the human nuclear exosome targeting (NEXT) complex
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    Downregulation of surface AMPA receptor expression in the striatum following prolonged social isolation, a role of mGlu5 receptors
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    Digital Cell Atlas of Mouse Uterus: From Regenerative Stage to Maturational Stage
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    frontiersin.org/article/10.3389/fgene.2022.847646/full
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    Drosophila gustatory projections are segregated by taste modality and connectivity
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    ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling
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    Deep cerebellar stimulation enhances cognitive recovery after prefrontal traumatic brain injury in rodent
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    Succinate metabolism in the retinal pigment epithelium uncouples respiration from ATP synthesis
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    Direct epitranscriptomic regulation of mammalian translation initiation through N4-acetylcytidine
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    Anion Transport Across Human Gallbladder Organoids and Monolayers
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    Embigin is a fibronectin receptor that affects sebaceous gland differentiation and metabolism
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    γδ T cells support antigen-specific αβ T cell–mediated antitumor responses during BCG treatment for bladder cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC8691423/
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    Global-run on sequencing identifies Gm11967 as an Akt-dependent long noncoding RNA involved in insulin sensitivity
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    ncbi.nlm.nih.gov/pmc/articles/PMC9156944/
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    Neural activation associated with outgroup helping in adolescent rats
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    ncbi.nlm.nih.gov/pmc/articles/PMC9160754/
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    A basement membrane discovery pipeline uncovers network complexity, regulators, and human disease associations
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    ncbi.nlm.nih.gov/pmc/articles/PMC9116610/
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    High-intensity interval training remodels the proteome and acetylome of human skeletal muscle
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    ncbi.nlm.nih.gov/pmc/articles/PMC9154743/
  76. www.nature.com www.nature.com
    BOD1 regulates the cerebellar IV/V lobe-fastigial nucleus circuit associated with motor coordination
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    nature.com/articles/s41392-022-00989-x
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    Targeting LIPA independent of its lipase activity is a therapeutic strategy in solid tumors via induction of endoplasmic reticulum stress
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    nature.com/articles/s43018-022-00389-8
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    Phosphoproteomic of the acetylcholine pathway enables discovery of the PKC-β-PIX-Rac1-PAK cascade as a stimulatory signal for aversive learning
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    nature.com/articles/s41380-022-01643-2
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    BCL6-dependent TCF-1+ progenitor cells maintain effector and helper CD4+ T cell responses to persistent antigen
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    sciencedirect.com/science/article/pii/S1074761322002230
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    A direct high-throughput protein quantification strategy facilitates discovery and characterization of a celastrol-derived BRD4 degrader
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    sciencedirect.com/science/article/pii/S2451945622001659
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    Bile acids induce Ca2+ signaling and membrane permeabilizations in vagal nodose ganglion neurons
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    sciencedirect.com/science/article/pii/S2405580822000887
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    JAZF1-SUZ12 dysregulates PRC2 function and gene expression during cell differentiation
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    Active APPL1 sequestration by Plasmodium favors liver-stage development
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    Intrinsic antiviral immunity of barrier cells revealed by an iPSC-derived blood-brain barrier cellular model
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    Muscle satellite cells are impaired in type 2 diabetic mice by elevated extracellular adenosine
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    A cholinergic medial septum input to medial habenula mediates generalization formation and extinction of visual aversion
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