1,124 Matching Annotations
  1. Nov 2021
  2. www.sciencedirect.com www.sciencedirect.com
    ADH5-mediated NO bioactivity maintains metabolic homeostasis in brown adipose tissue
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    1. scibot 17 Nov 2021
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    sciencedirect.com/science/article/pii/S2211124721014819
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    Efferocytosis induces macrophage proliferation to help resolve tissue injury
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    1. scibot 16 Nov 2021
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      DOI: 10.1016/j.cmet.2021.10.015

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    sciencedirect.com/science/article/pii/S1550413121005271
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    Hif-1a suppresses ROS-induced proliferation of cardiac fibroblasts following myocardial infarction
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    1. scibot 11 Nov 2021
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      DOI: 10.1016/j.stem.2021.10.009

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    sciencedirect.com/science/article/pii/S1934590921004215
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Acetyl-CoA derived from hepatic mitochondrial fatty acid β-oxidation aggravates inflammation by enhancing p65 acetylation
    1
    1. scibot 09 Nov 2021
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      DOI: 10.1016/j.isci.2021.103244

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    ncbi.nlm.nih.gov/pmc/articles/PMC8551082/
  6. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dietary nitrate supplementation prevents radiotherapy-induced xerostomia
    1
    1. scibot 09 Nov 2021
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      DOI: 10.7554/eLife.70710

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    ncbi.nlm.nih.gov/pmc/articles/PMC8563005/
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    GABAB1e promotes the malignancy of human cancer cells by targeting the tyrosine phosphatase PTPN12
    1
    1. scibot 09 Nov 2021
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      DOI: 10.1016/j.isci.2021.103311

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    sciencedirect.com/science/article/pii/S2589004221012803
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    Genomic alterations in PIK3CA-mutated breast cancer result in mTORC1 activation and limit the sensitivity to PI3Kα inhibitors
    1
    1. scibot 05 Nov 2021
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      DOI: 10.1158/0008-5472.CAN-20-3232

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    ncbi.nlm.nih.gov/pmc/articles/PMC8137641/
  9. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MiR-552-3p promotes malignant progression of gallbladder carcinoma by reactivating the Akt/β-catenin signaling pathway due to inhibition of the tumor suppressor gene RGMA
    1
    1. scibot 05 Nov 2021
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      DOI: 10.21037/atm-21-2013

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    ncbi.nlm.nih.gov/pmc/articles/PMC8506546/
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    LRG1 destabilizes tumor vessels and restricts immunotherapeutic potency
    1
    1. scibot 04 Nov 2021
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    sciencedirect.com/science/article/pii/S2666634021003421
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    Targeting glioblastoma signaling and metabolism with a re-purposed brain-penetrant drug
    1
    1. scibot 03 Nov 2021
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      DOI: 10.1016/j.celrep.2021.109957

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    sciencedirect.com/science/article/pii/S2211124721014340
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    FARP1, ARHGEF39, and TIAM2 are essential receptor tyrosine kinase effectors for Rac1-dependent cell motility in human lung adenocarcinoma
    1
    1. scibot 03 Nov 2021
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      DOI: 10.1016/j.celrep.2021.109905

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    sciencedirect.com/science/article/pii/S2211124721013759
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    Electroconvulsive seizure inhibits the mTOR signaling pathway via AMPK in the rat frontal cortex
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    1. scibot 02 Nov 2021
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    link.springer.com/article/10.1007/s00213-021-06015-2
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    Protocol for the assessment of mTOR activity in mouse primary hepatocytes
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    1. scibot 02 Nov 2021
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      DOI: 10.1016/j.xpro.2021.100918

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    sciencedirect.com/science/article/pii/S2666166721006249
  15. Oct 2021
  16. www.sciencedirect.com www.sciencedirect.com
    Rapamycin recruits SIRT2 for FKBP12 deacetylation during mTOR activity modulation in innate immunity
    1
    1. scibot 29 Oct 2021
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      DOI: 10.1016/j.isci.2021.103177

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    sciencedirect.com/science/article/pii/S2589004221011457
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    Type 2 diabetes sex-specific effects associated with E167K coding variant in TM6SF2
    1
    1. scibot 29 Oct 2021
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      DOI: 10.1016/j.isci.2021.103196

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    sciencedirect.com/science/article/pii/S2589004221011640
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    Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth
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    1. scibot 27 Oct 2021
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      DOI: 10.1016/j.chembiol.2021.10.006

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    sciencedirect.com/science/article/pii/S2451945621004402
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Bletinib ameliorates neutrophilic inflammation and lung injury by inhibiting Src family kinase phosphorylation and activity
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    1. scibot 23 Oct 2021
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    ncbi.nlm.nih.gov/pmc/articles/PMC8518616/
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    Glycogen accumulation and phase separation drives liver tumor initiation
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    1. scibot 22 Oct 2021
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      DOI: 10.1016/j.cell.2021.10.001

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    sciencedirect.com/science/article/pii/S0092867421011752
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    PI3Kδ coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8+ T cells at the expense of central memory
    1
    1. scibot 22 Oct 2021
      RRID:AB_231504

      DOI: 10.1016/j.celrep.2021.109804

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      Curator comments: Phospho-Akt (Ser473) (D9E) XP® Rabbit mAb antibody Cell Signaling Technology Cat# 4060

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    sciencedirect.com/science/article/pii/S221112472101264X
  22. www.sciencedirect.com www.sciencedirect.com
    RNF8-mediated regulation of Akt promotes lung cancer cell survival and resistance to DNA damage
    1
    1. scibot 21 Oct 2021
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      DOI: 10.1016/j.celrep.2021.109854

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    sciencedirect.com/science/article/pii/S2211124721013218
  23. www.sciencedirect.com www.sciencedirect.com
    Loss of FBXO31-mediated degradation of DUSP6 dysregulates ERK and PI3K-AKT signaling and promotes prostate tumorigenesis
    1
    1. scibot 21 Oct 2021
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      DOI: 10.1016/j.celrep.2021.109870

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    sciencedirect.com/science/article/pii/S2211124721013371
  24. josr-online.biomedcentral.com josr-online.biomedcentral.com
    Overexpression of FGF2 delays the progression of osteonecrosis of the femoral head activating the PI3K/Akt signaling pathway
    1
    1. scibot 19 Oct 2021
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      DOI: 10.1186/s13018-021-02715-9

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    josr-online.biomedcentral.com/articles/10.1186/s13018-021-02715-9
  25. academic.oup.com academic.oup.com
    A role for AKT1 in nonsense-mediated mRNA decay
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    1. scibot 15 Oct 2021
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    academic.oup.com/nar/advance-article/doi/10.1093/nar/gkab882/6389627
  26. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Bioenergetic Requirements and Spatiotemporal Profile of Nerve Growth Factor Induced PI3K-Akt Signaling Along Sensory Axons
    1
    1. scibot 13 Oct 2021
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      DOI: 10.3389/fnmol.2021.726331

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    ncbi.nlm.nih.gov/pmc/articles/PMC8497901/
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    Proteomics reveal cap-dependent translation inhibitors remodel the translation machinery and translatome
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    sciencedirect.com/science/article/pii/S2211124721012663
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    Serum- and glucocorticoid-induced kinase drives hepatic insulin resistance by directly inhibiting AMP-activated protein kinase
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    1. scibot 06 Oct 2021
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      DOI: 10.1016/j.celrep.2021.109785

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    sciencedirect.com/science/article/pii/S2211124721012444
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    Adaptations in Hippo-Yap signaling and myofibroblast fate underlie scar-free ear appendage wound healing in spiny mice
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    1. scibot 05 Oct 2021
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      DOI: 10.1016/j.devcel.2021.09.008

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    sciencedirect.com/science/article/pii/S1534580721007267
  30. academic.oup.com academic.oup.com
    Wnt5a Regulates Junctional Function of Sertoli cells Through PCP-Mediated Effects on mTORC1 and mTORC2
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      DOI: 10.1210/endocr/bqab149

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    academic.oup.com/endo/article/162/10/bqab149/6334711
  31. clincancerres.aacrjournals.org clincancerres.aacrjournals.org
    Preclinical and Clinical Characterization of Fibroblast-derived Neuregulin-1 on Trastuzumab and Pertuzumab Activity in HER2-positive Breast Cancer
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    1. scibot 01 Oct 2021
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      DOI: 10.1158/1078-0432.CCR-20-2915

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    clincancerres.aacrjournals.org/content/27/18/5096
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    Involvement of multiple scavenger receptors in advanced glycation end product-induced vessel tube formation in endothelial cells
    1
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      DOI: 10.1016/j.yexcr.2021.112857

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    sciencedirect.com/science/article/pii/S0014482721004110
  33. Sep 2021
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hepatocyte activity of the cholesterol sensor smoothened regulates cholesterol and bile acid homeostasis in mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC8449244/
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    H3K4 di-methylation governs smooth muscle lineage identity and promotes vascular homeostasis by restraining plasticity
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    sciencedirect.com/science/article/pii/S1534580721006821
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The pro-regenerative effects of hyperIL6 in drug-induced liver injury are unexpectedly due to competitive inhibition of IL11 signaling
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      DOI: 10.7554/eLife.68843

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    ncbi.nlm.nih.gov/pmc/articles/PMC8445623/
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cellular senescence promotes cancer metastasis by enhancing soluble E-cadherin production
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    ncbi.nlm.nih.gov/pmc/articles/PMC8426284/
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    Tumor-initiating stem cell shapes its microenvironment into an immunosuppressive barrier and pro-tumorigenic niche
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    sciencedirect.com/science/article/pii/S2211124721011189
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    SCIMP is a spatiotemporal transmembrane scaffold for Erk1/2 to direct pro-inflammatory signaling in TLR-activated macrophages
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    sciencedirect.com/science/article/pii/S2211124721011062
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Treatment of acromegaly by rosiglitazone via upregulating 15-PGDH in both pituitary adenoma and liver
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      DOI: 10.1016/j.isci.2021.102983

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    ncbi.nlm.nih.gov/pmc/articles/PMC8403734/
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    UV-induced reduction in Polycomb repression promotes epidermal pigmentation
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    sciencedirect.com/science/article/pii/S1534580721006365
  42. Aug 2021
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BAD-mediated neuronal apoptosis and neuroinflammation contribute to Alzheimer's disease pathology
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    ncbi.nlm.nih.gov/pmc/articles/PMC8369003/
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    Treatment during a developmental window prevents NF1-associated optic pathway gliomas by targeting Erk-dependent migrating glial progenitors
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    Identification of ApoA4 as a sphingosine 1-phosphate chaperone in ApoM- and albumin-deficient mice
    1
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      anti-Akt

      DOI: 10.1194/jlr.RA119000277

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  89. jcs.biologists.org jcs.biologists.org
    The Parkinson's gene PINK1 activates Akt via PINK1 kinase-dependent regulation of the phospholipid PI(3,4,5)P3
    1
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      P-Akt pSer437

      DOI: 10.1242/jcs.233221

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  90. academic.oup.com academic.oup.com
    Sex difference in corticosterone-induced insulin resistance in mice
    1
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      RRID:AB_2315049

      DOI: 10.1210/en.2019-00194

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  91. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      RRID:AB_2315049

      DOI: 10.1523/ENEURO.0086-19.2019

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  92. www.embopress.org www.embopress.org
    CDK12 drives breast tumor initiation and trastuzumab resistance via WNT and IRS1‐ErbB‐PI3K signaling
    1
    1. scibot 30 Jul 2021
      p‐AKT

      DOI: 10.15252/embr.201948058

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  93. www.cell.com www.cell.com
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      RRID:AB_2315049

      DOI: 10.1016/j.molcel.2017.01.027

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  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      DOI: 10.7554/eLife.40396

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  95. www.sciencedirect.com www.sciencedirect.com
    Nuclear PGK1 Alleviates ADP-Dependent Inhibition of CDC7 to Promote DNA Replication
    1
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      RRID:AB_2315049

      DOI: 10.1016/j.molcel.2018.09.007

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  96. onlinelibrary.wiley.com onlinelibrary.wiley.com
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      RRID:AB_2315049

      DOI: 10.1002/brb3.1123

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  97. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Effects of the presence and absence of amino acids on translation, signaling and long‐term depression in hippocampal slices from Fmr1 knockout mice
    1
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      RRID: AB_2315049

      DOI: 10.1111/jnc.14874

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  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Use of nonsteroidal anti-inflammatory drugs predicts improved patient survival for PIK3CA-altered head and neck cancer
    1
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      p-AKT-S473

      DOI: 10.1084/jem.20181936

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  99. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TrkB‐mediated activation of the phosphatidylinositol‐3‐kinase/Akt cascade reduces the damage inflicted by oxygen‐glucose deprivation in area CA3 of the rat hippocampus
    1
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  100. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  101. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Akt3-mTOR regulates hippocampal neurogenesis in adult mouse
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      DOI: 10.1111/jnc.15441

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  102. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Inactivation of Tp53 and Pten drives rapid development of pleural and peritoneal malignant mesotheliomas
    2
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      DOI: 10.1002/jcp.26830

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  103. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PTEN negatively regulates the cell lineage progression from NG2+ glial progenitor to oligodendrocyte via mTOR-independent signaling
    2
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      DOI: 10.7554/eLife.32021

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      DOI: 10.7554/eLife.32021

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  104. www.sciencedirect.com www.sciencedirect.com
    Vascular Endothelial Growth Factor–D (VEGF-D) Overexpression and Lymphatic Expansion in Murine Adipose Tissue Improves Metabolism in Obesity
    1
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      AB_2315049

      DOI: 10.1016/j.ajpath.2018.12.008

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  105. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Systemic network analysis identifies XIAP and IκBα as potential drug targets in TRAIL resistant BRAF mutated melanoma
    1
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      RRID:AB_2315049

      DOI: 10.1038/s41540-018-0075-y

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  106. www.sciencedirect.com www.sciencedirect.com
    Loss of Neurological Disease HSAN-I-Associated Gene SPTLC2 Impairs CD8+ T Cell Responses to Infection by Inhibiting T Cell Metabolic Fitness
    1
    1. scibot 28 Jul 2021
      Phospho-Akt (Ser473) (D9E) XPu00a0Rabbit mAb

      DOI: 10.1016/j.immuni.2019.03.005

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    sciencedirect.com/science/article/pii/S1074761319300950
  107. www.sciencedirect.com www.sciencedirect.com
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      DOI: 10.1016/j.immuni.2018.09.018

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    sciencedirect.com/science/article/pii/S1074761318304333
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    PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K
    1
    1. scibot 28 Jul 2021
      RRID:AB_2315049

      DOI: 10.1016/j.molcel.2017.09.024

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    sciencedirect.com/science/article/pii/S1097276517307025
  109. www.sciencedirect.com www.sciencedirect.com
    Tinagl1 Suppresses Triple-Negative Breast Cancer Progression and Metastasis by Simultaneously Inhibiting Integrin/FAK and EGFR Signaling
    1
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      RRID:AB_2315049

      DOI: 10.1016/j.ccell.2018.11.016

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    sciencedirect.com/science/article/pii/S1535610818305373
  110. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      DOI: 10.1016/j.molcel.2017.09.024

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    ncbi.nlm.nih.gov/pmc/articles/PMC5678281/
  111. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      RRID:AB_2315049

      DOI: 10.1016/j.cmet.2018.08.013

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  112. onlinelibrary.wiley.com onlinelibrary.wiley.com
    PTEN knockdown alters dendritic spine/protrusion morphology, not density
    1
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      Anti-pAKTMonoclonalRabbitEpitope surrounds serine 473 of AKT sequence1:200Cell Signaling4060AB_916027

      DOI: 10.1002/cne.23488

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    onlinelibrary.wiley.com/doi/10.1002/cne.23488/full
  113. onlinelibrary.wiley.com onlinelibrary.wiley.com
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      DOI: 10.1002/glia.23472

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    onlinelibrary.wiley.com/doi/full/10.1002/glia.23472
  114. www.cell.com www.cell.com
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    cell.com/developmental-cell/abstract/S1534-5807(17)30871-7
  115. onlinelibrary.wiley.com onlinelibrary.wiley.com
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      DOI: 10.1111/jnc.14311

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  116. www.heliyon.com www.heliyon.com
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  117. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  118. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  119. www.sciencedirect.com www.sciencedirect.com
    Brain Endothelial Cells Maintain Lactate Homeostasis and Control Adult Hippocampal Neurogenesis
    1
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      RRID:AB_10234665

      DOI: 10.1016/j.stem.2019.09.009

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  120. www.sciencedirect.com www.sciencedirect.com
    OVA66 promotes tumour angiogenesis and progression through enhancing autocrine VEGF-VEGFR2 signalling
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      DOI: 10.1016/j.ebiom.2019.02.051

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      DOI: 10.1016/j.neuron.2018.10.051

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  122. www.sciencedirect.com www.sciencedirect.com
    Dynamic Phosphorylation of the C Terminus of Hsp70 Regulates the Mitochondrial Import of SOD2 and Redox Balance
    1
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      DOI: 10.1016/j.celrep.2018.11.015

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  123. www.sciencedirect.com www.sciencedirect.com
    Angiotensin-II-induced Muscle Wasting is Mediated by 25-Hydroxycholesterol via GSK3β Signaling Pathway
    1
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      AB_916024

      DOI: 10.1016/j.ebiom.2017.01.040

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    Neuroplasticity and inflammatory alterations in the nucleus accumbens are corrected after risperidone treatment in a schizophrenia-related developmental model in rats
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  125. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phosphatidylinositol-3 kinase mediates the sweet suppressive effect of leptin in mouse taste cells
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      DOI: 10.1111/jnc.15268

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  126. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Thyroid hormone receptor beta inhibits the PI3K-Akt-mTOR signaling axis in anaplastic thyroid cancer cell lines via genomic mechanisms
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      AB_2315049

      DOI: 10.1210/jendso/bvab102

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    Microscopic image-based covariation network analysis for actin scaffold-modified insulin signaling
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    Brain endothelial PTEN/AKT/NEDD4-2/MFSD2A axis regulates blood-brain barrier permeability
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  130. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IL-17 Inhibits Oligodendrocyte Progenitor Cell Proliferation and Differentiation by Increasing K+ Channel Kv1.3
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    Kinome-wide RNAi screening for mediators of ABT-199 resistance in breast cancer cells identifies Wee1 as a novel therapeutic target
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    Synchronous effects of targeted mitochondrial complex I inhibitors on tumor and immune cells abrogate melanoma progression
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    Evolutionary predictability of genetic versus nongenetic resistance to anticancer drugs in melanoma
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  137. www.embopress.org www.embopress.org
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    β-elemene alleviates airway stenosis via the ILK/Akt pathway modulated by MIR143HG sponging miR-1275
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    A Novel Benzopyrane Derivative Targeting Cancer Cell Metabolic and Survival Pathways
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    MYC-mediated early glycolysis negatively regulates proinflammatory responses by controlling IRF4 in inflammatory macrophages
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    Targeted mass-spectrometry-based assays enable multiplex quantification of receptor tyrosine kinase, MAP kinase, and AKT signaling
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    Target identification for small-molecule discovery in the FOXO3a tumor-suppressor pathway using a biodiverse peptide library
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    TMBIM1 is an inhibitor of adipogenesis and its depletion promotes adipocyte hyperplasia and improves obesity-related metabolic disease
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    Reprogramming an energetic AKT-PAK5 axis boosts axon energy supply and facilitates neuron survival and regeneration after injury and ischemia
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  148. May 2021
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    Mismatch repair deficiency predicts response to HER2 blockade in HER2-negative breast cancer
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    Hepatic AKT orchestrates adipose tissue thermogenesis via FGF21-dependent and -independent mechanisms
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    The E3 ligase TRAF4 Promotes IGF Signaling by Mediating Atypical Ubiquitination of IRS-1
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    NC1-peptide from collagen α3 (IV) chains in the basement membrane of testes regulates spermatogenesis via p-FAK-Y407
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    Heparan Sulfate Synthesized by Ext1 Regulates Receptor Tyrosine Kinase Signaling and Promotes Resistance to EGFR Inhibitors in GBM
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    Removal of epididymal visceral adipose tissue prevents obesity-induced multi-organ insulin resistance in male mice
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    Hdac9 inhibits medial artery calcification through down-regulation of Osterix
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    Histone Acetyltransferase MOF Blocks Acquisition of Quiescence in Ground-State ESCs through Activating Fatty Acid Oxidation
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    Integrin-Linked Kinase Mediates Therapeutic Resistance of Quiescent CML Stem Cells to Tyrosine Kinase Inhibitors
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    Thymoquinone administration ameliorates Alzheimer's disease-like phenotype by promoting cell survival in the hippocampus of amyloid beta1-42 infused rat model
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    Akt-mTOR hypoactivity in bipolar disorder gives rise to cognitive impairments associated with altered neuronal structure and function
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    Serotonin Receptor 2A Activation Promotes Evolutionarily Relevant Basal Progenitor Proliferation in the Developing Neocortex
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    Control of Glucocorticoid Receptor Levels by PTEN Establishes a Failsafe Mechanism for Tumor Suppression
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    Structural Insights into Pseudokinase Domains of Receptor Tyrosine Kinases
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    Obesity-Linked PPARγ S273 Phosphorylation Promotes Insulin Resistance through Growth Differentiation Factor 3
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    Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade
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    Dipyridamole Inhibits Lipogenic Gene Expression by Retaining SCAP-SREBP in the Endoplasmic Reticulum
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    A hotspot mutation in transcription factor IKZF3 drives B cell neoplasia via transcriptional dysregulation
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    FSH Promotes Progesterone Synthesis by Enhancing Autophagy to Accelerate Lipid Droplet Degradation in Porcine Granulosa Cells
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    Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS
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    Maternal high fat diet multigenerationally impairs hippocampal synaptic plasticity and memory in male rat offspring
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    Acetyl-CoA Synthetase 2: A Critical Linkage in Obesity-Induced Tumorigenesis in Myeloma
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    PD-L1 Reverse Signaling in Dermal Dendritic Cells Promotes Dendritic Cell Migration Required for Skin Immunity
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    Exposure to low doses of Dechlorane Plus promotes adipose tissue dysfunction and glucose intolerance in male mice
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