1,739 Matching Annotations
  1. Jun 2022
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    cGAS and DDX41-STING mediated intrinsic immunity spreads intercellularly to promote neuroinflammation in SOD1 ALS model
    1
    1. scibot 17 Jun 2022
      RRID:AB_262044

      DOI: 10.1016/j.isci.2022.104404

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    ncbi.nlm.nih.gov/pmc/articles/PMC9194172/
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    Pathogenic LRRK2 regulates centrosome cohesion via Rab10/RILPL1-mediated CDK5RAP2 displacement
    1
    1. scibot 17 Jun 2022
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      DOI: 10.1016/j.isci.2022.104476

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    sciencedirect.com/science/article/pii/S2589004222007477
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    Tandem immuno-purification of affinity-tagged proteins from mouse testis extracts for MS analysis
    1
    1. scibot 15 Jun 2022
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      DOI: 10.1016/j.xpro.2022.101452

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    sciencedirect.com/science/article/pii/S266616672200332X
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    UBP12 and UBP13 deubiquitinases destabilize the CRY2 blue light receptor to regulate Arabidopsis growth
    1
    1. scibot 15 Jun 2022
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      DOI: 10.1016/j.cub.2022.05.046

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    sciencedirect.com/science/article/pii/S0960982222008491
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    TRPV1 SUMOylation suppresses itch by inhibiting TRPV1 interaction with H1 receptors
    1
    1. scibot 15 Jun 2022
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      DOI: 10.1016/j.celrep.2022.110972

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    sciencedirect.com/science/article/pii/S2211124722007586
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    Time-resolved Phosphoproteome and Proteome Analysis Reveals Kinase Signalling on Master Transcription Factors During Myogenesis
    1
    1. scibot 15 Jun 2022
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      DOI: 10.1016/j.isci.2022.104489

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    sciencedirect.com/science/article/pii/S258900422200760X
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    Structure and regulation of the nuclear exosome targeting complex guides RNA substrates to the exosome
    1
    1. scibot 10 Jun 2022
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      DOI: 10.1016/j.molcel.2022.04.011

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    sciencedirect.com/science/article/pii/S1097276522003227
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    An integrated model for Gpr124 function in Wnt7a/b signaling among vertebrates
    1
    1. scibot 03 Jun 2022
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      DOI: 10.1016/j.celrep.2022.110902

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    sciencedirect.com/science/article/pii/S2211124722006775
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    γ-secretase promotes Drosophila postsynaptic development through the cleavage of a Wnt receptor
    1
    1. scibot 02 Jun 2022
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      DOI: 10.1016/j.devcel.2022.05.006

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    sciencedirect.com/science/article/pii/S1534580722003343
  11. May 2022
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    DDX41 is required for cGAS-STING activation against DNA virus infection
    1
    1. scibot 26 May 2022
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      DOI: 10.1016/j.celrep.2022.110856

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    sciencedirect.com/science/article/pii/S2211124722006295
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    ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1
    1
    1. scibot 26 May 2022
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      DOI: 10.1016/j.molcel.2022.04.034

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    sciencedirect.com/science/article/pii/S1097276522004348
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    C/EBPδ-induced epigenetic changes control the dynamic gene transcription of S100a8 and S100a9
    1
    1. scibot 24 May 2022
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      DOI: 10.7554/eLife.75594

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    ncbi.nlm.nih.gov/pmc/articles/PMC9122501/
  15. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Norepinephrine activates β1-adrenergic receptors at the inner nuclear membrane in astrocytes
    1
    1. scibot 21 May 2022
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      DOI: 10.1002/glia.24219

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    onlinelibrary.wiley.com/doi/10.1002/glia.24219
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    Postnatal expression of cell cycle promoter Fam64a causes heart dysfunction by inhibiting cardiomyocyte differentiation through repression of Klf15
    1
    1. scibot 19 May 2022
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      DOI: 10.1016/j.isci.2022.104337

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    sciencedirect.com/science/article/pii/S2589004222006083
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    Mutations in DNA binding domain of p53 impede RSL1D1-p53 interaction to escape from degradation in human colorectal cancer cells
    1
    1. scibot 19 May 2022
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      DOI: 10.1016/j.yexcr.2022.113211

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    sciencedirect.com/science/article/pii/S001448272200204X
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    Chromatin remodeling is restricted by transient GATA6 binding during iPSC differentiation to definitive endoderm
    1
    1. scibot 12 May 2022
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      DOI: 10.1016/j.isci.2022.104300

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    sciencedirect.com/science/article/pii/S2589004222005703
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Study of novel NARS2 variants in patient of combined oxidative phosphorylation deficiency 24
    1
    1. scibot 12 May 2022
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      DOI: 10.21037/tp-21-570

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    ncbi.nlm.nih.gov/pmc/articles/PMC9085945/
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    Quantitative analysis of protein-RNA interactions in fission yeast
    1
    1. scibot 12 May 2022
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      DOI: 10.1016/j.xpro.2022.101373

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    sciencedirect.com/science/article/pii/S2666166722002532
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    Structures of oxysterol sensor EBI2/GPR183, a key regulator of the immune response
    1
    1. scibot 12 May 2022
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      DOI: 10.1016/j.str.2022.04.006

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    sciencedirect.com/science/article/pii/S0969212622001332
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    Adipose mitochondrial metabolism controls body growth by modulating systemic cytokine and insulin signaling
    1
    1. scibot 11 May 2022
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      DOI: 10.1016/j.celrep.2022.110802

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    sciencedirect.com/science/article/pii/S2211124722005691
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Retinoic acid-induced protein 14 controls dendritic spine dynamics associated with depressive-like behaviors
    1
    1. scibot 11 May 2022
      RRID:AB_262044

      DOI: 10.7554/eLife.77755

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    ncbi.nlm.nih.gov/pmc/articles/PMC9068211/
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    KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4
    1
    1. scibot 11 May 2022
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      DOI: 10.1016/j.celrep.2022.110788

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    sciencedirect.com/science/article/pii/S2211124722005551
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    BAG6 prevents the aggregation of neurodegeneration-associated fragments of TDP43
    1
    1. scibot 05 May 2022
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      DOI: 10.1016/j.isci.2022.104273

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    sciencedirect.com/science/article/pii/S2589004222005430
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    Gene regulatory networks shape developmental plasticity of root cell types under water extremes in rice
    1
    1. scibot 05 May 2022
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      DOI: 10.1016/j.devcel.2022.04.013

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    sciencedirect.com/science/article/pii/S1534580722002532
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    ISL2 is a putative tumor suppressor whose epigenetic silencing reprograms the metabolism of pancreatic cancer
    1
    1. scibot 05 May 2022
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      DOI: 10.1016/j.devcel.2022.04.014

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    sciencedirect.com/science/article/pii/S1534580722002544
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    Generation of RYBP FLAG-HA knock-in human embryonic stem cell line through CRISPR/Cas9-mediated homologous recombination
    1
    1. scibot 05 May 2022
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      DOI: 10.1016/j.scr.2022.102803

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    sciencedirect.com/science/article/pii/S1873506122001520
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    The Mettl3 epitranscriptomic writer amplifies p53 stress responses
    1
    1. scibot 05 May 2022
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      DOI: 10.1016/j.molcel.2022.04.010

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    sciencedirect.com/science/article/pii/S1097276522003215
  30. Apr 2022
  31. www.sciencedirect.com www.sciencedirect.com
    PIIS2589004222005594-html.html
    1
    1. scibot 30 Apr 2022
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      DOI: 10.1016/j.isci.2022.104289

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    sciencedirect.com/science/article/pii/S2589004222005594
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    Characterization and functional interrogation of the SARS-CoV-2 RNA interactome
    1
    1. scibot 27 Apr 2022
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      DOI: 10.1016/j.celrep.2022.110744

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    sciencedirect.com/science/article/pii/S2211124722005083
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    Purification and cryo-EM structure determination of VCP/p97 dodecamers from mammalian and bacterial cells
    1
    1. scibot 27 Apr 2022
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      DOI: 10.1016/j.xpro.2022.101339

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    sciencedirect.com/science/article/pii/S2666166722002192
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    Hexokinase 1 cellular localization regulates the metabolic fate of glucose
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      DOI: 10.1016/j.molcel.2022.02.028

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    sciencedirect.com/science/article/pii/S1097276522001666
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    Multilayered omics reveal sex- and depot-dependent adipose progenitor cell heterogeneity
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    1. scibot 21 Apr 2022
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      DOI: 10.1016/j.cmet.2022.03.012

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    sciencedirect.com/science/article/pii/S1550413122001267
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    A presynaptic phosphosignaling hub for lasting homeostatic plasticity
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      DOI: 10.1016/j.celrep.2022.110696

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    sciencedirect.com/science/article/pii/S2211124722004545
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    An oxygen-adaptive interaction between SNHG12 and occludin maintains blood-brain barrier integrity
    1
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      DOI: 10.1016/j.celrep.2022.110656

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    sciencedirect.com/science/article/pii/S2211124722004089
  38. www.nature.com www.nature.com
    Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation
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      DOI: 10.1038/s41418-022-00983-4

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    nature.com/articles/s41418-022-00983-4
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    CCT2 is an aggrephagy receptor for clearance of solid protein aggregates
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      DOI: 10.1016/j.cell.2022.03.005

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    sciencedirect.com/science/article/pii/S0092867422002653
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    Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis
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      DOI: 10.1016/j.molcel.2022.03.016

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    sciencedirect.com/science/article/pii/S1097276522002544
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    CTCF functions as an insulator for somatic genes and a chromatin remodeler for pluripotency genes during reprogramming
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    1. scibot 07 Apr 2022
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      DOI: 10.1016/j.celrep.2022.110626

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    sciencedirect.com/science/article/pii/S2211124722003746
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    Neurexins play a crucial role in cerebellar granule cell survival by organizing autocrine machinery for neurotrophins
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    1. scibot 07 Apr 2022
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      DOI: 10.1016/j.celrep.2022.110624

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    sciencedirect.com/science/article/pii/S2211124722003722
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    Deadenylase-dependent mRNA decay of GDF15 and FGF21 orchestrates food intake and energy expenditure
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      DOI: 10.1016/j.cmet.2022.03.005

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    sciencedirect.com/science/article/pii/S1550413122000936
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    Elucidation of a complete mechanical signaling and virulence activation pathway in enterohemorrhagic Escherichia coli
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    GFI1 cooperates with IKZF1/IKAROS to activate gene expression in T-cell acute lymphoblastic leukemia
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    The roles of RNA helicases in DNA damage repair and tumorigenesis reveal precision therapeutic strategies
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  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dual signaling via interferon and DNA damage response elicits entrapment by giant PML nuclear bodies
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    K27-linked ubiquitylation promotes p97 substrate processing and is essential for cell proliferation
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    Labeling of heterochronic ribosomes reveals C1ORF109 and SPATA5 control a late step in human ribosome assembly
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    Precision analysis of mutant U2AF1 activity reveals deployment of stress granules in myeloid malignancies
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    A local insulin reservoir in Drosophila alpha cell homologs ensures developmental progression under nutrient shortage
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    RUFY3 and RUFY4 are ARL8 effectors that promote coupling of endolysosomes to dynein-dynactin
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    Restriction factor screening identifies RABGAP1L-mediated disruption of endocytosis as a host antiviral defense
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    FBXO47 is essential for preventing the synaptonemal complex from premature disassembly in mouse male meiosis
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    Selective YAP activation in Procr cells is essential for ovarian stem/progenitor expansion and epithelium repair
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    Semaphorin3A/PlexinA3 association with the Scribble scaffold for cGMP increase is required for apical dendrite development
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    Identification of the global miR-130a targetome reveals a role for TBL1XR1 in hematopoietic stem cell self-renewal and t(8;21) AML
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    Notch-mediated lactate metabolism regulates MDSC development through the Hes1/MCT2/c-Jun axis
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    K48/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase regulates oxidative stress-induced autophagy
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    Eco1-dependent cohesin acetylation anchors chromatin loops and cohesion to define functional meiotic chromosome domains
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    Systematic mapping of nuclear domain-associated transcripts reveals speckles and lamina as hubs of functionally distinct retained introns
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    Phosphorylation of guanosine monophosphate reductase triggers a GTP-dependent switch from pro- to anti-oncogenic function of EPHA4
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    Epigenetic basis of oncogenic-Kras-mediated epithelial-cellular proliferation and plasticity
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    PD-L1 promotes myofibroblastic activation of hepatic stellate cells by distinct mechanisms selective for TGF-β receptor I versus II
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    CRAF dimerization with ARAF regulates KRAS-driven tumor growth
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    Identification of the nucleotide-free state as a therapeutic vulnerability for inhibition of selected oncogenic RAS mutants
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    Tethering Piezo channels to the actin cytoskeleton for mechanogating via the cadherin-β-catenin mechanotransduction complex
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    Co-adaptor driven assembly of a CUL3 E3 ligase complex
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    In vivo CRISPR screening identifies BAZ2 chromatin remodelers as druggable regulators of mammalian liver regeneration
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    Structurally-discovered KLF4 variants accelerate and stabilize reprogramming to pluripotency
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    Liquidambaric acid inhibits Wnt/β-catenin signaling and colon cancer via targeting TNF receptor-associated factor 2
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    Steroid hormone receptor and infiltrating immune cell status reveals therapeutic vulnerabilities of ESR1 mutant breast cancer.
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    An oncogenic enhancer encodes selective selenium dependency in AML
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    Activating JAK-mutations confer resistance to FLT3 kinase inhibitors in FLT3-ITD positive AML in vitro and in vivo
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    Regulation of mitochondrial fission by GIPC-mediated Drp1 retrograde transport
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    Regulation of reverse electron transfer at mitochondrial complex I by unconventional Notch action in cancer stem cells
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    Cas11 enables genome engineering in human cells with compact CRISPR-Cas3 systems
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    Selective autophagy controls innate immune response through a TAK1/TAB2/SH3PX1 axis
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    Structural basis of K63-ubiquitin chain formation by the Gordon-Holmes syndrome RBR E3 ubiquitin ligase RNF216
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    A fluorescence recovery after photobleaching protocol to measure surface diffusion of DAGLα in primary cultured cortical mouse neurons
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    Global RNA interactome of Salmonella discovers a 5′ UTR sponge for the MicF small RNA that connects membrane permeability to transport capacity
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    Metastasis enhancer PGRMC1 boosts store-operated Ca2+ entry by uncoiling Ca2+ sensor STIM1 for focal adhesion turnover and actomyosin formation
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    Nuclear NAD+-biosynthetic enzyme NMNAT1 facilitates development and early survival of retinal neurons
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    GS-CA1 and lenacapavir stabilize the HIV-1 core and modulate the core interaction with cellular factors
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    The sex determination gene doublesex regulates expression and secretion of the basement membrane protein Collagen IV
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    Recruitment of MLL1 complex is essential for SETBP1 to induce myeloid transformation
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    Identification and functional characterization of transcriptional activators in human cells
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    Evolutionary analyses of the gasdermin family suggest conserved roles in infection response despite loss of pore-forming functionality
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    An antisense transcript transcribed from Irs2 locus contributes to the pathogenesis of hepatic steatosis in insulin resistance
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    STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses
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    NAD kinase sustains lipogenesis and mitochondrial metabolismthrough fatty acid synthesis
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    Translocation of polyubiquitinated protein substrates by the hexameric Cdc48 ATPase
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    RNA circles with minimized immunogenicity as potent PKR inhibitors
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    Toxoplasma gondii SAG1 Targeting Host Cell S100A6 for Parasite Invasion and Host Immunity
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    SARS-CoV-2 nucleocapsid protein binds host mRNAs and attenuates stress granules to impair host stress response
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    Shed CNTNAP2 ectodomain is detectable in CSF and regulates Ca2+ homeostasis and network synchrony via PMCA2/ATP2B2
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    CD95/Fas suppresses NF-κB activation through recruitment of KPC2 in a CD95L/FasL-independent mechanism
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    Prolyl endopeptidase-like is a (thio)esterase involved in mitochondrial respiratory chain function
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    Elevated FBXO45 promotes liver tumorigenesis through enhancing IGF2BP1 ubiquitination and subsequent PLK1 upregulation
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    MYC assembles and stimulates topoisomerases 1 and 2 in a “topoisome”
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    The protease SPRTN and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability
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    Type 1 polyisoprenoid diphosphate phosphatase modulates geranylgeranyl-mediated control of HMG CoA reductase and UBIAD1
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    NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis
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    Anti-recombination function of MutSα restricts telomere extension by ALT-associated homology-directed repair
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    SUMOylation of linker histone H1 drives chromatin condensation and restriction of embryonic cell fate identity
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    Sumoylation of the human histone H4 tail inhibits p300-mediated transcription by RNA polymerase II in cellular extracts
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    Single-cell transcriptomics identifies Gadd45b as a regulator of herpesvirus-reactivating neurons
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    HRD1-mediated METTL14 degradation regulates m6A mRNA modification to suppress ER proteotoxic liver disease
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    p190RhoGAP Filters Competing Signals to Resolve Axon Guidance Conflicts
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  143. www.nature.com www.nature.com
    MDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA
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    LARP7 ameliorates cellular senescence and aging by allosterically enhancing SIRT1 deacetylase activity
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    MAR1 links membrane adhesion to membrane merger during cell-cell fusion in Chlamydomonas
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    Bi-allelic variants in OGDHL cause a neurodevelopmental spectrum disease featuring epilepsy, hearing loss, visual impairment, and ataxia
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    Structural mechanism for regulation of Rab7 by site-specific monoubiquitination
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    Cryo-Electron Microscopy Structures of VCP/p97 Reveal a New Mechanism of Oligomerization Regulation
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    TIAM1-RAC1 promote small-cell lung cancer cell survival through antagonizing Nur77-induced BCL2 conformational change
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    DDK/Hsk1 phosphorylates and targets fission yeast histone deacetylase Hst4 for degradation to stabilize stalled DNA replication forks
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    ORF3a of SARS-CoV-2 promotes lysosomal exocytosis-mediated viral egress
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    The Lon protease temporally restricts polar cell differentiation events during the Caulobacter cell cycle
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    Transcriptional and chromatin-based partitioning mechanisms uncouple protein scaling from cell size
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  155. Oct 2021
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    Rapamycin recruits SIRT2 for FKBP12 deacetylation during mTOR activity modulation in innate immunity
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    P5A ATPase controls ER translocation of Wnt in neuronal migration
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    Mitophagy antagonism by ZIKV reveals Ajuba as a regulator of PINK1 signaling, PKR-dependent inflammation, and viral invasion of tissues
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    Subtractive CRISPR screen identifies the ATG16L1/vacuolar ATPase axis as required for non-canonical LC3 lipidation
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    TRPM7 is critical for short-term synaptic depression by regulating synaptic vesicle endocytosis
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    Quantitative proteomics reveals the selectivity of ubiquitin-binding autophagy receptors in the turnover of damaged lysosomes by lysophagy
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    Increased ACTL6A occupancy within mSWI/SNF chromatin remodelers drives human squamous cell carcinoma
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    Phase separation drives RNA virus-induced activation of the NLRP6 inflammasome
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  166. www.sciencedirect.com www.sciencedirect.com
    An in vitro system to silence mitochondrial gene expression
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    The Hsp90 cochaperone TTT promotes cotranslational maturation of PIKKs prior to complex assembly
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    Adaptive translational pausing is a hallmark of the cellular response to severe environmental stress
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  169. www.sciencedirect.com www.sciencedirect.com
    Loss of FBXO31-mediated degradation of DUSP6 dysregulates ERK and PI3K-AKT signaling and promotes prostate tumorigenesis
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    Genome-wide RNA structure changes during human neurogenesis modulate gene regulatory networks
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    Gene bookmarking by the heat shock transcription factor programs the insulin-like signaling pathway
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  172. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SARS-CoV-2 integral membrane proteins shape the serological responses of patients with COVID-19
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    TRIP12 ubiquitination of glucocerebrosidase contributes to neurodegeneration in Parkinson’s disease
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    A phosphate starvation response-centered network regulates mycorrhizal symbiosis
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  175. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Melatonin pretreatment alleviates the long-term synaptic toxicity and dysmyelination induced by neonatal Sevoflurane exposure via MT1 receptor-mediated Wnt signaling modulation
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  176. www.embopress.org www.embopress.org
    Promyelocytic leukemia protein targets MK2 to promote cytotoxicity
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    Cancer cell immune mimicry delineates onco-immunologic modulation
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    The N-terminal domain of SARS-CoV-2 nsp1 plays key roles in suppression of cellular gene expression and preservation of viral gene expression
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    Adaptations in Hippo-Yap signaling and myofibroblast fate underlie scar-free ear appendage wound healing in spiny mice
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    RetroCHMP3 blocks budding of enveloped viruses without blocking cytokinesis
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  181. Sep 2021
  182. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification and Functional Characterization of a Novel Androgen Receptor Coregulator, EAP1
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  183. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cytosolic aggregation of mitochondrial proteins disrupts cellular homeostasis by stimulating the aggregation of other proteins
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  184. elifesciences.org elifesciences.org
    A prion accelerates proliferation at the expense of lifespan
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  185. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Analysis of meiosis in Pristionchus pacificus reveals plasticity in homolog pairing and synapsis in the nematode lineage
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  186. www.sciencedirect.com www.sciencedirect.com
    Structural basis and regulation of the reductive stress response
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    ERα determines the chemoresistant function of mutant p53 involving the switch between lincRNA-p21 and DDB2 expressions
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    ERα is an RNA-binding protein sustaining tumor cell survival and drug resistance
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    NSD2 dimethylation at H3K36 promotes lung adenocarcinoma pathogenesis
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    A hydride transfer complex reprograms NAD metabolism and bypasses senescence
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    Mitochondrial-derived compartments facilitate cellular adaptation to amino acid stress
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    The oncomicropeptide APPLE promotes hematopoietic malignancy by enhancing translation initiation
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  193. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A molecular sensor determines the ubiquitin substrate specificity of SARS-CoV-2 papain-like protease
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    DOT1L O-GlcNAcylation promotes its protein stability and MLL-fusion leukemia cell proliferation
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    The protein arginine methyltransferase PRMT1 promotes TBK1 activation through asymmetric arginine methylation
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    Brown adipocyte ATF4 activation improves thermoregulation and systemic metabolism
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    Splicing modulators elicit global translational repression by condensate-prone proteins translated from introns
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    Open-state structure and pore gating mechanism of the cardiac sodium channel
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    Controlled lipid β-oxidation and carnitine biosynthesis by a vitamin D metabolite
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    Cilium induction triggers differentiation of glioma stem cells
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    Ocular disease-associated mutations diminish the mitotic chromosome retention ability of PAX6
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    Widespread ribosome stalling in a genome-reduced bacterium and the need for translational quality control
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