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1,460 Matching Annotations

Aug 2023
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Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in amyotrophic lateral sclerosis

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1. scibot 10 Aug 2023
  
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  DOI: 10.1126/sciadv.adf6895
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10403219/
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Short-term PI3K inhibition prevents breast cancer in preclinical models

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  DOI: 10.1158/1940-6207.CAPR-22-0275
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9905287/
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Hepatic levels of S-adenosylmethionine regulate the adaptive response to fasting

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ncbi.nlm.nih.gov/pmc/articles/PMC10432853/
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Tryptophan metabolism promotes immune evasion in human pancreatic β cells

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  DOI: 10.1016/j.ebiom.2023.104740
  
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sciencedirect.com/science/article/pii/S2352396423003055
Jul 2023
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Pigment Epithelium-Derived Factor, a Novel Adipokine, Contributes to Gestational Diabetes Mellitus

1
1. scibot 29 Jul 2023
  
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  DOI: 10.1210/clinem/dgad413
  
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dx.doi.org/10.1210/clinem/dgad413
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FGFR-mediated ERK1/2 signaling contributes to mesendoderm and definitive endoderm formation in vitro

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ncbi.nlm.nih.gov/pmc/articles/PMC10368912/
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Targeting ITGB4/SOX2-driven lung cancer stem cells using proteasome inhibitors

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1. scibot 29 Jul 2023
  
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  DOI: 10.1016/j.isci.2023.107302
  
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sciencedirect.com/science/article/pii/S2589004223013792
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mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA translation and promotes cell phenotype switching

1
1. scibot 27 Jul 2023
  
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  DOI: 10.1016/j.celrep.2023.112868
  
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sciencedirect.com/science/article/pii/S2211124723008793
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Hexokinase 2-mediated gene expression via histone lactylation is required for hepatic stellate cell activation and liver fibrosis

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1. scibot 22 Jul 2023
  
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  DOI: 10.1016/j.cmet.2023.06.013
  
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sciencedirect.com/science/article/pii/S1550413123002231
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Widespread dysregulation of mRNA splicing implicates RNA processing in the development and progression of Huntington's disease

2
1. scibot 22 Jul 2023
  
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  DOI: 10.1016/j.ebiom.2023.104720
  
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Recency memory is altered in cocaine-withdrawn adolescent rats: Implication of cortical mTOR signaling

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1. scibot 13 Jul 2023
  
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  DOI: 10.1016/j.pnpbp.2023.110822
  
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sciencedirect.com/science/article/pii/S0278584623001082
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Genome-wide mapping of cancer dependency genes and genetic modifiers of chemotherapy in high-risk hepatoblastoma

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  DOI: 10.1038/s41467-023-39717-6
  
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nature.com/articles/s41467-023-39717-6
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Enhanced bypass of PD-L1 translation reduces the therapeutic response to mTOR kinase inhibitors

2
1. scibot 08 Jul 2023
  
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  DOI: 10.1016/j.celrep.2023.112764
  
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sciencedirect.com/science/article/pii/S2211124723007751
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ccr-23-0103-html.html

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  DOI: 10.1158/1078-0432.ccr-23-0103
  
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52.53.155.43/05abf3a0903b8473a428373dc7a2f791e1da90bb/ccr-23-0103-html.html
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Enhanced SARS-CoV-2 entry via UPR-dependent AMPK-related kinase NUAK2

1
1. scibot 08 Jul 2023
  
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  DOI: 10.1016/j.molcel.2023.06.020
  
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sciencedirect.com/science/article/pii/S1097276523004677
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The kinesin Kif21b binds myosin Va and mediates changes in actin dynamics underlying homeostatic synaptic downscaling

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  DOI: 10.1016/j.celrep.2023.112743
  
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Genome-wide CRISPR-Cas9 screen analyzed by SLIDER identifies network of repressor complexes that regulate TRIM24

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1. scibot 06 Jul 2023
  
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  DOI: 10.1016/j.isci.2023.107126
  
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sciencedirect.com/science/article/pii/S2589004223012038
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Transcription factors interact with RNA to regulate genes

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1. scibot 06 Jul 2023
  
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  DOI: 10.1016/j.molcel.2023.06.012
  
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sciencedirect.com/science/article/abs/pii/S1097276523004343
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Glutaminase 1 deficiency confined in forebrain neurons causes autism spectrum disorder-like behaviors

1
1. scibot 05 Jul 2023
  
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  DOI: 10.1016/j.celrep.2023.112712
  
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sciencedirect.com/science/article/pii/S2211124723007234
Jun 2023
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Restoration of mitochondrial function by Spirulina polysaccharide via upregulated SOD2 in aging fibroblasts

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1. scibot 29 Jun 2023
  
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  DOI: 10.1016/j.isci.2023.107113
  
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sciencedirect.com/science/article/pii/S2589004223011902
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Detection of Arc/Arg3.1 oligomers in rat brain: constitutive and synaptic activity-evoked dimer expression in vivo

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1. scibot 27 Jun 2023
  
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  DOI: 10.3389/fnmol.2023.1142361
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10289200/
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Ubiquitin ligase and signalling hub MYCBP2 is required for efficient EPHB2 tyrosine kinase receptor function

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1. scibot 27 Jun 2023
  
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  DOI: 10.1101/2023.06.12.544638
  
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biorxiv.org/content/10.1101/2023.06.12.544638v3
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SRSF10 regulates proliferation of neural progenitor cells and affects neurogenesis in developing mouse neocortex

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1. scibot 24 Jun 2023
  
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  DOI: 10.1016/j.isci.2023.107042
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10285642/
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Mesenchymal stem cells induce dynamic immunomodulation of airway and systemic immune cells in vivo but do not improve survival for mice with H1N1 virus-induced acute lung injury

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1. scibot 24 Jun 2023
  
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  DOI: 10.3389/fbioe.2023.1203387
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10285296/
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Molecular components of the circadian clock regulate HIV-1 replication

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  DOI: 10.1016/j.isci.2023.107007
  
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Identification of aryl hydrocarbon receptor as a barrier to HIV-1 infection and outgrowth in CD4+ T cells

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1. scibot 23 Jun 2023
  
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  DOI: 10.1016/j.celrep.2023.112634
  
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MCT4-dependent lactate secretion suppresses antitumor immunity in LKB1-deficient lung adenocarcinoma

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1. scibot 21 Jun 2023
  
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  DOI: 10.1016/j.ccell.2023.05.015
  
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sciencedirect.com/science/article/pii/S1535610823001824
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KIF4 regulates neuronal morphology and seizure susceptibility via the PARP1 signaling pathway

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1. scibot 10 Jun 2023
  
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  DOI: 10.1083/jcb.202208108
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9735414/
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LZTR1 mutation mediates oncogenesis through stabilization of EGFR and AXL

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  DOI: 10.1158/2159-8290.CD-22-0376
  
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dx.doi.org/10.1158/2159-8290.CD-22-0376
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APOE expression and secretion are modulated by mitochondrial dysfunction

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1. scibot 03 Jun 2023
  
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  DOI: 10.7554/eLife.85779
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10231934/
onlinelibrary.wiley.com onlinelibrary.wiley.com

Endonuclease VIII-like 1 deficiency potentiates nigrostriatal dopaminergic neuron degeneration in a male mouse model of Parkinson's disease

1
1. scibot 01 Jun 2023
  
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  DOI: 10.1111/jnc.15794
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.15794
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PICT-1 regulates p53 splicing and sensitivity of medullary thyroid carcinoma cells to Everolimus

1
1. scibot 01 Jun 2023
  
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  DOI: 10.1111/jne.13187
  
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onlinelibrary.wiley.com/doi/10.1111/jne.13187
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BPS Publications

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1. scibot 01 Jun 2023
  
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  DOI: 10.1111/bph.16093
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16093
May 2023
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Efficient self-organization of blastoids solely from mouse ESCs is facilitated by transient reactivation of 2C gene network

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1. scibot 27 May 2023
  
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  DOI: 10.1101/2023.04.12.536583
  
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52.53.155.43/d6c42894cd1d74c54111e2279a70a7e2e2f22de0/2023.04.12.536583v1.full-html.html
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ADAR1-mediated RNA editing promotes B cell lymphomagenesis

1
1. scibot 26 May 2023
  
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  DOI: 10.1016/j.isci.2023.106864
  
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BPS Publications

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p53-independent tumor suppression by cell-cycle arrest via CREB/ATF transcription factor OASIS

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Extracellular vesicles in fatty liver promote a metastatic tumor microenvironment

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Thyroid Stem Cell Speciation – A Major Role for PKC

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Relationships between gene expression and behavior in mice in response to systemic modulation of the O-GlcNAcylation pathway

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eIF3 mRNA selectivity profiling reveals eIF3k as a cancer-relevant regulator of ribosome content

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Hub genes and key pathways of traumatic brain injury:... : Neural Regeneration Research

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Comparative Analysis of Six IRF Family Members in Alveolar Epithelial Cell-Intrinsic Antiviral Responses

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BACE1 regulates expression of Clusterin in astrocytes for enhancing clearance of β-amyloid peptides

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Inhibition of BRAF and ERK1/2 has synergistic effects on thyroid cancer growth in vitro and in vivo

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N-myc downstream regulated family member 1 (NDRG1) is enriched in myelinating oligodendrocytes and impacts myelin degradation in response to demyelination

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Synaptic hyperexcitability of cytomegalic pyramidal neurons contributes to epileptogenesis in tuberous sclerosis complex

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The ubiquitin-ligase TRAF6 and TGFβ type I receptor form a complex with Aurora kinase B contributing to mitotic progression and cytokinesis in cancer cells

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FEBS Press

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Bromodomain protein BRD8 regulates cell cycle progression in colorectal cancer cells through a TIP60-independent regulation of the pre-RC complex

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IFITM3 blocks influenza virus entry by sorting lipids and stabilizing hemifusion

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Coronavirus Subverts ER-phagy by Hijacking FAM134B and ATL3 into p62 Condensates to Facilitate Viral Replication

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Targeting USP2 regulation of VPRBP-mediated degradation of p53 and PD-L1 for cancer therapy

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Buffering of transcription rate by mRNA half-life is a conserved feature of Rett syndrome models

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The mitochondrial protease OMA1 acts as a metabolic safeguard upon nuclear DNA damage

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Altered striatal actin dynamics drives behavioral inflexibility in a mouse model of fragile X syndrome

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A robust and efficient microvascular isolation method for multimodal characterization of the mouse brain vasculature

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Inter-axonal molecular crosstalk via Lumican proteoglycan sculpts murine cervical corticospinal innervation by distinct subpopulations

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Mutating novel interaction sites in NRP1 reduces SARS-CoV-2 spike protein internalization

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Remodeling of the Ribosomal Quality Control and Protein Translation by a Viral Ubiquitin Deconjugase

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Dysregulation of AMPA Receptor Trafficking and Intracellular Vesicular Sorting in the Prefrontal Cortex of Dopamine Transporter Knock-Out Rats

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Minimal upstream open reading frame of Per2 mediates phase fitness of the circadian clock to day/night physiological body temperature rhythm

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Targeting androgen receptor and the variants by an orally bioavailable Proteolysis Targeting Chimeras compound in castration resistant prostate cancer

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Harnessing transcriptionally driven chromosomal instability adaptation to target therapy-refractory lethal prostate cancer

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Psychological stress induces an increase in cholinergic enteric neuromuscular pathways mediated by glucocorticoid receptors

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Phosphoenolpyruvate regulates the Th17 transcriptional program and inhibits autoimmunity

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Genetic Val66Met BDNF Variant Increases Hyperphagia on Fat-rich Diets in Mice

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Prostaglandins limit nuclear actin to control nucleolar function during oogenesis

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IGF-binding proteins secreted by cancer-associated fibroblasts induce context-dependent drug sensitization of lung cancer cells

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cd-22-0376-html.html

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CD70 is a therapeutic target upregulated in EMT-associated EGFR tyrosine kinase inhibitor resistance

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Plk1 Inhibitors and Abiraterone Synergistically Disrupt Mitosis and Kill Cancer Cells of Disparate Origin Independently of Androgen Receptor Signaling

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Sigma-1 receptor maintains ATAD3A as a monomer to inhibit mitochondrial fragmentation at the mitochondria-associated membrane in amyotrophic lateral sclerosis

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BPS Publications

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Elevated PAF1-RAD52 axis confers chemoresistance to human cancers

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FUS ALS neurons activate major stress pathways and reduce translation as an early protective mechanism against neurodegeneration

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A p53-TLR3 axis ameliorates pulmonary hypertension by inducing BMPR2 via IRF3

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ADAR RNA editing on antisense RNAs results in apparent U-to-C base changes on overlapping sense transcripts

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Gasdermin D pore-forming activity is redox-sensitive

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Inositol pyrophosphate profiling reveals regulatory roles of IP6K2-dependent enhanced IP7 metabolism in the enteric nervous system

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Hippocampal dentate gyri proteomics reveals Wnt signaling involvement in the behavioral impairment in the THRSP-overexpressing ADHD mouse model

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Autotaxin facilitates selective LPA receptor signaling

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Transient neurogenesis in ischemic cortex from Sox2+... : Neural Regeneration Research

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Postnatal neuronal Bace1 deletion impairs neuroblast and oligodendrocyte maturation

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Development of CAR-T cells specifically targeting cancer stem cell antigen DNAJB8 against solid tumours

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The TAZ-CAMTA1 Fusion Protein Promotes Tumorigenesis via Connective Tissue Growth Factor and Ras–MAPK Signaling in Epithelioid Hemangioendothelioma

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Epithelial-to-Mesenchymal Transition Supports Ovarian Carcinosarcoma Tumorigenesis and Confers Sensitivity to Microtubule Targeting with Eribulin

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Pyruvate dehydrogenase kinase supports macrophage NLRP3 inflammasome activation during acute inflammation

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Remarkable Synergy When Combining EZH2 Inhibitors with YM155 Is H3K27me3-Independent

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Long-lasting BDNF signaling alterations in the amygdala of adolescent female rats exposed to the activity-based anorexia model

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Isoform requirement of clustered protocadherin for preventing neuronal apoptosis and neonatal lethality

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Human PSEN1 Mutant Glia Improve Spatial Learning and Memory in Aged Mice

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Increased replication origin firing links replication stress to whole chromosomal instability in human cancer

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The EMT transcription factor ZEB1 governs a fitness-promoting but vulnerable DNA replication stress response

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VLDL-VLDLR axis facilitates brown fat thermogenesis through replenishment of lipid fuels and PPARβ/δ activation

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Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death

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KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition

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Exosomal miR-23b from bone marrow mesenchymal stem cells alleviates oxidative stress and pyroptosis after intracerebral hemorrhage

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PERIOD 2 Regulates Low Dose Radioprotection via PER2/pGSK3β/β-Catenin/Per2 Loop

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Tip60-mediated H2A.Z acetylation promotes neuronal fate specification and bivalent gene activation

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Fibroblasts repair blood-brain barrier damage and hemorrhagic brain injury via TIMP2

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Downregulation of protein kinase C gamma reduces epithelial property and enhances malignant phenotypes in colorectal cancer cells

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B cell linker protein (BLNK) is a regulator of Met receptor signaling and trafficking in non-small cell lung cancer

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CRABP2 is associated with thyroid cancer recurrence and promotes invasion via the integrin/FAK/AKT pathway

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The Mitochondrial RNA Granule Modulates Manganese-Dependent Cell Toxicity

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AMPK directly phosphorylates TBK1 to integrate glucose sensing into innate immunity

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CD8+ T cell metabolic rewiring defined by scRNA-seq identifies a critical role of ASNS expression dynamics in T cell differentiation

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The adhesion G-protein-coupled receptor Gpr116 is essential to maintain the skeletal muscle stem cell pool

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FABP5 controls macrophage alternative activation and allergic asthma by selectively programming long-chain unsaturated fatty acid metabolism

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NEIL3 contributes to the Fanconi anemia/BRCA pathway by promoting the downstream double-strand break repair step

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Targeting the MITF/APAF-1 axis as salvage therapy for MAPK inhibitors in resistant melanoma

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Bortezomib inhibits ZIKV/DENV by interfering with viral polyprotein cleavage via the ERAD pathway

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Metabolic regulation by p53 prevents R-loop-associated genomic instability

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Deletion of Nox4 enhances remyelination following cuprizone-induced demyelination by increasing phagocytic capacity of microglia and macrophages in mice

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Brain Endothelial Cells in Contrary to the Aortic Do Not Transport but Degrade Low-Density Lipoproteins via Both LDLR and ALK1

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The proprotein convertase furin regulates the development of thymic epithelial cells to ensure central immune tolerance

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Long noncoding RNA Pvt1 promotes the proliferation and... : Neural Regeneration Research

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GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis

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The rheumatoid arthritis drug auranofin lowers leptin levels and exerts antidiabetic effects in obese mice

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Induction of the hepatic aryl hydrocarbon receptor by alcohol dysregulates autophagy and phospholipid metabolism via PPP2R2D

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Long-term potentiation reconstituted with an artificial TARP/PSD-95 complex

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Competition for endothelial cell polarity drives vascular morphogenesis in the mouse retina

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Validation of a non-oncogene encoded vulnerability to exportin 1 inhibition in pediatric renal tumors

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A genetically modified minipig model for Alzheimer’s disease with SORL1 haploinsufficiency

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NCOA4-mediated ferritinophagy is a pancreatic cancer dependency via maintenance of iron bioavailability for iron-sulfur cluster proteins

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S1-END-seq reveals DNA secondary structures in human cells

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m1A and m6A modifications function cooperatively to facilitate rapid mRNA degradation

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Convergent cerebrospinal fluid proteomes and metabolic ontologies in humans and animal models of Rett syndrome

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Huntingtin coordinates dendritic spine morphology and function through cofilin-mediated control of the actin cytoskeleton

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Mfsd2b and Spns2 are essential for maintenance of blood vessels during development and in anaphylactic shock

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Targeting HOTAIRM1 ameliorates glioblastoma by disrupting mitochondrial oxidative phosphorylation and serine metabolism

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BPS Publications

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Expression pattern of NLRC5 in the postnatal mouse brain

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DNA methyltransferase 3 alpha and TET methylcytosine dioxygenase 2 restrain mitochondrial DNA-mediated interferon signaling in macrophages

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Cancer genes disfavoring T cell immunity identified via integrated systems approach

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Regulation of alternative polyadenylation by the C2H2-zinc-finger protein Sp1

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A Method for In Situ Reverse Genetic Analysis of Proteins Involved mtDNA Replication

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Skeletal progenitors preserve proliferation and self-renewal upon inhibition of mitochondrial respiration by rerouting the TCA cycle

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LRRK2 kinase activity regulates GCase level and enzymatic activity differently depending on cell type in Parkinson’s disease

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IGSF1 deficiency leads to reduced TSH production independent of alterations in thyroid hormone action in male mice

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Poziotinib for EGFR exon 20-mutant NSCLC: Clinical efficacy, resistance mechanisms, and impact of insertion location on drug sensitivity

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A ROS-dependent mechanism promotes CDK2 phosphorylation to drive progression through S phase

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Upregulation of FOXO1 contributes to lipopolysaccharide-induced pulmonary endothelial injury by induction of autophagy

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BACE-1 inhibition facilitates the transition from homeostatic microglia to DAM-1

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Aberrant expression and subcellular localization of ECT2 drives colorectal cancer progression and growth

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Diverging regulation of Bach2 protein and RNA expression determine cell fate in early B cell response

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BAFFR activates PI3K/AKT signaling in human naive but not in switched memory B cells through direct interactions with B cell antigen receptors

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Clioquinol as an inhibitor of JmjC-histone demethylase exhibits common and unique histone methylome and transcriptome between clioquinol and hypoxia

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Mechanoreceptor Piezo1 Is Downregulated in Multiple Sclerosis Brain and Is Involved in the Maturation and Migration of Oligodendrocytes in vitro

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Senescence-induced endothelial phenotypes underpin immune-mediated senescence surveillance

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Riboregulation of Enolase 1 activity controls glycolysis and embryonic stem cell differentiation

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Monocarboxylate transporter 1 deficiency impacts CD8+ T lymphocytes proliferation and recruitment to adipose tissue during obesity

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A TET1-PSPC1-Neat1 molecular axis modulates PRC2 functions in controlling stem cell bivalency

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Selective endocytosis of Ca2+-permeable AMPARs by the Alzheimer’s disease risk factor CALM bidirectionally controls synaptic plasticity

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Selective endocytosis of Ca2+-permeable AMPARs by the Alzheimer’s disease risk factor CALM bidirectionally controls synaptic plasticity

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Sortilin Modulates Schwann Cell Signaling and Remak Bundle Regeneration Following Nerve Injury

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UPF1 promotes rapid degradation of m6A-containing RNAs

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DDX41 is required for cGAS-STING activation against DNA virus infection

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XIST loss impairs mammary stem cell differentiation and increases tumorigenicity through Mediator hyperactivation

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Increased microtubule growth triggered by microvesicle-mediated paracrine signaling is required for melanoma cancer cell invasion

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Intrinsically disordered regions couple the ligand binding and kinase activation of Trk neurotrophin receptors

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A family of conserved bacterial virulence factors dampens interferon responses by blocking calcium signaling

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CDX2-induced intestinal metaplasia in human gastric organoids derived from induced pluripotent stem cells

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NSD1 mediates antagonism between SWI/SNF and polycomb complexes and is required for transcriptional activation upon EZH2 inhibition

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Dysfunction of Inflammatory Pathways and Their Relationship With Psychological Factors in Adult Female Patients With Eating Disorders

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Convergent somatic mutations in metabolism genes in chronic liver disease

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Loss of PRMT7 reprograms glycine metabolism to selectively eradicate leukemia stem cells in CML

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Systematic discovery of mutation-directed neo-protein-protein interactions in cancer

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Selective requirement of MYB for oncogenic hyperactivation of a translocated enhancer in leukemia

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PIIS2589004222005594-html.html

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Adeno-associated-virus-mediated gene delivery to ovaries restores fertility in congenital infertile mice

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Energetic metabolic reprogramming in Jurkat DFF40-deficient cancer cells

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Rational Combination of CRM1 Inhibitor Selinexor and Olaparib Shows Synergy in Ovarian Cancer Cell Lines and Mouse Models

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CDYL1-dependent decrease in lysine crotonylation at DNA double-strand break sites functionally uncouples transcriptional silencing and repair

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DNA replication is highly resilient and persistent under the challenge of mild replication stress

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Glutamatergic synapses from the insular cortex to the basolateral amygdala encode observational pain

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A Foxo1-Klf2-S1pr1-Gnai1-Rac1 signaling axis is a critical mediator of Ostm1 regulatory network in T-lymphopoiesis

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Identification and evaluation of a lipid-lowering small compound in preclinical models and in a Phase I trial

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Effector membrane translocation biosensors reveal G protein and βarrestin coupling profiles of 100 therapeutically relevant GPCRs

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Rapid establishment of human colonic organoid knockout lines

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Interrogation of cancer gene dependencies reveals paralog interactions of autosome and sex chromosome-encoded genes

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Brown adipose tissue involution associated with progressive restriction in progenitor competence

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Epithelial STAT6 O-GlcNAcylation drives a concerted anti-helminth alarmin response dependent on tuft cell hyperplasia and Gasdermin C

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MIRO2 regulates prostate cancer cell growth via GCN1-dependent stress signaling

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Carbamazepine promotes surface expression of mutant Kir6.2-A28V ATP-sensitive potassium channels by modulating Golgi retention and autophagy

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Inflammasome activation and pyroptosis via a lipid-regulated SIRT1-p53-ASC axis in macrophages from male mice and humans

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δ-Tocotrienol is the most potent vitamin E form in inhibiting prostate cancer cell growth and inhibits prostate carcinogenesis in Ptenp-/- mice

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Dual signaling via interferon and DNA damage response elicits entrapment by giant PML nuclear bodies

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Mar 2022
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BPS Publications

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  DOI: 10.1111/bph.14558
  
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Acute inflammation down-regulates alpha-synuclein expression in enteric neurons

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Ligand-independent oligomerization of TACI is controlled by the transmembrane domain and regulates proliferation of activated B cells

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Quantitative interaction proteomics reveals differences in the interactomes of amyloid precursor protein isoforms

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Endosomal phosphatidylinositol 3-phosphate controls synaptic vesicle cycling and neurotransmission

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