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    Accumulation of APP C-terminal fragments causes endolysosomal dysfunction through the dysregulation of late endosome to lysosome-ER contact sites
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      DOI: 10.1016/j.devcel.2024.03.030

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    sciencedirect.com/science/article/pii/S1534580724001990
  3. 52.53.155.43 52.53.155.43
    elife-92755-v2-html.html
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      DOI: 10.7554/elife.92755

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  4. 52.53.155.43 52.53.155.43
    The regulation of enteric neuron connectivity by Semaphorin 5A is affected by the autism-associated S956G missense mutation
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  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RAD51 separation of function mutation disables replication fork maintenance but preserves DSB repair
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    ncbi.nlm.nih.gov/pmc/articles/PMC10993188/
  6. Apr 2024
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    Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy
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    nature.com/articles/s41419-024-06534-8
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    Berberine inhibits NLRP3 inflammasome activation and proinflammatory macrophage M1 polarization to accelerate peripheral nerve regeneration
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    sciencedirect.com/science/article/pii/S1878747924000333
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    NIBR-LTSi is a selective LATS kinase inhibitor activating YAP signaling and expanding tissue stem cells in vitro and in vivo
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      DOI: 10.1016/j.stem.2024.03.003

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    sciencedirect.com/science/article/pii/S1934590924000845
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    Astrocyte-secreted neurocan controls inhibitory synapse formation and function
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    sciencedirect.com/science/article/pii/S0896627324001612
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    Mitochondrial biogenesis in white adipose tissue mediated by JMJD1A-PGC-1 axis limits age-related metabolic disease
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      DOI: 10.1016/j.isci.2024.109398

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    ncbi.nlm.nih.gov/pmc/articles/PMC10966194/
  12. Mar 2024
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    FEAR antiviral response pathway is independent of interferons and countered by poxvirus proteins
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      DOI: 10.1038/s41564-024-01646-5

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    nature.com/articles/s41564-024-01646-5
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    Endocytic activation and exosomal secretion of matriptase stimulate the second wave of EGF signaling to promote skin and breast cancer invasion
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    sciencedirect.com/science/article/pii/S2211124724003309
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    The effects of Aurora Kinase inhibition on thyroid cancer growth and sensitivity to MAPK-directed therapies
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    1. scibot 27 Mar 2024
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      DOI: 10.1080/15384047.2024.2332000

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    ncbi.nlm.nih.gov/pmc/articles/PMC10962586/
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    Matrilin-3 supports neuroprotection in ischemic stroke by suppressing astrocyte-mediated neuroinflammation
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    1. scibot 27 Mar 2024
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    sciencedirect.com/science/article/pii/S2211124724003085
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    Chronic social defeat stress induces the down-regulation of the Nedd4L-GLT-1 ubiquitination pathway in the prefrontal cortex of mice
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    1. scibot 26 Mar 2024
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      DOI: 10.1111/jnc.16100

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    onlinelibrary.wiley.com/doi/10.1111/jnc.16100
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ΔNp63 regulates MDSC survival and metabolism in triple-negative breast cancer
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    1. scibot 22 Mar 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC10951988/
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Rho GTPase signaling and mDia facilitate endocytosis via presynaptic actin
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      DOI: 10.7554/eLife.92755

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    ncbi.nlm.nih.gov/pmc/articles/PMC10950329/
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    SUMOylation controls Hu antigen R posttranscriptional activity in liver cancer
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    sciencedirect.com/science/article/pii/S2211124724002523
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Regulation of hippocampal mossy fiber-CA3 synapse function by a Bcl11b/C1ql2/Nrxn3(25b+) pathway
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    1. scibot 19 Mar 2024
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      DOI: 10.7554/eLife.89854

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    ncbi.nlm.nih.gov/pmc/articles/PMC10942602/
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    Ankrd26 is a retinoic acid-responsive plasma membrane-binding and -shaping protein critical for proper cell differentiation
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    1. scibot 19 Mar 2024
      RRID:AB_476744

      DOI: 10.1016/j.celrep.2024.113939

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    sciencedirect.com/science/article/pii/S2211124724002675
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tumor acidosis-induced DNA damage response and tetraploidy enhance sensitivity to ATM and ATR inhibitors
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      DOI: 10.1038/s44319-024-00089-7

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    ncbi.nlm.nih.gov/pmc/articles/PMC10933359/
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mutant α-synuclein causes death of human cortical neurons via ERK1/2 and JNK activation
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    1. scibot 09 Mar 2024
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      DOI: 10.1186/s13041-024-01086-6

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    ncbi.nlm.nih.gov/pmc/articles/PMC10916047/
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    The decreased astrocyte-microglia interaction reflects the early characteristics of Alzheimer’s Disease
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      DOI: 10.1016/j.isci.2024.109281

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    sciencedirect.com/science/article/pii/S2589004224005029
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    Bactericidal/permeability-increasing protein instructs dendritic cells to elicit Th22 cell response
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    sciencedirect.com/science/article/pii/S2211124724002572
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    Poxvirus A51R proteins regulate microtubule stability and antagonize a cell-intrinsic antiviral response
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      DOI: 10.1016/j.celrep.2024.113882

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    sciencedirect.com/science/article/pii/S2211124724002109
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    CDK-independent role of D-type cyclins in regulating DNA mismatch repair
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      DOI: 10.1016/j.molcel.2024.02.010

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    sciencedirect.com/science/article/pii/S1097276524001291
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    MTOR modulation induces selective perturbations in histone methylation which influence the anti-proliferative effects of mTOR inhibitors
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      DOI: 10.1016/j.isci.2024.109188

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      DOI: 10.1016/j.isci.2024.109188

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    sciencedirect.com/science/article/pii/S2589004224004097
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    The transcription factor NF-κB orchestrates nucleosome remodeling during the primary response to Toll-like receptor 4 signaling
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      DOI: 10.1016/j.immuni.2024.02.004

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    sciencedirect.com/science/article/pii/S1074761324000803
  31. Feb 2024
  32. www.jneurosci.org www.jneurosci.org
    EHBP1 is critically involved in dendritic arbor formation and is coupled to factors promoting actin filament formation
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      DOI: 10.1523/JNEUROSCI.0236-23.2023

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    jneurosci.org/content/44/6/e0236232023
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    Sustained antidepressant effects of ketamine metabolite involve GABAergic inhibition-mediated molecular dynamics in aPVT glutamatergic neurons
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      DOI: 10.1016/j.neuron.2024.01.023

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    sciencedirect.com/science/article/pii/S0896627324000497
  34. 52.53.155.43 52.53.155.43
    Identification of an H-Ras nanocluster disrupting peptide
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      DOI: 10.1101/2023.09.07.556635

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    52.53.155.43/50febc729cb1f3f2f29f241e3592121bf7d8fba9/2023.09.07.556635v1.full-html.html
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    An improved PDE6D inhibitor combines with Sildenafil to synergistically inhibit KRAS mutant cancer cell growth
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      DOI: 10.1101/2023.08.23.554263

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    52.53.155.43/d64025fcba7405c73976a9e0dc65e9989e0d835f/2023.08.23.554263v1.full-html.html
  36. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Pyruvate dehydrogenase kinase 2 knockdown restores the ability of amyotrophic lateral sclerosis-linked SOD1G93A rat astrocytes to support motor neuron survival by increasing mitochondrial respiration
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      DOI: 10.1002/glia.24516

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    onlinelibrary.wiley.com/doi/10.1002/glia.24516
  37. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Brief exposure to enriched environment rapidly shapes the glutamate synapses in the rat brain: A metaplastic fingerprint
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      DOI: 10.1111/ejn.16279

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    onlinelibrary.wiley.com/doi/10.1111/ejn.16279
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PAF1c links S-phase progression to immune evasion and MYC function in pancreatic carcinoma
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      DOI: 10.1038/s41467-024-45760-8

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    ncbi.nlm.nih.gov/pmc/articles/PMC10873513/
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    The HRI branch of the integrated stress response selectively triggers mitophagy
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      DOI: 10.1016/j.molcel.2024.01.016

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    sciencedirect.com/science/article/pii/S1097276524000522
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Functional Heterogeneity in MET Pathway Activation in PDX Models of Osimertinib Resistant EGFR-Driven Lung Cancer
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      DOI: 10.1158/2767-9764.CRC-23-0321

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    A zebrafish model for C9orf72 ALS reveals RNA toxicity as a pathogenic mechanism
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    Hepatocyte CHRNA4 mediates the MASH-promotive effects of immune cell-produced acetylcholine and smoking exposure in mice and humans
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    High KIFC1 expression is associated with poor prognosis in prostate cancer
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    Aberrant N-glycosylation in pathogenic variants of adenosine deaminase 2 underlying human ADA2 deficiency
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    Ubiquitin ligase and signalling hub MYCBP2 is required for efficient EPHB2 tyrosine kinase receptor function
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    Oncogenic Transformation Drives DNA Methylation Loss and Transcriptional Activation of Transposable Element Loci
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    Chronic exposure to imipramine induces a switch from depression-like to mania-like behavior in female serotonin transporter knockout rats: Role of BDNF signaling in the infralimbic cortex
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    Histone lactylation inhibits RARγ expression in macrophages to promote colorectal tumorigenesis through activation of TRAF6-IL-6-STAT3 signaling
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    ZFP281 controls transcriptional and epigenetic changes promoting mouse pluripotent state transitions via DNMT3 and TET1
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    Discrete prefrontal neuronal circuits determine repeated stress-induced behavioral phenotypes in male mice
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    Lymph node and tumor-associated PD-L1+ macrophages antagonize dendritic cell vaccines by suppressing CD8+ T cells
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    β-Caryophyllene Inhibits Endothelial Tube Formation by Modulating the Secretome of Hypoxic Lung Cancer Cells—Possible Role of VEGF Downregulation
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    Downregulation of nutrition sensor GCN2 in macrophages contributes to poor wound healing in diabetes
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    Outcomes of early social experiences on glucocorticoid and endocannabinoid systems in the prefrontal cortex of male and female adolescent rats
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    Design, synthesis and mechanistic anticancer activity of new acetylated 5-aminosalicylate-thiazolinone hybrid derivatives
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    KDM5B predicts temozolomide-resistant subclones in glioblastoma
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    Epigenetic priming of an epithelial enhancer by p63 and CTCF controls expression of a skin-restricted gene XP33
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    The tumor-derived cytokine Chi3l1 induces neutrophil extracellular traps that promote T cell exclusion in triple-negative breast cancer
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    Hypoxia potentiates the inflammatory fibroblast phenotype promoted by pancreatic cancer cell-derived cytokines
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    In silico analysis and theratyping of an ultra-rare CFTR genotype (W57G/A234D) in primary human rectal and nasal epithelial cells
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    The γ-secretase substrate proteome and its role in cell signaling regulation
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    SERPINB3-MYC axis induces the basal-like/squamous subtype and enhances disease progression in pancreatic cancer
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    Stabilizing vimentin phosphorylation inhibits stem-like cell properties and metastasis of hybrid epithelial/mesenchymal carcinomas
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    Priming of macrophage by glycosphingolipids from extracellular vesicles facilitates immune tolerance for embryo-maternal crosstalk
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    Pathway-specific alterations in striatal excitability and cholinergic modulation in a SAPAP3 mouse model of compulsive motor behavior
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    Generation of a CRISPR/Cas9-edited Plakoglobin (JUP)knock-out (JMUi001-A-4) iPSC line to model the cardiac phenotype of arrhythmogenic cardiomyopathy
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  82. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MUC1-C INTEGRATES AEROBIC GLYCOLYSIS WITH SUPPRESSION OF OXIDATIVE PHOSPHORYLATION IN TRIPLE-NEGATIVE BREAST CANCER STEM CELLS
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  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Adavosertib Enhances Antitumor Activity of Trastuzumab Deruxtecan in HER2-Expressing Cancers
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  84. 52.53.155.43 52.53.155.43
    Molecular Oncology - 2023 - Pohlers - Th17 cells target the metabolic miR‐142‐5p succinate dehydrogenase subunit C D SDHC-html.html
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  85. Oct 2023
  86. www.sciencedirect.com www.sciencedirect.com
    SorCS2 binds progranulin to regulate motor neuron development
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    CD36 maintains lipid homeostasis via selective uptake of monounsaturated fatty acids during matrix detachment and tumor progression
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    Bilirubin impacts microglial autophagy via the Akt–mTOR signaling pathway
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    Serotonin 2C receptors are also important in head-twitch responses in male mice
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    Temporal dynamics of BDNF signaling recruitment in the rat prefrontal cortex and hippocampus following a single infusion of a translational dose of ketamine
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    Complementary CRISPR screen highlights the contrasting role of membrane-bound and soluble ICAM-1 in regulating antigen-specific tumor cell killing by cytotoxic T cells
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    Antiangiogenic Action of JZL184 on Endothelial Cells via Inhibition of VEGF Expression in Hypoxic Lung Cancer Cells
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    Non-Psychoactive Phytocannabinoids Inhibit Inflammation-Related Changes of Human Coronary Artery Smooth Muscle and Endothelial Cells
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    Development of novel cytoprotective small compounds inhibiting mitochondria-dependent cell death
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    HIV-1 neutralizing antibodies provide sterilizing immunity by blocking infection of the first cells
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    Splicing quality control mediated by DHX15 and its G-patch activator SUGP1
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    Ketogenesis promotes tolerance to Pseudomonas aeruginosa pulmonary infection
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    Linear ubiquitination at damaged lysosomes induces local NF-κB activation and controls cell survival
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    Immune–epithelial cell cross-talk enhances antiviral responsiveness to SARS-CoV-2 in children
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  101. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Carbonic Anhydrase IX/SLC1A5 Axis Regulates Glutamine Metabolism Dependent Ferroptosis in Hypoxic Tumor Cells
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    The senescent secretome drives PLVAP expression in cultured human hepatic endothelial cells to promote monocyte transmigration
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    Essential role of the amino-terminal region of Drosha for the Microprocessor function
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    Mitochondrial defects caused by PARL deficiency lead to arrested spermatogenesis and ferroptosis
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    Select symbionts drive high IgA levels in the mouse intestine
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    Crosstalk between integrin/FAK and Crk/Vps25 governs invasion of bovine mammary epithelial cells by S. agalactiae
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    WNK1 is required during male pachynema to sustain fertility.
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    Mitochondrial network adaptations of microglia reveal sex-specific stress response after injury and UCP2 knockout
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    Chronic Carbon Disulfide Exposure Induces Parkinsonian Pathology via α-Synuclein Aggregation and Necrosome Complex Interaction
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    Bace1 Deletion in the Adult Reverses Epileptiform Activity and Sleep–wake Disturbances in AD Mice
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    Cortical Brain Injury Causes Retrograde Degeneration of Afferent Basal Forebrain Cholinergic Neurons via the p75NTR
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    Identification of Selective ATP-Competitive CMG Helicase Inhibitors for Cancer Intervention that Disrupt CMG-Replisome Function
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    Lysosomal cystine governs ferroptosis sensitivity in cancer via cysteine stress response
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    mTORC2 orchestrates monocytic and granulocytic lineage commitment by an ATF5-mediated pathway
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    Neuroendocrine lineage commitment of small cell lung cancers can be leveraged into p53-independent non-cytotoxic therapy
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    Staphylococcus aureus phagocytosis is affected by senescence
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    Platelet-derived exerkine CXCL4/platelet factor 4 rejuvenates hippocampal neurogenesis and restores cognitive function in aged mice
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    Acetylation of p53 in the Cerebral Cortex after Photothrombotic Stroke
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      DOI: 10.1007/s12975-023-01183-z

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    FASN deficiency induces a cytosol-to-mitochondria citrate flux to mitigate detachment-induced oxidative stress
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  128. www.science.org www.science.org
    Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in amyotrophic lateral sclerosis
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  130. www.sciencedirect.com www.sciencedirect.com
    Proteogenomic insights suggest druggable pathways in endometrial carcinoma
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  131. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in amyotrophic lateral sclerosis
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    Tryptophan metabolism promotes immune evasion in human pancreatic β cells
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    Pigment Epithelium-Derived Factor, a Novel Adipokine, Contributes to Gestational Diabetes Mellitus
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    FGFR-mediated ERK1/2 signaling contributes to mesendoderm and definitive endoderm formation in vitro
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    Targeting ITGB4/SOX2-driven lung cancer stem cells using proteasome inhibitors
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    mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA translation and promotes cell phenotype switching
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    Hexokinase 2-mediated gene expression via histone lactylation is required for hepatic stellate cell activation and liver fibrosis
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    Widespread dysregulation of mRNA splicing implicates RNA processing in the development and progression of Huntington's disease
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    Recency memory is altered in cocaine-withdrawn adolescent rats: Implication of cortical mTOR signaling
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    Genome-wide mapping of cancer dependency genes and genetic modifiers of chemotherapy in high-risk hepatoblastoma
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    Enhanced bypass of PD-L1 translation reduces the therapeutic response to mTOR kinase inhibitors
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    Enhanced SARS-CoV-2 entry via UPR-dependent AMPK-related kinase NUAK2
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    The kinesin Kif21b binds myosin Va and mediates changes in actin dynamics underlying homeostatic synaptic downscaling
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    Genome-wide CRISPR-Cas9 screen analyzed by SLIDER identifies network of repressor complexes that regulate TRIM24
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    Glutaminase 1 deficiency confined in forebrain neurons causes autism spectrum disorder-like behaviors
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    Restoration of mitochondrial function by Spirulina polysaccharide via upregulated SOD2 in aging fibroblasts
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    Detection of Arc/Arg3.1 oligomers in rat brain: constitutive and synaptic activity-evoked dimer expression in vivo
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    Ubiquitin ligase and signalling hub MYCBP2 is required for efficient EPHB2 tyrosine kinase receptor function
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    Mesenchymal stem cells induce dynamic immunomodulation of airway and systemic immune cells in vivo but do not improve survival for mice with H1N1 virus-induced acute lung injury
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    Molecular components of the circadian clock regulate HIV-1 replication
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    Identification of aryl hydrocarbon receptor as a barrier to HIV-1 infection and outgrowth in CD4+ T cells
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    MCT4-dependent lactate secretion suppresses antitumor immunity in LKB1-deficient lung adenocarcinoma
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    KIF4 regulates neuronal morphology and seizure susceptibility via the PARP1 signaling pathway
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    LZTR1 mutation mediates oncogenesis through stabilization of EGFR and AXL
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  162. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  163. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Endonuclease VIII-like 1 deficiency potentiates nigrostriatal dopaminergic neuron degeneration in a male mouse model of Parkinson's disease
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    PICT-1 regulates p53 splicing and sensitivity of medullary thyroid carcinoma cells to Everolimus
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    Efficient self-organization of blastoids solely from mouse ESCs is facilitated by transient reactivation of 2C gene network
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    p53-independent tumor suppression by cell-cycle arrest via CREB/ATF transcription factor OASIS
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    Relationships between gene expression and behavior in mice in response to systemic modulation of the O-GlcNAcylation pathway
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  174. www.embopress.org www.embopress.org
    eIF3 mRNA selectivity profiling reveals eIF3k as a cancer-relevant regulator of ribosome content
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    Comparative Analysis of Six IRF Family Members in Alveolar Epithelial Cell-Intrinsic Antiviral Responses
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  177. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BACE1 regulates expression of Clusterin in astrocytes for enhancing clearance of β-amyloid peptides
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    N-myc downstream regulated family member 1 (NDRG1) is enriched in myelinating oligodendrocytes and impacts myelin degradation in response to demyelination
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  180. www.sciencedirect.com www.sciencedirect.com
    Synaptic hyperexcitability of cytomegalic pyramidal neurons contributes to epileptogenesis in tuberous sclerosis complex
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    The ubiquitin-ligase TRAF6 and TGFβ type I receptor form a complex with Aurora kinase B contributing to mitotic progression and cytokinesis in cancer cells
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  182. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
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  183. Apr 2023
  184. www.sciencedirect.com www.sciencedirect.com
    Bromodomain protein BRD8 regulates cell cycle progression in colorectal cancer cells through a TIP60-independent regulation of the pre-RC complex
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    IFITM3 blocks influenza virus entry by sorting lipids and stabilizing hemifusion
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    Coronavirus Subverts ER-phagy by Hijacking FAM134B and ATL3 into p62 Condensates to Facilitate Viral Replication
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    Targeting USP2 regulation of VPRBP-mediated degradation of p53 and PD-L1 for cancer therapy
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    Buffering of transcription rate by mRNA half-life is a conserved feature of Rett syndrome models
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    The mitochondrial protease OMA1 acts as a metabolic safeguard upon nuclear DNA damage
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  190. Mar 2023
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    Altered striatal actin dynamics drives behavioral inflexibility in a mouse model of fragile X syndrome
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    A robust and efficient microvascular isolation method for multimodal characterization of the mouse brain vasculature
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    Inter-axonal molecular crosstalk via Lumican proteoglycan sculpts murine cervical corticospinal innervation by distinct subpopulations
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    Mutating novel interaction sites in NRP1 reduces SARS-CoV-2 spike protein internalization
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    Remodeling of the Ribosomal Quality Control and Protein Translation by a Viral Ubiquitin Deconjugase
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    Dysregulation of AMPA Receptor Trafficking and Intracellular Vesicular Sorting in the Prefrontal Cortex of Dopamine Transporter Knock-Out Rats
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    Minimal upstream open reading frame of Per2 mediates phase fitness of the circadian clock to day/night physiological body temperature rhythm
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    Targeting androgen receptor and the variants by an orally bioavailable Proteolysis Targeting Chimeras compound in castration resistant prostate cancer
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    Harnessing transcriptionally driven chromosomal instability adaptation to target therapy-refractory lethal prostate cancer
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    Phosphoenolpyruvate regulates the Th17 transcriptional program and inhibits autoimmunity
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  202. Feb 2023
  203. academic.oup.com academic.oup.com
    Genetic Val66Met BDNF Variant Increases Hyperphagia on Fat-rich Diets in Mice
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