3,591 Matching Annotations
  1. May 2025
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    m6A/IGF2BP3-driven serine biosynthesis fuels AML stemness and metabolic vulnerability
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    pmc.ncbi.nlm.nih.gov/articles/PMC12056023/
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Sirt6 deficiency promotes senescence and age-associated intervertebral disc degeneration in mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC12059161/
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Nuclear mitochondrial acetyl-CoA acetyltransferase 1 orchestrates natural killer cell-dependent antitumor immunity in colorectal cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12034769/
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    FLT4 activation promotes acute lymphoid leukemia survival through stabilization of MDM2/MDMX and inactivation of p53
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    pmc.ncbi.nlm.nih.gov/articles/PMC12048674/
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Increased mGluR5 in somatostatin-positive interneurons mediates deactivation of the mPFC in a mouse model of neuropathic pain
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    pmc.ncbi.nlm.nih.gov/articles/PMC12046054/
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    hsa-miR-5688 inhibits FOXC1-OCT4/SOX2 feedforward loop that drives chemoresistance in breast cancer stem cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12051596/
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A novel exploration of COL11A1's role in regulating myeloid-derived suppressor cell activation within the colon cancer microenvironment
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    pmc.ncbi.nlm.nih.gov/articles/PMC12056792/
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    1-s2.0-S2589004225006479-main-html.html
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    pmc.ncbi.nlm.nih.gov/articles/PMC12052844/
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    IGFBP3 enhances adipose-derived stem cell function in soft tissue injury repair via ITGB1 and ERK pathway activation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12078396/
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Identification of a Biomarker Panel in Extracellular Vesicles Derived From Non‐Small Cell Lung Cancer (NSCLC) Through Proteomic Analysis and Machine Learning
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    pmc.ncbi.nlm.nih.gov/articles/PMC12077270/
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Helicobacter pylori CagA elevates FTO to induce gastric cancer progression via a “hit‐and‐run” paradigm
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    pmc.ncbi.nlm.nih.gov/articles/PMC12067399/
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Hyperactivation of RAB5 disrupts the endosomal Rab cascade leading to endolysosomal dysregulation in Down syndrome: A necessary role for increased APP gene dose
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    pmc.ncbi.nlm.nih.gov/articles/PMC12058456/
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Antisense oligonucleotides directed against App and Rab5 normalized endosomal Rab activity and reversed DS‐AD‐linked degenerative phenotypes in the Dp16 mouse model of Down syndrome
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    pmc.ncbi.nlm.nih.gov/articles/PMC12058459/
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Enhancing Prime Editing Efficiency Through Modulation of Methylation on the Newly Synthesized DNA Strand and Prolonged Expression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12061241/
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting COPA to Enhance Erdafitinib Sensitivity in FGFR‐Altered Bladder Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12079435/
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    Sickle cell disease induces chromatin introversion and ferroptosis in CD8+ T cells to suppress anti-tumor immunity
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    sciencedirect.com/science/article/pii/S1074761325001839
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SLK is mutated in individuals with a neurodevelopmental disorder
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    pmc.ncbi.nlm.nih.gov/articles/PMC12139437/
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    Model-guided design of microRNA-based gene circuits supports precise dosage of transgenic cargoes into diverse primary cells
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    sciencedirect.com/science/article/pii/S2405471225001024
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    A multimodal screening platform for endogenous dipeptide repeat proteins in C9orf72 patient iPSC neurons
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    sciencedirect.com/science/article/pii/S2211124725004668
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    IRE1α promotes phagosomal calcium flux to enhance macrophage fungicidal activity
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    cell.com/cell-reports/fulltext/S2211-1247(25)00465-6
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A dual-fluorescence assay for gene delivery vehicle screening in macrophages with an inflammation-inducible reporter construct
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    pmc.ncbi.nlm.nih.gov/articles/PMC12062070/
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The RBM39 degrader indisulam inhibits acute megakaryoblastic leukemia by altering the alternative splicing of ZMYND8
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    pmc.ncbi.nlm.nih.gov/articles/PMC11995665/
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Endogenous protein S100A14 stabilizes glutaminase to render hepatocellular carcinoma resistant to sorafenib
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    pmc.ncbi.nlm.nih.gov/articles/PMC11992768/
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    MEIS1 knockdown upregulates WNT signaling pathway genes in esophageal squamous cell carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC11983858/
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Abnormal phosphorylation of human LRH1 at Ser510 predicts poor prognosis and promotes cell viability in lung squamous cell carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12016208/
  27. 52.53.155.43 52.53.155.43
    PDF-html.html
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    52.53.155.43/581690a87db32a6cd802c9bdccaa776024adf4bf/PDF-html.html
  28. 52.53.155.43 52.53.155.43
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  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Reversible downregulation of HLA class I in adenoid cystic carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12010351/
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Engineering of CD8+ T cells with an HIV-specific synthetic notch receptor to secrete broadly therapeutic antibodies for combining antiviral humoral and cellular immune responses
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    pmc.ncbi.nlm.nih.gov/articles/PMC11980546/
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Window of opportunity trial reveals mechanisms of response and resistance to navtemadlin in patients with recurrent glioblastoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC11994224/
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Protecting centrosomes from fracturing enables efficient cell navigation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12024656/
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    EIF3D safeguards the homeostasis of key signaling pathways in human primed pluripotency
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    pmc.ncbi.nlm.nih.gov/articles/PMC11980838/
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    N‐Glycosylation Modification of Fzd4 Is Essential for the Fzd4‐Wnt‐β‐Catenin Signalling Axis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11997252/
  35. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/10.1111/febs.70125
  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SLAYER: a computational framework for identifying synthetic lethal interactions through integrated analysis of cancer dependencies
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    pmc.ncbi.nlm.nih.gov/articles/PMC12019633/
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Ubiquitin-mediated recruitment of the ATG9A-ATG2 lipid transfer complex drives clearance of phosphorylated p62 aggregates
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    pmc.ncbi.nlm.nih.gov/articles/PMC11809316/
  38. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Epstein-Barr virus deubiquitinase BPLF1 regulates stress-induced ribosome UFMylation and reticulophagy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12013442/
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    VDAC2 loss elicits tumour destruction and inflammation for cancer therapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12018455/
  40. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    MYC ecDNA promotes intratumour heterogeneity and plasticity in PDAC
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    pmc.ncbi.nlm.nih.gov/articles/PMC12003172/
  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Multipotent neural stem cells originating from neuroepithelium exist outside the mouse central nervous system
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    pmc.ncbi.nlm.nih.gov/articles/PMC11991921/
  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The mechanism of YAP/TAZ transactivation and dual targeting for cancer therapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12022045/
  43. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Lysosomal lipid peroxidation contributes to ferroptosis induction via lysosomal membrane permeabilization
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    pmc.ncbi.nlm.nih.gov/articles/PMC11997074/
  44. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Programmable protein stabilization with language model-derived peptide guides
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    pmc.ncbi.nlm.nih.gov/articles/PMC11997201/
  45. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A genome-wide screen identifies genes required for erythroid differentiation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11993733/
  46. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cross-talks between Metabolic and Translational Controls during Beige Adipocyte Differentiation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11982337/
  47. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    An unconventional autophagic pathway that inhibits ATP secretion during apoptotic cell death
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    pmc.ncbi.nlm.nih.gov/articles/PMC11986000/
  48. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genetic modulation of rare earth nanoparticle biotransformation shapes biological outcomes
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    pmc.ncbi.nlm.nih.gov/articles/PMC11985947/
  49. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Elevated mitochondrial membrane potential is a therapeutic vulnerability in Dnmt3a-mutant clonal hematopoiesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12003737/
  50. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Loss of VHL-mediated pRb regulation promotes clear cell renal cell carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12003641/
  51. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Temozolomide promotes glioblastoma stemness expression through senescence-associated reprogramming via HIF1α/HIF2α regulation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12009364/
  52. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Hydrogel-Based Multiplex Coculture Platform for Retinal Component Cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12015949/
  53. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Development of RelB-targeting small-molecule inhibitors of non-canonical NF-κB signaling with antitumor efficacy
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    pmc.ncbi.nlm.nih.gov/articles/PMC11997474/
  54. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    An inflammation-associated lncRNA induces neuronal damage via mitochondrial dysfunction
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    pmc.ncbi.nlm.nih.gov/articles/PMC12023888/
  55. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Single-guide RNA Cas9 and enhanced-deletion Cas9 rescue a recurrent USH2A-related splicing defect
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    pmc.ncbi.nlm.nih.gov/articles/PMC11999688/
  56. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Changes in adrenoceptor expression level contribute to the cellular plasticity of glioblastoma cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12002996/
  57. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The E3 ubiquitin ligase RNF126 facilitates quality control of unimported mitochondrial membrane proteins
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    pmc.ncbi.nlm.nih.gov/articles/PMC12005277/
  58. 52.53.155.43 52.53.155.43
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    The m5C methyltransferase NSUN2 promotes progression of acute myeloid leukemia by regulating serine metabolism
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    sciencedirect.com/science/article/pii/S2211124725004322
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    Condensation-dependent multivalent interactions of EB1 and CENP-R regulate chromosome oscillations in mitosis
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    sciencedirect.com/science/article/pii/S2211124725003316
  61. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Unraveling the Role of NeuroD2 in Ischemic Pathophysiology: Insight into Neuroprotection Mechanisms Associated with AKT Survival Kinase
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    pmc.ncbi.nlm.nih.gov/articles/PMC12003519/
  62. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Accumulation of Damaging Lipids in the Arf1-Ablated Neurons Promotes Neurodegeneration through Releasing mtDNA and Activating Inflammatory Pathways in Microglia
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    pmc.ncbi.nlm.nih.gov/articles/PMC12021055/
  63. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    LINC01235 Promotes Clonal Evolution through DNA Replication Licensing‐Induced Chromosomal Instability in Breast Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11984920/
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    Phagosomal RNA sensing through TLR8 controls susceptibility to tuberculosis
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    sciencedirect.com/science/article/pii/S2211124725004280
  65. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Loss of neurofibromin induces inflammatory macrophage phenotypic switch and retinal neovascularization via GLUT1 activation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12184535/
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    RNA polymerase II partitioning is a shared feature of diverse oncofusion condensates
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    sciencedirect.com/science/article/pii/S0092867425004040
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    Immunosequencing identifies signatures of T cell responses for early detection of nasopharyngeal carcinoma
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    sciencedirect.com/science/article/pii/S1535610825001680
  68. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    N‐terminomics and proteomics analysis of Calpain‐2 reveal key proteolytic processing of metabolic and cell adhesion proteins
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    pmc.ncbi.nlm.nih.gov/articles/PMC12023407/
  69. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Tumorigenesis Driven by BRAFV600E Requires Secondary Mutations That Overcome Its Feedback Inhibition of RAC1 and Migration
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    pmc.ncbi.nlm.nih.gov/articles/PMC12046322/
  70. Apr 2025
  71. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Optogenetically engineered Septin-7 enhances immune cell infiltration of tumor spheroids
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    Aberrant phase separation drives membranous organelle remodeling and tumorigenesis
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    sciencedirect.com/science/article/pii/S1097276525003041
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    SLIRP amplifies antiviral signaling via positive feedback regulation and contributes to autoimmune diseases
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    sciencedirect.com/science/article/pii/S2211124725003596
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    Mis-splicing-derived neoantigens and cognate TCRs in splicing factor mutant leukemias
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    sciencedirect.com/science/article/pii/S009286742500399X
  75. elifesciences.org elifesciences.org
    Microenvironmental arginine restriction sensitizes pancreatic cancers to polyunsaturated fatty acids by suppression of lipid synthesis
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    elifesciences.org/reviewed-preprints/106492
  76. www.nature.com www.nature.com
    Far-red chemigenetic kinase biosensors enable multiplexed and super-resolved imaging of signaling networks
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    nature.com/articles/s41587-025-02642-8
  77. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
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    febs.onlinelibrary.wiley.com/doi/10.1111/febs.70099
  78. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    p53 regulates DREAM complex-mediated repression in a p21-independent manner
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    pmc.ncbi.nlm.nih.gov/articles/PMC12000331/
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    The SWI/SNF PBAF complex facilitates REST occupancy at repressive chromatin
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  80. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Functional characterization of all CDKN2A missense variants and comparison to in silico models of pathogenicity
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    pmc.ncbi.nlm.nih.gov/articles/PMC12002794/
  81. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Myogenic IGFBP5 levels in rhabdomyosarcoma are nourished by mesenchymal stromal cells and regulate growth arrest and apoptosis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12001570/
  82. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    BET degraders reveal BRD4 disruption of 7SK and P-TEFb is critical for effective reactivation of latent HIV in CD4+ T-cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11998493/
  83. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Human long noncoding RNA VILMIR is induced by major respiratory viral infections and modulates the host interferon response
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    pmc.ncbi.nlm.nih.gov/articles/PMC11998520/
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    Genetically encoded tool for manipulation of ΔΨm identifies its role as the driver of ISR induced by ATP synthase dysfunction
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    sciencedirect.com/science/article/pii/S2451945625000972
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    Circular RMST cooperates with lineage-driving transcription factors to govern neuroendocrine transdifferentiation
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    sciencedirect.com/science/article/pii/S153561082500128X
  86. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Microenvironmental arginine restriction sensitizes pancreatic cancers to polyunsaturated fatty acids by suppression of lipid synthesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11952453/
  87. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    Comparative single-cell transcriptomic profiling of patient-derived renal carcinoma cells in cellular and animal models of kidney cancer
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