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935 Matching Annotations

Mar 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

ANKLE1 cleaves mitochondrial DNA and contributes to cancer risk by promoting apoptosis resistance and metabolic dysregulation

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1. scibot 04 Mar 2023
  
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  Plasmid_4813845
  
  DOI: 10.1038/s42003-023-04611-w
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9977882/
Feb 2023
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EndophilinA-dependent coupling between activity-induced calcium influx and synaptic autophagy is disrupted by a Parkinson-risk mutation

1
1. scibot 24 Feb 2023
  
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  RRID:Addgene_48138
  
  DOI: 10.1016/j.neuron.2023.02.001
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10166451/
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Growth cone advance requires EB1 as revealed by genomic replacement with a light-sensitive variant

1
1. scibot 15 Feb 2023
  
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  Addgene plasmid 48138
  
  DOI: 10.7554/eLife.84143
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9917429/
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Homology-directed repair of an MYBPC3 gene mutation in a rat model of hypertrophic cardiomyopathy

1
1. scibot 11 Feb 2023
  
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  RRID:Addgene_48138
  
  DOI: 10.1038/s41434-023-00384-3
  
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nature.com/articles/s41434-023-00384-3
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Senescence Rewires Microenvironment Sensing to Facilitate Antitumor Immunity

1
1. scibot 10 Feb 2023
  
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  Addgene_48138
  
  DOI: 10.1158/2159-8290.CD-22-0528
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9901536/
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Chikungunya virus entry and infectivity is primarily facilitated through cell line dependent attachment factors in mammalian and mosquito cells

1
1. scibot 08 Feb 2023
  
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  RRID:Addgene_48138
  
  DOI: 10.3389/fcell.2023.1085913
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9895848/
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Generation of two CRISPR/Cas edited human induced pluripotent stem cell lines (DHMi005-A-3 and DHMi005-A-4) carrying a FLAG-tag after exon 9 of the TBX5 gene

1
1. scibot 03 Feb 2023
  
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  RRID:Addgene_48138
  
  DOI: 10.1016/j.scr.2022.103011
  
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sciencedirect.com/science/article/pii/S1873506122003609
Jan 2023
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Selective PDE4 subtype inhibition provides new opportunities to intervene in neuroinflammatory versus myelin damaging hallmarks of multiple sclerosis

1
1. scibot 28 Jan 2023
  
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  RRID:Addgene_48138
  
  DOI: 10.1016/j.bbi.2022.12.020
  
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sciencedirect.com/science/article/pii/S0889159122004780
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Neutrophil-activating therapy for the treatment of cancer

1
1. scibot 27 Jan 2023
  
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  RRID:Addgene_48138
  
  DOI: 10.1016/j.ccell.2023.01.002
  
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sciencedirect.com/science/article/pii/S1535610823000028
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ADAR RNA editing on antisense RNAs results in apparent U-to-C base changes on overlapping sense transcripts

1
1. scibot 25 Jan 2023
  
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  RRID:Addgene_48138
  
  DOI: 10.3389/fcell.2022.1080626
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9852825/
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A genome-wide relay of signalling-responsive enhancers drives hematopoietic specification

1
1. scibot 20 Jan 2023
  
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  RRID:Addgene_48138
  
  DOI: 10.1038/s41467-023-35910-9
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9845378/
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An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes

1
1. scibot 19 Jan 2023
  
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  Plasmid_48138
  
  DOI: 10.1016/j.cell.2022.12.025
  
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sciencedirect.com/science/article/pii/S0092867422015380
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A deep learning platform to assess drug proarrhythmia risk

1
1. scibot 12 Jan 2023
  
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  RRID:Addgene_48138
  
  DOI: 10.1016/j.stem.2022.12.002
  
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sciencedirect.com/science/article/pii/S1934590922004866
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Targeting cancer glycosylation repolarizes tumor-associated macrophages allowing effective immune checkpoint blockade

1
1. scibot 12 Jan 2023
  
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  RRID:Addgene_48138
  
  DOI: 10.1126/scitranslmed.abj1270
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9812757/
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T cell-derived interleukin-22 drives the expression of CD155 by cancer cells to suppress NK cell function and promote metastasis

1
1. scibot 12 Jan 2023
  
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  RRID:Addgene_48138
  
  DOI: 10.1016/j.immuni.2022.12.010
  
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sciencedirect.com/science/article/pii/S107476132200646X
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Differential roles of type I interferon signaling in tumor versus host cells in experimental glioma models

1
1. scibot 06 Jan 2023
  
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  RRID:Addgene_48138
  
  DOI: 10.1016/j.tranon.2022.101607
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9800198/
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Histone Methyltransferase KMT2B Promotes Metastasis and Angiogenesis of Cervical Cancer by Upregulating EGF Expression

1
1. scibot 06 Jan 2023
  
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  RRID:Addgene_48138
  
  DOI: 10.7150/ijbs.72381
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9760441/
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ATM suppresses c-Myc overexpression in the mammary epithelium in response to estrogen

1
1. scibot 02 Jan 2023
  
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  Addgene_48138
  
  DOI: 10.1016/j.celrep.2022.111909
  
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sciencedirect.com/science/article/pii/S2211124722018083
Dec 2022
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Simultaneous loading of PCR-based multiple fragments on mouse artificial chromosome vectors in DT40 cell for gene delivery

1
1. scibot 31 Dec 2022
  
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  plasmid_48138
  
  DOI: 10.1038/s41598-022-25959-9
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9758134/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

CRISPR/Cas9-mediated LRP10 Knockout in HuTu-80 and HEK 293T Cell Lines

1
1. scibot 31 Dec 2022
  
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  RRID:Addgene_48138
  
  DOI: 10.21769/BioProtoc.4521
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9548521/
onlinelibrary.wiley.com onlinelibrary.wiley.com

Crosstalk between tumor acidosis, p53, and extracellular matrix regulates pancreatic cancer aggressiveness

1
1. scibot 22 Dec 2022
  
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  Addgene_48138
  
  DOI: 10.1002/ijc.34367
  
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onlinelibrary.wiley.com/doi/10.1002/ijc.34367
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Genome Editing Is Induced in a Binary Manner in Single Human Cells

1
1. scibot 09 Dec 2022
  
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  plasmid_48138
  
  DOI: 10.1016/j.isci.2022.105619
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9722467/
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Development of 89Zr-anti-CD103 PET imaging for non-invasive assessment of cancer reactive T cell infiltration

1
1. scibot 08 Dec 2022
  
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  RRID:Addgene_48138
  
  DOI: 10.1136/jitc-2022-004877
  
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jitc.bmj.com/content/10/12/e004877
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Human iPSC-hepatocyte modeling of alpha-1 antitrypsin heterozygosity reveals metabolic dysregulation and cellular heterogeneity

1
1. scibot 08 Dec 2022
  
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  RRID:Addgene_48138
  
  DOI: 10.1016/j.celrep.2022.111775
  
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sciencedirect.com/science/article/pii/S2211124722016588
Nov 2022
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Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies

1
1. scibot 24 Nov 2022
  
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  Addgene_48138
  
  DOI: 10.1016/j.celrep.2022.111678
  
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sciencedirect.com/science/article/pii/S2211124722015522
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Autophagy promotes cell survival by maintaining NAD levels

1
1. scibot 22 Nov 2022
  
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  48138
  
  DOI: 10.1016/j.devcel.2022.10.008
  
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sciencedirect.com/science/article/pii/S1534580722007602
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PARP10 Mediates Mono-ADP-Ribosylation of Aurora-A Regulating G2/M Transition of the Cell Cycle

1
1. scibot 18 Nov 2022
  
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  plasmid_48138
  
  DOI: 10.3390/cancers14215210
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9659153/
www.molbiolcell.org www.molbiolcell.org

Docking of Syk to FcεRI is enhanced by Lyn but limited in duration by SHIP1

1
1. scibot 17 Nov 2022
  
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  plasmid_48138
  
  DOI: 10.1091/mbc.E21-12-0603
  
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molbiolcell.org/doi/10.1091/mbc.E21-12-0603
www.researchsquare.com www.researchsquare.com

Home

1
1. scibot 11 Nov 2022
  
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  plasmid_48138
  
  DOI: 10.21203/rs.3.rs-658360/v1
  
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researchsquare.com/
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IL-17-induced dimerization of IL-17RA drives the formation of the IL-17 signalosome to potentiate signaling

1
1. scibot 05 Nov 2022
  
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  plasmid_48138
  
  DOI: 10.1016/j.celrep.2022.111489
  
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sciencedirect.com/science/article/pii/S2211124722013390
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Docking of Syk to FcεRI is enhanced by Lyn but limited in duration by SHIP1

1
1. scibot 04 Nov 2022
  
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  plasmid_48138
  
  DOI: 10.1091/mbc.E21-12-0603
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9582627/
Oct 2022
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Circadian lncRNA ADIRF-AS1 binds PBAF and regulates renal clear cell tumorigenesis

1
1. scibot 20 Oct 2022
  
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  plasmid_48138
  
  DOI: 10.1016/j.celrep.2022.111514
  
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sciencedirect.com/science/article/pii/S221112472201364X
academic.oup.com academic.oup.com

Two type I topoisomerases maintain DNA topology in human mitochondria

1
1. scibot 15 Oct 2022
  
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  RRID:Addgene_48138
  
  DOI: 10.1093/nar/gkac857
  
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academic.oup.com/nar/advance-article/doi/10.1093/nar/gkac857/6754920
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Generation of a human embryonic stem cell line targeted homozygous deletion of BMP10 (WAe007-A-2) by CRISPR/Cas9-dgRNA

1
1. scibot 14 Oct 2022
  
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  Addgene_48138
  
  DOI: 10.1016/j.scr.2022.102942
  
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sciencedirect.com/science/article/pii/S1873506122002914
www.nature.com www.nature.com

Caldesmon controls stress fiber force-balance through dynamic cross-linking of myosin II and actin-tropomyosin filaments

1
1. scibot 14 Oct 2022
  
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  plasmid_48138
  
  DOI: 10.1038/s41467-022-33688-w
  
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nature.com/articles/s41467-022-33688-w
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Long-term potentiation reconstituted with an artificial TARP/PSD-95 complex

1
1. scibot 12 Oct 2022
  
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  Addgene_48138
  
  DOI: 10.1016/j.celrep.2022.111483
  
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sciencedirect.com/science/article/pii/S221112472201333X
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Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas

1
1. scibot 07 Oct 2022
  
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  Cat#48138
  
  DOI: 10.1016/j.molcel.2022.09.007
  
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sciencedirect.com/science/article/pii/S1097276522008966
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Two independent respiratory chains adapt OXPHOS performance to glycolytic switch

1
1. scibot 05 Oct 2022
  
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  Addgene_48138
  
  DOI: 10.1016/j.cmet.2022.09.005
  
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Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair

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Systems analysis of de novo mutations in congenital heart diseases identified a protein network in the hypoplastic left heart syndrome

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Use of CRISPR/Cas9-edited HEK293 cells reveals that both conventional and novel protein kinase C isozymes are involved in mGlu5a receptor internalization

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Sublethal cytochrome c release generates drug-tolerant persister cells

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Aug 2022
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mcr-21-0058-html.html

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SOX transcription factors direct TCF-independent WNT/β-catenin responsive transcription to govern cell fate in human pluripotent stem cells

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Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IκBα

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Glycosphingolipids are mediators of cancer plasticity through independent signaling pathways

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Targeting the mRNA endonuclease CPSF73 inhibits breast cancer cell migration, invasion, and self-renewal

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A multimodal iPSC platform for cystic fibrosis drug testing

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Jul 2022
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Mapping subcellular localizations of unannotated microproteins and alternative proteins with MicroID

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“Stripe” transcription factors provide accessibility to co-binding partners in mammalian genomes

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The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de novo nucleotide synthesis

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Jun 2022
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Domain fusion TLR2-4 enhances the autophagy-dependent clearance of Staphylococcus aureus in the genetic engineering goat

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GSK3 inhibition rescues growth and telomere dysfunction in dyskeratosis congenita iPSC-derived type II alveolar epithelial cells

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Interplay between symmetric arginine dimethylation and ubiquitylation regulates TDP1 proteostasis for the repair of topoisomerase I-DNA adducts

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ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling

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A TRIM66/DAX1/Dux axis suppresses the totipotent 2-cell-like state in murine embryonic stem cells

2
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Gene-specific nonsense-mediated mRNA decay targeting for cystic fibrosis therapy

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Lymph node colonization induces tumor-immune tolerance to promote distant metastasis

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First Characterization of Human Dermal Fibroblasts Showing a Decreased Xylosyltransferase-I Expression Induced by the CRISPR/Cas9 System

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Generation of a MIR5004 knockout cell line from human induced Pluripotent Stem Cells by CRISPR/Cas9 gene editing

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The Mettl3 epitranscriptomic writer amplifies p53 stress responses

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Apr 2022
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Identification of a Crosstalk among TGR5, GLIS2, and TP53 Signaling Pathways in the Control of Undifferentiated Germ Cell Homeostasis and Chemoresistance

1
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  DOI: 10.1002/advs.202200626
  
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A rationalized definition of general tumor suppressor microRNAs excludes miR-34a

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  DOI: 10.1093/nar/gkac277
  
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academic.oup.com/nar/advance-article/doi/10.1093/nar/gkac277/6574673
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The cargo adaptor protein CLINT1 is phosphorylated by the Numb-associated kinase BIKE and mediates dengue virus infection

1
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  DOI: 10.1016/j.jbc.2022.101956
  
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RBPMS is an RNA-binding protein that mediates cardiomyocyte binucleation and cardiovascular development

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ANKLE1 cleaves mitochondrial DNA and contributes to cancer risk by driving the Warburg effect and apoptosis resistance

1
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  DOI: 10.1101/2021.10.27.466184
  
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biorxiv.org/content/10.1101/2021.10.27.466184v1
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Plet1 is an epigenetically regulated cell surface protein that provides essential cues to direct trophoblast stem cell differentiation

1
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GFPT2/GFAT2 and AMDHD2 act in tandem to control the hexosamine pathway

1
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Mar 2022
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Genome-wide analysis of haploinsufficiency in human embryonic stem cells

1
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Rif1 and Hmgn3 regulate the conversion of murine trophoblast stem cells

1
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Parallel kinase pathways stimulate actin polymerization at depolarized mitochondria

1
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  DOI: 10.1016/j.cub.2022.02.058
  
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CRISPR-Cas9-mediated induction of large chromosomal inversions in human bronchial epithelial cells

1
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  DOI: 10.1016/j.xpro.2022.101257
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8938320/
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Insights From Long-term Follow-up of a Girl With Adrenal Insufficiency and Sphingosine-1-Phosphate Lyase Deficiency

1
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  RRID:Addgene_48138
  
  DOI: 10.1210/jendso/bvac020
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8926068/
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The E3 ligase TRIM1 ubiquitinates LRRK2 and controls its localization, degradation, and toxicity

1
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  plasmid_48138
  
  DOI: 10.1083/jcb.202010065
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8919618/
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Applying Sodium Carbonate Extraction Mass Spectrometry to Investigate Defects in the Mitochondrial Respiratory Chain

1
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  RRID:Addgene_48138
  
  DOI: 10.3389/fcell.2022.786268
  
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The m6A(m)-independent role of FTO in regulating WNT signaling pathways

1
1. scibot 17 Mar 2022
  
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  RRID:Addgene_48138
  
  DOI: 10.26508/lsa.202101250
  
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A hotspot mutation targeting the R-RAS2 GTPase acts as a potent oncogenic driver in a wide spectrum of tumors

1
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  AddgeneCat# 48138
  
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Inhibition of SHP-1 activity by PKC-θ regulates NK cell activation threshold and cytotoxicity

1
1. scibot 11 Mar 2022
  
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  plasmid_48138
  
  DOI: 10.7554/eLife.73282
  
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Rap1 prevents colitogenic Th17 cell expansion and facilitates Treg cell differentiation and distal TCR signaling

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  RRID:Addgene_48138
  
  DOI: 10.1038/s42003-022-03129-x
  
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A ciliopathy complex builds distal appendages to initiate ciliogenesis

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  RRID:Addgene_48138
  
  DOI: 10.1083/jcb.202011133
  
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A simple protocol to isolate a single human cell PRDX1 knockout generated by CRISPR-Cas9 system

1
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  Addgene_48138
  
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Fumarate inhibits PTEN to promote tumorigenesis and therapeutic resistance of type2 papillary renal cell carcinoma

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1. scibot 04 Mar 2022
  
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  Plasmid_48138
  
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Diacylglycerol kinase η regulates cell proliferation and its levels are elevated by glucocorticoids in undifferentiated neuroblastoma cells

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  Plasmid_48138
  
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An HNF1α truncation associated with maturity-onset diabetes of the young impairs pancreatic progenitor differentiation by antagonizing HNF1β function

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  plasmid_48138
  
  DOI: 10.1016/j.celrep.2022.110425
  
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BMP gradient along the intestinal villus axis controls zonated enterocyte and goblet cell states

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  plasmid_48138
  
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Gene architecture directs splicing outcome in separate nuclear spatial regions

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  RRID:Addgene_48138
  
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TP53 promotes lineage commitment of human embryonic stem cells through ciliogenesis and sonic hedgehog signaling

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  Plasmid_48138
  
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The BCL-2 family member BOK promotes KRAS-driven lung cancer progression in a p53-dependent manner

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  RRID:Addgene_48138
  
  DOI: 10.1038/s41388-021-02161-1
  
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nature.com/articles/s41388-021-02161-1
Jan 2022
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Heparan Sulfate Proteoglycans (HSPGs) Serve as the Mediator Between Monomeric Tau and Its Subsequent Intracellular ERK1/2 Pathway Activation

1
1. scibot 20 Jan 2022
  
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  RRID:Addgene_48138
  
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Plasmolipin regulates basolateral-to-apical transcytosis of ICAM-1 and leukocyte adhesion in polarized hepatic epithelial cells

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  RRID:Addgene_48138
  
  DOI: 10.1007/s00018-021-04095-z
  
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Robust genome editing in adult vascular endothelium by nanoparticle delivery of CRISPR-Cas9 plasmid DNA

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  RRID:Addgene_48138
  
  DOI: 10.1016/j.celrep.2021.110196
  
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Disc Large Homolog 1 Is Critical for Early T Cell Receptor Micro Cluster Formation and Activation in Human T Cells

1
1. scibot 05 Jan 2022
  
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  plasmid_183
  
  DOI: 10.3390/vaccines9121446
  
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mdpi.com/2076-393X/9/12/1446/htm
Dec 2021
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Dichotomous Effects of Cellular Expression of STAT3 on Tumor Growth of HNSCC

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  RRID:Addgene_48138
  
  DOI: 10.1016/j.ymthe.2021.11.011
  
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Disc Large Homolog 1 Is Critical for Early T Cell Receptor Micro Cluster Formation and Activation in Human T Cells

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  RRID:Addgene_48138
  
  DOI: 10.3390/vaccines9121446
  
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Loss of hexokinase 1 sensitizes ovarian cancer to high-dose metformin

1
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  RRID:Addgene_48138
  
  DOI: 10.1186/s40170-021-00277-2
  
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A novel live-cell imaging assay reveals regulation of endosome maturation

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  RRID:Addgene_48138
  
  DOI: 10.7554/eLife.70982
  
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Anti-recombination function of MutSα restricts telomere extension by ALT-associated homology-directed repair

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  RRID:Addgene_48138
  
  DOI: 10.1016/j.celrep.2021.110088
  
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Jpx RNA regulates CTCF anchor site selection and formation of chromosome loops

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  Addgene Cat#48138
  
  DOI: 10.1016/j.cell.2021.11.012
  
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Evidence for nutrient-dependent regulation of the COPII coat by O-GlcNAcylation

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  plasmid_48138
  
  DOI: 10.1093/glycob/cwab055
  
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academic.oup.com/glycob/article/31/9/1102/6299516
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Dynamic Analysis of 4E-BP1 Phosphorylation in Neurons with Tsc2 or Depdc5 Knockout

1
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  addgene_48138
  
  DOI: 10.1016/j.expneurol.2020.113432
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8170708/
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Detection of Neanderthal Adaptively Introgressed Genetic Variants that Modulate Reporter Gene Expression in Human Immune Cells

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1. scibot 01 Dec 2021
  
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  RRID:Addgene_48138
  
  DOI: 10.1093/molbev/msab304
  
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academic.oup.com/mbe/advance-article/doi/10.1093/molbev/msab304/6400258
Nov 2021
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Generation of auxin inducible degron (AID) knock-in cell lines for targeted protein degradation in mammalian cells

1
1. scibot 23 Nov 2021
  
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  Addgene_48138
  
  DOI: 10.1016/j.xpro.2021.100949
  
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A recurrent chromosomal inversion suffices for driving escape from oncogene-induced senescence via subTAD reorganization

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  RRID:Addgene_48138
  
  DOI: 10.1016/j.molcel.2021.10.017
  
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FEBS Press

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  plasmid_48138
  
  DOI: 10.1002/1878-0261.13115
  
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febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13115
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Gene regulatory networks controlling temporal patterning, neurogenesis, and cell-fate specification in mammalian retina

1
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  Addgene_48138
  
  DOI: 10.1016/j.celrep.2021.109994
  
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New Hybrid Compounds Combining Fragments of Usnic Acid and Thioether Are Inhibitors of Human Enzymes TDP1, TDP2 and PARP1

1
1. scibot 15 Nov 2021
  
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  RRID:Addgene_48138
  
  DOI: 10.3390/ijms222111336
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8583042/
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Distinct regulation of tonic GABAergic inhibition by NMDA receptor subtypes

1
1. scibot 10 Nov 2021
  
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  Cat# 48138
  
  DOI: 10.1016/j.celrep.2021.109960
  
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sciencedirect.com/science/article/pii/S2211124721014376
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Mitochondrial respiration restricts Listeria monocytogenes infection by slowing down host cell receptor recycling

1
1. scibot 10 Nov 2021
  
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  plasmid_48138
  
  DOI: 10.1016/j.celrep.2021.109989
  
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Loss of SORCS2 is Associated with Neuronal DNA Double-Strand Breaks

1
1. scibot 09 Nov 2021
  
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  RRID:Addgene_48138
  
  DOI: 10.1007/s10571-021-01163-7
  
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link.springer.com/article/10.1007/s10571-021-01163-7
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Crystal structure of the Tspan15 LEL domain reveals a conserved ADAM10 binding site

1
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  Addgene Cat # 48138
  
  DOI: 10.1016/j.str.2021.10.007
  
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RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy

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  RRID:Addgene_48138
  
  DOI: 10.7554/eLife.65759
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8550759/
Oct 2021
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A bipartite element with allele-specific functions safeguards DNA methylation imprints at the Dlk1-Dio3 locus

1
1. scibot 28 Oct 2021
  
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  Plasmid_48138
  
  DOI: 10.1016/j.devcel.2021.10.004
  
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Loss of FBXO31-mediated degradation of DUSP6 dysregulates ERK and PI3K-AKT signaling and promotes prostate tumorigenesis

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Syndromic RNA Polymerase II insufficiency: Generation of a human induced pluripotent stem cell line (UUIGPi002A-5) with a heterozygous disruption of POLR2A

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Generation of a homozygous CIITA knockout iPS cell line using the CRISPR-Cas9 system

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NRF1 association with AUTS2-Polycomb mediates specific gene activation in the brain

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NR4A1 regulates expression of immediate early genes, suppressing replication stress in cancer

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The drebrin/EB3 pathway regulates cytoskeletal dynamics to drive neuritogenesis in embryonic cortical neurons

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A mouse model of brittle cornea syndrome caused by mutation in Zfp469

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Loss of cancer cell STAT1 improves response to radiation therapy and promotes T cell activation in head and neck squamous cell carcinoma

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MultiEditR: The first tool for detection and quantification of multiple RNA editing sites from Sanger sequencing demonstrates comparable fidelity to RNA-seq

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The oncomicropeptide APPLE promotes hematopoietic malignancy by enhancing translation initiation

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Mild phenotype of knockouts of the major apurinic/apyrimidinic endonuclease APEX1 in a non-cancer human cell line

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RARG variant predictive of doxorubicin-induced cardiotoxicity identifies a cardioprotective therapy

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Wnt target enhancer regulation by a CDX/TCF transcription factor collective and a novel DNA motif

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Mechanism of noncoding RNA-associated N6-methyladenosine recognition by an RNA processing complex during IgH DNA recombination

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Sequential inverse dysregulation of the RNA helicases DDX3X and DDX3Y facilitates MYC-driven lymphomagenesis

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Topological isolation of developmental regulators in mammalian genomes

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Formation of Lipofuscin-Like Autofluorescent Granules in the Retinal Pigment Epithelium Requires Lysosome Dysfunction

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Overlapping roles of JIP3 and JIP4 in promoting axonal transport of lysosomes in human iPSC-derived neurons

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Integration of T helper and BCR signals governs enhanced plasma cell differentiation of memory B cells by regulation of CD45 phosphatase activity

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The biochemical basis of mitochondrial dysfunction in Zellweger Spectrum Disorder

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The ALPK1 pathway drives the inflammatory response to Campylobacter jejuni in human intestinal epithelial cells

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Overlapping Role of SCYL1 and SCYL3 in Maintaining Motor Neuron Viability

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Generation of GLA-Knockout Human Embryonic Stem Cell Lines to Model Autophagic Dysfunction and Exosome Secretion in Fabry Disease-Associated Hypertrophic Cardiomyopathy

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In vivo proximity proteomics of nascent synapses reveals a novel regulator of cytoskeleton-mediated synaptic maturation.

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A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family

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ASCL1 Reorganizes Chromatin to Direct Neuronal Fate and Suppress Tumorigenicity of Glioblastoma Stem Cells

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Exosome RNA Unshielding Couples Stromal Activation to Pattern Recognition Receptor Signaling in Cancer

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Exosome-mediated delivery of CRISPR/Cas9 for targeting of oncogenic KrasG12D in pancreatic cancer

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Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD

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cell.com/cell-host-microbe/abstract/S1931-3128(17)30245-7
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The E3 ubiquitin ligase RNF10 modifies 40S ribosomal subunits of ribosomes compromised in translation

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Innate immune response orchestrates phosphoribosyl pyrophosphate synthetases to support DNA repair

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jneurosci.org/content/38/10/2615
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Disruption of Coronin 1 Signaling in T Cells Promotes Allograft Tolerance while Maintaining Anti-Pathogen Immunity

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Identification of TMEM206 proteins as pore of PAORAC/ASOR acid-sensitive chloride channels

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  RRID:Addgene_48138
  
  DOI: 10.7554/eLife.49187
  
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CRISPR-READI: Efficient Generation of Knockin Mice by CRISPR RNP Electroporation and AAV Donor Infection

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The TIA1 RNA-Binding Protein Family Regulates EIF2AK2-Mediated Stress Response and Cell Cycle Progression

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Structural Basis of Teneurin-Latrophilin Interaction in Repulsive Guidance of Migrating Neurons

1
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  DOI: 10.1016/j.cell.2019.12.014
  
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Dectin-1 Binding to Annexins on Apoptotic Cells Induces Peripheral Immune Tolerance via NADPH Oxidase-2

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  Addgene_48138
  
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Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR

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Translational Control through Differential Ribosome Pausing during Amino Acid Limitation in Mammalian Cells

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Are Small Nucleolar RNAs “CRISPRable”? A Report on Box C/D Small Nucleolar RNA Editing in Human Cells

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Intron 1-Mediated Regulation of EGFR Expression In EGFR-Dependent Malignancies is Mediated by AP-1 and BET Proteins

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The Leukemogenic TCF3-HLF Complex Rewires Enhancers Driving Cellular Identity and Self-Renewal Conferring EP300 Vulnerability

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Restore natural fertility of <Emphasis Type="Italic">Kit</Emphasis><Superscript><Emphasis Type="Italic">w</Emphasis></Superscript><Emphasis Type="Italic">/Kit</Emphasis><Superscript><Emphasis Type="Italic">wv</Emphasis></Superscript> mouse with nonobstructive azoospermia through gene editing on SSCs mediated by CRISPR-Cas9

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A Pliable Mediator Acts as a Functional Rather Than an Architectural Bridge between Promoters and Enhancers

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Untitled document

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A Lamina-Associated Domain Border Governs Nuclear Lamina Interactions, Transcription, and Recombination of the Tcrb Locus

1
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  plasmid_48138
  
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A Dock-and-Lock Mechanism Clusters ADAM10 at Cell-Cell Junctions to Promote α-Toxin Cytotoxicity

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Transcription-mediated supercoiling regulates genome folding and loop formation

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Targeted protein degradation reveals a direct role of SPT6 in RNAPII elongation and termination

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New Hybrid Compounds Combining Fragments of Usnic Acid and Monoterpenoids for Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibition

1
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The RAS GTPase RIT1 compromises mitotic fidelity through spindle assembly checkpoint suppression

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BAP1/ASXL complex modulation regulates epithelial-mesenchymal transition during trophoblast differentiation and invasion

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Derivation of induced pluripotent stem cells line (RCPCMi007-A-1) with inactivation of the beta-2-microblogulin gene by CRISPR/Cas9 genome editing

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Jun 2021
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Revealing molecular pathways for cancer cell fitness through a genetic screen of the cancer translatome

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  Addgene_48138
  
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BAP1 enhances Polycomb repression by counteracting widespread H2AK119ub1 deposition and chromatin condensation

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Cysteamine–bicalutamide combination therapy corrects proximal tubule phenotype in cystinosis

1
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  DOI: 10.15252/emmm.202013067
  
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embopress.org/doi/full/10.15252/emmm.202013067
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Validating TDP1 as an Inhibition Target for the Development of Chemosensitizers for Camptothecin-Based Chemotherapy Drugs

1
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  DOI: 10.1007/s40487-021-00158-0
  
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HNRNP A1 Promotes Lung Cancer Cell Proliferation by Modulating VRK1 Translation

1
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  RRID:Addgene_48138
  
  DOI: 10.3390/ijms22115506
  
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STAG2 loss rewires oncogenic and developmental programs to promote metastasis in Ewing sarcoma

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  DOI: 10.1016/j.ccell.2021.05.007
  
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cell.com/cancer-cell/fulltext/S1535-6108(21)00273-7
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A role for the Cockayne Syndrome B (CSB)-Elongin ubiquitin ligase complex in signal-dependent RNA polymerase II transcription

1
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Wnt- and glutamate-receptors orchestrate stem cell dynamics and asymmetric cell division

1
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  RRID:Addgene_48138
  
  DOI: 10.7554/eLife.59791
  
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Distinct expression requirements and rescue strategies for BEST1 loss- and gain-of-function mutations

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  DOI: 10.7554/eLife.67622
  
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PHAROH lncRNA regulates Myc translation in hepatocellular carcinoma via sequestering TIAR

1
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  DOI: 10.7554/eLife.68263
  
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Choline kinase alpha 2 acts as a protein kinase to promote lipolysis of lipid droplets

1
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  Plasmid_48138
  
  DOI: 10.1016/j.molcel.2021.05.005
  
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sciencedirect.com/science/article/pii/S1097276521003622
May 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

SAM homeostasis is regulated by CFIm-mediated splicing of MAT2A

1
1. scibot 27 May 2021
  
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  Addgene_48138
  
  DOI: 10.7554/eLife.64930
  
  Resource: RRID:Addgene_48138
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8139829/
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Adhesion-mediated mechanosignaling forces mitohormesis

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1. scibot 21 May 2021
  
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  Addgene_48138
  
  DOI: 10.1016/j.cmet.2021.04.017
  
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Transcriptional co-activator regulates melanocyte differentiation and oncogenesis by integrating cAMP and MAPK/ERK pathways

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1. scibot 19 May 2021
  
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  plasmid_48138
  
  DOI: 10.1016/j.celrep.2021.109136
  
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sciencedirect.com/science/article/pii/S2211124721004757
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An Intronic Variant of CHD7 Identified in Autism Patients Interferes with Neuronal Differentiation and Development

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1. scibot 12 May 2021
  
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  Addgene_48138
  
  DOI: 10.1007/s12264-021-00685-w
  
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link.springer.com/article/10.1007/s12264-021-00685-w
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Chromatin accessibility governs the differential response of cancer and T cells to arginine starvation

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1. scibot 12 May 2021
  
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  RRID:Addgene_48138
  
  DOI: 10.1016/j.celrep.2021.109101
  
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sciencedirect.com/science/article/pii/S2211124721004356
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Multiple interactions of the oncoprotein transcription factor MYC with the SWI/SNF chromatin remodeler

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1. scibot 10 May 2021
  
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  RRID:Addgene_48138
  
  DOI: 10.1038/s41388-021-01804-7
  
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nature.com/articles/s41388-021-01804-7
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ATG4 family proteins drive phagophore growth independently of the LC3/GABARAP lipidation system

1
1. scibot 08 May 2021
  
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  plasmid_48138
  
  DOI: 10.1016/j.molcel.2021.03.001
  
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Paradoxical Mitophagy Regulation by PINK1 and TUFm

1
1. scibot 07 May 2021
  
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  Addgene_48138
  
  DOI: 10.1016/j.molcel.2020.10.007
  
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GIGYF2 and 4EHP Inhibit Translation Initiation of Defective Messenger RNAs to Assist Ribosome-Associated Quality Control

1
1. scibot 07 May 2021
  
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  plasmid_48138
  
  DOI: 10.1016/j.molcel.2020.07.007
  
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ERK2 Phosphorylates PFAS to Mediate Posttranslational Control of De Novo Purine Synthesis

1
1. scibot 07 May 2021
  
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  Plasmid_48138
  
  DOI: 10.1016/j.molcel.2020.05.001
  
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SH3BP4 promotes neuropilin-1 and α5-integrin endocytosis and is inhibited by Akt

1
1. scibot 06 May 2021
  
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  Addgene_48138
  
  DOI: 10.1016/j.devcel.2021.03.009
  
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sciencedirect.com/science/article/pii/S1534580721002069

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