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Sep 2024
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Structural and Functional Characterization of the Most Frequent Pathogenic PRKN Substitution p.R275W

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  DOI: 10.3390/cells13181540
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11430725/
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Dihydrotestosterone Enhances MICA-Mediated Immune Responses to Epstein–Barr Virus-Associated Gastric Carcinoma

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  DOI: 10.3390/cancers16183219
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11429822/
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SPRED3 regulates the NF-κB signaling pathway in thyroid cancer and promotes the proliferation

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  DOI: 10.1038/s41598-024-61075-6
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11372091/
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PRKDC Induces Chemoresistance in Osteosarcoma by Recruiting GDE2 to Stabilize GNAS and Activate AKT

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  DOI: 10.1158/0008-5472.CAN-24-0163
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11372366/
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RUVBL1/2 Blockade Targets YTHDF1 Activity to Suppress m6A-Dependent Oncogenic Translation and Colorectal Tumorigenesis

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  DOI: 10.1158/0008-5472.CAN-23-2081
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11372367/
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The V-ATPase complex component RNAseK is required for lysosomal hydrolase delivery and autophagosome degradation

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  plasmid_52961
  
  DOI: 10.1038/s41467-024-52049-3
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11374810/
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Ubiquitin-specific peptidase 22 controls integrin-dependent cancer cell stemness and metastasis

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  DOI: 10.1016/j.isci.2024.110592
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11378969/
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USP26 as a hepatitis B virus-induced deubiquitinase primes hepatocellular carcinogenesis by epigenetic remodeling

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  DOI: 10.1038/s41467-024-52201-z
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11385750/
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N-glycosylation by Mgat5 imposes a targetable constraint on immune-mediated tumor clearance

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  DOI: 10.1172/jci.insight.178804
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11383181/
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4EBP1-mediated SLC7A11 protein synthesis restrains ferroptosis triggered by MEK inhibitors in advanced ovarian cancer

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  lentiCRISPR v2
  
  DOI: 10.1172/jci.insight.177857
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11383183/
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Cyclophilin J limits linear ubiquitin signaling and controls colorectal cancer progression

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  DOI: 10.1016/j.jbc.2024.107610
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11386053/
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DBT is a metabolic switch for maintenance of proteostasis under proteasomal impairment

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  DOI: 10.7554/eLife.91002
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11386957/
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Mitochondrial RNA cytosolic leakage drives the SASP

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  DOI: 10.21203/rs.3.rs-4876596/v1
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11384804/
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KAT6A Condensates Impair PARP1 Trapping of PARP Inhibitors in Ovarian Cancer

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  Addgene_52
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11425913/
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Glaesserella parasuis serotype 4 exploits fibronectin via RlpA for tracheal colonization following porcine circovirus type 2 infection

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  lentiCRISPR v2
  
  DOI: 10.1371/journal.ppat.1012513
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11392263/
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Tumor suppressor BAP1 suppresses disulfidptosis through the regulation of SLC7A11 and NADPH levels

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  DOI: 10.1038/s41389-024-00535-0
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11393423/
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DPM1 modulates desmosomal adhesion and epidermal differentiation through SERPINB5

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  DOI: 10.1083/jcb.202305006
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10937187/
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A heterocyclic compound inhibits viral release by inducing cell surface BST2/Tetherin/CD317/HM1.24

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  lentiCRISPR v2
  
  DOI: 10.1016/j.jbc.2024.107701
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11419809/
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EspH utilizes phosphoinositide and Rab binding domains to interact with plasma membrane infection sites and Rab GTPases*

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  DOI: 10.1080/19490976.2024.2400575
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11421376/
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Induction of immortal-like and functional CAR T cells by defined factors

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  DOI: 10.1084/jem.20232368
  
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pmc.ncbi.nlm.nih.gov/articles/PMC10965394/
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HDAC8 Enhances the Function of HIF‐2α by Deacetylating ETS1 to Decrease the Sensitivity of TKIs in ccRCC

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  DOI: 10.1002/advs.202401142
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11423204/
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Saturation mutagenesis-reinforced functional assays for disease-related genes

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  Plasmid_52961
  
  DOI: 10.1016/j.cell.2024.08.047
  
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sciencedirect.com/science/article/pii/S0092867424009760
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PEBP1 amplifies mitochondrial dysfunction induced integrated stress response

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  RRID:Addgene_52961
  
  DOI: 10.1101/2024.09.20.614039
  
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biorxiv.org/content/10.1101/2024.09.20.614039v1
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FEBS Press

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  RRID:Addgene_52961
  
  DOI: 10.1002/1878-0261.13728
  
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febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13728
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BCL-2 and BOK regulate apoptosis by interaction of their C-terminal transmembrane domains

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  Addgene_52961
  
  DOI: 10.1038/s44319-024-00206-6
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11387410/
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Retinoic acid-induced protein 14 links mechanical forces to Hippo signaling

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  Addgene_52961
  
  DOI: 10.1038/s44319-024-00228-0
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11387738/
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A suite of genome-engineered hepatic cells provides novel insights into the spatiotemporal metabolism of apolipoprotein B and apolipoprotein B–containing lipoprotein secretion

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  Addgene_52961
  
  DOI: 10.1093/cvr/cvae121
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11416059/
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Human tetraspanin CD81 facilitates invasion of Salmonella enterica into human epithelial cells

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  RRID:Addgene_52961
  
  DOI: 10.1080/21505594.2024.2399792
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11423668/
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STIM1 promotes acquired resistance to sorafenib by attenuating ferroptosis in hepatocellular carcinoma

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  lentiCRISPR v2
  
  DOI: 10.1016/j.gendis.2024.101281
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11402164/
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Knockout of the WD40 domain of ATG16L1 enhances foot and mouth disease virus replication

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  lentiCRISPRv2
  
  DOI: 10.1186/s12864-024-10703-6
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11342673/
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Decoding sunitinib resistance in ccRCC: Metabolic-reprogramming-induced ABAT and GABAergic system shifts

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  Lenti-CRISPR v2
  
  DOI: 10.1016/j.isci.2024.110415
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11295714/
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Circumventing resistance within the Ewing sarcoma microenvironment by combinatorial innate immunotherapy

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  plasmid_52961
  
  DOI: 10.1136/jitc-2024-009726
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11404285/
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Recruitment of the m6A/m6Am demethylase FTO to target RNAs by the telomeric zinc finger protein ZBTB48

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  plasmid_52961
  
  DOI: 10.1186/s13059-024-03392-7
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11414060/
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Characterization of the AGR2-NPM3 axis uncovers the AGR2 involvement in PD-L1 regulation in colorectal cancer

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  DOI: 10.1038/s41598-024-72990-z
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11413233/
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Identification of genes supporting cold resistance of mammalian cells: lessons from a hibernator

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  DOI: 10.1038/s41419-024-07059-w
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11413375/
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SARS-CoV-2 ORF10 hijacking ubiquitination machinery reveals potential unique drug targeting sites

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  52961
  
  DOI: 10.1016/j.apsb.2024.05.018
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11413682/
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ASCT2 is a major contributor to serine uptake in cancer cells

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  52961
  
  DOI: 10.1016/j.celrep.2024.114552
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11406281/
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RNA helicase SKIV2L limits antiviral defense and autoinflammation elicited by the OAS-RNase L pathway

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  52961
  
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A Platform to Deliver Single and Bi-specific Cas9/guide RNA to Perturb Genes in Vitro and in Vivo

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  RRID:Addgene_52961
  
  DOI: 10.1016/j.ymthe.2024.07.025
  
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Targeting NAT10 inhibits osteosarcoma progression via ATF4/ASNS-mediated asparagine biosynthesis

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Contribution of A1 to macrophage survival in cooperation with MCL-1 and BCL-XL in a murine cell model of myeloid differentiation

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Differential utilization of vitamin B12-dependent and independent pathways for propionate metabolism across human cells

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A TBK1-independent primordial function of STING in lysosomal biogenesis

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  plasmid_52961
  
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Genome-wide CRISPR screening identifies tyrosylprotein sulfotransferase-2 as a target for augmenting anti-PD1 efficacy

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  plasmid_52
  
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The expression of PD-L1 on tumor-derived exosomes enhances infiltration and anti-tumor activity of αCD3 × αPD-L1 bispecific antibody-armed T cells

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  plasmid_52
  
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Enzalutamide Sensitizes Castration‐Resistant Prostate Cancer to Copper‐Mediated Cell Death

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  Addgene_52
  
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CRISPR-Cas and CRISPR-based screening system for precise gene editing and targeted cancer therapy

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  Addgene_52
  
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Elongin B promotes breast cancer progression by ubiquitinating tumor suppressor p14/ARF

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  Plasmid_52
  
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Dampened Regulatory Circuitry of TEAD1/ITGA1/ITGA2 Promotes TGFβ1 Signaling to Orchestrate Prostate Cancer Progression

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  plasmid_52
  
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The GSK-3β-FBXL21 Axis Contributes to Circadian TCAP Degradation and Skeletal Muscle Function

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  RRID:Addgene_80089
  
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RUNX1 interacts with lncRNA SMANTIS to regulate monocytic cell functions

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  RRID:Addgene_52961
  
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FHL2 expression by cancer-associated fibroblasts promotes metastasis and angiogenesis in lung adenocarcinoma

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  RRID:Addgene_52961
  
  DOI: 10.1002/ijc.35174
  
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Proteomic landscape of tunneling nanotubes reveals CD9 and CD81 tetraspanins as key regulators

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  Addgene_52961
  
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Netrin-1 and UNC5B Cooperate with Integrins to Mediate YAP-Driven Cytostasis

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  RRID:Addgene_52961
  
  DOI: 10.1158/2767-9764.CRC-24-0101
  
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Proteomic landscape profiling of primary prostate cancer reveals a 16-protein panel for prognosis prediction

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  Plasmid_52961
  
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The SWI/SNF PBAF complex facilitates REST occupancy at repressive chromatin

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  Addgene_52961
  
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Pooled endogenous protein tagging and recruitment for systematic profiling of protein function

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  Addgene 52961
  
  DOI: 10.1016/j.xgen.2024.100651
  
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Pharmacogenomic discovery of genetically targeted cancer therapies optimized against clinical outcomes

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  RRID:Addgene_52961
  
  DOI: 10.1038/s41698-024-00673-z
  
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Inhibitory co-receptor Lag3 supports Foxp3+ regulatory T cell function by restraining Myc-dependent metabolic programming

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  RRID:Addgene_52961
  
  DOI: 10.1016/j.immuni.2024.08.008
  
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A potent and selective ENL degrader suppresses oncogenic gene expression and leukemia progression

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  Addgene_52961
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11352836/
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ANGPTL4 suppresses clear cell renal cell carcinoma via inhibition of lysosomal acid lipase

1
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  RRID:Addgene_52961
  
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Gemcitabine therapeutically disrupts essential SIRT1-mediated p53 repression in atypical teratoid/rhabdoid tumors

1
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  Addgene_52961
  
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Cellular turnover and degradation of the most common missense cystathionine beta‐synthase variants causing homocystinuria

1
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  DOI: 10.1002/pro.5123
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11264351/
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UNC13B regulates the sensitivity of Wilms' tumor cells to doxorubicin by modulating lysosomes

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  52961
  
  DOI: 10.3892/ol.2024.14579
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11292464/
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Translation efficiency covariation across cell types is a conserved organizing principle of mammalian transcriptomes

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  DOI: 10.1101/2024.08.11.607360
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11326257/
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TFE3 fusions direct an oncogenic transcriptional program that drives OXPHOS and unveils vulnerabilities in translocation renal cell carcinoma

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ncbi.nlm.nih.gov/pmc/articles/PMC11326252/
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Synergistic combination of RAD51-SCR7 improves CRISPR-Cas9 genome editing efficiency by preventing R-loop accumulation

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  lentiCRISPRv2
  
  DOI: 10.1016/j.omtn.2024.102274
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11331969/
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Disturbed glycolipid metabolism activates CXCL13-CXCR5 axis in senescent TSCs to promote heterotopic ossification

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  52,961
  
  DOI: 10.1007/s00018-024-05302-3
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11335191/
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FYN-mediated phosphorylation of BCKDK at Y151 promotes GBM proliferation by increasing the oncogenic metabolite N-acetyl-L-alanine

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  52961
  
  DOI: 10.1016/j.heliyon.2024.e33663
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11336342/
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Genome-wide CRISPR screening identifies critical role of phosphatase and tensin homologous (PTEN) in sensitivity of acute myeloid leukemia to chemotherapy

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  lentiCRISPRv2
  
  DOI: 10.1631/jzus.B2300555
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11337085/
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Targeting Nr2e3 to Modulate Tet2 Expression: Therapeutic Potential for Depression Treatment

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1. scibot 26 Aug 2024
  
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  lenti‐CRISPR v2
  
  DOI: 10.1002/advs.202400726
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11336902/
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A plug-and-play monofunctional platform for targeted degradation of extracellular proteins and vesicles

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  DOI: 10.1038/s41467-024-51720-z
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11341853/
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PUS7‐dependent pseudouridylation of ALKBH3 mRNA inhibits gastric cancer progression

1
1. scibot 26 Aug 2024
  
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  lentiCRISPR V2
  
  DOI: 10.1002/ctm2.1811
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11341916/
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STAT3 in acute myeloid leukemia facilitates natural killer cell-mediated surveillance

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  Addgene_52961
  
  DOI: 10.3389/fimmu.2024.1374068
  
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IRF2BP2 counteracts the ATF7/JDP2 AP-1 heterodimer to prevent inflammatory overactivation in acute myeloid leukemia (AML) cells

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Leveraging biotin-based proximity labeling to identify cellular factors governing early alphaherpesvirus infection

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The histamine receptor H1 acts as an alternative receptor for SARS-CoV-2 | mBio

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TBK1 and IKKε protect target cells from IFNγ-mediated T cell killing via an inflammatory apoptotic mechanism

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Development of a highly sensitive platform for protein–protein interaction detection and regulation of T cell function

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Sub-genomic flaviviral RNA elements increase the stability and abundance of recombinant AAV vector transcripts

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Lipid synthesis, triggered by PPARγ T166 dephosphorylation, sustains reparative function of macrophages during tissue repair

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A genetic basis for sex differences in Xp11 translocation renal cell carcinoma

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Valproic acid targets IDH1 mutants through alteration of lipid metabolism

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Functional characterization of the SDR42E1 reveals its role in vitamin D biosynthesis

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A cellular reporter system to evaluate endogenous fetal hemoglobin induction and screen for therapeutic compounds

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Integrative genomics identifies SHPRH as a tumor suppressor gene in lung adenocarcinoma that regulates DNA damage response

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CA19-9-Positive Extracellular Vesicle Is a Risk Factor for Cancer-Associated Thrombosis in Pancreatic Cancer

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The actin binding protein profilin 1 localizes inside mitochondria and is critical for their function

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HDAC4 influences the DNA damage response and counteracts senescence by assembling with HDAC1/HDAC2 to control H2BK120 acetylation and homology-directed repair

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RPL22 is a tumor suppressor in MSI-high cancers and a splicing regulator of MDM4

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The deubiquitinating enzyme USP35 regulates the stability of NRF2 protein

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The caspase-activated DNase promotes cellular senescence

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  lentiCRISPR v2
  
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Integrative plasma and fecal metabolomics identify functional metabolites in adenoma-colorectal cancer progression and as early diagnostic biomarkers

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Oxysterole-binding protein targeted by SARS-CoV-2 viral proteins regulates coronavirus replication

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Dual inhibition of ATR and DNA-PKcs radiosensitizes ATM-mutant prostate cancer

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SYNGAP1 deficiency disrupts synaptic neoteny in xenotransplanted human cortical neurons in vivo

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cell.com/neuron/abstract/S0896-6273(24)00529-4
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Time- and cell-specific activation of BMP signaling restrains chondrocyte hypertrophy

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Spindle assembly checkpoint-dependent mitotic delay is required for cell division in absence of centrosomes

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MAST4 regulates stem cell maintenance with DLX3 for epithelial development and amelogenesis

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Systematic transcriptome profiling of hPSC-derived osteoblasts unveils CORIN's mastery in governing osteogenesis through CEBPD modulation

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Epitranscriptomic m5C methylation of SARS-CoV-2 RNA regulates viral replication and the virulence of progeny viruses in the new infection

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Necroptosis‐Mediated Synergistic Photodynamic and Glutamine‐Metabolic Therapy Enabled by a Biomimetic Targeting Nanosystem for Cholangiocarcinoma

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Transcriptional regulation of adipocyte lipolysis by IRF2BP2

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  plasmid_52961
  
  DOI: 10.1101/2024.07.31.605689
  
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Blocking methionine catabolism induces senescence and confers vulnerability to GSK3 inhibition in liver cancer

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TXNRD1 drives innate immune response in senescent cells with implications in age-associated inflammation

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PD-L1 deglycosylation promotes its nuclear translocation and accelerates DNA double-strand-break repair in cancer

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  lentiCRISPRv2
  
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Metastatic breast cancer cells are metabolically reprogrammed to maintain redox homeostasis during metastasis

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LACTB suppresses liver cancer progression through regulation of ferroptosis

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  DOI: 10.1016/j.redox.2024.103270
  
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OPA1 promotes ferroptosis by augmenting mitochondrial ROS and suppressing an integrated stress response

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  Cat# 52961
  
  DOI: 10.1016/j.molcel.2024.07.020
  
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A deep learning model of tumor cell architecture elucidates response and resistance to CDK4/6 inhibitors

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Integrative functional genomic analyses identify genetic variants influencing skin pigmentation in Africans

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  DOI: 10.1038/s41588-023-01626-1
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11005318/
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A digital microfluidic device integrated with electrochemical sensor and 3D matrix for detecting soluble PD-L1

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Arachidonic acid released by PIK3CA mutant tumor cells triggers malignant transformation of colonic epithelium by inducing chromatin remodeling

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  LentiCRISPR V2
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11148513/
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Inhibition of HDAC2 sensitises antitumour therapy by promoting NLRP3/GSDMD-mediated pyroptosis in colorectal cancer

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PAX6 promotes neuroendocrine phenotypes of prostate cancer via enhancing MET/STAT5A-mediated chromatin accessibility

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2024.04.26.591029v1.full-html.html

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Frontiers | The Nonvesicular Sterol Transporter Aster-C Plays a Minor Role in Whole Body Cholesterol Balance

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  Lenti-CRISPER v2
  
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METTL17 is an Fe-S cluster checkpoint for mitochondrial translation

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A tangible method to assess native ferroptosis suppressor activity

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FLIP(C1orf112)-FIGNL1 complex regulates RAD51 chromatin association to promote viability after replication stress

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  LentiCrispr v2
  
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biosignaling.biomedcentral.com biosignaling.biomedcentral.com

Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival

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Opa1 and Drp1 reciprocally regulate cristae morphology, ETC function, and NAD+ regeneration in KRas-mutant lung adenocarcinoma

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Activating STING1-dependent immune signaling in TP53 mutant and wild-type acute myeloid leukemia

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  Addgene plasmid No. 52961
  
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Mismatch repair deficiency in canine neoplasms - Sakuya Inanaga, Masaya Igase, Yusuke Sakai, Mika Tanabe, Nozomi Shimonohara, Kazuhito Itamoto, Munekazu Nakaichi, Takuya Mizuno, 2021

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A method for benchmarking genetic screens reveals a predominant mitochondrial bias

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The KAT module of the SAGA complex maintains the oncogenic gene expression program in MYCN-amplified neuroblastoma

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Artesunate induces melanoma cell ferroptosis and augments antitumor immunity through targeting Ido1

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ZNF397 Deficiency Triggers TET2-Driven Lineage Plasticity and AR-Targeted Therapy Resistance in Prostate Cancer

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Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of α-synuclein inclusions

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VHL loss enhances antitumor immunity by activating the anti-viral DNA-sensing pathway

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PELI2 is a negative regulator of STING signaling that is dynamically repressed during viral infection

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pLxIS-containing domains are biochemically flexible regulators of interferons and metabolism

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The splicing factor CCAR1 regulates the Fanconi anemia/BRCA pathway

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cell.com/molecular-cell/fulltext/S1097-2765(24)00538-0
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Netrin signaling mediates survival of dormant epithelial ovarian cancer cells

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ncbi.nlm.nih.gov/pmc/articles/PMC11257678/
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AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine

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HMMR triggers immune evasion of hepatocellular carcinoma by inactivation of phagocyte killing

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PD-L1 promotes oncolytic virus infection via a metabolic shift that inhibits the type I IFN pathway

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rupress.org/jem/article/221/7/e20221721/276807/PD-L1-promotes-oncolytic-virus-infection-via-a
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The_identification_of_CELSR3_and_other_p-html.html

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Metabolic stress induces a double-positive feedback loop between AMPK and SQSTM1/p62 conferring dual activation of AMPK and NFE2L2/NRF2 to synergize antioxidant defense

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Cross-species analysis of viral nucleic acid interacting proteins identifies TAOKs as innate immune regulators

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ncbi.nlm.nih.gov/pmc/articles/PMC8636641/
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The COMPASS complex maintains the metastatic capacity imparted by a subpopulation of cells in UPS

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ncbi.nlm.nih.gov/pmc/articles/PMC11233968/
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Alpha-defensin binding expands human adenovirus tropism

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Synthetic lethal CRISPR screen identifies a cancer cell-intrinsic role of PD-L1 in regulation of vulnerability to ferroptosis

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SigmaR1 shapes rough endoplasmic reticulum membrane sheets

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cell.com/developmental-cell/fulltext/S1534-5807(24)00382-4
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A non-canonical role for a small nucleolar RNA in ribosome biogenesis and senescence

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cell.com/cell/fulltext/S0092-8674(24)00693-7
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Depletion of Mettl3 in cholinergic neurons causes adult-onset neuromuscular degeneration

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ncbi.nlm.nih.gov/pmc/articles/PMC11216409/
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The two-faced role of RNA methyltransferase METTL3 on cellular response to cisplatin in head and neck squamous cell carcinoma in vitro model

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  DOI: 10.3389/fonc.2024.1402126
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11223524/
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Precise excision of HTLV-1 provirus with a designer-recombinase

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Local vascular Klotho mediates diabetes-induced atherosclerosis via ERK1/2 and PI3-kinase-dependent signaling pathways.

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  DOI: 10.1016/j.atherosclerosis.2024.118531
  
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γ-secretase facilitates retromer-mediated retrograde transport

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  pLentiCRISPRv2
  
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Low BCL-xL expression in triple-negative breast cancer cells favors chemotherapy efficacy, and this effect is limited by cancer-associated fibroblasts

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ncbi.nlm.nih.gov/pmc/articles/PMC11187150/
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LIMA1 links the E3 ubiquitin ligase RNF40 to lipid metabolism

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  DOI: 10.1038/s41420-024-02072-6
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11193757/
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DNA-PK participates in pre-rRNA biogenesis independent of DNA double-strand break repair

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1. scibot 30 Jun 2024
  
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  LentiCRISPR v2 vector
  
  DOI: 10.1093/nar/gkae316
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11194077/
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Vimentin-mediated buffering of internal integrin β1 pool increases survival of cells from anoikis

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3D Chromatin Alteration by Disrupting β-Catenin/CBP Interaction Is Enriched with Insulin Signaling in Pancreatic Cancer

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  DOI: 10.3390/cancers16122202
  
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BET bromodomain inhibition potentiates radiosensitivity in models of H3K27-altered diffuse midline glioma

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ncbi.nlm.nih.gov/pmc/articles/PMC11213469/
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l-2-Hydroxyglutarate remodeling of the epigenome and epitranscriptome creates a metabolic vulnerability in kidney cancer models

1
1. scibot 30 Jun 2024
  
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Somatic structural variants drive distinct modes of oncogenesis in melanoma

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Joint genotypic and phenotypic outcome modeling improves base editing variant effect quantification

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  RRID Addgene 52961
  
  DOI: 10.1038/s41588-024-01726-6
  
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  RRID Addgene 52961
  
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The ufmylation cascade controls COPII recruitment, anterograde transport, and sorting of nascent GPCRs at ER

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  DOI: 10.1126/sciadv.adm9216
  
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Evolution of STAT2 resistance to flavivirus NS5 occurred multiple times despite genetic constraints

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  Addgene_52961
  
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Tripartite Motif-Containing Protein 65 (TRIM65) Inhibits Hepatitis B Virus Transcription

1
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  Addgene_52961
  
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An HIV-1 CRISPR-Cas9 membrane trafficking screen reveals a role for PICALM intersecting endolysosomes and immunity

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  Plasmid_52961
  
  DOI: 10.1016/j.isci.2024.110131
  
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cell.com/iscience/abstract/S2589-0042(24)01356-7
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CRISPR/Cas9 screening reveals a distinct class of MHC-I binders with precise HLA-peptide recognition

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  Addgene_52961
  
  DOI: 10.1016/j.isci.2024.110120
  
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Co-targeting JAK1/STAT6/GAS6/TAM signaling improves chemotherapy efficacy in Ewing sarcoma

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The homeobox transcription factor DUXBL controls exit from totipotency

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ncbi.nlm.nih.gov/pmc/articles/PMC11149696/
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PPIA dictates NRF2 stability to promote lung cancer progression

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  DOI: 10.1038/s41467-024-48364-4
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11148020/
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Genome-wide CRISPR/Cas9 screen reveals JunB downmodulation of HIV co-receptor CXCR4

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  DOI: 10.3389/fmicb.2024.1342444
  
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The context-dependent epigenetic and organogenesis programs determine 3D vs. 2D cellular fitness of MYC-driven cancer

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  DOI: 10.21203/rs.3.rs-4390765/v1
  
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Electron transport chain inhibition increases cellular dependence on purine transport and salvage

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  RRID:Addgene_52961
  
  DOI: 10.1016/j.cmet.2024.05.014
  
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sciencedirect.com/science/article/pii/S1550413124001906
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An autoinhibitory switch of the LSD1 disordered region controls enhancer silencing

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  Addgene_52961
  
  DOI: 10.1016/j.molcel.2024.05.017
  
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VCP regulates early tau seed amplification via specific cofactors

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  Addgene_52961
  
  DOI: 10.21203/rs.3.rs-4307848/v1
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11142303/
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An efficient low cost means of biophysical gene transfection in primary cells

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  Addgene_52961
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11161637/
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ASXLs binding to the PHD2/3 fingers of MLL4 provides a mechanism for the recruitment of BAP1 to active enhancers

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  Addgene_52961
  
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A targetable PRR11-DHODH axis drives ferroptosis- and temozolomide-resistance in glioblastoma

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  DOI: 10.1016/j.redox.2024.103220
  
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DPP3 promotes breast cancer tumorigenesis by stabilizing FASN and promoting lipid synthesis: DPP3 promotes breast cancer tumorigenesis

1
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  lentiCRISPR v2
  
  DOI: 10.3724/abbs.2024054
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11177116/
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Chromosomal 3q amplicon encodes essential regulators of secretory vesicles that drive secretory addiction in cancer

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  DOI: 10.1172/JCI176355
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11178546/
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Mechanistic patterns and clinical implications of oncogenic tyrosine kinase fusions in human cancers

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  plasmid_52961
  
  DOI: 10.1038/s41467-024-49499-0
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11178778/
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CRISPR-Cas9 screens reveal common essential miRNAs in human cancer cell lines

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  Addgene_52961
  
  DOI: 10.1186/s13073-024-01341-4
  
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ADH1B, the adipocyte-enriched alcohol dehydrogenase, plays an essential, cell-autonomous role in human adipogenesis

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  plasmid_52961
  
  DOI: 10.1073/pnas.2319301121
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11181076/
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MYG1 drives glycolysis and colorectal cancer development through nuclear-mitochondrial collaboration

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  LentiCRISPRv2
  
  DOI: 10.1038/s41467-024-49221-0
  
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Dux activates metabolism-lactylation-MET network during early iPSC reprogramming with Brg1 as the histone lactylation reader

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  Plasmid_52961
  
  DOI: 10.1093/nar/gkae183
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11162783/
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UBE2D3 facilitates NHEJ by orchestrating ATM signalling through multi-level control of RNF168

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  plasmid_52961
  
  DOI: 10.1038/s41467-024-49431-6
  
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IL-6 promotes tumor growth through immune evasion but is dispensable for cachexia

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  Addgene_52961
  
  DOI: 10.1038/s44319-024-00144-3
  
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Ileal Crohn’s Disease Exhibits Reduced Activity of Phospholipase C-β3-Dependent Wnt/β-Catenin Signaling Pathway

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  RRID:Addgene_52961
  
  DOI: 10.3390/cells13110986
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11171731/
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Lysine acetyltransferase 14 mediates TGF-β-induced fibrosis in ovarian endometrioma via co-operation with serum response factor

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1. scibot 14 Jun 2024
  
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  RRID:Addgene_52961
  
  DOI: 10.1186/s12967-024-05243-2
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11167823/
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CRISPR-Cas9 editing of synaptic genes in human embryonic stem cells for functional analysis in induced human neurons

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1. scibot 10 Jun 2024
  
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  52961
  
  DOI: 10.1016/j.xpro.2024.103089
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11152723/
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Targeting pyruvate dehydrogenase kinase 1 overcomes EGFR C797S mutation-driven osimertinib resistance in non-small cell lung cancer

1
1. scibot 10 Jun 2024
  
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  lentiCRISPR v2
  
  DOI: 10.1038/s12276-024-01221-2
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11148081/
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Dynamic control of gene expression by ISGF3 and IRF1 during IFNβ and IFNγ signaling

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1. scibot 10 Jun 2024
  
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  DOI: 10.1038/s44318-024-00092-7
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11148166/
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Targeting the DYRK1A kinase prevents cancer progression and metastasis and promotes cancer cells response to G1/S targeting chemotherapy drugs

1
1. scibot 10 Jun 2024
  
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  plasmid_52961
  
  DOI: 10.1038/s41698-024-00614-w
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11153725/
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HMMR triggers immune evasion of hepatocellular carcinoma by inactivation of phagocyte killing

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1. scibot 08 Jun 2024
  
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  RRID:Addgene_52961
  
  DOI: 10.1126/sciadv.adl6083
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11152120/
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Mitochondrial respiratory function is preserved under cysteine starvation via glutathione catabolism in NSCLC

1
1. scibot 07 Jun 2024
  
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  52961
  
  DOI: 10.1038/s41467-024-48695-2
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11102494/
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Methods for investigating STAT3 regulation of lysosomal function in mammary epithelial cells

1
1. scibot 07 Jun 2024
  
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  DOI: 10.1007/s10911-024-09563-3
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11102350/
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CRISPR Screen Reveals PACT as a Pro-Viral Factor for Dengue Viral Replication

1
1. scibot 07 Jun 2024
  
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  52961
  
  DOI: 10.3390/v16050725
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11125577/
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CXCL8 Knockout: A Key to Resisting Pasteurella multocida Toxin-Induced Cytotoxicity

1
1. scibot 07 Jun 2024
  
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  DOI: 10.3390/ijms25105330
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11121343/
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A Bidirectional Non-Coding RNA Promoter Mediates Long-Range Gene Expression Regulation

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1. scibot 07 Jun 2024
  
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  plasmid_52961
  
  DOI: 10.3390/genes15050549
  
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Genome-wide CRISPR screens in spheroid culture reveal that the tumor suppressor LKB1 inhibits growth via the PIKFYVE lipid kinase

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1. scibot 06 Jun 2024
  
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  DOI: 10.1073/pnas.2403685121
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11127050/

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