1,731 Matching Annotations
  1. Mar 2025
  2. www.sciencedirect.com www.sciencedirect.com
    Transcription-coupled AID deamination damage depends on ELOF1-associated RNA polymerase II
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    sciencedirect.com/science/article/pii/S109727652500111X
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    ENKD1 modulates innate immune responses through enhanced geranylgeranyl pyrophosphate synthase activity
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    sciencedirect.com/science/article/pii/S2211124725001688
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    Integrated computational analysis identifies therapeutic targets with dual action in cancer cells and T cells
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    sciencedirect.com/science/article/pii/S107476132500072X
  5. Feb 2025
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Host cell lectins ASGR1 and DC-SIGN jointly with TMEM106B confer ACE2 independence and imdevimab resistance to SARS-CoV-2 pseudovirus with spike mutation E484D
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    pmc.ncbi.nlm.nih.gov/articles/PMC11852847/
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    Restraint of inflammasome-driven cytokine responses through the mRNA stability protein TTP
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    sciencedirect.com/science/article/pii/S2211124725001111
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Lamin B1 regulates RNA splicing factor expression by modulating the spatial positioning and chromatin interactions of the ETS1 gene locus
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    pmc.ncbi.nlm.nih.gov/articles/PMC11834782/
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting ELOVL6 to disrupt c-MYC driven lipid metabolism in pancreatic cancer enhances chemosensitivity
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    pmc.ncbi.nlm.nih.gov/articles/PMC11830767/
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PARP7 inhibits type I interferon signaling to prevent autoimmunity and lung disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC11837972/
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TRIP13 protects pancreatic cancer cells against intrinsic and therapy-induced DNA replication stress
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    pmc.ncbi.nlm.nih.gov/articles/PMC11838190/
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Non-AUG HIV-1 uORF translation elicits specific T cell immune response and regulates viral transcript expression
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    pmc.ncbi.nlm.nih.gov/articles/PMC11836288/
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    A KIF1C-CNBP motor-adaptor complex for trafficking mRNAs to cell protrusions
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    sciencedirect.com/science/article/pii/S2211124725001172
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    mTOR-mediated p62/SQSTM1 stabilization confers a robust survival mechanism for ovarian cancer
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    sciencedirect.com/science/article/pii/S0304383525001296
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    FBXO31-mediated ubiquitination of OGT maintains O-GlcNAcylation homeostasis to restrain endometrial malignancy
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    pmc.ncbi.nlm.nih.gov/articles/PMC11788441/
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Brd7 loss reawakens dormant metastasis initiating cells in lung by forging an immunosuppressive niche
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    pmc.ncbi.nlm.nih.gov/articles/PMC11799300/
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Host 3’ flap endonuclease Mus81 plays a critical role in trimming the terminal redundancy of hepatitis B virus relaxed circular DNA during covalently closed circular DNA formation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11801639/
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Identification of selective SWI/SNF dependencies in enzalutamide-resistant prostate cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11794516/
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The O-glycosyltransferase C1GALT1 promotes EWSR1::FLI1 expression and is a therapeutic target for Ewing sarcoma
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11788431/
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Interleukin-1 prevents SARS-CoV-2-induced membrane fusion to restrict viral transmission via induction of actin bundles
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11820142/
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Aberrant expression of GTPase-activating protein ARAP1 triggers circular dorsal ruffles associated with malignancy in hepatocellular carcinoma Hep3B cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11816549/
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Multi-omics analysis reveals the impact of YAP/TEAD4-mediated EIF5A1 expression on mitochondrial apoptosis and bladder cancer progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC11817321/
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    In vivo CRISPR–Cas9 genome editing in mice identifies genetic modifiers of somatic CAG repeat instability in Huntington’s disease
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11821541/
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Bat genomes illuminate adaptations to viral tolerance and disease resistance
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    pmc.ncbi.nlm.nih.gov/articles/PMC11821529/
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Loss-of-function mutations in the dystonia gene THAP1 impair proteasome function by inhibiting PSMB5 expression
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    pmc.ncbi.nlm.nih.gov/articles/PMC11811203/
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Circadian period is compensated for repressor protein turnover rates in single cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11348271/
  27. www.cell.com www.cell.com
    Genomic mediators of acquired resistance to immunotherapy in metastatic melanoma
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    cell.com/cancer-cell/abstract/S1535-6108(25)00027-3
  28. www.sciencedirect.com www.sciencedirect.com
    RIOK3 mediates the degradation of 40S ribosomes
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    sciencedirect.com/science/article/pii/S1097276525000486
  29. aacrjournals.org aacrjournals.org
    MEK inhibitors lead to PDGFR pathway upregulation and sensitize tumors to RAF dimer inhibitors in NF1-deficient malignant peripheral nerve sheath tumor (MPNST)
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    aacrjournals.org/clincancerres/article/30/22/5154/749570/MEK-Inhibitors-Lead-to-PDGFR-Pathway-Upregulation
  30. aacrjournals.org aacrjournals.org
    A novel human SDHA‑knockout cell line model for the functional analysis of clinically‑relevant SDHA variants
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    aacrjournals.org/clincancerres/article/30/23/5399/750191/A-Novel-Human-SDHA-Knockout-Cell-Line-Model-for
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    E6AP is essential for the proliferation of HPV-positive cancer cells by preventing senescence
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    pmc.ncbi.nlm.nih.gov/articles/PMC11805377/
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Regulation of cell distancing in peri-plaque glial nets by Plexin-B1 affects glial activation and amyloid compaction in Alzheimer’s disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC11346591/
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    GUK1 activation is a metabolic liability in lung cancer
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    sciencedirect.com/science/article/pii/S0092867425000935
  34. 52.53.155.43 52.53.155.43
    Single cell variation and rapid emergence of phenotypic heterogeneity in cell lines- a cautionary tale for devotees of CRISPR-Cas9.
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    52.53.155.43/6c385708921a0bf3be8e1bc925dfecc0377aeb77/2024.09.27.615490.full-html.html
  35. Jan 2025
  36. 52.53.155.43 52.53.155.43
    PDF-html.html
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    52.53.155.43/c74348c45bccaf197fb20d31d8b35ab413c8424c/PDF-html.html
  37. link.springer.com link.springer.com
    Protein kinase C iota (PKCι) and pVHL are both needed for lysosomal degradation of α5 integrin in renal carcinoma cells
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    link.springer.com/article/10.1007/s11033-025-10272-1
  38. elifesciences.org elifesciences.org
    PEBP1 amplifies mitochondrial dysfunction-induced integrated stress response
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    elifesciences.org/articles/102852
  39. www.sciencedirect.com www.sciencedirect.com
    Targeting pancreatic cancer glutamine dependency confers vulnerability to GPX4-dependent ferroptosis
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    sciencedirect.com/science/article/pii/S2666379125000011
  40. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The RING Finger E3 Ligase RNF25 Protects DNA Replication Forks Independently of its Canonical Roles in Ubiquitin Signaling
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    pmc.ncbi.nlm.nih.gov/articles/PMC11741350/
  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The context-dependent epigenetic and organogenesis programs determine 3D vs. 2D cellular fitness of MYC-driven murine liver cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11160912/
  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ROR1 CAR-T cells and ferroptosis inducers orchestrate tumor ferroptosis via PC-PUFA2
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    pmc.ncbi.nlm.nih.gov/articles/PMC11756136/
  43. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Rh-relaxin-2 attenuates oxidative stress and neuronal apoptosis via ERK-nNOS-NO pathway after germinal matrix hemorrhage in rats
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    pmc.ncbi.nlm.nih.gov/articles/PMC11734463/
  44. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    An epigenetic pathway regulates MHC-II expression and function in B cell lymphoma models
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    pmc.ncbi.nlm.nih.gov/articles/PMC11735100/
  45. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Transcriptional regulation of adipocyte lipolysis by IRF2BP2
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    pmc.ncbi.nlm.nih.gov/articles/PMC11698119/
  46. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    WWC proteins–mediated compensatory mechanism restricts schwannomatosis driven by NF2 loss of function
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    pmc.ncbi.nlm.nih.gov/articles/PMC11753430/
  47. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cell cycle progression of under-replicated cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11707533/
  48. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Inactivation of glutathione S-transferase alpha 4 blocks Enterococcus faecalis-induced bystander effect by promoting macrophage ferroptosis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11740687/
  49. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mechanisms of KRAS inhibitor resistance in KRAS-mutant colorectal cancer harboring Her2 amplification and aberrant KRAS localization
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    pmc.ncbi.nlm.nih.gov/articles/PMC11704227/
  50. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Invasion of pancreatic ductal epithelial cells by Enterococcus faecalis is mediated by fibronectin and enterococcal fibronectin-binding protein A
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    pmc.ncbi.nlm.nih.gov/articles/PMC11747100/
  51. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Herpesviruses mimic zygotic genome activation to promote viral replication
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    pmc.ncbi.nlm.nih.gov/articles/PMC11735616/
  52. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The TLR7/9 adaptors TASL and TASL2 mediate IRF5-dependent antiviral responses and autoimmunity in mouse
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    pmc.ncbi.nlm.nih.gov/articles/PMC11759703/
  53. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Coordination of Focal Adhesion Nanoarchitecture and Dynamics in Mechanosensing for Cardiomyoblast Differentiation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11758775/
  54. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    VCP regulates early tau seed amplification via specific cofactors
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    pmc.ncbi.nlm.nih.gov/articles/PMC11707990/
  55. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Single-base m6A epitranscriptomics reveals novel HIV-1 host interaction targets in primary CD4+ T cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11722377/
  56. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Long non-coding RNAs direct the SWI/SNF complex to cell type-specific enhancers
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    pmc.ncbi.nlm.nih.gov/articles/PMC11695977/
  57. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Defining ortholog-specific UHRF1 inhibition by STELLA for cancer therapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC11707192/
  58. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Natural killer cell–mediated cytotoxicity shapes the clonal evolution of B cell leukaemia
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    pmc.ncbi.nlm.nih.gov/articles/PMC7617306/
  59. www.sciencedirect.com www.sciencedirect.com
    MFGE8 induces anti-PD-1 therapy resistance by promoting extracellular vesicle sorting of PD-L1
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    sciencedirect.com/science/article/pii/S2666379124006931
  60. www.sciencedirect.com www.sciencedirect.com
    C2H2-zinc-finger transcription factors bind RNA and function in diverse post-transcriptional regulatory processes
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    sciencedirect.com/science/article/pii/S1097276524007330
  61. www.sciencedirect.com www.sciencedirect.com
    TRMT1L-catalyzed m22G27 on tyrosine tRNA is required for efficient mRNA translation and cell survival under oxidative stress
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    sciencedirect.com/science/article/pii/S2211124724015183
  62. 52.53.155.43 52.53.155.43
    Roles for the long non-coding RNA Pax6os1/PAX6-AS1 in pancreatic beta cell function
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    52.53.155.43/bb3fc3d48d1d1a3ea4bd88205a0b31e5070fc2a9/PDF-html.html
  63. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Tau is a receptor with low affinity for glucocorticoids and is required for glucocorticoid-induced bone loss
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    pmc.ncbi.nlm.nih.gov/articles/PMC11701132/
  64. www.sciencedirect.com www.sciencedirect.com
    Gut microbiota protect against colorectal tumorigenesis through lncRNA Snhg9
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    sciencedirect.com/science/article/pii/S1534580724007342
  65. www.sciencedirect.com www.sciencedirect.com
    The efflux pump ABCC1/MRP1 constitutively restricts PROTAC sensitivity in cancer cells
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    sciencedirect.com/science/article/pii/S2451945624004896
  66. www.cell.com www.cell.com
    The differential interactomes of the KRAS splice variants identify BIRC6 as a ubiquitin ligase for KRAS4A
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    cell.com/cell-reports/fulltext/S2211-1247(24)01438-4
  67. www.tandfonline.com www.tandfonline.com
    Blocking autophagosome closure manifests the roles of mammalian Atg8-family proteins in phagophore formation and expansion during nutrient starvation
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    tandfonline.com/doi/full/10.1080/15548627.2024.2443300
  68. Dec 2024
  69. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    5-Hydroxytryptamine G-Protein-Coupled Receptor Family Genes: Key Players in Cancer Prognosis, Immune Regulation, and Therapeutic Response
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    pmc.ncbi.nlm.nih.gov/articles/PMC11675146/
  70. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Tumor Intrinsic Immunogenicity Suppressor SETDB1 Worsens the Prognosis of Patients with Hepatocellular Carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC11675013/
  71. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Upregulated YTHDC1 mediates trophoblastic dysfunction inducing preterm birth in ART conceptions through enhanced RPL37 translation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11671673/
  72. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Restoring Mitochondrial Quantity and Quality to Reverse Warburg Effect and Drive Tumor Differentiation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11661309/
  73. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dipeptidyl peptidases and E3 ligases of N-degron pathways cooperate to regulate protein stability
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    pmc.ncbi.nlm.nih.gov/articles/PMC11178506/
  74. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains
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    pmc.ncbi.nlm.nih.gov/articles/PMC11654995/
  75. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The ribotoxic stress response drives acute inflammation, cell death, and epidermal thickening in UV-irradiated skin in vivo
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    pmc.ncbi.nlm.nih.gov/articles/PMC11671030/
  76. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Alternative splicing regulation by tumor suppressing subtransferable candidate 4: a pathway to tumor suppression
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    pmc.ncbi.nlm.nih.gov/articles/PMC11652373/
  77. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cysteine Rich Intestinal Protein 2 is a copper-responsive regulator of skeletal muscle differentiation and metal homeostasis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11671023/
  78. www.pnas.org www.pnas.org
    Docetaxel response in BRCA1,p53-deficient mammary tumor cells is affected by Huntingtin and BAP1
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    pnas.org/doi/abs/10.1073/pnas.2402849121
  79. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PP2A B55α Inhibits Epithelial-Mesenchymal Transition Via Regulation of Slug Expression in Non-Small Cell Lung Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11670312/
  80. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    LMAN1 serves as a cargo receptor for thrombopoietin
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    pmc.ncbi.nlm.nih.gov/articles/PMC11665562/
  81. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Macrophages promote pre-metastatic niche formation of breast cancer through aryl hydrocarbon receptor activity
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    pmc.ncbi.nlm.nih.gov/articles/PMC11652640/
  82. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Development of a Proteomic Workflow for the Identification of Heparan Sulphate Proteoglycan‐Binding Substrates of ADAM17
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    pmc.ncbi.nlm.nih.gov/articles/PMC11648071/
  83. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    GO-CRISPR: A highly controlled workflow to discover gene essentiality in loss-of-function screens
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    pmc.ncbi.nlm.nih.gov/articles/PMC11654918/
  84. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Impaired branched-chain amino acid (BCAA) catabolism during adipocyte differentiation decreases glycolytic flux
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    pmc.ncbi.nlm.nih.gov/articles/PMC11667163/
  85. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Identification of α-galactosylceramide as an endogenous mammalian antigen for iNKT cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11660903/
  86. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TGFβ signaling sensitizes MEKi-resistant human melanoma to targeted therapy-induced apoptosis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11663225/
  87. www.sciencedirect.com www.sciencedirect.com
    MYO1F positions cGAS on the plasma membrane to ensure full and functional signaling
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    sciencedirect.com/science/article/pii/S1097276524009511
  88. www.sciencedirect.com www.sciencedirect.com
    Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening
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    A TBK1-independent primordial function of STING in lysosomal biogenesis
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    Genome-wide CRISPR screening identifies tyrosylprotein sulfotransferase-2 as a target for augmenting anti-PD1 efficacy
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  182. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  183. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Enzalutamide Sensitizes Castration‐Resistant Prostate Cancer to Copper‐Mediated Cell Death
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  184. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  185. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  186. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dampened Regulatory Circuitry of TEAD1/ITGA1/ITGA2 Promotes TGFβ1 Signaling to Orchestrate Prostate Cancer Progression
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    The GSK-3β-FBXL21 Axis Contributes to Circadian TCAP Degradation and Skeletal Muscle Function
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    RUNX1 interacts with lncRNA SMANTIS to regulate monocytic cell functions
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  189. onlinelibrary.wiley.com onlinelibrary.wiley.com
    FHL2 expression by cancer-associated fibroblasts promotes metastasis and angiogenesis in lung adenocarcinoma
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  190. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Proteomic landscape of tunneling nanotubes reveals CD9 and CD81 tetraspanins as key regulators
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    The SWI/SNF PBAF complex facilitates REST occupancy at repressive chromatin
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    Inhibitory co-receptor Lag3 supports Foxp3+ regulatory T cell function by restraining Myc-dependent metabolic programming
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  197. Aug 2024
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    A potent and selective ENL degrader suppresses oncogenic gene expression and leukemia progression
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    ANGPTL4 suppresses clear cell renal cell carcinoma via inhibition of lysosomal acid lipase
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    Cellular turnover and degradation of the most common missense cystathionine beta‐synthase variants causing homocystinuria
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  203. www.biorxiv.org www.biorxiv.org
    Translation efficiency covariation across cell types is a conserved organizing principle of mammalian transcriptomes
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    TFE3 fusions direct an oncogenic transcriptional program that drives OXPHOS and unveils vulnerabilities in translocation renal cell carcinoma
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