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Feb 2024
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NSD1 supports cell growth and regulates autophagy in HPV-negative head and neck squamous cell carcinoma

1
1. scibot 15 Feb 2024
  
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  DOI: 10.1038/s41420-024-01842-6
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10861597/
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Protocol for organelle-specific cysteine capture and quantification of cysteine oxidation state

1
1. scibot 15 Feb 2024
  
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  Addgene_8454
  
  DOI: 10.1016/j.xpro.2024.102865
  
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sciencedirect.com/science/article/pii/S2666166724000303
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Transcription-Coupled Repair of DNA Interstrand Crosslinks by UVSSA

1
1. scibot 13 Feb 2024
  
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  8454
  
  DOI: 10.1101/2023.05.10.538304
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10197625/
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Characterization of dabrafenib-induced drug insensitivity via cellular barcoding and collateral sensitivity to second-line therapeutics

1
1. scibot 13 Feb 2024
  
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  8454
  
  DOI: 10.1038/s41598-023-50443-3
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10762103/
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USP54 is a potential therapeutic target in castration-resistant prostate cancer

1
1. scibot 13 Feb 2024
  
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  8454
  
  DOI: 10.1186/s12894-024-01418-7
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10845770/
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Three-step docking by WIPI2, ATG16L1, and ATG3 delivers LC3 to the phagophore

1
1. scibot 13 Feb 2024
  
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  8454
  
  DOI: 10.1126/sciadv.adj8027
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10851258/
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Integrated multi-omics analyses identify anti-viral host factors and pathways controlling SARS-CoV-2 infection

1
1. scibot 08 Feb 2024
  
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  8454
  
  DOI: 10.1038/s41467-023-44175-1
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10761986/
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Mitofusin 1 silencing decreases the senescent associated secretory phenotype, promotes immune cell recruitment and delays melanoma tumor growth after chemotherapy

1
1. scibot 08 Feb 2024
  
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  8454
  
  DOI: 10.1038/s41598-024-51427-7
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10776601/
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Pharmacological inhibition of neddylation impairs long interspersed element 1 retrotransposition

1
1. scibot 08 Feb 2024
  
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  RRID:Addgene_8454
  
  DOI: 10.1016/j.celrep.2024.113749
  
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sciencedirect.com/science/article/pii/S2211124724000779
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Effect of Octamer-Binding Transcription Factor 4 Overexpression on the Neural Induction of Human Dental Pulp Stem Cells

1
1. scibot 07 Feb 2024
  
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  RRID:Addgene_8454
  
  DOI: 10.1007/s12015-024-10678-7
  
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link.springer.com/article/10.1007/s12015-024-10678-7
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One-pot DTECT enables rapid and efficient capture of genetic signatures for precision genome editing and clinical diagnostics

1
1. scibot 07 Feb 2024
  
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  RRID:Addgene_8454
  
  DOI: 10.1016/j.crmeth.2024.100698
  
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sciencedirect.com/science/article/pii/S2667237524000043
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Direct reprogramming of non-limb fibroblasts to cells with properties of limb progenitors

1
1. scibot 06 Feb 2024
  
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  Addgene_8454
  
  DOI: 10.1016/j.devcel.2023.12.010
  
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sciencedirect.com/science/article/pii/S1534580723006901
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Micronucleus is not a potent inducer of the cGAS/STING pathway

1
1. scibot 05 Feb 2024
  
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  8454
  
  DOI: 10.26508/lsa.202302424
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10837050/
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Germinal Center Cytokines Driven Epigenetic Control of Epstein-Barr Virus Latency Gene Expression

1
1. scibot 05 Feb 2024
  
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  plasmid_8454
  
  DOI: 10.1101/2024.01.02.573986
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10802360/
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PNMA2 forms immunogenic non-enveloped virus-like capsids associated with paraneoplastic neurological syndrome

1
1. scibot 02 Feb 2024
  
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  RRID: Addgene_8454
  
  DOI: 10.1016/j.cell.2024.01.009
  
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sciencedirect.com/science/article/pii/S0092867424000114
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CAG repeat expansions create splicing acceptor sites and produce aberrant repeat-containing RNAs

1
1. scibot 02 Feb 2024
  
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  plasmid_8454
  
  DOI: 10.1016/j.molcel.2024.01.006
  
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sciencedirect.com/science/article/pii/S1097276524000078
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K-Ras(V12) differentially affects the three Akt isoforms in lung and pancreatic carcinoma cells and upregulates E-cadherin and NCAM via Akt3

1
1. scibot 01 Feb 2024
  
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  pCMV-VSV-G
  
  DOI: 10.1186/s12964-024-01484-2
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10826106/
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MRE11 liberates cGAS from nucleosome sequestration during tumorigenesis

1
1. scibot 01 Feb 2024
  
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  8454
  
  DOI: 10.1038/s41586-023-06889-6
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10794148/
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Charting Single Cell Lineage Dynamics and Mutation Networks via Homing CRISPR

1
1. scibot 01 Feb 2024
  
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  8454
  
  DOI: 10.1101/2024.01.05.574236
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10802354/
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Gene engineered exosome reverses T cell exhaustion in cancer immunotherapy

1
1. scibot 01 Feb 2024
  
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  plasmid_8454
  
  DOI: 10.1016/j.bioactmat.2024.01.008
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10825617/
Jan 2024
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PD-1 signaling uncovers a pathogenic subset of T cells in inflammatory arthritis

1
1. scibot 30 Jan 2024
  
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  AddGene 8454
  
  DOI: 10.1186/s13075-023-03259-5
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10801937/
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Hydroxynorketamine, but not ketamine, acts via α7 nicotinic acetylcholine receptor to control presynaptic function and gene expression

1
1. scibot 30 Jan 2024
  
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  #8454, Addgene
  
  DOI: 10.1038/s41398-024-02744-y
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10803733/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Involvement of Protease-Activated Receptor2 Pleckstrin Homology Binding Domain in Ovarian Cancer: Expression in Fallopian Tubes and Drug Design

1
1. scibot 30 Jan 2024
  
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  8454
  
  DOI: 10.3390/biomedicines12010246
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10813316/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Nonsynonymous Mutations in Intellectual Disability and Autism Spectrum Disorder Gene PTCHD1 Disrupt N-Glycosylation and Reduce Protein Stability

1
1. scibot 29 Jan 2024
  
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  #8454; Addgene
  
  DOI: 10.3390/cells13020199
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10814814/
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D-type cyclins regulate DNA mismatch repair in the G1 and S phases of the cell cycle, maintaining genome stability

1
1. scibot 29 Jan 2024
  
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  Plasmid_8454
  
  DOI: 10.1101/2024.01.12.575420
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10802603/
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Massively parallel disruption of enhancers active in human neural stem cells

2
1. scibot 25 Jan 2024
  
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  Plasmid_8454
  
  DOI: 10.1016/j.celrep.2024.113693
  
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2. scibot 25 Jan 2024
  
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  Plasmid_8454
  
  DOI: 10.1016/j.celrep.2024.113693
  
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sciencedirect.com/science/article/pii/S2211124724000214
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Cholinergic signaling via muscarinic M1 receptor confers resistance to docetaxel in prostate cancer

1
1. scibot 23 Jan 2024
  
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  RRID: Addgene_8454
  
  DOI: 10.1016/j.xcrm.2023.101388
  
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sciencedirect.com/science/article/pii/S2666379123006171
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Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines

1
1. scibot 18 Jan 2024
  
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  plasmid_8454
  
  DOI: 10.1126/sciadv.ade1282
  
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science.org/doi/10.1126/sciadv.ade1282
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Nuclear phosphoproteome reveals Prolyl Isomerase PIN1 as a modulator of oncogene-induced senescence.

1
1. scibot 18 Jan 2024
  
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  RRID:Addgene_8454
  
  DOI: 10.1016/j.mcpro.2024.100715
  
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sciencedirect.com/science/article/pii/S1535947624000057
dx.doi.org dx.doi.org

Kaposi's sarcoma herpesvirus exploits the DNA damage response to circularize its genome

1
1. scibot 10 Jan 2024
  
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  RRID:Addgene_8454
  
  DOI: 10.1093/nar/gkad1224
  
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dx.doi.org/10.1093/nar/gkad1224
Dec 2023
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An ERK5-PFKFB3 axis regulates glycolysis and represents a therapeutic vulnerability in pediatric diffuse midline glioma

1
1. scibot 23 Dec 2023
  
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  RRID:Addgene_8454
  
  DOI: 10.1016/j.celrep.2023.113557
  
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sciencedirect.com/science/article/pii/S2211124723015693
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Non-canonical Hedgehog signaling mediates profibrotic hematopoiesis-stroma crosstalk in myeloproliferative neoplasms

1
1. scibot 22 Dec 2023
  
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  Addgene_8454
  
  DOI: 10.1016/j.celrep.2023.113608
  
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sciencedirect.com/science/article/pii/S2211124723016200
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KDM5B predicts temozolomide-resistant subclones in glioblastoma

2
1. scibot 20 Dec 2023
  
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  RRID: Addgene_8454
  
  DOI: 10.1016/j.isci.2023.108596
  
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2. scibot 20 Dec 2023
  
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  RRID:Addgene_8454
  
  DOI: 10.1016/j.isci.2023.108596
  
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sciencedirect.com/science/article/pii/S2589004223026731
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The MHC-E peptide ligands for checkpoint CD94/NKG2A are governed by inflammatory signals, whereas LILRB1/2 receptors are peptide indifferent

1
1. scibot 20 Dec 2023
  
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  Addgene Cat: 8454
  
  DOI: 10.1016/j.celrep.2023.113516
  
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sciencedirect.com/science/article/pii/S2211124723015280
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Single-genome analysis reveals heterogeneous association of the Herpes Simplex Virus genome with H3K27me2 and the reader PHF20L1 following infection of human fibroblasts

1
1. scibot 20 Dec 2023
  
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  RRID:Addgene_8454
  
  DOI: 10.1101/2023.12.03.569766
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10705572/
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Profiling nuclear cysteine ligandability and effects on nuclear localization using proximity labeling-coupled chemoproteomics

1
1. scibot 17 Dec 2023
  
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  RRID:Addgene_8454
  
  DOI: 10.1016/j.chembiol.2023.11.010
  
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sciencedirect.com/science/article/pii/S2451945623004257
52.53.155.43 52.53.155.43

978-1-0716-3593-3-html.html

1
1. scibot 16 Dec 2023
  
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  Addgene_8454
  
  DOI: 10.1038/s41573-021-00189-2
  
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Rational optimization of a transcription factor activation domain inhibitor

1
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  DOI: 10.1038/s41594-023-01159-5
  
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The RNA helicase DDX39A binds a conserved structure in chikungunya virus RNA to control infection

1
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  DOI: 10.1016/j.molcel.2023.10.008
  
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A combinatorial therapeutic approach to enhance FLT3-ITD AML treatment

1
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Differences in syncytia formation by SARS-CoV-2 variants modify host chromatin accessibility and cellular senescence via TP53

3
1. scibot 22 Nov 2023
  
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Aryl Hydrocarbon Receptor is a Tumor Promoter in MYCN-Amplified Neuroblastoma Cells Through Suppression of Differentiation

1
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  DOI: 10.1016/j.isci.2023.108303
  
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Convergent activation of two-pore channels mediated by the NAADP-binding proteins JPT2 and LSM12

1
1. scibot 15 Nov 2023
  
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  Addgene_8454
  
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Gasdermin D permeabilization of mitochondrial inner and outer membranes accelerates and enhances pyroptosis

1
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  DOI: 10.1016/j.immuni.2023.10.004
  
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Neuronal activation of Gαq EGL-30/GNAQ late in life rejuvenates cognition across species

1
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  DOI: 10.1016/j.celrep.2023.113151
  
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Chimeric autoantibody receptor T cells deplete NMDA receptor-specific B cells

1
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  plasmid_8454
  
  DOI: 10.1016/j.cell.2023.10.001
  
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CRISPR/Cas9 screens unravel miR-3689a-3p regulating sorafenib resistance in hepatocellular carcinoma via suppressing CCS/SOD1-dependent mitochondrial oxidative stress

1
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Oct 2023
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A dual sgRNA library design to probe genetic modifiers using genome-wide CRISPRi screens

1
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  DOI: 10.1186/s12864-023-09754-y
  
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CD36 maintains lipid homeostasis via selective uptake of monounsaturated fatty acids during matrix detachment and tumor progression

1
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cell.com/cell-metabolism/fulltext/S1550-4131(23)00368-6
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Dicer deficiency in microglia leads to accelerated demyelination and failed remyelination

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  DOI: 10.1101/2023.10.17.562812
  
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Genome-wide CRISPR/Cas9 screen identifies MAT2A as a critical host factor for BK Polyomavirus

1
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  DOI: 10.1101/2023.10.20.563362
  
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Sequential activation of E2F via Rb degradation and c-Myc drives resistance to CDK4/6 inhibitors in breast cancer

1
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  RRID:Addgene_8454
  
  DOI: 10.1016/j.celrep.2023.113198
  
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Activation of Chaperone-Mediated Autophagy Inhibits the Aryl Hydrocarbon Receptor Function by Degrading This Receptor in Human Lung Epithelial Carcinoma A549 Cells

1
1. scibot 22 Oct 2023
  
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  RRID:Addgene_8454
  
  DOI: 10.3390/ijms242015116
  
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Mitigation of chromosome loss in clinical CRISPR-Cas9-engineered T cells

1
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  Addgene_8454
  
  DOI: 10.1016/j.cell.2023.08.041
  
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DNA damage induces nuclear envelope rupture through ATR-mediated phosphorylation of lamin A/C

1
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  DOI: 10.1016/j.molcel.2023.09.023
  
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Atypical peripheral actin band formation via overactivation of RhoA and nonmuscle myosin II in mitofusin 2-deficient cells

1
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  DOI: 10.7554/eLife.88828
  
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Pyruvate Kinase Activity Regulates Cystine Starvation Induced Ferroptosis through Malic Enzyme 1 in Pancreatic Cancer Cells

1
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  plasmid_8454
  
  DOI: 10.1101/2023.09.15.557984
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10516027/
Sep 2023
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Generation of mouse models carrying B cell restricted single or multiplexed loss-of-function mutations through CRISPR-Cas9 gene editing

1
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  DOI: 10.1016/j.xpro.2023.102165
  
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The IFT81‐IFT74 complex acts as an unconventional RabL2 GTPase‐activating protein during intraflagellar transport

1
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  plasmid_8454
  
  DOI: 10.15252/embj.2022111807
  
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microRNAs slow translating ribosomes to prevent protein misfolding in eukaryotes

1
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  Addgene_8454
  
  DOI: 10.15252/embj.2022112469
  
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Targeting KDM2A Enhances T Cell Infiltration in NSD1-Deficient Head and Neck Squamous Cell Carcinoma

1
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  DOI: 10.1158/0008-5472.CAN-22-3114
  
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Host-derived growth factors drive ERK phosphorylation and MCL1 expression to promote osteosarcoma cell survival during metastatic lung colonization

1
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  RRID:Addgene_8454
  
  DOI: 10.1007/s13402-023-00867-w
  
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Usp25-Erlin1/2 activity limits cholesterol flux to restrict virus infection

1
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Aug 2023
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SMC3 epigenetic silencing regulates Rab27a expression and drives pancreatic cancer progression

1
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  RRID:Addgene_8454
  
  DOI: 10.1186/s12967-023-04448-1
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10463307/
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A dual sgRNA library design to probe genetic modifiers using genome-wide CRISPRi screens

1
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  RRID:Addgene_8454
  
  DOI: 10.1101/2023.01.22.525086
  
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MARCH7-mediated ubiquitination decreases the solubility of ATG14 to inhibit autophagy

1
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  RRID:Addgene_8454
  
  DOI: 10.1016/j.celrep.2023.113045
  
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Convergent activation of two-pore channels mediated by the NAADP-binding proteins JPT2 and LSM12

1
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  Addgene_8454
  
  DOI: 10.1126/scisignal.adg0485
  
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Pyruvate anaplerosis is a targetable vulnerability in persistent leukaemic stem cells

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  DOI: 10.1038/s41467-023-40222-z
  
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An idiosyncratic zonated stroma encapsulates desmoplastic liver metastases and originates from injured liver

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  Addgene_8454
  
  DOI: 10.1038/s41467-023-40688-x
  
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nature.com/articles/s41467-023-40688-x
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IL-2 can signal via chemokine receptors to promote regulatory T cells’ suppressive function

1
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  RRID:Addgene_8454
  
  DOI: 10.1016/j.celrep.2023.112996
  
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Discovery of oncogenic ROS1 missense mutations with sensitivity to tyrosine kinase inhibitors

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  DOI: 10.15252/emmm.202217367
  
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SOCS3 deletion in effector T cells confers an anti-tumorigenic role of IL-6 to the pro-tumorigenic cytokine

2
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  Plasmid_8454
  
  DOI: 10.1016/j.celrep.2023.112940
  
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  DOI: 10.1016/j.celrep.2023.112940
  
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The Interferon γ Pathway Enhances Pluripotency and X-Chromosome Reactivation in iPSC reprogramming

3
1. scibot 12 Aug 2023
  
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Regulation of store-operated Ca2+ entry by IP3 receptors independent of their ability to release Ca2+

1
1. scibot 09 Aug 2023
  
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  plasmid_8454
  
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Proteasome Inhibition Sensitizes Liposarcoma to MDM2 Inhibition with Nutlin-3 by Activating the ATF4/CHOP Stress Response Pathway

1
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Arginine dependency is a therapeutically exploitable vulnerability in chronic myeloid leukaemic stem cells

1
1. scibot 29 Jul 2023
  
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  RRID:Addgene_8454
  
  DOI: 10.15252/embr.202256279
  
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Parallel genome-scale CRISPR screens distinguish pluripotency and self-renewal

1
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Neuronal Activation of the Gαq Protein EGL-30/GNAQ Late in Life Rejuvenates Cognition Across Species

1
1. scibot 13 Jul 2023
  
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can-22-3173-html.html

1
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Jun 2023
52.53.155.43 52.53.155.43

can-22-3173-html.html

1
1. scibot 30 Jun 2023
  
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LC3B is lipidated to large lipid droplets during prolonged starvation for noncanonical autophagy

1
1. scibot 23 Jun 2023
  
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  RRID:Addgene_8454
  
  DOI: 10.1016/j.devcel.2023.05.009
  
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CDT1 inhibits CMG helicase in early S phase to separate origin licensing from DNA synthesis

1
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Oncogenic IDH mutations increase heterochromatin-related replication stress without impacting homologous recombination

1
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Coupled protein quality control during nonsense-mediated mRNA decay

1
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May 2023
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AKT activation because of PTEN loss upregulates xCT via GSK3β/NRF2, leading to inhibition of ferroptosis in PTEN-mutant tumor cells

1
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ATR protects centromere identity by promoting DAXX association with PML nuclear bodies

1
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  Plasmid_8454
  
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MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells

1
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Membrane-Tethered Mucin 1 Is Stimulated by Interferon and Virus Infection in Multiple Cell Types and Inhibits Influenza A Virus Infection in Human Airway Epithelium

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  DOI: 10.1128/mbio.01055-22
  
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Apr 2023
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Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines

1
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  plasmid_8454
  
  DOI: 10.1126/sciadv.ade1282
  
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ATG5 provides host protection acting as a switch in the atg8ylation cascade between autophagy and secretion

1
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  Addgene_8454
  
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Intronic Cis-Element DR8 in hTERT Is Bound by Splicing Factor SF3B4 and Regulates hTERT Splicing in Non-Small Cell Lung Cancer

1
1. scibot 12 Apr 2023
  
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  RRID:Addgene_8454
  
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NFATc1 marks articular cartilage progenitors and negatively determines articular chondrocyte differentiation

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  DOI: 10.7554/eLife.81569
  
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Harnessing matrix stiffness to engineer a bone marrow niche for hematopoietic stem cell rejuvenation

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The mitochondrial protease OMA1 acts as a metabolic safeguard upon nuclear DNA damage

1
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  Plasmid_8454
  
  DOI: 10.1016/j.celrep.2023.112332
  
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Mar 2023
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LIN28 and histone H3K4 methylase induce TLR4 to generate tumor-initiating stem-like cells

1
1. scibot 22 Mar 2023
  
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  DOI: 10.1016/j.isci.2023.106254
  
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A central chaperone-like role for 14-3-3 proteins in human cells

1
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Tumor PD-L1 engages myeloid PD-1 to suppress type I interferon to impair cytotoxic T lymphocyte recruitment

1
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  DOI: 10.1016/j.ccell.2023.02.005
  
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Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause deadly disease

1
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IFNγ is a central node of cancer immune equilibrium

1
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  plasmid_8454
  
  DOI: 10.1016/j.celrep.2023.112219
  
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CAR-T Cells with Phytohemagglutinin (PHA) Provide Anti-Cancer Capacity with Better Proliferation, Rejuvenated Effector Memory, and Reduced Exhausted T Cell Frequencies

1
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Feb 2023
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Exercise-activated hepatic autophagy via the FN1-α5β1 integrin pathway drives metabolic benefits of exercise

1
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  DOI: 10.1016/j.cmet.2023.01.011
  
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Baculovirus displaying SARS-CoV-2 spike RBD promotes neutralizing antibody production in a mouse model

1
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  DOI: 10.1186/s43141-023-00472-2
  
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Monitoring cell fate in 3D organotypic human squamous epithelial cultures

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Combinatorial Treatment with Poly(ADP-ribose) Polymerase-1 Inhibitors and Cisplatin Attenuates Cervical Cancer Growth Through Fos-Driven Changes in Gene Expression

1
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  DOI: 10.1158/1541-7786.MCR-22-0111
  
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KDM5A Inhibits Antitumor Immune Responses Through Downregulation of the Antigen-Presentation Pathway in Ovarian Cancer

1
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  DOI: 10.1158/2326-6066.CIR-22-0088
  
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T-REX17 is a transiently expressed non-coding RNA essential for human endoderm formation

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  DOI: 10.7554/eLife.83077
  
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Jan 2023
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Pyruvate kinase M2 mediates IL-17 signaling in keratinocytes driving psoriatic skin inflammation

2
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  DOI: 10.1016/j.celrep.2022.111897
  
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Species-specific self-DNA detection mechanisms by mammalian cyclic GMP-AMP synthases

1
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The selective autophagy adaptor p62/SQSTM1 forms phase condensates regulated by HSP27 that facilitate the clearance of damaged lysosomes via lysophagy

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Neurotransmitter release progressively desynchronizes in induced human neurons during synapse maturation and aging

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RNA mis-splicing drives viral mimicry response after DNMTi therapy in SETD2-mutant kidney cancer

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Area postrema neurons mediate interleukin-6 function in cancer-associated cachexia

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Reversibility and developmental neuropathology of linear nevus sebaceous syndrome caused by dysregulation of the RAS pathway

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SSRN-id4267401-html.html

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Repeat-associated non-AUG translation induces cytoplasmic aggregation of CAG repeat-containing RNAs

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T cell-derived interleukin-22 drives the expression of CD155 by cancer cells to suppress NK cell function and promote metastasis

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Identification of β2 microglobulin, the product of B2M gene, as a Host Factor for Vaccinia Virus Infection by Genome-Wide CRISPR genetic screens

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Deletion of Bak1 alleviates microglial necroptosis and neuroinflammation after experimental subarachnoid hemorrhage

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PRC2 Inactivating Mutations in Cancer Enhance Cytotoxic Response to DNMT1 Targeted Therapy via Enhanced Viral Mimicry

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Functional partitioning of transcriptional regulators by patterned charge blocks

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PAX8 modulates the tumor microenvironment of high grade serous ovarian cancer through changes in the secretome

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A novel intergenic enhancer that regulates Bdnf expression in developing cortical neurons

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Transposon Mutagenesis Reveals RBMS3 Silencing as a Promoter of Malignant Progression of BRAFV600E-Driven Lung Tumorigenesis

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Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death

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Heterogeneous nuclear ribonucleoprotein K is overexpressed in acute myeloid leukemia and causes myeloproliferation in mice via altered Runx1 splicing

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MUC5B mobilizes and MUC5AC spatially aligns mucociliary transport on human airway epithelium

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CEACAM1 is a direct SOX10 target and inhibits melanoma immune infiltration and stemness

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The Sall2 transcription factor promotes cell migration regulating focal adhesion turnover and integrin β1 expression

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Bcl-2 Family Members Bcl-xL and Bax Cooperatively Contribute to Bortezomib Resistance in Mantle Cell Lymphoma

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Autophagy promotes cell survival by maintaining NAD levels

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HIV-induced bystander cell death in astrocytes requires cell-to-cell viral transmission

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Genome-scale CRISPR screening in a single mouse liver

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Loss of neuronal Tet2 enhances hippocampal-dependent cognitive function

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NF1 loss of function as an alternative initiating event in pancreatic ductal adenocarcinoma

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Tumor-intrinsic SIRPA promotes sensitivity to checkpoint inhibition immunotherapy in melanoma

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Protocol to image and quantify nucleocytoplasmic transport in cultured cells using fluorescent in situ hybridization and a dual reporter system

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Ferroptosis inhibition by lysosome-dependent catabolism of extracellular protein

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Angiotensin II receptor type 1 blockade regulates Klotho expression to induce TSC2-deficient cell death

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In vitro neurons learn and exhibit sentience when embodied in a simulated game-world

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Induced retinal pigment epithelial cells with anti-epithelial-to-mesenchymal transition ability delay retinal degeneration

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The lncRNA ALPHA specifically targets chikungunya virus to control infection

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Effects of stem cells and amniotic fluid on uterus and ovaries in a rat model of abdominal adhesions: a controlled study

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Meteorin links the bone marrow hypoxic state to hematopoietic stem/progenitor cell mobilization

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Development and Characterization of a Luciferase Labeled, Syngeneic Murine Model of Ovarian Cancer

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Membrane-Tethered Mucin 1 Is Stimulated by Interferon and Virus Infection in Multiple Cell Types and Inhibits Influenza A Virus Infection in Human Airway Epithelium

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RBM45 is an m6A-binding protein that affects neuronal differentiation and the splicing of a subset of mRNAs

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52.53.155.43 52.53.155.43

cd-21-1671-html.html

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mcr-21-0058-html.html

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Krüppel-like factor 5 rewires NANOG regulatory network to activate human naive pluripotency specific LTR7Ys and promote naive pluripotency

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Aberrant Cholesterol Metabolism and Wnt/β-Catenin Signaling Coalesce via Frizzled5 in Supporting Cancer Growth

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Chromatin-bound RB targets promoters, enhancers, and CTCF-bound loci and is redistributed by cell-cycle progression

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Stromal remodeling regulates dendritic cell abundance and activity in the tumor microenvironment

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Epigenetic reader SP140 loss of function drives Crohn’s disease due to uncontrolled macrophage topoisomerases

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Saturation of the mitochondrial NADH shuttles drives aerobic glycolysis in proliferating cells

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Identification of a drug-response gene in multiple myeloma through longitudinal single-cell transcriptome sequencing

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Jul 2022
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cir-22-0088-html.html

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Direct reprogramming of adult adipose-derived regenerative cells toward cardiomyocytes using six transcriptional factors

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Jun 2022
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mcr-22-0111-html.html

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Engagement of TRAIL triggers degranulation and IFNγ production in human natural killer cells

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A New Functional Screening Platform Identifies Colistin Sulfate as an Enhancer of Natural Killer Cell Cytotoxicity

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Lenalidomide bypasses CD28 co-stimulation to reinstate PD-1 immunotherapy by activating Notch signaling

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LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions

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Analysis of estrogen-regulated enhancer RNAs identifies a functional motif required for enhancer assembly and gene expression

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May 2022
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C/EBPδ-induced epigenetic changes control the dynamic gene transcription of S100a8 and S100a9

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Lymph node colonization induces tumor-immune tolerance to promote distant metastasis

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Loss of PRMT7 reprograms glycine metabolism to selectively eradicate leukemia stem cells in CML

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Apr 2022
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Hypoxic, glycolytic metabolism is a vulnerability of B-acute lymphoblastic leukemia-initiating cells

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The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes

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Mitochondrial dynamics regulate genome stability via control of caspase-dependent DNA damage

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Functional elements of the cis-regulatory lincRNA-p21

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The interferon-stimulated gene RIPK1 regulates cancer cell intrinsic and extrinsic resistance to immune checkpoint blockade

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Mar 2022
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Genome-wide analysis of haploinsufficiency in human embryonic stem cells

1
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Müller glia fused with adult stem cells undergo neural differentiation in human retinal models

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Confined migration promotes cancer metastasis through resistance to anoikis and increased invasiveness

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Deletion of STAT3 from Foxd1 cell population protects mice from kidney fibrosis by inhibiting pericytes trans-differentiation and migration

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Glutamine-dependent signaling controls pluripotent stem cell fate

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MLL::AF9 degradation induces rapid changes in transcriptional elongation and subsequent loss of an active chromatin landscape

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The Natural Chemotherapeutic Capsaicin Activates AMPK through LKB1 Kinase and TRPV1 Receptors in Prostate Cancer Cells

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  DOI: 10.3390/pharmaceutics14020329
  
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Pathway-specific effects of ADSL deficiency on neurodevelopment

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P2Y1 purinergic receptor identified as a diabetes target in a small-molecule screen to reverse circadian β-cell failure

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YAP regulates an SGK1/mTORC1/SREBP-dependent lipogenic program to support proliferation and tissue growth

2
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sciencedirect.com/science/article/pii/S1534580722000703
Feb 2022
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

TBK1-METTL3 axis facilitates antiviral immunity

1
1. scibot 16 Feb 2022
  
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  AddGeneCat#8454
  
  DOI: 10.1016/j.celrep.2022.110373
  
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pubmed.ncbi.nlm.nih.gov/35172162/
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Deletion of β-Neurexins in Mice Alters the Distribution of Dense-Core Vesicles in Presynapses of Hippocampal and Cerebellar Neurons

1
1. scibot 16 Feb 2022
  
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  RRID:Addgene_8454
  
  DOI: 10.3389/fnana.2021.757017
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8841415/
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Phosphorylation of guanosine monophosphate reductase triggers a GTP-dependent switch from pro- to anti-oncogenic function of EPHA4

4
1. scibot 11 Feb 2022
  
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  RRID:Addgene_8454
  
  DOI: 10.1016/j.chembiol.2022.01.007
  
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  RRID:Addgene_8454
2. scibot 11 Feb 2022
  
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  plasmid_8454
  
  DOI: 10.1016/j.chembiol.2022.01.007
  
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3. scibot 11 Feb 2022
  
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  RRID:Addgene_8454
  
  DOI: 10.1016/j.chembiol.2022.01.007
  
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4. scibot 11 Feb 2022
  
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  plasmid_8454
  
  DOI: 10.1016/j.chembiol.2022.01.007
  
  Resource: RRID:Addgene_8454
  
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sciencedirect.com/science/article/pii/S2451945622000496
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Mechanistic impact of oligomer poisoning by dominant-negative CARD11 variants

2
1. scibot 11 Feb 2022
  
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  Plasmid_8454
  
  DOI: 10.1016/j.isci.2022.103810
  
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2. scibot 09 Feb 2022
  
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  Plasmid_8454
  
  DOI: 10.1016/j.isci.2022.103810
  
  Resource: RRID:Addgene_8454
  
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sciencedirect.com/science/article/pii/S2589004222000803
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Development of human alveolar epithelial cell models to study distal lung biology and disease

1
1. scibot 04 Feb 2022
  
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  DOI: 10.1016/j.isci.2022.103780
  
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sciencedirect.com/science/article/pii/S2589004222000505

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