2,057 Matching Annotations
  1. Jan 2023
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    The CNC-family transcription factor Nrf3 coordinates the melanogenesis cascade through macropinocytosis and autophagy regulation
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    sciencedirect.com/science/article/pii/S2211124722018058
  3. Dec 2022
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    POU1F1/Pou1f1 c.143-83A > G variant disrupts the branch site in pre-mRNA and leads dwarfism
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    52.53.155.43/ca4b171f4584f28dba639bfded212cd30876080e/bqac198-html.html
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    The ADP-ribose hydrolase NUDT5 is important for DNA repair
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    sciencedirect.com/science/article/pii/S2211124722017624
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    The Sag-Shoc2 axis regulates conversion of mPanINs to cystic lesions in Kras pancreatic tumor model
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    sciencedirect.com/science/article/pii/S2211124722017296
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    Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis
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    ΔNp63/p73 drive metastatic colonization by controlling a regenerative epithelial stem cell program in quasi-mesenchymal cancer stem cells
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    sciencedirect.com/science/article/pii/S1534580722008152
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    Protocol to purify and detect ubiquitinated phospholipids in budding yeast and human cell lines
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    Epidermal stratification requires retromer-mediated desmoglein-1 recycling
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    Elongation factor-specific capture of RNA polymerase II complexes
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    PALI1 promotes tumor growth through competitive recruitment of PRC2 to G9A-target chromatin for dual epigenetic silencing
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    Mitochondrial cristae architecture protects against mtDNA release and inflammation
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    Characterization of huntingtin interactomes and their dynamic responses in living cells by proximity proteomics
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    onlinelibrary.wiley.com/doi/full/10.1111/jnc.15726
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    IFT-A structure reveals carriages for membrane protein transport into cilia
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    Androgen-regulated MafB drives cell migration via MMP11-dependent extracellular matrix remodeling in mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC9713376/
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    Enhanced AMPAR-dependent synaptic transmission by S-nitrosylation in the vmPFC contributes to chronic inflammatory pain-induced persistent anxiety in mice
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    nature.com/articles/s41401-022-01024-z
  18. Nov 2022
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mcm2 promotes stem cell differentiation via its ability to bind H3-H4
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    The oncogenic JAG1 intracellular domain is a transcriptional cofactor that acts in concert with DDX17/SMAD3/TGIF2
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    Branched-chain amino acid catabolism breaks glutamine addiction to sustain hepatocellular carcinoma progression
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    Deconvolution of in vivo protein-RNA contacts using fractionated eCLIP-seq
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    FEBS Press
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    Downregulation of protein kinase C gamma reduces epithelial property and enhances malignant phenotypes in colorectal cancer cells
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    Dysregulated endolysosomal trafficking in cells arrested in the G1 phase of the host cell cycle impairs Salmonella vacuolar replication
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    ncbi.nlm.nih.gov/pmc/articles/PMC9450962/
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    B cell linker protein (BLNK) is a regulator of Met receptor signaling and trafficking in non-small cell lung cancer
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    Purification of exosome-enriched proteins produced in a Drosophila cell line by size exclusion chromatography
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    CROCCP2 acts as a human-specific modifier of cilia dynamics and mTOR signaling to promote expansion of cortical progenitors
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    LncRNA CCTT-mediated RNA-DNA and RNA-protein interactions facilitate the recruitment of CENP-C to centromeric DNA during kinetochore assembly
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    Cancer cell intrinsic TIM-3 induces glioblastoma progression
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    V-ATPase/TORC1-mediated ATFS-1 translation directs mitochondrial UPR activation in C. elegans
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    Targeted degradation of PCNA outperforms stoichiometric inhibition to result in programed cell death
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    An enChIP system for the analysis of genome functions in budding yeast
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  34. Oct 2022
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    Structure and functionality of a multimeric human COQ7:COQ9 complex
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    Prdm14 promotes mouse ESC self-renewal and PGCLC specification through enhancement of Stat3 activity
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    METTL3 regulates m6A methylation of PTCH1 and GLI2 in Sonic hedgehog signaling to promote tumor progression in SHH-medulloblastoma
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    A critical developmental window for ELAV/Hu-dependent mRNA signatures at the onset of neuronal differentiation
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    ZBTB7A promotes virus-host homeostasis during human coronavirus 229E infection
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    Metabolomic fingerprinting of renal disease progression in Bardet-Biedl syndrome reveals mitochondrial dysfunction in kidney tubular cells
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    ATP13A1 prevents ERAD of folding-competent mislocalized and misoriented proteins
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    Hotspot mutations in the structured ENL YEATS domain link aberrant transcriptional condensates and cancer
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    Argininosuccinate lyase drives activation of mutant TERT promoter in glioblastomas
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    RAD51AP1 regulates ALT-HDR through chromatin-directed homeostasis of TERRA
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    Allelic variation in the Arabidopsis TNL CHS3/CSA1 immune receptor pair reveals two functional cell-death regulatory modes
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    CasPlay provides a gRNA-barcoded CRISPR-based display platform for antibody repertoire profiling
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    Brain-wide connectivity map of mouse thermosensory cortices
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    academic.oup.com/cercor/advance-article/doi/10.1093/cercor/bhac386/6762895
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    A feed-forward pathway drives LRRK2 kinase membrane recruitment and activation
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    elifesciences.org/articles/79771
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    GPC3-Unc5 receptor complex structure and role in cell migration
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    Motor neurons use push-pull signals to direct vascular remodeling critical for their connectivity
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    Spatial epitope barcoding reveals clonal tumor patch behaviors
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    The FDA-approved drug Auranofin has a dual inhibitory effect on SARS-CoV-2 entry and NF-κB signaling
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    Enzyme-free targeted DNA demethylation using CRISPR–dCas9-based steric hindrance to identify DNA methylation marks causal to altered gene expression
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    nature.com/articles/s41596-022-00741-3
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dissection of the MEF2D-IRF8 transcriptional circuit dependency in acute myeloid leukemia
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    Mechanisms and significance of tissue-specific MICU regulation of the mitochondrial calcium uniporter complex
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  56. Sep 2022
  57. www.embopress.org www.embopress.org
    Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair
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    Continuous double-strand break induction and their differential processing sustain chiasma formation during Caenorhabditis elegans meiosis
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  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Distinct regions of H. pylori’s bactofilin CcmA regulate protein–protein interactions to control helical cell shape
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  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The core PCP protein Prickle2 regulates axon number and AIS maturation by binding to AnkG and modulating microtubule bundling
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    ncbi.nlm.nih.gov/pmc/articles/PMC9462691/
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    Myhre syndrome is caused by dominant-negative dysregulation of SMAD4 and other co-factors
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    Protocol to detect in vitro and in cell ubiquitylation of mitochondrial DNA polymerase gamma by mitochondrial E3 ligase MITOL
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  63. www.authorea.com www.authorea.com
    ISX9, a small molecule targeting Axin, activates Wnt/β-catenin signaling and promotes hair regrowth
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  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CTCF DNA-binding domain undergoes dynamic and selective protein–protein interactions
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  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding
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    ATP hydrolysis tunes specificity of a AAA+ protease
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    Synthetic refactor of essential genes decodes functionally constrained sequences in yeast genome
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    Structure and mechanism of human cystine exporter cystinosin
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    Sensing of individual stalled 80S ribosomes by Fap1 for nonfunctional rRNA turnover
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    Control of ribosomal RNA synthesis by hematopoietic transcription factors
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    Pak2-mediated phosphorylation promotes RORγt ubiquitination and inhibits colonic inflammation
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    Endothelial cells regulated by RNF20 orchestrate the proliferation and differentiation of neural precursor cells during embryonic development
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    Activation and expansion of presynaptic signaling foci drives presynaptic homeostatic plasticity
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    Shear stress activates nociceptors to drive Drosophila mechanical nociception
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    Target protein localization and its impact on PROTAC-mediated degradation
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    Runx2 regulates chromatin accessibility to direct the osteoblast program at neonatal stages
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    A family of C. elegans VASA homologs control Argonaute pathway specificity and promote transgenerational silencing
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    Integrative RNA-omics discovers GNAS alternative splicing as a phenotypic driver of splicing factor-mutant neoplasms
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  79. Aug 2022
  80. www.sciencedirect.com www.sciencedirect.com
    RBM45 is an m6A-binding protein that affects neuronal differentiation and the splicing of a subset of mRNAs
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    ABL kinases regulate translation in HER2+ cells through Y-box-binding protein 1 to facilitate colonization of the brain
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    Ubiquitination of phosphatidylethanolamine in organellar membranes
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    Activation of mitochondrial TRAP1 stimulates mitochondria-lysosome crosstalk and correction of lysosomal dysfunction
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    Identification of the NRF2 transcriptional network as a therapeutic target for trigeminal neuropathic pain
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    ncbi.nlm.nih.gov/pmc/articles/PMC9348805/
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    trim-21 promotes proteasomal degradation of CED-1 for apoptotic cell clearance in C. elegans
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    ncbi.nlm.nih.gov/pmc/articles/PMC9388098/
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    Induction of A Disintegrin and Metalloproteinase with Thrombospondin motifs 1 by a rare variant or cognitive activities reduces hippocampal amyloid-β and consequent Alzheimer’s disease risk
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    The AMPK-HOXB9-KRAS axis regulates lung adenocarcinoma growth in response to cellular energy alterations
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    Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IκBα
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    N1-methylpseudouridine found within COVID-19 mRNA vaccines produces faithful protein products
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    Protocol for viral vector-mediated measurement of transcription factor activity of mouse brain
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    De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma
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    Neuronal paxillin and drebrin mediate BDNF-induced force transduction and growth cone turning in a soft-tissue-like environment
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    Epigenetic reader SP140 loss of function drives Crohn’s disease due to uncontrolled macrophage topoisomerases
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