3,923 Matching Annotations
  1. Jun 2025
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CCDC50 mediates the clearance of protein aggregates to prevent cellular proteotoxicity
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    pmc.ncbi.nlm.nih.gov/articles/PMC11572255/
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Loss of LAPTM4A inhibits M2 polarization of tumor-associated macrophages in glioblastoma, promoting immune activation and enhancing anti-PD1 therapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12159176/
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Neuronal aging causes mislocalization of splicing proteins and unchecked cellular stress
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    pmc.ncbi.nlm.nih.gov/articles/PMC12148940/
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12158785/
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Control of epithelial tissue organization by mRNA localization
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    pmc.ncbi.nlm.nih.gov/articles/PMC12141530/
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SWI/SNF ATPase silenced HLF potentiates lung metastasis in solid cancers
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    pmc.ncbi.nlm.nih.gov/articles/PMC12141477/
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Active R-RAS2/TC21 prevents cell cycle arrest and morphological alterations in mouse embryonic fibroblasts lacking RAS proteins
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    pmc.ncbi.nlm.nih.gov/articles/PMC12143975/
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    Combined inhibition of KAT6A/B and Menin reverses estrogen receptor-driven gene expression programs in breast cancer
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    sciencedirect.com/science/article/pii/S2666379125002654
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Co-targeting BMI1 and MYC to eliminate cancer stem cells in squamous cell carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12147845/
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    GLI2-HRD1 axis facilitates 5-FU resistance in gastric cancer cells by regulating ubiquitination degradation of UCK2
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    pmc.ncbi.nlm.nih.gov/articles/PMC12159939/
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Hepatic ChREBP reciprocally modulates systemic insulin sensitivity in NAFLD
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    pmc.ncbi.nlm.nih.gov/articles/PMC12155594/
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    NUDT16 enhances the resistance of cancer cells to DNA-damaging agents by regulating replication fork stability via reversing HMGA1 ADP-ribosylation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12151214/
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Heat shock induces alternative polyadenylation through dynamic DNA methylation and chromatin looping
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    pmc.ncbi.nlm.nih.gov/articles/PMC12162027/
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    SLIRP amplifies antiviral signaling via positive feedback regulation and contributes to autoimmune diseases
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    sciencedirect.com/science/article/pii/S2211124725003596
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Phosphorylation-induced SUMOylation promotes Ulk4 condensation at the ciliary tip to transduce Hedgehog signal
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    pmc.ncbi.nlm.nih.gov/articles/PMC12148026/
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cell‐Type‐Specific Autophagy in Human Leukocytes
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    pmc.ncbi.nlm.nih.gov/articles/PMC12159969/
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Discovery of potential small molecule inhibitors against β-hCG: an in silico study with in vitro validation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12150210/
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    β-propeller protein-associated neurodegeneration protein WDR45 regulates stress granule disassembly via phase separation with Caprin-1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12141619/
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CRISPR antiviral inhibits neurotrophic JC polyomavirus in 2D and 3D culture models through dual-gRNA excision by SaCas9
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    pmc.ncbi.nlm.nih.gov/articles/PMC12159223/
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CRAMP1-dependent histone H1 biogenesis is essential for topoisomerase II inhibitor tolerance
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    pmc.ncbi.nlm.nih.gov/articles/PMC12240685/
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RalGAP complexes control secretion and primary cilia in pancreatic disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC12149561/
  23. 52.53.155.43 52.53.155.43
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  24. 52.53.155.43 52.53.155.43
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  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Delta-catenin is required for cell proliferation in virus-positive Merkel cell carcinoma cell lines but not in human fibroblasts
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    pmc.ncbi.nlm.nih.gov/articles/PMC12153310/
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    Protocol for genetic dissection of class switch recombination using genome-editing tools
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    sciencedirect.com/science/article/pii/S2666166725002886
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    The immortality mechanism of TERT promoter mutant cancers is self-reinforcing and reversible
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    sciencedirect.com/science/article/pii/S1097276525004654
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    The integrated stress response fine-tunes stem cell fate decisions upon serine deprivation and tissue injury
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    cell.com/cell-metabolism/fulltext/S1550-4131(25)00266-9
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    Vault RNAs aid RNA virus infection by facilitating cytoplasmic localization of hnRNP C and ELAVL1
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    sciencedirect.com/science/article/pii/S2211124725005947
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    The RNA-stability-independent role of the RNA m6A reader YTHDF2 in promoting protein translation to confer tumor chemotherapy resistance
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    sciencedirect.com/science/article/pii/S109727652500454X
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    NDF/GLYR1 Promotes RNA Polymerase II Processivity via Pol II Binding and Nucleosome Destabilization
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    pmc.ncbi.nlm.nih.gov/articles/PMC12112590/
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting the Glucose–Insulin Link in Head and Neck Squamous Cell Carcinoma Induces Cytotoxic Oxidative Stress and Inhibits Cancer Growth
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    pmc.ncbi.nlm.nih.gov/articles/PMC12141995/
  33. 52.53.155.43 52.53.155.43
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    Regulation of Rho guanine nucleotide exchange factor 3 by phosphorylation in the PH domain
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    sciencedirect.com/science/article/pii/S2589004225010144
  36. elifesciences.org elifesciences.org
    A Commander-independent function of COMMD3 in endosomal trafficking
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    elifesciences.org/reviewed-preprints/105264
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mutation of SMARCA4 Induces Cancer Cell–Intrinsic Defects in the Enhancer Landscape and Resistance to Immunotherapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12127800/
  38. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Prolonged Half-Life of the p53 Missense Variant R248Q Promotes Accumulation and Heterotetramer Formation with Wild-Type p53 to Exert the Dominant-Negative Effect
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    pmc.ncbi.nlm.nih.gov/articles/PMC12127799/
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Phosphatase activity is dispensable for PRL-3-mediated oncogenesis and tumor progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12132575/
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    Glucose-1-phosphate promotes compartmentalization of glycogen with the pentose phosphate pathway in CD8+ memory T cells
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    sciencedirect.com/science/article/pii/S1097276525004587
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    Structures of butyrophilin multimers reveal a plier-like mechanism for Vγ9Vδ2 T cell receptor activation
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    sciencedirect.com/science/article/pii/S1074761325002328
  42. 52.53.155.43 52.53.155.43
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  43. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Fitness and transcriptional plasticity of human breast cancer single-cell-derived clones
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    pmc.ncbi.nlm.nih.gov/articles/PMC12117018/
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    Screening a living biobank identifies cabazitaxel as a strategy to combat acquired taxol resistance in high-grade serous ovarian cancer
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    sciencedirect.com/science/article/pii/S2666379125002332
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    Targeting IDH2 promotes antitumor immunity through epigenetic activation of cGAS-STING pathway
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    sciencedirect.com/science/article/pii/S0169500225005033
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    Efflux of N1-acetylspermidine from hepatoma fosters macrophage-mediated immune suppression to dampen immunotherapeutic efficacy
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    sciencedirect.com/science/article/pii/S1074761325002274
  47. May 2025
  48. www.sciencedirect.com www.sciencedirect.com
    Coiled-coil-domain-mediated TRIM E3 protein condensation modulates enzymatic activity and functional specificity
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    sciencedirect.com/science/article/pii/S2211124725005376
  49. www.nature.com www.nature.com
    hnRNPL phase separation activates PIK3CB transcription and promotes glycolysis in ovarian cancer
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    nature.com/articles/s41467-025-60115-7
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    IGF2BP1 restricts the induction of human primordial germ cell fate in an m6A-dependent manner
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    sciencedirect.com/science/article/pii/S193459092500181X
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    Machine-learning-assisted universal protein activation in living mice
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    sciencedirect.com/science/article/pii/S0092867425005173
  52. journals.asm.org journals.asm.org
    Delta-catenin is required for cell proliferation in virus-positive Merkel cell carcinoma cell lines but not in human fibroblasts
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    journals.asm.org/doi/10.1128/mbio.00832-25
  53. www.sciencedirect.com www.sciencedirect.com
    Direct Arp2/3-vinculin binding is required for pseudopod extension, but only on compliant substrates and in 3D
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    sciencedirect.com/science/article/pii/S2589004225008843
  54. www.sciencedirect.com www.sciencedirect.com
    KDM3A and KDM3B regulate alternative splicing in mouse pluripotent stem cells
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    sciencedirect.com/science/article/pii/S2589004225008739
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    Engineered vasculature induces functional maturation of pluripotent stem cell-derived islet organoids
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    sciencedirect.com/science/article/pii/S153458072500262X
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  57. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    HBV sequence integrated to enhancer acting as oncogenic driver epigenetically promotes hepatocellular carcinoma development
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    pmc.ncbi.nlm.nih.gov/articles/PMC12096768/
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    IMPDH inhibition induces DNA replication stress and ATR sensitivity in Merkel cell carcinoma
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    sciencedirect.com/science/article/pii/S2589004225008284
  59. 52.53.155.43 52.53.155.43
    CapdevilaCastillo_columbia_0054D_18600-html.html
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    52.53.155.43/defa13d4e31bf105e951133a04f91af42d68a175/CapdevilaCastillo_columbia_0054D_18600-html.html
  60. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SFSWAP is a negative regulator of OGT intron detention and global pre-mRNA splicing
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    pmc.ncbi.nlm.nih.gov/articles/PMC12017769/
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    Division of labor among H3K4 methyltransferases defines distinct facets of homeostatic plasticity
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    sciencedirect.com/science/article/pii/S2211124725005170
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    PUS10-induced tRNA fragmentation impacts retrotransposon-driven inflammation
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    sciencedirect.com/science/article/pii/S2211124725005066
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    Targeting WEE1 in tumor-associated dendritic cells potentiates antitumor immunity via the cGAS/STING pathway
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    sciencedirect.com/science/article/pii/S2211124725005042
  64. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Design and Characterization of Inhibitors of Cell-Mediated Degradation of APOBEC3G That Decrease HIV-1 Infectivity
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    pmc.ncbi.nlm.nih.gov/articles/PMC12031279/
  65. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting PCSK9 in Liver Cancer Cells Triggers Metabolic Exhaustion and Cell Death by Ferroptosis
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    pmc.ncbi.nlm.nih.gov/articles/PMC9818499/
  66. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Coordinated regulation of IGF1R by HIF1α and HIF2α enhances chemoresistance in glioblastoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12021886/
  67. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CLEC12A-directed immunocytokine with target cell–restricted IL-15 activity for treatment of acute myeloid leukemia
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    pmc.ncbi.nlm.nih.gov/articles/PMC11983603/
  68. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RBM15-mediated metabolic reprogramming boosts immune response in colorectal cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12075365/
  69. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SAMHD1 knockout hiPSC model enables high lentiviral transduction efficiency in myeloid cell types
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    pmc.ncbi.nlm.nih.gov/articles/PMC12009803/
  70. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Incomplete paralog compensation generates selective dependency on TRA2A in cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12077678/
  71. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Predicting adenine base editing efficiencies in different cellular contexts by deep learning
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    pmc.ncbi.nlm.nih.gov/articles/PMC12060317/
  72. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The evolution of AKAPs and emergence of PKA isotype selective anchoring determinants
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    pmc.ncbi.nlm.nih.gov/articles/PMC12083921/
  73. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Neuroendocrine Differentiation in Prostate Cancer Requires ASCL1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11534540/
  74. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CRB2 Depletion Induces YAP Signaling and Disrupts Mechanosensing in Podocytes
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    pmc.ncbi.nlm.nih.gov/articles/PMC12076484/
  75. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RAB5 is a host dependency factor for the generation of SARS-CoV-2 replication organelles
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    pmc.ncbi.nlm.nih.gov/articles/PMC12077180/
  76. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Acute BRCAness induction and AR pathway blockage through CDK12/7/9 degradation enhances PARP inhibitor sensitivity in prostate cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12017310/
  77. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    In vivo functional screens reveal KEAP1 loss as a driver of chemoresistance in small cell lung cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12017300/
  78. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Complete Loss of PAX4 causes Transient Neonatal Diabetes in Humans
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    pmc.ncbi.nlm.nih.gov/articles/PMC11998800/
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    Chromatin modification abnormalities by CHD7 and KMT2C loss promote medulloblastoma progression
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    sciencedirect.com/science/article/pii/S2211124725004449
  80. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Engineering Chromosome Bridges Through CRISPR/Cas9 to Decipher the Impact of Intercentromeric Distance on Resolution Dynamics
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    pmc.ncbi.nlm.nih.gov/articles/PMC12057592/
  81. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dynamic activation of rAAV transgene expression by a small molecule that recruits endogenous transcriptional machinery
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    pmc.ncbi.nlm.nih.gov/articles/PMC12038400/
  82. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Praja2 controls P-body assembly and translation in glioblastoma by non-proteolytic ubiquitylation of DDX6
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    pmc.ncbi.nlm.nih.gov/articles/PMC12069581/
  83. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeted protein degraders of SARS-CoV-2 Mpro are more active than enzymatic inhibition alone with activity against nirmatrelvir resistant virus
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    pmc.ncbi.nlm.nih.gov/articles/PMC12033352/
  84. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SARS-CoV-2 ORF3a drives dynamic dense body formation for optimal viral infectivity
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    pmc.ncbi.nlm.nih.gov/articles/PMC12069715/
  85. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TRIM52 maintains cellular fitness and is under tight proteolytic control by multiple giant E3 ligases
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    pmc.ncbi.nlm.nih.gov/articles/PMC12022042/
  86. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Allelic effects on KLHL17 expression underlie a pancreatic cancer genome-wide association signal at chr1p36.33
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    pmc.ncbi.nlm.nih.gov/articles/PMC12044007/
  87. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Single influenza A viruses induce nanoscale cellular reprogramming at the virus-cell interface
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