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Sep 2022
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Sublethal cytochrome c release generates drug-tolerant persister cells

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1. scibot 03 Sep 2022
  
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  DOI: 10.1016/j.cell.2022.07.025
  
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sciencedirect.com/science/article/pii/S0092867422009783
Aug 2022
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mcr-21-0058-html.html

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  DOI: 10.1158/1541-7786.MCR-21-0058
  
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52.53.155.43/b2945508dd72ea968b40713e7d1d3d2b4a0923f9/mcr-21-0058-html.html
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SOX transcription factors direct TCF-independent WNT/β-catenin responsive transcription to govern cell fate in human pluripotent stem cells

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1. scibot 26 Aug 2022
  
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  DOI: 10.1016/j.celrep.2022.111247
  
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sciencedirect.com/science/article/pii/S2211124722010658
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Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IκBα

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  Plasmid_48138
  
  DOI: 10.1016/j.cmet.2022.08.002
  
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sciencedirect.com/science/article/pii/S155041312200345X
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Glycosphingolipids are mediators of cancer plasticity through independent signaling pathways

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1. scibot 17 Aug 2022
  
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sciencedirect.com/science/article/pii/S2211124722009949
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Targeting the mRNA endonuclease CPSF73 inhibits breast cancer cell migration, invasion, and self-renewal

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1. scibot 10 Aug 2022
  
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sciencedirect.com/science/article/pii/S2589004222010768
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A multimodal iPSC platform for cystic fibrosis drug testing

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  DOI: 10.1038/s41467-022-31854-8
  
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nature.com/articles/s41467-022-31854-8
Jul 2022
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Mapping subcellular localizations of unannotated microproteins and alternative proteins with MicroID

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1. scibot 30 Jul 2022
  
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  DOI: 10.1016/j.molcel.2022.06.035
  
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sciencedirect.com/science/article/pii/S1097276522006530
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“Stripe” transcription factors provide accessibility to co-binding partners in mammalian genomes

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1. scibot 27 Jul 2022
  
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sciencedirect.com/science/article/pii/S1097276522006128
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The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de novo nucleotide synthesis

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1. scibot 02 Jul 2022
  
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  DOI: 10.1016/j.molcel.2022.06.008
  
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sciencedirect.com/science/article/pii/S1097276522005445
Jun 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Domain fusion TLR2-4 enhances the autophagy-dependent clearance of Staphylococcus aureus in the genetic engineering goat

1
1. scibot 30 Jun 2022
  
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  RRID:Addgene_48138
  
  DOI: 10.7554/eLife.78044
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9239677/
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GSK3 inhibition rescues growth and telomere dysfunction in dyskeratosis congenita iPSC-derived type II alveolar epithelial cells

1
1. scibot 17 Jun 2022
  
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  Addgene_48138
  
  DOI: 10.7554/eLife.64430
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9200405/
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Interplay between symmetric arginine dimethylation and ubiquitylation regulates TDP1 proteostasis for the repair of topoisomerase I-DNA adducts

1
1. scibot 15 Jun 2022
  
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  AddgeneCat#48138
  
  DOI: 10.1016/j.celrep.2022.110940
  
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sciencedirect.com/science/article/pii/S2211124722007227
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ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling

1
1. scibot 09 Jun 2022
  
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  RRID:Addgene_48138
  
  DOI: 10.1083/jcb.202106046
  
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rupress.org/jcb/article/221/7/e202106046/213259/ER-lysosome-lipid-transfer-protein-VPS13C-PARK23
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A TRIM66/DAX1/Dux axis suppresses the totipotent 2-cell-like state in murine embryonic stem cells

2
1. scibot 03 Jun 2022
  
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  DOI: 10.1016/j.stem.2022.05.004
  
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2. scibot 03 Jun 2022
  
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  Addgene_48138
  
  DOI: 10.1016/j.stem.2022.05.004
  
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sciencedirect.com/science/article/pii/S1934590922002041
May 2022
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Gene-specific nonsense-mediated mRNA decay targeting for cystic fibrosis therapy

1
1. scibot 28 May 2022
  
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  plasmid_48138
  
  DOI: 10.1038/s41467-022-30668-y
  
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nature.com/articles/s41467-022-30668-y
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Lymph node colonization induces tumor-immune tolerance to promote distant metastasis

1
1. scibot 12 May 2022
  
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  plasmid_48138
  
  DOI: 10.1016/j.cell.2022.04.019
  
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sciencedirect.com/science/article/pii/S0092867422004664
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First Characterization of Human Dermal Fibroblasts Showing a Decreased Xylosyltransferase-I Expression Induced by the CRISPR/Cas9 System

1
1. scibot 10 May 2022
  
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  RRID:Addgene_48138
  
  DOI: 10.3390/ijms23095045
  
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mdpi.com/1422-0067/23/9/5045
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Generation of a MIR5004 knockout cell line from human induced Pluripotent Stem Cells by CRISPR/Cas9 gene editing

1
1. scibot 05 May 2022
  
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  RRID:Addgene_48138
  
  DOI: 10.1016/j.scr.2022.102805
  
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sciencedirect.com/science/article/pii/S1873506122001544
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The Mettl3 epitranscriptomic writer amplifies p53 stress responses

1
1. scibot 05 May 2022
  
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  Plasmid_48138
  
  DOI: 10.1016/j.molcel.2022.04.010
  
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sciencedirect.com/science/article/pii/S1097276522003215
Apr 2022
onlinelibrary.wiley.com onlinelibrary.wiley.com

Identification of a Crosstalk among TGR5, GLIS2, and TP53 Signaling Pathways in the Control of Undifferentiated Germ Cell Homeostasis and Chemoresistance

1
1. scibot 30 Apr 2022
  
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  Plasmid_48138
  
  DOI: 10.1002/advs.202200626
  
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onlinelibrary.wiley.com/doi/10.1002/advs.202200626
academic.oup.com academic.oup.com

A rationalized definition of general tumor suppressor microRNAs excludes miR-34a

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1. scibot 30 Apr 2022
  
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  RRID:Addgene_48138
  
  DOI: 10.1093/nar/gkac277
  
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academic.oup.com/nar/advance-article/doi/10.1093/nar/gkac277/6574673
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The cargo adaptor protein CLINT1 is phosphorylated by the Numb-associated kinase BIKE and mediates dengue virus infection

1
1. scibot 29 Apr 2022
  
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  plasmid_48138
  
  DOI: 10.1016/j.jbc.2022.101956
  
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sciencedirect.com/science/article/pii/S0021925822003969
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RBPMS is an RNA-binding protein that mediates cardiomyocyte binucleation and cardiovascular development

1
1. scibot 28 Apr 2022
  
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  RRID:Addgene_48138
  
  DOI: 10.1016/j.devcel.2022.03.017
  
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sciencedirect.com/science/article/pii/S1534580722002118
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ANKLE1 cleaves mitochondrial DNA and contributes to cancer risk by driving the Warburg effect and apoptosis resistance

1
1. scibot 27 Apr 2022
  
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  Plasmid_48138
  
  DOI: 10.1101/2021.10.27.466184
  
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biorxiv.org/content/10.1101/2021.10.27.466184v1
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Plet1 is an epigenetically regulated cell surface protein that provides essential cues to direct trophoblast stem cell differentiation

1
1. scibot 13 Apr 2022
  
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  Plasmid_48138
  
  DOI: 10.1038/srep25112
  
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ncbi.nlm.nih.gov/pmc/articles/PMC4848516/
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GFPT2/GFAT2 and AMDHD2 act in tandem to control the hexosamine pathway

1
1. scibot 02 Apr 2022
  
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  RRID:Addgene_48138
  
  DOI: 10.7554/eLife.69223
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8970586/
Mar 2022
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Genome-wide analysis of haploinsufficiency in human embryonic stem cells

1
1. scibot 30 Mar 2022
  
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  Addgene Cat. # 48138
  
  DOI: 10.1016/j.celrep.2022.110573
  
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sciencedirect.com/science/article/pii/S2211124722003175
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Rif1 and Hmgn3 regulate the conversion of murine trophoblast stem cells

1
1. scibot 30 Mar 2022
  
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  Plasmid_48138
  
  DOI: 10.1016/j.celrep.2022.110570
  
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sciencedirect.com/science/article/pii/S221112472200314X
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Parallel kinase pathways stimulate actin polymerization at depolarized mitochondria

1
1. scibot 26 Mar 2022
  
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  plasmid_48138
  
  DOI: 10.1016/j.cub.2022.02.058
  
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sciencedirect.com/science/article/pii/S0960982222003281
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

CRISPR-Cas9-mediated induction of large chromosomal inversions in human bronchial epithelial cells

1
1. scibot 26 Mar 2022
  
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  RRID:Addgene_48138
  
  DOI: 10.1016/j.xpro.2022.101257
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8938320/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Insights From Long-term Follow-up of a Girl With Adrenal Insufficiency and Sphingosine-1-Phosphate Lyase Deficiency

1
1. scibot 23 Mar 2022
  
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  RRID:Addgene_48138
  
  DOI: 10.1210/jendso/bvac020
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8926068/
rupress.org rupress.org

The E3 ligase TRIM1 ubiquitinates LRRK2 and controls its localization, degradation, and toxicity

1
1. scibot 18 Mar 2022
  
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  plasmid_48138
  
  DOI: 10.1083/jcb.202010065
  
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rupress.org/jcb/article/221/4/e202010065/213061/The-E3-ligase-TRIM1-ubiquitinates-LRRK2-and
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Applying Sodium Carbonate Extraction Mass Spectrometry to Investigate Defects in the Mitochondrial Respiratory Chain

1
1. scibot 18 Mar 2022
  
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  RRID:Addgene_48138
  
  DOI: 10.3389/fcell.2022.786268
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8921082/
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The m6A(m)-independent role of FTO in regulating WNT signaling pathways

1
1. scibot 17 Mar 2022
  
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  RRID:Addgene_48138
  
  DOI: 10.26508/lsa.202101250
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8860091/
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A hotspot mutation targeting the R-RAS2 GTPase acts as a potent oncogenic driver in a wide spectrum of tumors

1
1. scibot 16 Mar 2022
  
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  AddgeneCat# 48138
  
  DOI: 10.1016/j.celrep.2022.110522
  
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sciencedirect.com/science/article/pii/S2211124722002583
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Inhibition of SHP-1 activity by PKC-θ regulates NK cell activation threshold and cytotoxicity

1
1. scibot 11 Mar 2022
  
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  plasmid_48138
  
  DOI: 10.7554/eLife.73282
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8903836/
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Rap1 prevents colitogenic Th17 cell expansion and facilitates Treg cell differentiation and distal TCR signaling

1
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  RRID:Addgene_48138
  
  DOI: 10.1038/s42003-022-03129-x
  
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A ciliopathy complex builds distal appendages to initiate ciliogenesis

1
1. scibot 09 Mar 2022
  
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  RRID:Addgene_48138
  
  DOI: 10.1083/jcb.202011133
  
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A simple protocol to isolate a single human cell PRDX1 knockout generated by CRISPR-Cas9 system

1
1. scibot 09 Mar 2022
  
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  Addgene_48138
  
  DOI: 10.1016/j.xpro.2022.101216
  
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Fumarate inhibits PTEN to promote tumorigenesis and therapeutic resistance of type2 papillary renal cell carcinoma

1
1. scibot 04 Mar 2022
  
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  Plasmid_48138
  
  DOI: 10.1016/j.molcel.2022.01.029
  
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Diacylglycerol kinase η regulates cell proliferation and its levels are elevated by glucocorticoids in undifferentiated neuroblastoma cells

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  Plasmid_48138
  
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An HNF1α truncation associated with maturity-onset diabetes of the young impairs pancreatic progenitor differentiation by antagonizing HNF1β function

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  plasmid_48138
  
  DOI: 10.1016/j.celrep.2022.110425
  
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BMP gradient along the intestinal villus axis controls zonated enterocyte and goblet cell states

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  plasmid_48138
  
  DOI: 10.1016/j.celrep.2022.110438
  
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Gene architecture directs splicing outcome in separate nuclear spatial regions

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  RRID:Addgene_48138
  
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TP53 promotes lineage commitment of human embryonic stem cells through ciliogenesis and sonic hedgehog signaling

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1. scibot 16 Feb 2022
  
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  Plasmid_48138
  
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The BCL-2 family member BOK promotes KRAS-driven lung cancer progression in a p53-dependent manner

1
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  RRID:Addgene_48138
  
  DOI: 10.1038/s41388-021-02161-1
  
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nature.com/articles/s41388-021-02161-1
Jan 2022
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Heparan Sulfate Proteoglycans (HSPGs) Serve as the Mediator Between Monomeric Tau and Its Subsequent Intracellular ERK1/2 Pathway Activation

1
1. scibot 20 Jan 2022
  
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  RRID:Addgene_48138
  
  DOI: 10.1007/s12031-021-01943-2
  
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Plasmolipin regulates basolateral-to-apical transcytosis of ICAM-1 and leukocyte adhesion in polarized hepatic epithelial cells

1
1. scibot 11 Jan 2022
  
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  RRID:Addgene_48138
  
  DOI: 10.1007/s00018-021-04095-z
  
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Robust genome editing in adult vascular endothelium by nanoparticle delivery of CRISPR-Cas9 plasmid DNA

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  RRID:Addgene_48138
  
  DOI: 10.1016/j.celrep.2021.110196
  
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Disc Large Homolog 1 Is Critical for Early T Cell Receptor Micro Cluster Formation and Activation in Human T Cells

1
1. scibot 05 Jan 2022
  
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  plasmid_183
  
  DOI: 10.3390/vaccines9121446
  
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Dec 2021
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Dichotomous Effects of Cellular Expression of STAT3 on Tumor Growth of HNSCC

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  RRID:Addgene_48138
  
  DOI: 10.1016/j.ymthe.2021.11.011
  
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Disc Large Homolog 1 Is Critical for Early T Cell Receptor Micro Cluster Formation and Activation in Human T Cells

1
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  RRID:Addgene_48138
  
  DOI: 10.3390/vaccines9121446
  
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Loss of hexokinase 1 sensitizes ovarian cancer to high-dose metformin

1
1. scibot 15 Dec 2021
  
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  RRID:Addgene_48138
  
  DOI: 10.1186/s40170-021-00277-2
  
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A novel live-cell imaging assay reveals regulation of endosome maturation

1
1. scibot 08 Dec 2021
  
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  RRID:Addgene_48138
  
  DOI: 10.7554/eLife.70982
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8635980/
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Anti-recombination function of MutSα restricts telomere extension by ALT-associated homology-directed repair

1
1. scibot 08 Dec 2021
  
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  RRID:Addgene_48138
  
  DOI: 10.1016/j.celrep.2021.110088
  
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Jpx RNA regulates CTCF anchor site selection and formation of chromosome loops

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1. scibot 02 Dec 2021
  
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  Addgene Cat#48138
  
  DOI: 10.1016/j.cell.2021.11.012
  
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Evidence for nutrient-dependent regulation of the COPII coat by O-GlcNAcylation

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1. scibot 02 Dec 2021
  
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  plasmid_48138
  
  DOI: 10.1093/glycob/cwab055
  
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academic.oup.com/glycob/article/31/9/1102/6299516
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Dynamic Analysis of 4E-BP1 Phosphorylation in Neurons with Tsc2 or Depdc5 Knockout

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  addgene_48138
  
  DOI: 10.1016/j.expneurol.2020.113432
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8170708/
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Detection of Neanderthal Adaptively Introgressed Genetic Variants that Modulate Reporter Gene Expression in Human Immune Cells

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1. scibot 01 Dec 2021
  
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  RRID:Addgene_48138
  
  DOI: 10.1093/molbev/msab304
  
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academic.oup.com/mbe/advance-article/doi/10.1093/molbev/msab304/6400258
Nov 2021
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Generation of auxin inducible degron (AID) knock-in cell lines for targeted protein degradation in mammalian cells

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1. scibot 23 Nov 2021
  
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  Addgene_48138
  
  DOI: 10.1016/j.xpro.2021.100949
  
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A recurrent chromosomal inversion suffices for driving escape from oncogene-induced senescence via subTAD reorganization

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1. scibot 18 Nov 2021
  
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  RRID:Addgene_48138
  
  DOI: 10.1016/j.molcel.2021.10.017
  
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FEBS Press

1
1. scibot 17 Nov 2021
  
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  plasmid_48138
  
  DOI: 10.1002/1878-0261.13115
  
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febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13115
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Gene regulatory networks controlling temporal patterning, neurogenesis, and cell-fate specification in mammalian retina

1
1. scibot 17 Nov 2021
  
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  Addgene_48138
  
  DOI: 10.1016/j.celrep.2021.109994
  
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New Hybrid Compounds Combining Fragments of Usnic Acid and Thioether Are Inhibitors of Human Enzymes TDP1, TDP2 and PARP1

1
1. scibot 15 Nov 2021
  
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  RRID:Addgene_48138
  
  DOI: 10.3390/ijms222111336
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8583042/
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Distinct regulation of tonic GABAergic inhibition by NMDA receptor subtypes

1
1. scibot 10 Nov 2021
  
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  Cat# 48138
  
  DOI: 10.1016/j.celrep.2021.109960
  
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Mitochondrial respiration restricts Listeria monocytogenes infection by slowing down host cell receptor recycling

1
1. scibot 10 Nov 2021
  
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  plasmid_48138
  
  DOI: 10.1016/j.celrep.2021.109989
  
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Loss of SORCS2 is Associated with Neuronal DNA Double-Strand Breaks

1
1. scibot 09 Nov 2021
  
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  RRID:Addgene_48138
  
  DOI: 10.1007/s10571-021-01163-7
  
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Crystal structure of the Tspan15 LEL domain reveals a conserved ADAM10 binding site

1
1. scibot 05 Nov 2021
  
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  Addgene Cat # 48138
  
  DOI: 10.1016/j.str.2021.10.007
  
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RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy

1
1. scibot 05 Nov 2021
  
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  RRID:Addgene_48138
  
  DOI: 10.7554/eLife.65759
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8550759/
Oct 2021
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A bipartite element with allele-specific functions safeguards DNA methylation imprints at the Dlk1-Dio3 locus

1
1. scibot 28 Oct 2021
  
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  Plasmid_48138
  
  DOI: 10.1016/j.devcel.2021.10.004
  
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Loss of FBXO31-mediated degradation of DUSP6 dysregulates ERK and PI3K-AKT signaling and promotes prostate tumorigenesis

1
1. scibot 21 Oct 2021
  
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  Cat. No. 48138
  
  DOI: 10.1016/j.celrep.2021.109870
  
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Syndromic RNA Polymerase II insufficiency: Generation of a human induced pluripotent stem cell line (UUIGPi002A-5) with a heterozygous disruption of POLR2A

1
1. scibot 20 Oct 2021
  
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  plasmid_48138
  
  DOI: 10.1016/j.scr.2021.102577
  
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Generation of a homozygous CIITA knockout iPS cell line using the CRISPR-Cas9 system

1
1. scibot 20 Oct 2021
  
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  RRID:Addgene_48138
  
  DOI: 10.1016/j.scr.2021.102580
  
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NRF1 association with AUTS2-Polycomb mediates specific gene activation in the brain

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1. scibot 12 Oct 2021
  
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NR4A1 regulates expression of immediate early genes, suppressing replication stress in cancer

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The drebrin/EB3 pathway regulates cytoskeletal dynamics to drive neuritogenesis in embryonic cortical neurons

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A mouse model of brittle cornea syndrome caused by mutation in Zfp469

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Loss of cancer cell STAT1 improves response to radiation therapy and promotes T cell activation in head and neck squamous cell carcinoma

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MultiEditR: The first tool for detection and quantification of multiple RNA editing sites from Sanger sequencing demonstrates comparable fidelity to RNA-seq

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The oncomicropeptide APPLE promotes hematopoietic malignancy by enhancing translation initiation

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Mild phenotype of knockouts of the major apurinic/apyrimidinic endonuclease APEX1 in a non-cancer human cell line

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RARG variant predictive of doxorubicin-induced cardiotoxicity identifies a cardioprotective therapy

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Wnt target enhancer regulation by a CDX/TCF transcription factor collective and a novel DNA motif

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Mechanism of noncoding RNA-associated N6-methyladenosine recognition by an RNA processing complex during IgH DNA recombination

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Sequential inverse dysregulation of the RNA helicases DDX3X and DDX3Y facilitates MYC-driven lymphomagenesis

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Topological isolation of developmental regulators in mammalian genomes

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Formation of Lipofuscin-Like Autofluorescent Granules in the Retinal Pigment Epithelium Requires Lysosome Dysfunction

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Overlapping roles of JIP3 and JIP4 in promoting axonal transport of lysosomes in human iPSC-derived neurons

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Integration of T helper and BCR signals governs enhanced plasma cell differentiation of memory B cells by regulation of CD45 phosphatase activity

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The biochemical basis of mitochondrial dysfunction in Zellweger Spectrum Disorder

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The ALPK1 pathway drives the inflammatory response to Campylobacter jejuni in human intestinal epithelial cells

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Overlapping Role of SCYL1 and SCYL3 in Maintaining Motor Neuron Viability

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Generation of GLA-Knockout Human Embryonic Stem Cell Lines to Model Autophagic Dysfunction and Exosome Secretion in Fabry Disease-Associated Hypertrophic Cardiomyopathy

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In vivo proximity proteomics of nascent synapses reveals a novel regulator of cytoskeleton-mediated synaptic maturation.

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A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family

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ASCL1 Reorganizes Chromatin to Direct Neuronal Fate and Suppress Tumorigenicity of Glioblastoma Stem Cells

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Exosome RNA Unshielding Couples Stromal Activation to Pattern Recognition Receptor Signaling in Cancer

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Exosome-mediated delivery of CRISPR/Cas9 for targeting of oncogenic KrasG12D in pancreatic cancer

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Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD

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The E3 ubiquitin ligase RNF10 modifies 40S ribosomal subunits of ribosomes compromised in translation

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Innate immune response orchestrates phosphoribosyl pyrophosphate synthetases to support DNA repair

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Disruption of Coronin 1 Signaling in T Cells Promotes Allograft Tolerance while Maintaining Anti-Pathogen Immunity

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Identification of TMEM206 proteins as pore of PAORAC/ASOR acid-sensitive chloride channels

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elifesciences.org/articles/49187
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CRISPR-READI: Efficient Generation of Knockin Mice by CRISPR RNP Electroporation and AAV Donor Infection

1
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  RRID:Addgene_48138
  
  DOI: 10.1016/j.celrep.2019.05.103
  
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The TIA1 RNA-Binding Protein Family Regulates EIF2AK2-Mediated Stress Response and Cell Cycle Progression

1
1. scibot 31 Jul 2021
  
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  Addgene_48138
  
  DOI: 10.1016/j.molcel.2018.01.011
  
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  RRID:Addgene_48138
  
  DOI: 10.1371/journal.ppat.1007694
  
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Untitled document

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  plasmid_48138
  
  DOI: 10.1016/j.celrep.2019.01.075
  
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sciencedirect.com/science/article/pii/S2211124719301044
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Untitled document

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  RRID:Addgene_48138
  
  DOI: 10.1016/j.celrep.2019.01.043
  
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Structural Basis of Teneurin-Latrophilin Interaction in Repulsive Guidance of Migrating Neurons

1
1. scibot 30 Jul 2021
  
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  RRID:Addgene_48138
  
  DOI: 10.1016/j.cell.2019.12.014
  
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Dectin-1 Binding to Annexins on Apoptotic Cells Induces Peripheral Immune Tolerance via NADPH Oxidase-2

1
1. scibot 30 Jul 2021
  
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  Addgene_48138
  
  DOI: 10.1016/j.celrep.2019.11.086
  
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Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR

1
1. scibot 30 Jul 2021
  
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  plasmid_48138
  
  DOI: 10.1016/j.cell.2018.05.009
  
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Translational Control through Differential Ribosome Pausing during Amino Acid Limitation in Mammalian Cells

1
1. scibot 30 Jul 2021
  
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  Addgene_48138
  
  DOI: 10.1016/j.molcel.2018.06.041
  
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Are Small Nucleolar RNAs “CRISPRable”? A Report on Box C/D Small Nucleolar RNA Editing in Human Cells

1
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  Addgene, #48138
  
  DOI: 10.3389/fphar.2019.01246
  
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mcr.aacrjournals.org mcr.aacrjournals.org

Intron 1-Mediated Regulation of EGFR Expression In EGFR-Dependent Malignancies is Mediated by AP-1 and BET Proteins

1
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mcr.aacrjournals.org/content/17/11/2208
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The Leukemogenic TCF3-HLF Complex Rewires Enhancers Driving Cellular Identity and Self-Renewal Conferring EP300 Vulnerability

1
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Restore natural fertility of <Emphasis Type="Italic">Kit</Emphasis><Superscript><Emphasis Type="Italic">w</Emphasis></Superscript><Emphasis Type="Italic">/Kit</Emphasis><Superscript><Emphasis Type="Italic">wv</Emphasis></Superscript> mouse with nonobstructive azoospermia through gene editing on SSCs mediated by CRISPR-Cas9

1
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  Addgene plasmid 48138
  
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A Pliable Mediator Acts as a Functional Rather Than an Architectural Bridge between Promoters and Enhancers

1
1. scibot 29 Jul 2021
  
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bmcbiol.biomedcentral.com bmcbiol.biomedcentral.com

Untitled document

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  plasmid_48138
  
  DOI: 10.1186/s12915-017-0453-8
  
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bmcbiol.biomedcentral.com/articles/10.1186/s12915-017-0453-8
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

A Lamina-Associated Domain Border Governs Nuclear Lamina Interactions, Transcription, and Recombination of the Tcrb Locus

1
1. scibot 29 Jul 2021
  
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  plasmid_48138
  
  DOI: 10.1016/j.celrep.2018.10.052
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6287930/
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A Dock-and-Lock Mechanism Clusters ADAM10 at Cell-Cell Junctions to Promote α-Toxin Cytotoxicity

1
1. scibot 27 Jul 2021
  
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  48138
  
  DOI: 10.1016/j.celrep.2018.10.088
  
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sciencedirect.com/science/article/pii/S2211124718316929
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Transcription-mediated supercoiling regulates genome folding and loop formation

1
1. scibot 23 Jul 2021
  
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  RRID:Addgene_48138
  
  DOI: 10.1016/j.molcel.2021.06.009
  
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cell.com/molecular-cell/fulltext/S1097-2765(21)00456-1
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Targeted protein degradation reveals a direct role of SPT6 in RNAPII elongation and termination

1
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  Addgene_48138
  
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New Hybrid Compounds Combining Fragments of Usnic Acid and Monoterpenoids for Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibition

1
1. scibot 09 Jul 2021
  
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  RRID:Addgene_48138
  
  DOI: 10.3390/biom11070973
  
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mdpi.com/2218-273X/11/7/973
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The RAS GTPase RIT1 compromises mitotic fidelity through spindle assembly checkpoint suppression

1
1. scibot 09 Jul 2021
  
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  plasmid_48138
  
  DOI: 10.1016/j.cub.2021.06.030
  
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sciencedirect.com/science/article/pii/S0960982221008253
elifesciences.org elifesciences.org

BAP1/ASXL complex modulation regulates epithelial-mesenchymal transition during trophoblast differentiation and invasion

1
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  RRID:Addgene_48138
  
  DOI: 10.7554/eLife.63254
  
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elifesciences.org/articles/63254
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Derivation of induced pluripotent stem cells line (RCPCMi007-A-1) with inactivation of the beta-2-microblogulin gene by CRISPR/Cas9 genome editing

1
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  RRID:Addgene_48138
  
  DOI: 10.1016/j.scr.2021.102451
  
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sciencedirect.com/science/article/pii/S1873506121002981
Jun 2021
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Revealing molecular pathways for cancer cell fitness through a genetic screen of the cancer translatome

1
1. scibot 30 Jun 2021
  
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  Addgene_48138
  
  DOI: 10.1016/j.celrep.2021.109321
  
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sciencedirect.com/science/article/pii/S2211124721006975
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BAP1 enhances Polycomb repression by counteracting widespread H2AK119ub1 deposition and chromatin condensation

1
1. scibot 30 Jun 2021
  
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  plasmid_48138
  
  DOI: 10.1016/j.molcel.2021.06.020
  
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sciencedirect.com/science/article/pii/S1097276521005001
www.embopress.org www.embopress.org

Cysteamine–bicalutamide combination therapy corrects proximal tubule phenotype in cystinosis

1
1. scibot 26 Jun 2021
  
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  Addgene_48138
  
  DOI: 10.15252/emmm.202013067
  
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embopress.org/doi/full/10.15252/emmm.202013067
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Validating TDP1 as an Inhibition Target for the Development of Chemosensitizers for Camptothecin-Based Chemotherapy Drugs

1
1. scibot 26 Jun 2021
  
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  RRID:Addgene_48138
  
  DOI: 10.1007/s40487-021-00158-0
  
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link.springer.com/article/10.1007/s40487-021-00158-0
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HNRNP A1 Promotes Lung Cancer Cell Proliferation by Modulating VRK1 Translation

1
1. scibot 17 Jun 2021
  
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  RRID:Addgene_48138
  
  DOI: 10.3390/ijms22115506
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8197126/
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STAG2 loss rewires oncogenic and developmental programs to promote metastasis in Ewing sarcoma

1
1. scibot 15 Jun 2021
  
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  RRID:Addgene_48138
  
  DOI: 10.1016/j.ccell.2021.05.007
  
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cell.com/cancer-cell/fulltext/S1535-6108(21)00273-7
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A role for the Cockayne Syndrome B (CSB)-Elongin ubiquitin ligase complex in signal-dependent RNA polymerase II transcription

1
1. scibot 12 Jun 2021
  
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  RRID:Addgene_48138
  
  DOI: 10.1016/j.jbc.2021.100862
  
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sciencedirect.com/science/article/pii/S0021925821006621
elifesciences.org elifesciences.org

Wnt- and glutamate-receptors orchestrate stem cell dynamics and asymmetric cell division

1
1. scibot 11 Jun 2021
  
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  RRID:Addgene_48138
  
  DOI: 10.7554/eLife.59791
  
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elifesciences.org/articles/59791
elifesciences.org elifesciences.org

Distinct expression requirements and rescue strategies for BEST1 loss- and gain-of-function mutations

1
1. scibot 05 Jun 2021
  
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  RRID :Addgene_48138
  
  DOI: 10.7554/eLife.67622
  
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elifesciences.org/articles/67622
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PHAROH lncRNA regulates Myc translation in hepatocellular carcinoma via sequestering TIAR

1
1. scibot 05 Jun 2021
  
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  Addgene_48138
  
  DOI: 10.7554/eLife.68263
  
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elifesciences.org/articles/68263
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Choline kinase alpha 2 acts as a protein kinase to promote lipolysis of lipid droplets

1
1. scibot 02 Jun 2021
  
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  Plasmid_48138
  
  DOI: 10.1016/j.molcel.2021.05.005
  
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sciencedirect.com/science/article/pii/S1097276521003622
May 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

SAM homeostasis is regulated by CFIm-mediated splicing of MAT2A

1
1. scibot 27 May 2021
  
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  Addgene_48138
  
  DOI: 10.7554/eLife.64930
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8139829/
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Adhesion-mediated mechanosignaling forces mitohormesis

1
1. scibot 21 May 2021
  
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  Addgene_48138
  
  DOI: 10.1016/j.cmet.2021.04.017
  
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sciencedirect.com/science/article/pii/S1550413121001832
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Transcriptional co-activator regulates melanocyte differentiation and oncogenesis by integrating cAMP and MAPK/ERK pathways

1
1. scibot 19 May 2021
  
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  plasmid_48138
  
  DOI: 10.1016/j.celrep.2021.109136
  
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An Intronic Variant of CHD7 Identified in Autism Patients Interferes with Neuronal Differentiation and Development

1
1. scibot 12 May 2021
  
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  Addgene_48138
  
  DOI: 10.1007/s12264-021-00685-w
  
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Chromatin accessibility governs the differential response of cancer and T cells to arginine starvation

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Multiple interactions of the oncoprotein transcription factor MYC with the SWI/SNF chromatin remodeler

1
1. scibot 10 May 2021
  
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  RRID:Addgene_48138
  
  DOI: 10.1038/s41388-021-01804-7
  
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ATG4 family proteins drive phagophore growth independently of the LC3/GABARAP lipidation system

1
1. scibot 08 May 2021
  
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Paradoxical Mitophagy Regulation by PINK1 and TUFm

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GIGYF2 and 4EHP Inhibit Translation Initiation of Defective Messenger RNAs to Assist Ribosome-Associated Quality Control

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ERK2 Phosphorylates PFAS to Mediate Posttranslational Control of De Novo Purine Synthesis

1
1. scibot 07 May 2021
  
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  Plasmid_48138
  
  DOI: 10.1016/j.molcel.2020.05.001
  
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SH3BP4 promotes neuropilin-1 and α5-integrin endocytosis and is inhibited by Akt

1
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Cell-Cycle-Dependent ERK Signaling Dynamics Direct Fate Specification in the Mammalian Preimplantation Embryo

2
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Inositol Polyphosphate Multikinase Inhibits Liquid-Liquid Phase Separation of TFEB to Negatively Regulate Autophagy Activity

1
1. scibot 05 May 2021
  
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A Membrane-Tethered Ubiquitination Pathway Regulates Hedgehog Signaling and Heart Development

1
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Endogenous Retrovirus-Derived lncRNA BANCR Promotes Cardiomyocyte Migration in Humans and Non-human Primates

1
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Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth

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1. scibot 01 May 2021
  
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  plasmid_48138
  
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Apr 2021
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Convergence of mammalian RQC and C-end rule proteolytic pathways via alanine tailing

1
1. scibot 28 Apr 2021
  
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  plasmid_48138
  
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Cross-Comparison of Human iPSC Motor Neuron Models of Familial and Sporadic ALS Reveals Early and Convergent Transcriptomic Disease Signatures

1
1. scibot 27 Apr 2021
  
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iPSC modeling of stage-specific leukemogenesis reveals BAALC as a key oncogene in severe congenital neutropenia

1
1. scibot 24 Apr 2021
  
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  Plasmid_48138
  
  DOI: 10.1016/j.stem.2021.03.023
  
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Generation of disease-specific and CRISPR/Cas9-mediated gene-corrected iPS cells from a patient with adult progeria Werner syndrome

1
1. scibot 24 Apr 2021
  
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  plasmid_48138
  
  DOI: 10.1016/j.scr.2021.102360
  
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Generation of a FTO gene knockout human embryonic stem cell line using CRISPR/Cas9 editing

1
1. scibot 23 Apr 2021
  
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  48138, Addgene
  
  DOI: 10.1016/j.scr.2021.102362
  
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High-Resolution mRNA and Secretome Atlas of Human Enteroendocrine Cells

1
1. scibot 23 Apr 2021
  
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  DOI: 10.1016/j.cell.2020.04.036
  
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MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway

1
1. scibot 22 Apr 2021
  
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  Plasmid Cat #48138
  
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Elevated CXorf67 Expression in PFA Ependymomas Suppresses DNA Repair and Sensitizes to PARP Inhibitors

1
1. scibot 22 Apr 2021
  
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CRL4 AMBRA1 is a master regulator of D-type cyclins

1
1. scibot 22 Apr 2021
  
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  plasmid_48138
  
  DOI: 10.1038/s41586-021-03445-y
  
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nature.com/articles/s41586-021-03445-y
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IL6/STAT3 Signaling Hijacks Estrogen Receptor α Enhancers to Drive Breast Cancer Metastasis

1
1. scibot 20 Apr 2021
  
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cell.com/cancer-cell/fulltext/S1535-6108(20)30311-1
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The deubiquitinase Usp9x regulates PRC2-mediated chromatin reprogramming during mouse development

1
1. scibot 20 Apr 2021
  
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  RRID:Addgene_48138
  
  DOI: 10.1038/s41467-021-21910-0
  
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Tau aggregates are RNA-protein assemblies that mislocalize multiple nuclear speckle components

1
1. scibot 13 Apr 2021
  
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  RRID:Addgene_48138
  
  DOI: 10.1016/j.neuron.2021.03.026
  
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Evaluation of AXIN1 and AXIN2 as targets of tankyrase inhibition in hepatocellular carcinoma cell lines

1
1. scibot 10 Apr 2021
  
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  DOI: 10.1038/s41598-021-87091-4
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8018973/
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mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis

1
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  Plasmid_48138
  
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sciencedirect.com/science/article/pii/S1097276521001775
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An early cell shape transition drives evolutionary expansion of the human forebrain

1
1. scibot 26 Mar 2021
  
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  RRID:Addgene_48138
  
  DOI: 10.1016/j.cell.2021.02.050
  
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Deletion of the XIST promoter from the human inactive X chromosome compromises polycomb heterochromatin maintenance

1
1. scibot 26 Mar 2021
  
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  RRID:Addgene_48138
  
  DOI: 10.1007/s00412-021-00754-z
  
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link.springer.com/article/10.1007/s00412-021-00754-z
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TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation

1
1. scibot 20 Mar 2021
  
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  plasmid_48138
  
  DOI: 10.7554/eLife.62873
  
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elifesciences.org/articles/62873
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A genome-wide CRISPR screen identifies UFMylation and TRAMP-like complexes as host factors required for hepatitis A virus infection

1
1. scibot 17 Mar 2021
  
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  Plasmid_48138
  
  DOI: 10.1016/j.celrep.2021.108859
  
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Reversal of the Inflammatory Responses in Fabry Patient iPSC-Derived Cardiovascular Endothelial Cells by CRISPR/Cas9-Corrected Mutation

1
1. scibot 17 Mar 2021
  
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  RRID:Addgene_48138
  
  DOI: 10.3390/ijms22052381
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7956852/
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Integrative identification of the pathogenic role of a novel G6PD missense mutation c.697G>C

1
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  RRID:Addgene_48138
  
  DOI: 10.21037/atm-20-3941
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7940930/
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LAP2alpha maintains a mobile and low assembly state of A-type lamins in the nuclear interior

1
1. scibot 13 Mar 2021
  
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  RRID:Addgene_48138
  
  DOI: 10.7554/eLife.63476
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7939549/
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Follistatin is a novel therapeutic target and biomarker in FLT3/ITD acute myeloid leukemia

1
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  Addgene_48138
  
  DOI: 10.15252/emmm.201910895
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7136967/
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NAD+ enhances ribitol and ribose rescue of α-dystroglycan functional glycosylation in human FKRP-mutant myotubes

1
1. scibot 09 Mar 2021
  
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  plasmid_48138
  
  DOI: 10.7554/eLife.65443
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7924940/
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Functionally expressed bitter taste receptor TAS2R14 in human epidermal keratinocytes serves as a chemosensory receptor

1
1. scibot 04 Mar 2021
  
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  plasmid_48138
  
  DOI: 10.1111/exd.14250
  
  Resource: RRID:Addgene_48138
  
  Curator: @Naa003
  
  SciCrunch record: RRID:Addgene_48138
  
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  RRIDCUR:Validated RRID:Addgene_48138
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onlinelibrary.wiley.com/doi/10.1111/exd.14250
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Omnitemporal choreographies of all five STIM/Orai and IP3Rs underlie the complexity of mammalian Ca2+ signaling

1
1. scibot 03 Mar 2021
  
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  Addgene_48138
  
  DOI: 10.1016/j.celrep.2021.108760
  
  Resource: RRID:Addgene_48138
  
  Curator: @Naa003
  
  SciCrunch record: RRID:Addgene_48138
  
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  RRID:Addgene_48138 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2211124721000735
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Autophagy blockade limits HER2+ breast cancer tumorigenesis by perturbing HER2 trafficking and promoting release via small extracellular vesicles

1
1. scibot 01 Mar 2021
  
  in Public
  
  plasmid_48138
  
  DOI: 10.1016/j.devcel.2020.12.016
  
  Resource: RRID:Addgene_48138
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_48138
  
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  RRID:Addgene_48138
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sciencedirect.com/science/article/pii/S1534580720310224
Feb 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients

1
1. scibot 27 Feb 2021
  
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  plasmid_48138
  
  DOI: 10.7554/eLife.62611
  
  Resource: RRID:Addgene_48138
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_48138
  
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  RRID:Addgene_48138
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ncbi.nlm.nih.gov/pmc/articles/PMC7785296/
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H3K27M in Gliomas Causes a One-Step Decrease in H3K27 Methylation and Reduced Spreading within the Constraints of H3K36 Methylation

1
1. scibot 27 Feb 2021
  
  in Public
  
  plasmid_48138
  
  DOI: 10.1016/j.celrep.2020.108390
  
  Resource: RRID:Addgene_48138
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_48138
  
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  RRID:Addgene_48138
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sciencedirect.com/science/article/pii/S2211124720313796
elifesciences.org elifesciences.org

Long-term potentiation is independent of the C-tail of the GluA1 AMPA receptor subunit

1
1. scibot 26 Feb 2021
  
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  RRID:Addgene_48138
  
  DOI: 10.7554/eLife.58042
  
  Resource: RRID:Addgene_48138
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_48138
  
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  RRID:Addgene_48138
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elifesciences.org/articles/58042
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Multiplexed measurement of variant abundance and activity reveals VKOR topology, active site and human variant impact

1
1. scibot 26 Feb 2021
  
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  RRID:Addgene_48138
  
  DOI: 10.7554/eLife.58026
  
  Resource: RRID:Addgene_48138
  
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  SciCrunch record: RRID:Addgene_48138
  
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  RRID:Addgene_48138
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ncbi.nlm.nih.gov/pmc/articles/PMC7462613/
www.nature.com www.nature.com

A molecular mechanism explaining albuminuria in kidney disease

1
1. scibot 26 Feb 2021
  
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  RRID:Addgene_48138
  
  DOI: 10.1038/s42255-020-0204-y
  
  Resource: RRID:Addgene_48138
  
  Curator: @Naa003
  
  SciCrunch record: RRID:Addgene_48138
  
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  RRIDCUR:Validated RRID:Addgene_48138
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nature.com/articles/s42255-020-0204-y
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The corepressors GPS2 and SMRT control enhancer and silencer remodeling via eRNA transcription during inflammatory activation of macrophages

1
1. scibot 24 Feb 2021
  
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  48138
  
  DOI: 10.1016/j.molcel.2020.12.040
  
  Resource: RRID:Addgene_48138
  
  Curator: @Naa003
  
  SciCrunch record: RRID:Addgene_48138
  
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  RRIDCUR:Missing RRID:Addgene_48138
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sciencedirect.com/science/article/pii/S1097276520309618
www.cell.com www.cell.com

Loss of Human TGS1 Hypermethylase Promotes Increased Telomerase RNA and Telomere Elongation

1
1. scibot 24 Feb 2021
  
  in Public
  
  RRID:Addgene_48138
  
  DOI: 10.1016/j.celrep.2020.01.004
  
  Resource: RRID:Addgene_48138
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_48138
  
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  RRID:Addgene_48138
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cell.com/cell-reports/abstract/S2211-1247(20)30013-9
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Structural Basis of Teneurin-Latrophilin Interaction in Repulsive Guidance of Migrating Neurons

1
1. scibot 24 Feb 2021
  
  in Public
  
  RRID:Addgene_48138
  
  DOI: 10.1016/j.cell.2019.12.014
  
  Resource: RRID:Addgene_48138
  
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sciencedirect.com/science/article/pii/S0092867419313765
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Incontinentia Pigmenti: Generation of an IKBKG deficient human iPSC line (KICRi002-A-1) on a 46,XY background using CRISPR/Cas9

1
1. scibot 13 Feb 2021
  
  in Public
  
  plasmid_48138
  
  DOI: 10.1016/j.scr.2020.101739
  
  Resource: RRID:Addgene_48138
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:Addgene_48138
  
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  RRID:Addgene_48138 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S187350612030043X

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