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Nov 2020
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Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser

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ARID1A Mutations Promote P300-Dependent Endometrial Invasion through Super-Enhancer Hyperacetylation

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Loss of Muscle Carnitine Palmitoyltransferase 2 Prevents Diet-Induced Obesity and Insulin Resistance despite Long-Chain Acylcarnitine Accumulation

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pubmed.ncbi.nlm.nih.gov/33176143/
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The γ-Protocadherins Regulate the Survival of GABAergic Interneurons during Developmental Cell Death

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  DOI: 10.1523/JNEUROSCI.1636-20.2020
  
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jneurosci.org/content/40/45/8652
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Cdc42 is involved in NC1 peptide–regulated BTB dynamics through actin and microtubule cytoskeletal reorganization

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ncbi.nlm.nih.gov/pmc/articles/PMC6894087/
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Myogenin is an essential regulator of adult myofibre growth and muscle stem cell homeostasis

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  DOI: 10.7554/eLife.60445
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7599067/
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Novel guanidine compounds inhibit platelet‐derived growth factor receptor alpha transcription and oligodendrocyte precursor cell proliferation

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  DOI: 10.1002/glia.23930
  
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onlinelibrary.wiley.com/doi/full/10.1002/glia.23930
Oct 2020
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TET2-Loss-of-Function-Driven Clonal Hematopoiesis Exacerbates Experimental Insulin Resistance in Aging and Obesity

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sciencedirect.com/science/article/pii/S2211124720313152
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PKM2 Determines Myofiber Hypertrophy In Vitro and Increases in Response to Resistance Exercise in Human Skeletal Muscle

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1. scibot 31 Oct 2020
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7583908/
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A Regulation Loop between YAP and NR4A1 Balances Cell Proliferation and Apoptosis

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  DOI: 10.1016/j.celrep.2020.108284
  
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sciencedirect.com/science/article/pii/S2211124720312730
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Optical control of ERK and AKT signaling promotes axon regeneration and functional recovery of PNS and CNS in Drosophila

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1. scibot 24 Oct 2020
  
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  DOI: 10.7554/eLife.57395
  
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elifesciences.org/articles/57395
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Increased dopamine and its receptor dopamine receptor D1 promote tumor growth in human hepatocellular carcinoma

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1. scibot 10 Oct 2020
  
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  p‐AKT
  
  DOI: 10.1002/cac2.12103
  
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onlinelibrary.wiley.com/doi/full/10.1002/cac2.12103
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A Marine Alkaloid, Ascomylactam A, Suppresses Lung Tumorigenesis via Inducing Cell Cycle G1/S Arrest through ROS/Akt/Rb Pathway

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1. scibot 03 Oct 2020
  
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  DOI: 10.3390/md18100494
  
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pubmed.ncbi.nlm.nih.gov/32992455/
Sep 2020
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Reducing NADPH Synthesis Counteracts Diabetic Nephropathy through Restoration of AMPK Activity in Type 1 Diabetic Rats

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1. scibot 30 Sep 2020
  
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  DOI: 10.1016/j.celrep.2020.108207
  
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sciencedirect.com/science/article/pii/S2211124720311967
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Divergent Roles of PI3K Isoforms in PTEN-Deficient Glioblastomas

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  DOI: 10.1016/j.celrep.2020.108196
  
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pubmed.ncbi.nlm.nih.gov/32997991/
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BPS Publications

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1. scibot 26 Sep 2020
  
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  DOI: 10.1111/bph.14980
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.14980
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Rheb1-Independent Activation of mTORC1 in Mammary Tumors Occurs through Activating Mutations in mTOR

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1. scibot 26 Sep 2020
  
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  DOI: 10.1016/j.celrep.2020.107571
  
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sciencedirect.com/science/article/pii/S2211124720305209
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A Live-Cell Screen for Altered Erk Dynamics Reveals Principles of Proliferative Control

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  DOI: 10.1016/j.cels.2020.02.005
  
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sciencedirect.com/science/article/pii/S2405471220300752
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Secreted Phospholipase PLA2G2D Contributes to Metabolic Health by Mobilizing ω3 Polyunsaturated Fatty Acids in WAT

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  DOI: 10.1016/j.celrep.2020.107579
  
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sciencedirect.com/science/article/pii/S2211124720305283
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GLP-1 Receptor Signaling in Astrocytes Regulates Fatty Acid Oxidation, Mitochondrial Integrity, and Function

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  DOI: 10.1016/j.cmet.2020.05.001
  
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sciencedirect.com/science/article/pii/S1550413120302400
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An Acetylation Switch of the NLRP3 Inflammasome Regulates Aging-Associated Chronic Inflammation and Insulin Resistance

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ncbi.nlm.nih.gov/pmc/articles/PMC7104778/
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11q Deletion or ALK Activity Curbs DLG2 Expression to Maintain an Undifferentiated State in Neuroblastoma

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sciencedirect.com/science/article/pii/S2211124720311608
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The Kinase Activity of Drosophila BubR1 Is Required for Insulin Signaling-Dependent Stem Cell Maintenance

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  DOI: 10.1016/j.celrep.2020.107794
  
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sciencedirect.com/science/article/pii/S2211124720307750
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BPS Publications

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  DOI: 10.1111/bph.15010
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15010
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Entosis and apical cell extrusion constitute a tumor-suppressive mechanism downstream of MatriptaseThe double face of Matriptase

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  DOI: 10.1083/jcb.201905190
  
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rupress.org/jcb/article/219/2/e201905190/132730/Entosis-and-apical-cell-extrusion-constitute-a
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Tau Reduction Prevents Key Features of Autism in Mouse Models

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  DOI: 10.1016/j.neuron.2020.01.038
  
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sciencedirect.com/science/article/pii/S0896627320300659
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Leukemogenic Chromatin Alterations Promote AML Leukemia Stem Cells via a KDM4C-ALKBH5-AXL Signaling Axis

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  DOI: 10.1016/j.stem.2020.04.001
  
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sciencedirect.com/science/article/pii/S1934590920301405
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Macropinocytosis Renders a Subset of Pancreatic Tumor Cells Resistant to mTOR Inhibition

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  DOI: 10.1016/j.celrep.2020.01.080
  
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Methylglyoxal Scavengers Resensitize KRAS-Mutated Colorectal Tumors to Cetuximab

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cell.com/cell-reports/abstract/S2211-1247(20)30021-8
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ADORA1 Inhibition Promotes Tumor Immune Evasion by Regulating the ATF3-PD-L1 Axis

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  DOI: 10.1016/j.ccell.2020.02.006
  
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sciencedirect.com/science/article/pii/S1535610820300957
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Tumor Microenvironment-Derived NRG1 Promotes Antiandrogen Resistance in Prostate Cancer

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  DOI: 10.1016/j.ccell.2020.06.005
  
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Adipocyte-Derived Versican and Macrophage-Derived Biglycan Control Adipose Tissue Inflammation in Obesity

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  DOI: 10.1016/j.celrep.2020.107818
  
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Functional Analysis of KIT Gene Structural Mutations Causing the Porcine Dominant White Phenotype Using Genome Edited Mouse Models

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  DOI: 10.3389/fgene.2020.00138
  
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  DOI: 10.3389/fgene.2020.00138
  
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UBE3A-mediated p18/LAMTOR1 ubiquitination and degradation regulate mTORC1 activity and synaptic plasticity

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Glioblastoma Cell Resistance to EGFR and MET Inhibition Can Be Overcome via Blockade of FGFR-SPRY2 Bypass Signaling

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Multiple Signaling Roles of CD3ε and Its Application in CAR-T Cell Therapy

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Runx2+ Niche Cells Maintain Incisor Mesenchymal Tissue Homeostasis through IGF Signaling

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Secreted Pyruvate Kinase M2 Promotes Lung Cancer Metastasis through Activating the Integrin Beta1/FAK Signaling Pathway

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Targeting the Tie2–α v β 3 integrin axis with bi-specific reagents for the inhibition of angiogenesis

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Consumption of a palatable diet rich in simple sugars during development impairs memory of different degrees of emotionality and changes hippocampal plasticity according to the age of the rats

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Antidiabetic activity in vitro and in vivo of BDB, protein tyrosine phosphatase 1B selective inhibitor from Rhodonela conferviodes

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Failed Apoptosis Enhances Melanoma Cancer Cell Aggressiveness

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Vessel-derived angiocrine IGF-1 promotes Meckel's cartilage proliferation to drive jaw growth during embryogenesis

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Glycolysis-Independent Glucose Metabolism Distinguishes TE from ICM Fate during Mammalian Embryogenesis

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Knocking Out Non-muscle Myosin II in Retinal Ganglion Cells Promotes Long-Distance Optic Nerve Regeneration

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BPS Publications

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Inhibition of MEK1/2 Forestalls the Onset of Acquired Resistance to Entrectinib in Multiple Models of NTRK1-Driven Cancer

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Predictive and Pharmacodynamic Biomarkers of Response to the Phosphatidylinositol 3-Kinase Inhibitor Taselisib in Breast Cancer Preclinical Models

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Opposing p53 and mTOR/AKT promote an in vivo switch from apoptosis to senescence upon telomere shortening in zebrafish

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H1N1 Influenza Virus Cross-Activates Gli1 to Disrupt the Intercellular Junctions of Alveolar Epithelial Cells

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Neurofibromin Is an Estrogen Receptor-α Transcriptional Co-repressor in Breast Cancer

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Activation of metabotropic glutamate receptor 4 regulates proliferation and neural differentiation in neural stem/progenitor cells of the rat subventricular zone and increases phosphatase and tensin homolog protein expression

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Defining and Targeting Adaptations to Oncogenic KRASG12C Inhibition Using Quantitative Temporal Proteomics

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TNFAIP3 Interacting Protein 3 Overexpression Suppresses Nonalcoholic Steatohepatitis by Blocking TAK1 Activation

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Reelin activates the small GTPase TC10 and VAMP7 to promote neurite outgrowth and regeneration of dorsal root ganglia (DRG) neurons

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Periostin Promotes Colorectal Tumorigenesis through Integrin-FAK-Src Pathway-Mediated YAP/TAZ Activation

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Proximal Tubule mTORC1 Is a Central Player in the Pathophysiology of Diabetic Nephropathy and Its Correction by SGLT2 Inhibitors

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BPS Publications

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Genetic inactivation of mTORC1 or mTORC2 in neurons reveals distinct functions in glutamatergic synaptic transmission

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Gut hormone GIP induces inflammation and insulin resistance in the hypothalamus

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Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids

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Genome-wide kinetic properties of transcriptional bursting in mouse embryonic stem cells

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HNF1A is a novel oncogene that regulates human pancreatic cancer stem cell properties

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PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells

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  Phospho-AKT ser473
  
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Pyruvate Kinase M2 Promotes the Activation of Dendritic Cells by Enhancing IL-12p35 Expression

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  Anti-phospho-Akt (Ser473)
  
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Disc1 Carrier Mice Exhibit Alterations in Neural pIGF-1Rβ and Related Kinase Expression

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  Rabbit anti-Phospho Akt: Ser473
  
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Aster‐C coordinates with COP I vesicles to regulate lysosomal trafficking and activation of mTORC1

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  DOI: 10.15252/embr.201949898
  
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Looking for a Better Characterization of Triple-Negative Breast Cancer by Means of Circulating Tumor Cells

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Low-density lipoprotein receptor-related protein 1 deficiency in cardiomyocytes reduces susceptibility to insulin resistance and obesity

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Phenotypic Screen with TSC-Deficient Neurons Reveals Heat-Shock Machinery as a Druggable Pathway for mTORC1 and Reduced Cilia

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Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies

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Gab1 mediates PDGF signaling and is essential to oligodendrocyte differentiation and CNS myelination

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Blocking EGFR palmitoylation suppresses PI3K signaling and mutant KRAS lung tumorigenesis

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  pS473-AKT
  
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IGF-1 Signalling Regulates Mitochondria Dynamics and Turnover through a Conserved GSK-3β–Nrf2–BNIP3 Pathway

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IKKε and TBK1 in diffuse large B‐cell lymphoma: A possible mechanism of action of an IKKε/TBK1 inhibitor to repress NF‐κB and IL‐10 signalling

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High expression of miR-135b predicts malignant transformation and poor prognosis of gastric cancer

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  anti-phospho-Akt (Ser473) (D9E) XP® rabbit mAb
  
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Dual Regulation of Histone Methylation by mTOR Complexes Controls Glioblastoma Tumor Cell Growth via EZH2 and SAM

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  p-Akt
  
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Lactational metformin exposure programs offspring white adipose tissue glucose homeostasis and resilience to metabolic stress in a sex-dependent manner | American Journal of Physiology-Endocrinology and Metabolism

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  monoclonal rabbit phospho-Akt S473
  
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Fibroblast-Derived STC-1 Modulates Tumor-Associated Macrophages and Lung Adenocarcinoma Development

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Intermittent fasting promotes adult hippocampal neuronal differentiation by activating GSK‐3β in 3xTg‐AD mice

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Biallelic Mutations in TSC2 Lead to Abnormalities Associated with Cortical Tubers in Human iPSC-Derived Neurons

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Untitled document

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Synthetic Essentiality of Metabolic Regulator PDHK1 in PTEN-Deficient Cells and Cancers

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Altered Central Nutrient Sensing in Male Mice Lacking Insulin Receptors in Glut4-expressing Neurons

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  DOI: 10.1210/en.2019-00341
  
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Mesothelial Cell HIF1α Expression Is Metabolically Downregulated by Metformin to Prevent Oncogenic Tumor-Stromal Crosstalk

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An mTORC1-to-CDK1 Switch Maintains Autophagy Suppression during Mitosis

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Angiotensinogen in hepatocytes contributes to Western diet-induced liver steatosis

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Nutrient restriction causes reversible G2 arrest in Xenopus neural progenitors

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Discovery of Small-Molecule Selective mTORC1 Inhibitors via Direct Inhibition of Glucose Transporters

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TRIM32/USP11 Balances ARID1A Stability and the Oncogenic/Tumor-Suppressive Status of Squamous Cell Carcinoma

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Upregulation of GLT-1 via PI3K/Akt Pathway Contributes to Neuroprotection Induced by Dexmedetomidine

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Identification of a Paracrine Signaling Mechanism Linking CD34high Progenitors to the Regulation of Visceral Fat Expansion and Remodeling

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EGFR-Pak Signaling Selectively Regulates Glutamine Deprivation-Induced Macropinocytosis

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Keratinocyte growth factor reduces injury and leads to early recovery from cyclophosphamide bladder injury

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Co-chaperones TIMP2 and AHA1 Competitively Regulate Extracellular HSP90:Client MMP2 Activity and Matrix Proteolysis

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eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma

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nature.com/articles/s41467-019-13086-5
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Extracellular Pgk1 enhances neurite outgrowth of motoneurons through Nogo66/NgR-independent targeting of NogoA

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  DOI: 10.7554/eLife.49175
  
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Branched-Chain Amino Acid Metabolic Reprogramming Orchestrates Drug Resistance to EGFR Tyrosine Kinase Inhibitors

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Calorie-Restriction-Induced Insulin Sensitivity Is Mediated by Adipose mTORC2 and Not Required for Lifespan Extension

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NOX1-Dependent mTORC1 Activation via S100A9 Oxidation in Cancer Stem-like Cells Leads to Colon Cancer Progression

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Phosphoethanolamine Accumulation Protects Cancer Cells under Glutamine Starvation through Downregulation of PCYT2

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Synergistic Highly Potent Targeted Drug Combinations in different Pheochromocytoma Models including Human Tumor Cultures

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Mechanical loading stimulates hypertrophy in tissue‐engineered skeletal muscle: Molecular and phenotypic responses

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TRPML1 Promotes Protein Homeostasis in Melanoma Cells by Negatively Regulating MAPK and mTORC1 Signaling

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Naa10p Inhibits Beige Adipocyte-Mediated Thermogenesis through N-α-acetylation of Pgc1α

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Deficiency in BDNF/TrkB Neurotrophic Activity Stimulates δ-Secretase by Upregulating C/EBPβ in Alzheimer’s Disease

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Akt Regulates a Rab11-Effector Switch Required for Ciliogenesis

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Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8+ T Cells

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Tumor Heterogeneity Underlies Differential Cisplatin Sensitivity in Mouse Models of Small-Cell Lung Cancer

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Microglial Hv1 proton channels promote white matter injuries after chronic hypoperfusion in mice

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A Yap-Myc-Sox2-p53 Regulatory Network Dictates Metabolic Homeostasis and Differentiation in Kras-Driven Pancreatic Ductal Adenocarcinomas

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Insulin Potentiates JAK/STAT Signaling to Broadly Inhibit Flavivirus Replication in Insect Vectors

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Cell-autonomous regulation of epithelial cell quiescence by calcium channel Trpv6

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Isoform-Specific Destabilization of the Active Site Reveals a Molecular Mechanism of Intrinsic Activation of KRas G13D

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Accelerated phosphatidylcholine turnover in macrophages promotes adipose tissue inflammation in obesity

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The Axonal Membrane Protein PRG2 Inhibits PTEN and Directs Growth to Branches

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Reduction of Global H3K27me3 Enhances HER2/ErbB2 Targeted Therapy

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CD146 Regulates Growth Factor-Induced mTORC2 Activity Independent of the PI3K and mTORC1 Pathways

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The Schizophrenia Susceptibility Gene OPCML Regulates Spine Maturation and Cognitive Behaviors through Eph-Cofilin Signaling

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TAZ Is a Negative Regulator of PPARγ Activity in Adipocytes and TAZ Deletion Improves Insulin Sensitivity and Glucose Tolerance

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The Polycomb Repressor Complex 1 Drives Double-Negative Prostate Cancer Metastasis by Coordinating Stemness and Immune Suppression

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Oncogenic Mutations Rewire Signaling Pathways by Switching Protein Recruitment to Phosphotyrosine Sites

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Mice deficient in the C-terminal domain of TAR DNA-binding protein 43 develop age-dependent motor dysfunction associated with impaired Notch1−Akt signaling pathway

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Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling

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Individual Cells Can Resolve Variations in Stimulus Intensity along the IGF-PI3K-AKT Signaling Axis

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Macrophage MerTK Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis

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Ghrelin-Induced Sodium Reabsorption is Mediated by PKA and Microtubule-Dependent αE Na C Translocation In Female Rats

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Torin2 Exploits Replication and Checkpoint Vulnerabilities to Cause Death of PI3K-Activated Triple-Negative Breast Cancer Cells

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Risperidone ameliorates prefrontal cortex neural atrophy and oxidative/nitrosative stress in brain and peripheral blood of rats with neonatal ventral hippocampus lesion

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Systematic Analysis of Drug Vulnerabilities Conferred by Tumor Suppressor Loss

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MAPK Erk5 in leptin receptor-expressing neurons controls body weight and systemic energy homeostasis in female mice

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PTEN Suppresses Glycolysis by Dephosphorylating and Inhibiting Autophosphorylated PGK1

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A Novel Allosteric Inhibitor of Phosphoglycerate Mutase 1 Suppresses Growth and Metastasis of Non-Small-Cell Lung Cancer

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Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers

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Quantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks

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Targeting 7-Dehydrocholesterol Reductase Integrates Cholesterol Metabolism and IRF3 Activation to Eliminate Infection

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Metallothionein 3 Controls the Phenotype and Metabolic Programming of Alternatively Activated Macrophages

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Intranasal Targeting of Hypothalamic PTP1B and TCPTP Reinstates Leptin and Insulin Sensitivity and Promotes Weight Loss in Obesity

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A GPR17-cAMP-Lactate Signaling Axis in Oligodendrocytes Regulates Whole-Body Metabolism

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Adipocyte ACLY Facilitates Dietary Carbohydrate Handling to Maintain Metabolic Homeostasis in Females

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p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors

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Hippo Kinases Mst1 and Mst2 Sense and Amplify IL-2R−STAT5 Signaling in Regulatory T Cells to Establish Stable Regulatory Activity

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Aldosterone Modulates the Mechanistic Target of Rapamycin Signaling in Male Mice

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Mature Human White Adipocytes Cultured under Membranes Maintain Identity, Function, and Can Transdifferentiate into Brown-like Adipocytes

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TOP2β-Dependent Nuclear DNA Damage Shapes Extracellular Growth Factor Responses via Dynamic AKT Phosphorylation to Control Virus Latency

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Pink1 regulates FKBP5 interaction with AKT/PHLPP and protects neurons from neurotoxin stress induced by MPP+

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Diosmetin induces apoptosis and enhances the chemotherapeutic efficacy of paclitaxel in non‐small cell lung cancer cells via Nrf2 inhibition

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PI3K Inhibition Activates SGK1 via a Feedback Loop to Promote Chromatin-Based Regulation of ER-Dependent Gene Expression

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The Expression of Key Guidance Genes at a Forebrain Axon Turning Point Is Maintained by Distinct Fgfr Isoforms but a Common Downstream Signal Transduction Mechanism

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Lymphocyte Activation Gene-3 Maintains Mitochondrial and Metabolic Quiescence in Naive CD4+ T Cells

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Inactivation of the tyrosine phosphatase SHP-2 drives vascular dysfunction in Sepsis

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Lysosome Positioning Influences mTORC2 and AKT Signaling

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Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC

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Mutational Landscape of Secondary Glioblastoma Guides MET-Targeted Trial in Brain Tumor

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Insulin regulates POMC neuronal plasticity to control glucose metabolism

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Notch Signaling Controls Transdifferentiation of Pulmonary Neuroendocrine Cells in Response to Lung Injury

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Lipolysis Triggers a Systemic Insulin Response Essential for Efficient Energy Replenishment of Activated Brown Adipose Tissue in Mice

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Subversion of Systemic Glucose Metabolism as a Mechanism to Support the Growth of Leukemia Cells

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Divergent Matrix-Remodeling Strategies Distinguish Developmental from Neoplastic Mammary Epithelial Cell Invasion Programs

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Vascular and Neurogenic Rejuvenation in Aging Mice by Modulation of ASM

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A Loss of Epigenetic Control Can Promote Cell Death through Reversing the Balance of Pathways in a Signaling Network

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PI3Kγ promotes vascular smooth muscle cell phenotypic modulation and transplant arteriosclerosis via a SOX9-dependent mechanism

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Curcumin Attenuates gp120-Induced Microglial Inflammation by Inhibiting Autophagy via the PI3K Pathway

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Overcoming Resistance to Dual Innate Immune and MEK Inhibition Downstream of KRAS

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Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A

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Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies

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Lin28 Signaling Supports Mammalian PNS and CNS Axon Regeneration

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Testosterone regulates myosin II isoforms expression and functional activity in the rat prostate

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