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Loss of FBXO31-mediated degradation of DUSP6 dysregulates ERK and PI3K-AKT signaling and promotes prostate tumorigenesis

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Overexpression of FGF2 delays the progression of osteonecrosis of the femoral head activating the PI3K/Akt signaling pathway

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A role for AKT1 in nonsense-mediated mRNA decay

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Bioenergetic Requirements and Spatiotemporal Profile of Nerve Growth Factor Induced PI3K-Akt Signaling Along Sensory Axons

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Proteomics reveal cap-dependent translation inhibitors remodel the translation machinery and translatome

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Serum- and glucocorticoid-induced kinase drives hepatic insulin resistance by directly inhibiting AMP-activated protein kinase

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Adaptations in Hippo-Yap signaling and myofibroblast fate underlie scar-free ear appendage wound healing in spiny mice

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Wnt5a Regulates Junctional Function of Sertoli cells Through PCP-Mediated Effects on mTORC1 and mTORC2

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Preclinical and Clinical Characterization of Fibroblast-derived Neuregulin-1 on Trastuzumab and Pertuzumab Activity in HER2-positive Breast Cancer

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Involvement of multiple scavenger receptors in advanced glycation end product-induced vessel tube formation in endothelial cells

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Hepatocyte activity of the cholesterol sensor smoothened regulates cholesterol and bile acid homeostasis in mice

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H3K4 di-methylation governs smooth muscle lineage identity and promotes vascular homeostasis by restraining plasticity

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The pro-regenerative effects of hyperIL6 in drug-induced liver injury are unexpectedly due to competitive inhibition of IL11 signaling

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Cellular senescence promotes cancer metastasis by enhancing soluble E-cadherin production

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Tumor-initiating stem cell shapes its microenvironment into an immunosuppressive barrier and pro-tumorigenic niche

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SCIMP is a spatiotemporal transmembrane scaffold for Erk1/2 to direct pro-inflammatory signaling in TLR-activated macrophages

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Treatment of acromegaly by rosiglitazone via upregulating 15-PGDH in both pituitary adenoma and liver

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UV-induced reduction in Polycomb repression promotes epidermal pigmentation

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BAD-mediated neuronal apoptosis and neuroinflammation contribute to Alzheimer's disease pathology

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Treatment during a developmental window prevents NF1-associated optic pathway gliomas by targeting Erk-dependent migrating glial progenitors

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BPS Publications

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Coordination of tumor growth and host wasting by tumor-derived Upd3

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NGPF2 triggers synaptic scaling up through ALK-LIMK-cofilin-mediated mechanisms

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Functional diagnostics using fresh uncultured lung tumor cells to guide personalized treatments

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The FAPα-activated prodrug Z-GP-DAVLBH inhibits the growth and pulmonary metastasis of osteosarcoma cells by suppressing the AXL pathway

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Hormonally regulated myogenic miR-486 influences sex-specific differences in cancer-induced skeletal muscle defects

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Chemical tools for epichaperome-mediated interactome dysfunctions of the central nervous system

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Mutations in the transcription factor FOXO1 mimic positive selection signals to promote germinal center B cell expansion and lymphomagenesis

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A proteomic and phosphoproteomic landscape of KRAS mutant cancers identifies combination therapies

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Identification of response signatures for tankyrase inhibitor treatment in tumor cell lines

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Multiple regulatory intrinsically disordered motifs control FOXO4 transcription factor binding and function

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A fluorescent reporter assay of differential gene expression response to insulin in hepatocytes

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Untitled document

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Chronic VEGFR-3 signaling preserves dendritic arborization and sensitization under stress

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KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance

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Decreased rates of cerebral protein synthesis measured in vivo in a mouse model of Tuberous Sclerosis Complex: unexpected consequences of reduced tuberin

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Fendiline Enhances the Cytotoxic Effects of Therapeutic Agents on PDAC Cells by Inhibiting Tumor-Promoting Signaling Events: A Potential Strategy to Combat PDAC

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Nuclear PGK1 Alleviates ADP-Dependent Inhibition of CDC7 to Promote DNA Replication

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Effects of the presence and absence of amino acids on translation, signaling and long‐term depression in hippocampal slices from Fmr1 knockout mice

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Use of nonsteroidal anti-inflammatory drugs predicts improved patient survival for PIK3CA-altered head and neck cancer

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TrkB‐mediated activation of the phosphatidylinositol‐3‐kinase/Akt cascade reduces the damage inflicted by oxygen‐glucose deprivation in area CA3 of the rat hippocampus

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Akt3-mTOR regulates hippocampal neurogenesis in adult mouse

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  DOI: 10.1111/jnc.15441
  
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Inactivation of Tp53 and Pten drives rapid development of pleural and peritoneal malignant mesotheliomas

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PTEN negatively regulates the cell lineage progression from NG2+ glial progenitor to oligodendrocyte via mTOR-independent signaling

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Vascular Endothelial Growth Factor–D (VEGF-D) Overexpression and Lymphatic Expansion in Murine Adipose Tissue Improves Metabolism in Obesity

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Systemic network analysis identifies XIAP and IκBα as potential drug targets in TRAIL resistant BRAF mutated melanoma

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Loss of Neurological Disease HSAN-I-Associated Gene SPTLC2 Impairs CD8+ T Cell Responses to Infection by Inhibiting T Cell Metabolic Fitness

1
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  Phospho-Akt (Ser473) (D9E) XPu00a0Rabbit mAb
  
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PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K

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Tinagl1 Suppresses Triple-Negative Breast Cancer Progression and Metastasis by Simultaneously Inhibiting Integrin/FAK and EGFR Signaling

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PTEN knockdown alters dendritic spine/protrusion morphology, not density

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  Anti-pAKTMonoclonalRabbitEpitope surrounds serine 473 of AKT sequence1:200Cell Signaling4060AB_916027
  
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cell.com/developmental-cell/abstract/S1534-5807(17)30871-7
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Brain Endothelial Cells Maintain Lactate Homeostasis and Control Adult Hippocampal Neurogenesis

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OVA66 promotes tumour angiogenesis and progression through enhancing autocrine VEGF-VEGFR2 signalling

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Dynamic Phosphorylation of the C Terminus of Hsp70 Regulates the Mitochondrial Import of SOD2 and Redox Balance

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Angiotensin-II-induced Muscle Wasting is Mediated by 25-Hydroxycholesterol via GSK3β Signaling Pathway

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  AB_916024
  
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Neuroplasticity and inflammatory alterations in the nucleus accumbens are corrected after risperidone treatment in a schizophrenia-related developmental model in rats

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Phosphatidylinositol-3 kinase mediates the sweet suppressive effect of leptin in mouse taste cells

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Thyroid hormone receptor beta inhibits the PI3K-Akt-mTOR signaling axis in anaplastic thyroid cancer cell lines via genomic mechanisms

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  AB_2315049
  
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Microscopic image-based covariation network analysis for actin scaffold-modified insulin signaling

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An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress

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Brain endothelial PTEN/AKT/NEDD4-2/MFSD2A axis regulates blood-brain barrier permeability

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IL-17 Inhibits Oligodendrocyte Progenitor Cell Proliferation and Differentiation by Increasing K+ Channel Kv1.3

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Kinome-wide RNAi screening for mediators of ABT-199 resistance in breast cancer cells identifies Wee1 as a novel therapeutic target

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  4060
  
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Synchronous effects of targeted mitochondrial complex I inhibitors on tumor and immune cells abrogate melanoma progression

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OTULIN allies with LUBAC to govern angiogenesis by editing ALK1 linear polyubiquitin

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Evolutionary predictability of genetic versus nongenetic resistance to anticancer drugs in melanoma

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Canonical NF-κB signaling maintains corneal epithelial integrity and prevents corneal aging via retinoic acid

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Gut microbiota-CRAMP axis shapes intestinal barrier function and immune responses in dietary gluten-induced enteropathy

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β-elemene alleviates airway stenosis via the ILK/Akt pathway modulated by MIR143HG sponging miR-1275

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A Novel Benzopyrane Derivative Targeting Cancer Cell Metabolic and Survival Pathways

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MYC-mediated early glycolysis negatively regulates proinflammatory responses by controlling IRF4 in inflammatory macrophages

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NADK is activated by oncogenic signaling to sustain pancreatic ductal adenocarcinoma

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FEBS Press

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Targeted mass-spectrometry-based assays enable multiplex quantification of receptor tyrosine kinase, MAP kinase, and AKT signaling

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Target identification for small-molecule discovery in the FOXO3a tumor-suppressor pathway using a biodiverse peptide library

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TMBIM1 is an inhibitor of adipogenesis and its depletion promotes adipocyte hyperplasia and improves obesity-related metabolic disease

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Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma

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Reprogramming an energetic AKT-PAK5 axis boosts axon energy supply and facilitates neuron survival and regeneration after injury and ischemia

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Mismatch repair deficiency predicts response to HER2 blockade in HER2-negative breast cancer

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The autophagy protein Becn1 improves insulin sensitivity by promoting adiponectin secretion via exocyst binding

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Limited inhibition of multiple nodes in a driver network blocks metastasis

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A novel oncotherapy strategy: Direct thrombin inhibitors suppress progression, dissemination and spontaneous metastasis in non-small cell lung cancer

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UBTD1 regulates ceramide balance and endolysosomal positioning to coordinate EGFR signaling

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Hepatic AKT orchestrates adipose tissue thermogenesis via FGF21-dependent and -independent mechanisms

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The E3 ligase TRAF4 Promotes IGF Signaling by Mediating Atypical Ubiquitination of IRS-1

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NC1-peptide from collagen α3 (IV) chains in the basement membrane of testes regulates spermatogenesis via p-FAK-Y407

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SMRT Regulates Metabolic Homeostasis and Adipose Tissue Macrophage Phenotypes in Tandem

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Heparan Sulfate Synthesized by Ext1 Regulates Receptor Tyrosine Kinase Signaling and Promotes Resistance to EGFR Inhibitors in GBM

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Removal of epididymal visceral adipose tissue prevents obesity-induced multi-organ insulin resistance in male mice

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Specific inhibition of oncogenic RAS using cell-permeable RAS-binding domains

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BPS Publications

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Hdac9 inhibits medial artery calcification through down-regulation of Osterix

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Histone Acetyltransferase MOF Blocks Acquisition of Quiescence in Ground-State ESCs through Activating Fatty Acid Oxidation

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Integrin-Linked Kinase Mediates Therapeutic Resistance of Quiescent CML Stem Cells to Tyrosine Kinase Inhibitors

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Thymoquinone administration ameliorates Alzheimer's disease-like phenotype by promoting cell survival in the hippocampus of amyloid beta1-42 infused rat model

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Akt-mTOR hypoactivity in bipolar disorder gives rise to cognitive impairments associated with altered neuronal structure and function

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Serotonin Receptor 2A Activation Promotes Evolutionarily Relevant Basal Progenitor Proliferation in the Developing Neocortex

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Control of Glucocorticoid Receptor Levels by PTEN Establishes a Failsafe Mechanism for Tumor Suppression

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Structural Insights into Pseudokinase Domains of Receptor Tyrosine Kinases

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Eomes-Dependent Loss of the Co-activating Receptor CD226 Restrains CD8+ T Cell Anti-tumor Functions and Limits the Efficacy of Cancer Immunotherapy

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An Oncogenic Alteration Creates a Microenvironment that Promotes Tumor Progression by Conferring a Metabolic Advantage to Regulatory T Cells

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Anti-inflammatory Roles of Glucocorticoids Are Mediated by Foxp3+ Regulatory T Cells via a miR-342-Dependent Mechanism

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The Rag GTPase Regulates the Dynamic Behavior of TSC Downstream of Both Amino Acid and Growth Factor Restriction

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An Excitable Ras/PI3K/ERK Signaling Network Controls Migration and Oncogenic Transformation in Epithelial Cells

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Parvalbumin affects skeletal muscle trophism through modulation of mitochondrial calcium uptake

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Metabolic stress drives sympathetic neuropathy within the liver

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Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations

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Obesity-Linked PPARγ S273 Phosphorylation Promotes Insulin Resistance through Growth Differentiation Factor 3

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Dissociation of Muscle Insulin Resistance from Alterations in Mitochondrial Substrate Preference

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A Membrane-Bound Diacylglycerol Species Induces PKCϵ-Mediated Hepatic Insulin Resistance

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Glutamine deficiency promotes stemness and chemoresistance in tumor cells through DRP1-induced mitochondrial fragmentation

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Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade

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Dipyridamole Inhibits Lipogenic Gene Expression by Retaining SCAP-SREBP in the Endoplasmic Reticulum

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An Organoid Biobank of Neuroendocrine Neoplasms Enables Genotype-Phenotype Mapping

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Neurons Release Serine to Support mRNA Translation in Pancreatic Cancer

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Cancer Burden Is Controlled by Mural Cell-β3-Integrin Regulated Crosstalk with Tumor Cells

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A hotspot mutation in transcription factor IKZF3 drives B cell neoplasia via transcriptional dysregulation

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Cell Lineage-Based Stratification for Glioblastoma

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SETD2 Restricts Prostate Cancer Metastasis by Integrating EZH2 and AMPK Signaling Pathways

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Regulation of PTEN translation by PI3K signaling maintains pathway homeostasis

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Blocking Fra-1 sensitizes triple-negative breast cancer to PARP inhibitor

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Metabolomic analysis of a selective ABCA1 inducer in obesogenic challenge provides a rationale for therapeutic development

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S1PR3–G12-biased agonist ALESIA targets cancer metabolism and promotes glucose starvation

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SGK1 signaling promotes glucose metabolism and survival in extracellular matrix detached cells

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Primary cilia-dependent lipid raft/caveolin dynamics regulate adipogenesis

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BPS Publications

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FSH Promotes Progesterone Synthesis by Enhancing Autophagy to Accelerate Lipid Droplet Degradation in Porcine Granulosa Cells

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Autophagy blockade limits HER2+ breast cancer tumorigenesis by perturbing HER2 trafficking and promoting release via small extracellular vesicles

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Recombinant human growth hormone activates neuroprotective growth factors in hypoxic brain injury in neonatal mice

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Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy

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Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS

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Maternal high fat diet multigenerationally impairs hippocampal synaptic plasticity and memory in male rat offspring

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Acetyl-CoA Synthetase 2: A Critical Linkage in Obesity-Induced Tumorigenesis in Myeloma

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PD-L1 Reverse Signaling in Dermal Dendritic Cells Promotes Dendritic Cell Migration Required for Skin Immunity

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Exposure to low doses of Dechlorane Plus promotes adipose tissue dysfunction and glucose intolerance in male mice

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Knocking Out Non-muscle Myosin II in Retinal Ganglion Cells Promotes Long-Distance Optic Nerve Regeneration

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A Gatekeeping Role of ESR2 to Maintain the Primordial Follicle Reserve

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L-plastin Ser5 phosphorylation is modulated by the PI3K/SGK pathway and promotes breast cancer cell invasiveness

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Glucocorticoids attenuate interleukin‐6‐induced c‐Fos and Egr1 expression and impair neuritogenesis in PC12 cells

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The kinase PDK1 is critical for promoting T follicular helper cell differentiation

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Negative regulation of AMPK signaling by high glucose via E3 ubiquitin ligase MG53

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Targeting EphA2 suppresses hepatocellular carcinoma initiation and progression by dual inhibition of JAK1/STAT3 and AKT signaling

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Comprehensive pharmacogenomic characterization of gastric cancer

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Suppression of adipocyte differentiation by low‐intensity pulsed ultrasound via inhibition of insulin signaling and promotion of CCN family protein 2

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Methylglyoxal Scavengers Resensitize KRAS-Mutated Colorectal Tumors to Cetuximab

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(+)-Usnic Acid Induces ROS-dependent Apoptosis via Inhibition of Mitochondria Respiratory Chain Complexes and Nrf2 Expression in Lung Squamous Cell Carcinoma

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Gnrh3 regulates PGC proliferation and sex differentiation in developing zebrafish

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Cdc42 is involved in NC1 peptide–regulated BTB dynamics through actin and microtubule cytoskeletal reorganization

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MiR-3121-3p promotes tumor invasion and metastasis by suppressing Rap1GAP in papillary thyroid cancer in vitro

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Single-cell resolved imaging reveals intra-tumor heterogeneity in glycolysis, transitions between metabolic states, and their regulatory mechanisms

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An mTORC1-dependent switch orchestrates the transition between mouse spermatogonial stem cells and clones of progenitor spermatogonia

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Prenatal correction of IGF2 to rescue the growth phenotypes in mouse models of Beckwith-Wiedemann and Silver-Russell syndromes

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Gαo is a major determinant of cAMP signaling in the pathophysiology of movement disorders

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The ER-embedded UBE2J1/RNF26 ubiquitylation complex exerts spatiotemporal control over the endolysosomal pathway

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  Rabbit anti-AKT S473
  
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ApoE4 Impairs Neuron-Astrocyte Coupling of Fatty Acid Metabolism

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