1,399 Matching Annotations
  1. Jul 2021
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    Brain endothelial PTEN/AKT/NEDD4-2/MFSD2A axis regulates blood-brain barrier permeability
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    sciencedirect.com/science/article/pii/S2211124721007038
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    IL-17 Inhibits Oligodendrocyte Progenitor Cell Proliferation and Differentiation by Increasing K+ Channel Kv1.3
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    ncbi.nlm.nih.gov/pmc/articles/PMC8258110/
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    Kinome-wide RNAi screening for mediators of ABT-199 resistance in breast cancer cells identifies Wee1 as a novel therapeutic target
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    sciencedirect.com/science/article/pii/S1357272521001060
  5. Jun 2021
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    Synchronous effects of targeted mitochondrial complex I inhibitors on tumor and immune cells abrogate melanoma progression
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    cell.com/iscience/abstract/S2589-0042(21)00621-0
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    OTULIN allies with LUBAC to govern angiogenesis by editing ALK1 linear polyubiquitin
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    sciencedirect.com/science/article/pii/S1097276521004445
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    Evolutionary predictability of genetic versus nongenetic resistance to anticancer drugs in melanoma
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    sciencedirect.com/science/article/pii/S1535610821002816
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    Canonical NF-κB signaling maintains corneal epithelial integrity and prevents corneal aging via retinoic acid
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    ncbi.nlm.nih.gov/pmc/articles/PMC8192125/
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    Gut microbiota-CRAMP axis shapes intestinal barrier function and immune responses in dietary gluten-induced enteropathy
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    embopress.org/doi/abs/10.15252/emmm.202114059
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    β-elemene alleviates airway stenosis via the ILK/Akt pathway modulated by MIR143HG sponging miR-1275
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    cmbl.biomedcentral.com/articles/10.1186/s11658-021-00261-0
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    A Novel Benzopyrane Derivative Targeting Cancer Cell Metabolic and Survival Pathways
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    ncbi.nlm.nih.gov/pmc/articles/PMC8201054/
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    MYC-mediated early glycolysis negatively regulates proinflammatory responses by controlling IRF4 in inflammatory macrophages
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    NADK is activated by oncogenic signaling to sustain pancreatic ductal adenocarcinoma
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    Targeted mass-spectrometry-based assays enable multiplex quantification of receptor tyrosine kinase, MAP kinase, and AKT signaling
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    Target identification for small-molecule discovery in the FOXO3a tumor-suppressor pathway using a biodiverse peptide library
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    sciencedirect.com/science/article/pii/S2451945621002543
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    TMBIM1 is an inhibitor of adipogenesis and its depletion promotes adipocyte hyperplasia and improves obesity-related metabolic disease
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    Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma
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    Reprogramming an energetic AKT-PAK5 axis boosts axon energy supply and facilitates neuron survival and regeneration after injury and ischemia
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  21. May 2021
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    Mismatch repair deficiency predicts response to HER2 blockade in HER2-negative breast cancer
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    The autophagy protein Becn1 improves insulin sensitivity by promoting adiponectin secretion via exocyst binding
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    sciencedirect.com/science/article/pii/S2211124721005295
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    Limited inhibition of multiple nodes in a driver network blocks metastasis
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    ncbi.nlm.nih.gov/pmc/articles/PMC8128439/
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    A novel oncotherapy strategy: Direct thrombin inhibitors suppress progression, dissemination and spontaneous metastasis in non-small cell lung cancer
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15384
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    UBTD1 regulates ceramide balance and endolysosomal positioning to coordinate EGFR signaling
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    Hepatic AKT orchestrates adipose tissue thermogenesis via FGF21-dependent and -independent mechanisms
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    The E3 ligase TRAF4 Promotes IGF Signaling by Mediating Atypical Ubiquitination of IRS-1
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    NC1-peptide from collagen α3 (IV) chains in the basement membrane of testes regulates spermatogenesis via p-FAK-Y407
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    SMRT Regulates Metabolic Homeostasis and Adipose Tissue Macrophage Phenotypes in Tandem
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    Heparan Sulfate Synthesized by Ext1 Regulates Receptor Tyrosine Kinase Signaling and Promotes Resistance to EGFR Inhibitors in GBM
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    Removal of epididymal visceral adipose tissue prevents obesity-induced multi-organ insulin resistance in male mice
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    Specific inhibition of oncogenic RAS using cell-permeable RAS-binding domains
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    Hdac9 inhibits medial artery calcification through down-regulation of Osterix
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    Histone Acetyltransferase MOF Blocks Acquisition of Quiescence in Ground-State ESCs through Activating Fatty Acid Oxidation
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    Integrin-Linked Kinase Mediates Therapeutic Resistance of Quiescent CML Stem Cells to Tyrosine Kinase Inhibitors
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    Thymoquinone administration ameliorates Alzheimer's disease-like phenotype by promoting cell survival in the hippocampus of amyloid beta1-42 infused rat model
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    Akt-mTOR hypoactivity in bipolar disorder gives rise to cognitive impairments associated with altered neuronal structure and function
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    Serotonin Receptor 2A Activation Promotes Evolutionarily Relevant Basal Progenitor Proliferation in the Developing Neocortex
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    Control of Glucocorticoid Receptor Levels by PTEN Establishes a Failsafe Mechanism for Tumor Suppression
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    Structural Insights into Pseudokinase Domains of Receptor Tyrosine Kinases
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    Eomes-Dependent Loss of the Co-activating Receptor CD226 Restrains CD8+ T Cell Anti-tumor Functions and Limits the Efficacy of Cancer Immunotherapy
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    An Oncogenic Alteration Creates a Microenvironment that Promotes Tumor Progression by Conferring a Metabolic Advantage to Regulatory T Cells
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    Anti-inflammatory Roles of Glucocorticoids Are Mediated by Foxp3+ Regulatory T Cells via a miR-342-Dependent Mechanism
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    The Rag GTPase Regulates the Dynamic Behavior of TSC Downstream of Both Amino Acid and Growth Factor Restriction
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    An Excitable Ras/PI3K/ERK Signaling Network Controls Migration and Oncogenic Transformation in Epithelial Cells
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    Parvalbumin affects skeletal muscle trophism through modulation of mitochondrial calcium uptake
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    Metabolic stress drives sympathetic neuropathy within the liver
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  50. Apr 2021
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    Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations
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    Obesity-Linked PPARγ S273 Phosphorylation Promotes Insulin Resistance through Growth Differentiation Factor 3
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    sciencedirect.com/science/article/pii/S1550413120304769
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    Dissociation of Muscle Insulin Resistance from Alterations in Mitochondrial Substrate Preference
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    sciencedirect.com/science/article/pii/S1550413120304861
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    A Membrane-Bound Diacylglycerol Species Induces PKCϵ-Mediated Hepatic Insulin Resistance
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    Glutamine deficiency promotes stemness and chemoresistance in tumor cells through DRP1-induced mitochondrial fragmentation
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    link.springer.com/article/10.1007/s00018-021-03818-6
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    Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade
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    Dipyridamole Inhibits Lipogenic Gene Expression by Retaining SCAP-SREBP in the Endoplasmic Reticulum
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    An Organoid Biobank of Neuroendocrine Neoplasms Enables Genotype-Phenotype Mapping
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    Neurons Release Serine to Support mRNA Translation in Pancreatic Cancer
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    Cancer Burden Is Controlled by Mural Cell-β3-Integrin Regulated Crosstalk with Tumor Cells
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    A hotspot mutation in transcription factor IKZF3 drives B cell neoplasia via transcriptional dysregulation
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    Cell Lineage-Based Stratification for Glioblastoma
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    SETD2 Restricts Prostate Cancer Metastasis by Integrating EZH2 and AMPK Signaling Pathways
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    Regulation of PTEN translation by PI3K signaling maintains pathway homeostasis
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    Blocking Fra-1 sensitizes triple-negative breast cancer to PARP inhibitor
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  66. Mar 2021
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    Metabolomic analysis of a selective ABCA1 inducer in obesogenic challenge provides a rationale for therapeutic development
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    S1PR3–G12-biased agonist ALESIA targets cancer metabolism and promotes glucose starvation
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    SGK1 signaling promotes glucose metabolism and survival in extracellular matrix detached cells
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    Primary cilia-dependent lipid raft/caveolin dynamics regulate adipogenesis
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    FSH Promotes Progesterone Synthesis by Enhancing Autophagy to Accelerate Lipid Droplet Degradation in Porcine Granulosa Cells
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    Autophagy blockade limits HER2+ breast cancer tumorigenesis by perturbing HER2 trafficking and promoting release via small extracellular vesicles
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    Recombinant human growth hormone activates neuroprotective growth factors in hypoxic brain injury in neonatal mice
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    Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy
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  76. Feb 2021
  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS
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    ncbi.nlm.nih.gov/pmc/articles/PMC7909318/
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    Maternal high fat diet multigenerationally impairs hippocampal synaptic plasticity and memory in male rat offspring
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    Acetyl-CoA Synthetase 2: A Critical Linkage in Obesity-Induced Tumorigenesis in Myeloma
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    PD-L1 Reverse Signaling in Dermal Dendritic Cells Promotes Dendritic Cell Migration Required for Skin Immunity
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    ncbi.nlm.nih.gov/pmc/articles/PMC7688291/
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    Exposure to low doses of Dechlorane Plus promotes adipose tissue dysfunction and glucose intolerance in male mice
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    Knocking Out Non-muscle Myosin II in Retinal Ganglion Cells Promotes Long-Distance Optic Nerve Regeneration
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    A Gatekeeping Role of ESR2 to Maintain the Primordial Follicle Reserve
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    L-plastin Ser5 phosphorylation is modulated by the PI3K/SGK pathway and promotes breast cancer cell invasiveness
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    The kinase PDK1 is critical for promoting T follicular helper cell differentiation
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    Negative regulation of AMPK signaling by high glucose via E3 ubiquitin ligase MG53
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    Targeting EphA2 suppresses hepatocellular carcinoma initiation and progression by dual inhibition of JAK1/STAT3 and AKT signaling
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    Suppression of adipocyte differentiation by low‐intensity pulsed ultrasound via inhibition of insulin signaling and promotion of CCN family protein 2
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    Methylglyoxal Scavengers Resensitize KRAS-Mutated Colorectal Tumors to Cetuximab
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    Gnrh3 regulates PGC proliferation and sex differentiation in developing zebrafish
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