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2,193 Matching Annotations

Sep 2022
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Sensing of individual stalled 80S ribosomes by Fap1 for nonfunctional rRNA turnover

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1. scibot 16 Sep 2022
  
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  DOI: 10.1016/j.molcel.2022.08.018
  
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Control of ribosomal RNA synthesis by hematopoietic transcription factors

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  DOI: 10.1016/j.molcel.2022.08.027
  
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Pak2-mediated phosphorylation promotes RORγt ubiquitination and inhibits colonic inflammation

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  DOI: 10.1016/j.celrep.2022.111345
  
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Endothelial cells regulated by RNF20 orchestrate the proliferation and differentiation of neural precursor cells during embryonic development

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1. scibot 15 Sep 2022
  
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  DOI: 10.1016/j.celrep.2022.111350
  
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Activation and expansion of presynaptic signaling foci drives presynaptic homeostatic plasticity

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1. scibot 10 Sep 2022
  
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  DOI: 10.1016/j.neuron.2022.08.016
  
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pmc.ncbi.nlm.nih.gov/articles/PMC9671843/
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Shear stress activates nociceptors to drive Drosophila mechanical nociception

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  DOI: 10.1016/j.neuron.2022.08.015
  
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Target protein localization and its impact on PROTAC-mediated degradation

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1. scibot 08 Sep 2022
  
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  DOI: 10.1016/j.chembiol.2022.08.004
  
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Runx2 regulates chromatin accessibility to direct the osteoblast program at neonatal stages

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A family of C. elegans VASA homologs control Argonaute pathway specificity and promote transgenerational silencing

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1. scibot 08 Sep 2022
  
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  DOI: 10.1016/j.celrep.2022.111265
  
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Integrative RNA-omics discovers GNAS alternative splicing as a phenotypic driver of splicing factor-mutant neoplasms

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  DOI: 10.1158/2159-8290.CD-21-0508
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8904276/
Aug 2022
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RBM45 is an m6A-binding protein that affects neuronal differentiation and the splicing of a subset of mRNAs

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1. scibot 31 Aug 2022
  
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  DOI: 10.1016/j.celrep.2022.111293
  
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ABL kinases regulate translation in HER2+ cells through Y-box-binding protein 1 to facilitate colonization of the brain

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1. scibot 31 Aug 2022
  
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  DOI: 10.1016/j.celrep.2022.111268
  
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Ubiquitination of phosphatidylethanolamine in organellar membranes

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1. scibot 31 Aug 2022
  
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  DOI: 10.1016/j.molcel.2022.08.008
  
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Activation of mitochondrial TRAP1 stimulates mitochondria-lysosome crosstalk and correction of lysosomal dysfunction

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1. scibot 30 Aug 2022
  
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  DOI: 10.1016/j.isci.2022.104941
  
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sciencedirect.com/science/article/pii/S2589004222012135
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ccr-21-3603-html.html

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1. scibot 27 Aug 2022
  
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  DOI: 10.1158/1078-0432.ccr-21-3603
  
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52.53.155.43/de81104a0064110ab6f8eb2e443412de8e9dbc9e/ccr-21-3603-html.html
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Identification of the NRF2 transcriptional network as a therapeutic target for trigeminal neuropathic pain

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1. scibot 26 Aug 2022
  
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  DOI: 10.1126/sciadv.abo5633
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9348805/
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trim-21 promotes proteasomal degradation of CED-1 for apoptotic cell clearance in C. elegans

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1. scibot 26 Aug 2022
  
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  DOI: 10.7554/eLife.76436
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9388098/
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Induction of A Disintegrin and Metalloproteinase with Thrombospondin motifs 1 by a rare variant or cognitive activities reduces hippocampal amyloid-β and consequent Alzheimer’s disease risk

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1. scibot 26 Aug 2022
  
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  DOI: 10.3389/fnagi.2022.896522
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9395645/
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The AMPK-HOXB9-KRAS axis regulates lung adenocarcinoma growth in response to cellular energy alterations

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1. scibot 26 Aug 2022
  
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  DOI: 10.1016/j.celrep.2022.111210
  
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Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IκBα

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  DOI: 10.1016/j.cmet.2022.08.002
  
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N1-methylpseudouridine found within COVID-19 mRNA vaccines produces faithful protein products

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  DOI: 10.1016/j.celrep.2022.111300
  
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Protocol for viral vector-mediated measurement of transcription factor activity of mouse brain

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1. scibot 22 Aug 2022
  
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  DOI: 10.1016/j.xpro.2022.101633
  
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De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma

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1. scibot 22 Aug 2022
  
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  DOI: 10.1016/j.ccell.2022.07.011
  
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Neuronal paxillin and drebrin mediate BDNF-induced force transduction and growth cone turning in a soft-tissue-like environment

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1. scibot 17 Aug 2022
  
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Epigenetic reader SP140 loss of function drives Crohn’s disease due to uncontrolled macrophage topoisomerases

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1. scibot 17 Aug 2022
  
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  DOI: 10.1016/j.cell.2022.06.048
  
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Multi-facet roles of RNA editing in promoting loss-of-function of PODXL in cancer

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  DOI: 10.1016/j.isci.2022.104836
  
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TMUB1 is an endoplasmic reticulum-resident escortase that promotes the p97-mediated extraction of membrane proteins for degradation

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1. scibot 12 Aug 2022
  
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  DOI: 10.1016/j.molcel.2022.07.006
  
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BCL10 mutations define distinct dependencies guiding precision therapy for DLBCL

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  DOI: 10.1158/2159-8290.CD-21-1566
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9357155/
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Rhomboid protease RHBDL4 promotes retrotranslocation of aggregation-prone proteins for degradation

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  DOI: 10.1016/j.celrep.2022.111175
  
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sciencedirect.com/science/article/pii/S2211124722009883
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Broad-spectrum chemicals block ROS detoxification to prevent plant fungal invasion

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1. scibot 06 Aug 2022
  
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  DOI: 10.1016/j.cub.2022.07.022
  
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cell.com/current-biology/fulltext/S0960-9822(22)01123-X
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Systematic exploration of dynamic splicing networks reveals conserved multistage regulators of neurogenesis

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  DOI: 10.1016/j.molcel.2022.06.036
  
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Ras Inhibitor Lonafarnib Rescues Structural and Functional Impairments of Synapses of Aβ1-42 Mice via α7nAChR-Dependent BDNF Upregulation

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1. scibot 04 Aug 2022
  
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  DOI: 10.1523/JNEUROSCI.1989-21.2022
  
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jneurosci.org/content/42/31/6090
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The endoplasmic reticulum membrane complex promotes proteostasis of GABAA receptors

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  DOI: 10.1016/j.isci.2022.104754
  
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A dRASSF-STRIPAK-Imd-JAK/STAT axis controls antiviral immune response in Drosophila

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  DOI: 10.1016/j.celrep.2022.111143
  
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PABP/purine-rich motif as an initiation module for cap-independent translation in pattern-triggered immunity

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1. scibot 02 Aug 2022
  
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  DOI: 10.1016/j.cell.2022.06.037
  
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Regulation of alternative polyadenylation by the C2H2-zinc-finger protein Sp1

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  DOI: 10.1016/j.molcel.2022.06.031
  
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JNEUROSCI.1989-21.2022.full-html.html

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Phosphoproteomics of three exercise modalities identifies canonical signaling and C18ORF25 as an AMPK substrate regulating skeletal muscle function

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Varicella‐Zoster virus ORF9 is an antagonist of the DNA sensor cGAS

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Filter trapping protocol to detect aggregated proteins in human cell lines

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Long non-coding RNA EVADR induced by Fusobacterium nucleatum infection promotes colorectal cancer metastasis

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Acetylation of p62 regulates base excision repair through interaction with APE1

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Sen1 is a key regulator of transcription-driven conflicts

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Resolution of R-loops by topoisomerase III-β (TOP3B) in coordination with the DEAD-box helicase DDX5

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CaMKII binds both substrates and activators at the active site

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Recognition of HIV-1 capsid by PQBP1 licenses an innate immune sensing of nascent HIV-1 DNA

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Calpain-mediated cleavage generates a ZBTB18 N-terminal product that regulates HIF1A signaling and glioblastoma metabolism

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The SARS-CoV-2 protein NSP2 impairs the silencing capacity of the human 4EHP-GIGYF2 complex

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FKBP11 rewires UPR signaling to promote glucose homeostasis in type 2 diabetes and obesity

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Protective roles of MITOL against myocardial senescence and ischemic injury partly via Drp1 regulation

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Methionine oxidation activates pyruvate kinase M2 to promote pancreatic cancer metastasis

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Robust anti-SARS-CoV2 single domain antibodies cross neutralize multiple viruses

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MacroH2As regulate enhancer-promoter contacts affecting enhancer activity and sensitivity to inflammatory cytokines

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Protein interactome and cell-type expression analyses reveal that cytoplasmic FMR1-interacting protein 1 (CYFIP1), but not CYFIP2, associates with astrocytic focal adhesion

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cGAS and DDX41-STING mediated intrinsic immunity spreads intercellularly to promote neuroinflammation in SOD1 ALS model

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Pathogenic LRRK2 regulates centrosome cohesion via Rab10/RILPL1-mediated CDK5RAP2 displacement

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Tandem immuno-purification of affinity-tagged proteins from mouse testis extracts for MS analysis

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UBP12 and UBP13 deubiquitinases destabilize the CRY2 blue light receptor to regulate Arabidopsis growth

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TRPV1 SUMOylation suppresses itch by inhibiting TRPV1 interaction with H1 receptors

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Time-resolved Phosphoproteome and Proteome Analysis Reveals Kinase Signalling on Master Transcription Factors During Myogenesis

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Structure and regulation of the nuclear exosome targeting complex guides RNA substrates to the exosome

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An integrated model for Gpr124 function in Wnt7a/b signaling among vertebrates

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γ-secretase promotes Drosophila postsynaptic development through the cleavage of a Wnt receptor

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DDX41 is required for cGAS-STING activation against DNA virus infection

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ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1

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C/EBPδ-induced epigenetic changes control the dynamic gene transcription of S100a8 and S100a9

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Norepinephrine activates β1-adrenergic receptors at the inner nuclear membrane in astrocytes

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Postnatal expression of cell cycle promoter Fam64a causes heart dysfunction by inhibiting cardiomyocyte differentiation through repression of Klf15

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Mutations in DNA binding domain of p53 impede RSL1D1-p53 interaction to escape from degradation in human colorectal cancer cells

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Chromatin remodeling is restricted by transient GATA6 binding during iPSC differentiation to definitive endoderm

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Study of novel NARS2 variants in patient of combined oxidative phosphorylation deficiency 24

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Quantitative analysis of protein-RNA interactions in fission yeast

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Structures of oxysterol sensor EBI2/GPR183, a key regulator of the immune response

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Adipose mitochondrial metabolism controls body growth by modulating systemic cytokine and insulin signaling

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Retinoic acid-induced protein 14 controls dendritic spine dynamics associated with depressive-like behaviors

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KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4

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BAG6 prevents the aggregation of neurodegeneration-associated fragments of TDP43

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Gene regulatory networks shape developmental plasticity of root cell types under water extremes in rice

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ISL2 is a putative tumor suppressor whose epigenetic silencing reprograms the metabolism of pancreatic cancer

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Generation of RYBP FLAG-HA knock-in human embryonic stem cell line through CRISPR/Cas9-mediated homologous recombination

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The Mettl3 epitranscriptomic writer amplifies p53 stress responses

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PIIS2589004222005594-html.html

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Characterization and functional interrogation of the SARS-CoV-2 RNA interactome

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Purification and cryo-EM structure determination of VCP/p97 dodecamers from mammalian and bacterial cells

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Hexokinase 1 cellular localization regulates the metabolic fate of glucose

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Multilayered omics reveal sex- and depot-dependent adipose progenitor cell heterogeneity

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A presynaptic phosphosignaling hub for lasting homeostatic plasticity

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An oxygen-adaptive interaction between SNHG12 and occludin maintains blood-brain barrier integrity

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Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation

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CCT2 is an aggrephagy receptor for clearance of solid protein aggregates

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Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis

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CTCF functions as an insulator for somatic genes and a chromatin remodeler for pluripotency genes during reprogramming

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Neurexins play a crucial role in cerebellar granule cell survival by organizing autocrine machinery for neurotrophins

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Deadenylase-dependent mRNA decay of GDF15 and FGF21 orchestrates food intake and energy expenditure

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Elucidation of a complete mechanical signaling and virulence activation pathway in enterohemorrhagic Escherichia coli

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GFI1 cooperates with IKZF1/IKAROS to activate gene expression in T-cell acute lymphoblastic leukemia

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The roles of RNA helicases in DNA damage repair and tumorigenesis reveal precision therapeutic strategies

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Dual signaling via interferon and DNA damage response elicits entrapment by giant PML nuclear bodies

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GFPT2/GFAT2 and AMDHD2 act in tandem to control the hexosamine pathway

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K27-linked ubiquitylation promotes p97 substrate processing and is essential for cell proliferation

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Chromatin modifier HUSH co-operates with RNA decay factor NEXT to restrict transposable element expression

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Labeling of heterochronic ribosomes reveals C1ORF109 and SPATA5 control a late step in human ribosome assembly

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Chromatin-associated orphan snoRNA regulates DNA damage-mediated differentiation via a non-canonical complex

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Resolving the deceptive isoform and complex selectivity of HDAC1/2 inhibitors

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Precision analysis of mutant U2AF1 activity reveals deployment of stress granules in myeloid malignancies

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A local insulin reservoir in Drosophila alpha cell homologs ensures developmental progression under nutrient shortage

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RUFY3 and RUFY4 are ARL8 effectors that promote coupling of endolysosomes to dynein-dynactin

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Restriction factor screening identifies RABGAP1L-mediated disruption of endocytosis as a host antiviral defense

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SPT16 ubiquitylation by DCAF14-CRL4 regulates FACT binding to histones

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Neddylation is essential for β-catenin degradation in Wnt signaling pathway

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BMI-1 regulates DNA end resection and homologous recombination repair

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FBXO47 is essential for preventing the synaptonemal complex from premature disassembly in mouse male meiosis

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BPS Publications

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Selective YAP activation in Procr cells is essential for ovarian stem/progenitor expansion and epithelium repair

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Sox2-Evf2 lncRNA-mediated mechanisms of chromosome topological control in developing forebrain

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Regulation of mitochondrial fission by GIPC-mediated Drp1 retrograde transport

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Semaphorin3A/PlexinA3 association with the Scribble scaffold for cGMP increase is required for apical dendrite development

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Identification of the global miR-130a targetome reveals a role for TBL1XR1 in hematopoietic stem cell self-renewal and t(8;21) AML

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Notch-mediated lactate metabolism regulates MDSC development through the Hes1/MCT2/c-Jun axis

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Robust regulatory architecture of pan-neuronal gene expression

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K48/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase regulates oxidative stress-induced autophagy

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Eco1-dependent cohesin acetylation anchors chromatin loops and cohesion to define functional meiotic chromosome domains

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Fumarate inhibits PTEN to promote tumorigenesis and therapeutic resistance of type2 papillary renal cell carcinoma

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Generation of a GFI1-flag knock-in human embryonic stem cell line using CRISPR-Cas9 technology

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Micropeptide PACMP inhibition elicits synthetic lethal effects by decreasing CtIP and poly(ADP-ribosyl)ation

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Liquid-liquid phase separation of RBGD2/4 is required for heat stress resistance in Arabidopsis

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Cryo-EM structure of the human TACAN in a closed state

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Systematic mapping of nuclear domain-associated transcripts reveals speckles and lamina as hubs of functionally distinct retained introns

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Unresolved stalled ribosome complexes restrict cell-cycle progression after genotoxic stress

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LAMTOR1 inhibition of TRPML1-dependent lysosomal calcium release regulates dendritic lysosome trafficking and hippocampal neuronal function

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Phosphorylation of guanosine monophosphate reductase triggers a GTP-dependent switch from pro- to anti-oncogenic function of EPHA4

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The MuvB complex binds and stabilizes nucleosomes downstream of the transcription start site of cell-cycle dependent genes

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Mechanistic impact of oligomer poisoning by dominant-negative CARD11 variants

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Epigenetic basis of oncogenic-Kras-mediated epithelial-cellular proliferation and plasticity

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PD-L1 promotes myofibroblastic activation of hepatic stellate cells by distinct mechanisms selective for TGF-β receptor I versus II

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CRAF dimerization with ARAF regulates KRAS-driven tumor growth

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Identification of the nucleotide-free state as a therapeutic vulnerability for inhibition of selected oncogenic RAS mutants

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Tethering Piezo channels to the actin cytoskeleton for mechanogating via the cadherin-β-catenin mechanotransduction complex

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Co-adaptor driven assembly of a CUL3 E3 ligase complex

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In vivo CRISPR screening identifies BAZ2 chromatin remodelers as druggable regulators of mammalian liver regeneration

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Structurally-discovered KLF4 variants accelerate and stabilize reprogramming to pluripotency

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Liquidambaric acid inhibits Wnt/β-catenin signaling and colon cancer via targeting TNF receptor-associated factor 2

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Steroid hormone receptor and infiltrating immune cell status reveals therapeutic vulnerabilities of ESR1 mutant breast cancer.

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An oncogenic enhancer encodes selective selenium dependency in AML

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Activating JAK-mutations confer resistance to FLT3 kinase inhibitors in FLT3-ITD positive AML in vitro and in vivo

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Regulation of mitochondrial fission by GIPC-mediated Drp1 retrograde transport

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Regulation of reverse electron transfer at mitochondrial complex I by unconventional Notch action in cancer stem cells

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Cas11 enables genome engineering in human cells with compact CRISPR-Cas3 systems

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Compartmentalization of telomeres through DNA-scaffolded phase separation

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Selective autophagy controls innate immune response through a TAK1/TAB2/SH3PX1 axis

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Structural basis of K63-ubiquitin chain formation by the Gordon-Holmes syndrome RBR E3 ubiquitin ligase RNF216

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Type I and II PRMTs inversely regulate post-transcriptional intron detention through Sm and CHTOP methylation

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A fluorescence recovery after photobleaching protocol to measure surface diffusion of DAGLα in primary cultured cortical mouse neurons

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Global RNA interactome of Salmonella discovers a 5′ UTR sponge for the MicF small RNA that connects membrane permeability to transport capacity

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insomniac links the development and function of a sleep-regulatory circuit

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Metastasis enhancer PGRMC1 boosts store-operated Ca2+ entry by uncoiling Ca2+ sensor STIM1 for focal adhesion turnover and actomyosin formation

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Nuclear NAD+-biosynthetic enzyme NMNAT1 facilitates development and early survival of retinal neurons

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Innate immune sensing of influenza A viral RNA through IFI16 promotes pyroptotic cell death

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Endoplasmic reticulum-translocation is essential for APOL1 cellular toxicity

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GS-CA1 and lenacapavir stabilize the HIV-1 core and modulate the core interaction with cellular factors

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The sex determination gene doublesex regulates expression and secretion of the basement membrane protein Collagen IV

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Recruitment of MLL1 complex is essential for SETBP1 to induce myeloid transformation

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Identification and functional characterization of transcriptional activators in human cells

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Evolutionary analyses of the gasdermin family suggest conserved roles in infection response despite loss of pore-forming functionality

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Transmembrane topology and oligomeric nature of an astrocytic membrane protein, MLC1

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An antisense transcript transcribed from Irs2 locus contributes to the pathogenesis of hepatic steatosis in insulin resistance

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STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses

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NAD kinase sustains lipogenesis and mitochondrial metabolismthrough fatty acid synthesis

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Translocation of polyubiquitinated protein substrates by the hexameric Cdc48 ATPase

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RNA circles with minimized immunogenicity as potent PKR inhibitors

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Toxoplasma gondii SAG1 Targeting Host Cell S100A6 for Parasite Invasion and Host Immunity

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SARS-CoV-2 nucleocapsid protein binds host mRNAs and attenuates stress granules to impair host stress response

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Shed CNTNAP2 ectodomain is detectable in CSF and regulates Ca2+ homeostasis and network synchrony via PMCA2/ATP2B2

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  DOI: 10.1016/j.neuron.2021.11.025
  
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CD95/Fas suppresses NF-κB activation through recruitment of KPC2 in a CD95L/FasL-independent mechanism

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Prolyl endopeptidase-like is a (thio)esterase involved in mitochondrial respiratory chain function

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  DOI: 10.1016/j.isci.2021.103460
  
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Elevated FBXO45 promotes liver tumorigenesis through enhancing IGF2BP1 ubiquitination and subsequent PLK1 upregulation

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  DOI: 10.7554/eLife.70715
  
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Experiments from unfinished Registered Reports in the Reproducibility Project: Cancer Biology

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MYC assembles and stimulates topoisomerases 1 and 2 in a “topoisome”

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The protease SPRTN and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability

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Type 1 polyisoprenoid diphosphate phosphatase modulates geranylgeranyl-mediated control of HMG CoA reductase and UBIAD1

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NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis

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Anti-recombination function of MutSα restricts telomere extension by ALT-associated homology-directed repair

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SUMOylation of linker histone H1 drives chromatin condensation and restriction of embryonic cell fate identity

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Sumoylation of the human histone H4 tail inhibits p300-mediated transcription by RNA polymerase II in cellular extracts

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Single-cell transcriptomics identifies Gadd45b as a regulator of herpesvirus-reactivating neurons

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HRD1-mediated METTL14 degradation regulates m6A mRNA modification to suppress ER proteotoxic liver disease

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Elucidation and refinement of synthetic receptor mechanisms

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p190RhoGAP Filters Competing Signals to Resolve Axon Guidance Conflicts

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  DOI: 10.1016/j.neuron.2019.02.034
  
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MDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA

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  DOI: 10.1038/s41467-021-27062-5
  
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LARP7 ameliorates cellular senescence and aging by allosterically enhancing SIRT1 deacetylase activity

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MAR1 links membrane adhesion to membrane merger during cell-cell fusion in Chlamydomonas

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Bi-allelic variants in OGDHL cause a neurodevelopmental spectrum disease featuring epilepsy, hearing loss, visual impairment, and ataxia

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