Hypothesis

1,483 Matching Annotations

Jul 2023
52.53.155.43 52.53.155.43

qiad076-html.html

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1. scibot 07 Jul 2023
  
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  plasmid_52961
  
  DOI: 10.1093/jleuko/qiad076
  
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52.53.155.43/d58f6f13e6cc8ca0bc487138d6ae8d2f57dd2a0f/qiad076-html.html
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Cross-reactivity of anti-human programmed cell death ligand 1 (PD-L1) monoclonal antibody, clone 28-8 against feline PD-L1

1
1. scibot 06 Jul 2023
  
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  RRID:Addgene_52961
  
  DOI: 10.1292/jvms.23-0003
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10315546/
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Oncogenic K-Ras suppresses global miRNA function

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1. scibot 06 Jul 2023
  
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  Addgene_52961
  
  DOI: 10.1016/j.molcel.2023.06.008
  
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sciencedirect.com/science/article/pii/S109727652300429X
Jun 2023
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Microbiota-produced indole metabolites disrupt mitochondrial function and inhibit Cryptosporidium parvum growth

1
1. scibot 29 Jun 2023
  
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  Plasmid_52961
  
  DOI: 10.1016/j.celrep.2023.112680
  
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sciencedirect.com/science/article/pii/S2211124723006915
52.53.155.43 52.53.155.43

can-22-2220-html.html

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1. scibot 29 Jun 2023
  
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  RRID:Addgene_52961
  
  DOI: 10.1158/0008-5472.CAN-22-2220
  
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52.53.155.43/c22b1c168eadce7fd44ace820b381d5bba4fef1e/can-22-2220-html.html
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A functional link between lariat debranching enzyme and the intron-binding complex is defective in non-photosensitive trichothiodystrophy

1
1. scibot 28 Jun 2023
  
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  Addgene_52961
  
  DOI: 10.1016/j.molcel.2023.06.011
  
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sciencedirect.com/science/article/pii/S1097276523004331
www.nature.com www.nature.com

Extracellular vesicle-associated IGF2BP3 tunes Ewing sarcoma cell migration and affects PI3K/Akt pathway in neighboring cells

1
1. scibot 27 Jun 2023
  
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  RRID:Addgene_52961
  
  DOI: 10.1038/s41417-023-00637-8
  
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nature.com/articles/s41417-023-00637-8
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The effect of inhibition of receptor tyrosine kinase AXL on DNA damage response in ovarian cancer

1
1. scibot 24 Jun 2023
  
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  RRID:Addgene_52961
  
  DOI: 10.1038/s42003-023-05045-0
  
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nature.com/articles/s42003-023-05045-0
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Polycomb repressive complex 2 binds and stabilizes NANOG to suppress differentiation-related genes to promote self-renewal

1
1. scibot 23 Jun 2023
  
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  Plasmid_52961
  
  DOI: 10.1016/j.isci.2023.107035
  
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sciencedirect.com/science/article/pii/S2589004223011124
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FIRRM/C1orf112 is synthetic lethal with PICH and mediates RAD51 dynamics

1
1. scibot 23 Jun 2023
  
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  Addgene_52961
  
  DOI: 10.1016/j.celrep.2023.112668
  
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sciencedirect.com/science/article/pii/S2211124723006794
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Targeting fatty acid reprogramming suppresses CARM1-expressing ovarian cancer

1
1. scibot 22 Jun 2023
  
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  RRID:Addgene_52961
  
  DOI: 10.1158/2767-9764.CRC-23-0030
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10281290/
www.biorxiv.org www.biorxiv.org

Host ZCCHC3 blocks HIV-1 infection and production by a dual mechanism

1
1. scibot 22 Jun 2023
  
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  RRID:Addgene_52961
  
  DOI: 10.1101/2023.06.14.544911
  
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biorxiv.org/content/10.1101/2023.06.14.544911v2
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IKKα kinase coordinates BRD4 and JAK/STAT signaling to subvert DNA damage-based anticancer therapy

1
1. scibot 22 Jun 2023
  
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  RRID:Addgene_52961
  
  DOI: 10.1101/2023.06.13.544711
  
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biorxiv.org/content/10.1101/2023.06.13.544711v1
www.embopress.org www.embopress.org

DOT1L bridges transcription and heterochromatin formation at mammalian pericentromeres

1
1. scibot 22 Jun 2023
  
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  RRID:Addgene_52961
  
  DOI: 10.15252/embr.202256492
  
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embopress.org/doi/10.15252/embr.202256492
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Acetate controls endothelial-to-mesenchymal transition

1
1. scibot 21 Jun 2023
  
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  Addgene_52961
  
  DOI: 10.1016/j.cmet.2023.05.010
  
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sciencedirect.com/science/article/pii/S1550413123002036
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A mitochondrial iron-responsive pathway regulated by DELE1

1
1. scibot 21 Jun 2023
  
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  Addgene_52961
  
  DOI: 10.1016/j.molcel.2023.05.031
  
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sciencedirect.com/science/article/pii/S1097276523004136
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Exploring the Immunogenicity of Noncanonical HLA-I Tumor Ligands Identified through Proteogenomics

1
1. scibot 17 Jun 2023
  
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  RRID:Addgene_52961
  
  DOI: 10.1158/1078-0432.CCR-22-3298
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10261919/
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Oncogenic IDH mutations increase heterochromatin-related replication stress without impacting homologous recombination

1
1. scibot 16 Jun 2023
  
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  RRID:Addgene_52961
  
  DOI: 10.1016/j.molcel.2023.05.026
  
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sciencedirect.com/science/article/pii/S1097276523003829
aacrjournals.org aacrjournals.org

EBV-upregulated B7-H3 inhibits NK cell-mediated antitumor function and contributes to nasopharyngeal carcinoma progression

1
1. scibot 10 Jun 2023
  
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  RRID:Addgene_52961
  
  DOI: 10.1158/2326-6066.CIR-22-0374
  
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aacrjournals.org/cancerimmunolres/article/11/6/830/726521/EBV-Upregulated-B7-H3-Inhibits-NK-cell-Mediated
aacrjournals.org aacrjournals.org

(R)-2-hydroxyglutarate inhibits KDM5 histone lysine demethylases to drive transformation in IDH-mutant cancers

1
1. scibot 10 Jun 2023
  
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  RRID:Addgene_52961
  
  DOI: 10.1158/2159-8290.CD-22-0825
  
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aacrjournals.org/cancerdiscovery/article/13/6/1478/726967/R-2-Hydroxyglutarate-Inhibits-KDM5-Histone-Lysine
aacrjournals.org aacrjournals.org

MYC/glutamine dependency is a therapeutic vulnerability in pancreatic cancer with deoxycytidine kinase inactivation-induced gemcitabine resistance

1
1. scibot 10 Jun 2023
  
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  RRID:Addgene_52961
  
  DOI: 10.1158/1541-7786.MCR-22-0554
  
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aacrjournals.org/mcr/article/21/5/444/726027/MYC-Glutamine-Dependency-Is-a-Therapeutic
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Acid-adapted cancer cells alkalinize their cytoplasm by degrading the acid-loading membrane transporter anion exchanger 2, SLC4A2

1
1. scibot 07 Jun 2023
  
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  RRID:Addgene_52961
  
  DOI: 10.1016/j.celrep.2023.112601
  
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sciencedirect.com/science/article/pii/S2211124723006125
www.embopress.org www.embopress.org

STAT1 is required to establish but not maintain interferon-γ-induced transcriptional memory

1
1. scibot 06 Jun 2023
  
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  Addgene_52961
  
  DOI: 10.15252/embj.2022112259
  
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embopress.org/doi/10.15252/embj.2022112259
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Interplay between Furin and Sialoglycans in Modulating Adeno-Associated Viral Cell Entry

1
1. scibot 03 Jun 2023
  
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  RRID:Addgene_52961
  
  DOI: 10.1128/jvi.00093-23
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10231208/
febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com

Dual VEGFA/BRAF targeting boosts PD-1 blockade in melanoma through GM-CSF-mediated infiltration of M1 macrophages

1
1. scibot 01 Jun 2023
  
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  Addgene_52961
  
  DOI: 10.1002/1878-0261.13450
  
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febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13450
May 2023
www.sciencedirect.com www.sciencedirect.com

EWSR1 maintains centromere identity

1
1. scibot 27 May 2023
  
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  Plasmid_52961
  
  DOI: 10.1016/j.celrep.2023.112568
  
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sciencedirect.com/science/article/pii/S221112472300579X
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CDKN2A deletion remodels lipid metabolism to prime glioblastoma for ferroptosis

1
1. scibot 26 May 2023
  
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  RRID:Addgene_52961
  
  DOI: 10.1016/j.ccell.2023.05.001
  
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sciencedirect.com/science/article/pii/S153561082300168X
www.biorxiv.org www.biorxiv.org

Copyback viral genomes trigger stress granule formation independent of the antiviral response to interfere with viral translation in acute and persistent infections

1
1. scibot 25 May 2023
  
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  RRID:Addgene_52961
  
  DOI: 10.1101/2023.05.17.541157
  
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biorxiv.org/content/10.1101/2023.05.17.541157v1
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Multi-omics analysis reveals distinct non-reversion mechanisms of PARPi resistance in BRCA1- versus BRCA2-deficient mammary tumors

1
1. scibot 25 May 2023
  
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  RRID:Addgene_52961
  
  DOI: 10.1016/j.celrep.2023.112538
  
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sciencedirect.com/science/article/pii/S2211124723005491
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

ERK3/MAPK6 dictates CDC42/RAC1 activity and ARP2/3-dependent actin polymerization

1
1. scibot 21 May 2023
  
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  plasmid_52961
  
  DOI: 10.7554/eLife.85167
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10191626/
www.biorxiv.org www.biorxiv.org

Electron transport chain inhibition increases cellular dependence on purine transport and salvage

1
1. scibot 18 May 2023
  
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  RRID:Addgene_52961
  
  DOI: 10.1101/2023.05.11.540429
  
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biorxiv.org/content/10.1101/2023.05.11.540429v1
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Ubiquitin-independent proteasomal degradation driven by C-degron pathways

1
1. scibot 18 May 2023
  
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  Addgene_52961
  
  DOI: 10.1016/j.molcel.2023.04.023
  
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sciencedirect.com/science/article/pii/S1097276523003179
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Loss of AMPKα2 promotes melanoma tumor growth and brain metastasis

1
1. scibot 17 May 2023
  
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  Plasmid_52961
  
  DOI: 10.1016/j.isci.2023.106791
  
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sciencedirect.com/science/article/pii/S2589004223008684
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MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells

2
1. scibot 10 May 2023
  
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  RRID: Addgene_52961
  
  DOI: 10.1016/j.celrep.2023.112484
  
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2. scibot 10 May 2023
  
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  RRID:Addgene_52961
  
  DOI: 10.1016/j.celrep.2023.112484
  
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sciencedirect.com/science/article/pii/S2211124723004953
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Optimized metrics for orthogonal combinatorial CRISPR screens

1
1. scibot 09 May 2023
  
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  RRID:Addgene_52961
  
  DOI: 10.1038/s41598-023-34597-8
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10164157/
www.mdpi.com www.mdpi.com

Comparative Analysis of Six IRF Family Members in Alveolar Epithelial Cell-Intrinsic Antiviral Responses

1
1. scibot 06 May 2023
  
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  52961
  
  DOI: 10.3390/cells10102600
  
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  RRID:Addgene_52961 RRIDCUR:Missing
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mdpi.com/2073-4409/10/10/2600/htm
www.nature.com www.nature.com

Methionine consumption by cancer cells drives a progressive upregulation of PD-1 expression in CD4 T cells

2
1. scibot 06 May 2023
  
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  plasmid_52961
  
  DOI: 10.1038/s41467-023-38316-9
  
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Stress-induced perturbations in intracellular amino acids reprogram mRNA translation in osmoadaptation independently of the ISR

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Membrane-Tethered Mucin 1 Is Stimulated by Interferon and Virus Infection in Multiple Cell Types and Inhibits Influenza A Virus Infection in Human Airway Epithelium

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Neuropilin-1 Knockout and Rescue Confirms Its Role to Promote Metastasis in MDA-MB-231 Breast Cancer Cells

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Interplay between Furin and Sialoglycans in Modulating Adeno-Associated Viral Cell Entry

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Development of anti-feline PD-1 antibody and its functional analysis

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Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity

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A genome-wide CRISPR screen maps endogenous regulators of PPARG gene expression in bladder cancer

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VMP1 affects endoplasmic reticulum stress sensitivity via differential modulation of the three unfolded protein response arms

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Distinct roles of Bdnf I and Bdnf IV transcript variant expression in hippocampal neurons

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Targeting the mevalonate pathway suppresses ARID1A-inactivated cancers by promoting pyroptosis

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Ether phospholipids are required for mitochondrial reactive oxygen species homeostasis

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CRISPR-suppressor scanning for systematic discovery of drug resistance mutations

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The orphan receptor Nur77 binds cytoplasmic LPS to activate the non-canonical NLRP3 inflammasome

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Mar 2023
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Alternative splicing of its 5’ untranslated region controls CD20 mRNA translation and enables resistance to CD20-directed immunotherapies

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Primate TRIM34 is a broadly-acting, TRIM5-dependent lentiviral restriction factor

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Loss of the Volume-regulated Anion Channel Components LRRC8A and LRRC8D Limits Platinum Drug Efficacy

1
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Checkpoint kinase 1/2 inhibition potentiates anti-tumoral immune response and sensitizes gliomas to immune checkpoint blockade

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Tumor PD-L1 engages myeloid PD-1 to suppress type I interferon to impair cytotoxic T lymphocyte recruitment

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VCP/p97, a pleiotropic protein regulator of the DNA damage response and proteostasis, is a potential therapeutic target in KRAS-mutant pancreatic cancer

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IFNγ is a central node of cancer immune equilibrium

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KIF16B mediates anterograde transport and modulates lysosomal degradation of the HIV-1 envelope glycoprotein

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LRP6 Is a Functional Receptor for Attenuated Canine Distemper Virus

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LCP1 Regulates Cell Motility in Chondrosarcoma and Correlates with Metastatic Potential and Poor Patient Outcomes

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SYNGAP1 deficiency disrupts neoteny in human cortical neurons in vivo

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NF-κB activation enhances STING signaling by altering microtubule-mediated STING trafficking

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Activity-based CRISPR scanning uncovers allostery in DNA methylation maintenance machinery

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An adverse tumor-protective effect of IDO1 inhibition

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Huntingtin S421 phosphorylation increases kinesin and dynein engagement on early endosomes and lysosomes

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ERdj5 protects goblet cells from endoplasmic reticulum stress-mediated apoptosis under inflammatory conditions

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A modular CRISPR screen identifies individual and combination pathways contributing to HIV-1 latency

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CRISPR screening reveals a dependency on ribosome recycling for efficient SARS-CoV-2 programmed ribosomal frameshifting and viral replication

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KDM5A Inhibits Antitumor Immune Responses Through Downregulation of the Antigen-Presentation Pathway in Ovarian Cancer

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FKBP12 is a major regulator of ALK2 activity in multiple myeloma cells

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The endothelial-enriched lncRNA LINC00607 mediates angiogenic function

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Jan 2023
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ADAR RNA editing on antisense RNAs results in apparent U-to-C base changes on overlapping sense transcripts

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Smarcd3 is an epigenetic modulator of the metabolic landscape in pancreatic ductal adenocarcinoma

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TRIM28 secures skeletal stem cell fate during skeletogenesis by silencing neural gene expression and repressing GREM1/AKT/mTOR signaling axis

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LRP6 Is a Functional Receptor for Attenuated Canine Distemper Virus

1
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  DOI: 10.1128/mbio.03114-22
  
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Identifying the Transcriptional Drivers of Metastasis Embedded within Localized Melanoma

1
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SSRN-id4265019-html.html

3
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  DOI: 10.2139/ssrn.4265019
  
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Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression

1
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SSRN-id4267401-html.html

1
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Partial Truncation of the C-Terminal Domain of PTCH1 in Cancer Enhances Autophagy and Metabolic Adaptability

1
1. scibot 12 Jan 2023
  
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DIAPH3 condensates formed by liquid-liquid phase separation act as a regulatory hub for stress-induced actin cytoskeleton remodeling

1
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Identification of β2 microglobulin, the product of B2M gene, as a Host Factor for Vaccinia Virus Infection by Genome-Wide CRISPR genetic screens

1
1. scibot 11 Jan 2023
  
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Immune checkpoint therapy-elicited sialylation of IgG antibodies impairs antitumorigenic type I interferon responses in hepatocellular carcinoma

1
1. scibot 10 Jan 2023
  
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PRC2 Inactivating Mutations in Cancer Enhance Cytotoxic Response to DNMT1 Targeted Therapy via Enhanced Viral Mimicry

1
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Exosomal miR-27b-3p secreted by visceral adipocytes contributes to endothelial inflammation and atherogenesis

1
1. scibot 07 Jan 2023
  
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Ribosomal RNA-based epitranscriptomic regulation of chondrocyte translation and proteome in osteoarthritis

1
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Immortalization of primary marmoset skin fibroblasts by CRISPR-Cas9-mediated gene targeting

1
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  DOI: 10.1080/19768354.2022.2151509
  
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Metabolic enzyme UAP1 mediates IRF3 pyrophosphorylation to facilitate innate immune response

1
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Functional partitioning of transcriptional regulators by patterned charge blocks

1
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Palmitoylation prevents sustained inflammation by limiting NLRP3 inflammasome activation through chaperone-mediated autophagy

1
1. scibot 04 Jan 2023
  
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  DOI: 10.1016/j.molcel.2022.12.002
  
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Genetic and pharmacological modulation of DNA mismatch repair heterogeneous tumors promotes immune surveillance

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  DOI: 10.1016/j.ccell.2022.12.003
  
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cell.com/cancer-cell/fulltext/S1535-6108(22)00589-X
Dec 2022
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DNA damage repair kinase DNA-PK and cGAS synergize to induce cancer-related inflammation in glioblastoma

4
1. scibot 31 Dec 2022
  
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  DOI: 10.15252/embj.2022111961
  
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Characterizing the metabolic role of STAT3 in canine osteosarcoma

1
1. scibot 30 Dec 2022
  
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  DOI: 10.1111/vco.12841
  
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Calcium phosphate-based nanomedicine mediated CRISPR/Cas9 delivery for prostate cancer therapy

1
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  DOI: 10.3389/fbioe.2022.1078342
  
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The Golgi-resident protein ACBD3 concentrates STING at ER-Golgi contact sites to drive export from the ER

1
1. scibot 24 Dec 2022
  
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ΔNp63/p73 drive metastatic colonization by controlling a regenerative epithelial stem cell program in quasi-mesenchymal cancer stem cells

1
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Macrophage NFATC2 mediates angiogenic signaling during mycobacterial infection

1
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Hyaluronan driven by epithelial aPKC deficiency remodels the microenvironment and creates a vulnerability in mesenchymal colorectal cancer

1
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  DOI: 10.1016/j.ccell.2022.11.016
  
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SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-β signaling

1
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  DOI: 10.1038/s41467-022-34910-5
  
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nature.com/articles/s41467-022-34910-5
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An ER phospholipid hydrolase drives ER-associated mitochondrial constriction for fission and fusion

1
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  DOI: 10.7554/eLife.84279
  
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USP32-regulated LAMTOR1 ubiquitination impacts mTORC1 activation and autophagy induction

1
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  plasmid_52961
  
  DOI: 10.1016/j.celrep.2022.111653
  
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MUC5B mobilizes and MUC5AC spatially aligns mucociliary transport on human airway epithelium

1
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  DOI: 10.1126/sciadv.abq5049
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9699686/
www.tandfonline.com www.tandfonline.com

Immortalization of primary marmoset skin fibroblasts by CRISPR-Cas9-mediated gene targeting

1
1. scibot 05 Dec 2022
  
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  RRID:Addgene_52961
  
  DOI: 10.1080/19768354.2022.2151509
  
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Specific and efficient gene knockout and overexpression in mouse interscapular brown adipocytes in vivo

1
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  DOI: 10.1016/j.xpro.2022.101895
  
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BRAFV600E in colorectal cancer reduces sensitivity to oxidative stress and promotes site-specific metastasis by stimulating glutathione synthesis

1
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LPA maintains innate antiviral immunity in a pro-active state via STK38L-mediated IRF3 Ser303 phosphorylation

1
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Human IFNAR2 Mutant Generated by CRISPR/Cas9-Induced Exon Skipping Upregulates a Subset of Tonic-Like Interferon-Stimulated Genes Upon IFNβ Stimulation

2
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  RRID:Addgene_52961
  
  DOI: 10.1089/jir.2022.0158
  
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  DOI: 10.1089/jir.2022.0158
  
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liebertpub.com/doi/full/10.1089/jir.2022.0158
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POLθ processes ssDNA gaps and promotes replication fork progression in BRCA1-deficient cells

1
1. scibot 18 Nov 2022
  
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  RRID:Addgene_52961
  
  DOI: 10.1016/j.celrep.2022.111716
  
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Arc controls alcohol cue relapse by a central amygdala mechanism

1
1. scibot 15 Nov 2022
  
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  DOI: 10.1038/s41380-022-01849-4
  
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1. scibot 11 Nov 2022
  
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  RRID:Addgene_52961
  
  DOI: 10.21203/rs.3.rs-658360/v1
  
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Systematic generation and imaging of tandem repeats reveal base-pairing properties that promote RNA aggregation

1
1. scibot 10 Nov 2022
  
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  DOI: 10.1016/j.crmeth.2022.100334
  
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Dissecting the genetic and microenvironmental factors of gastric tumorigenesis in mice

1
1. scibot 05 Nov 2022
  
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Lysosome Docking to WIPI1 Rings and ER-connected Phagophores Occurs During DNAJB12 and GABARAP-Dependent Selective Autophagy of Misfolded P23H-Rhodopsin

1
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Genome-wide base editor screen identifies regulators of protein abundance in yeast

1
1. scibot 04 Nov 2022
  
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Multiphase coalescence mediates Hippo pathway activation

1
1. scibot 03 Nov 2022
  
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52.53.155.43 52.53.155.43

The lysosome membrane protein, Sidt2: A novel insulin granule membrane protein regulates β cell dedifferentiation by a new pathway involving insulin secretion

1
1. scibot 03 Nov 2022
  
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  DOI: 10.21203/rs.3.rs-1957968/v1
  
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52.53.155.43 52.53.155.43

Arc controls alcohol cue relapse by a central amygdala mechanism

1
1. scibot 03 Nov 2022
  
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  RRID:Addgene_52961
  
  DOI: 10.21203/rs.3.rs-1917417/v1
  
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HIF1α-AS1 is a DNA:DNA:RNA triplex-forming lncRNA interacting with the HUSH complex

1
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  DOI: 10.1038/s41467-022-34252-2
  
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Oct 2022
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Highly Conserved Interaction Profiles between Clinically Relevant Mutants of the Cytomegalovirus CDK-like Kinase pUL97 and Human Cyclins: Functional Significance of Cyclin H

1
1. scibot 26 Oct 2022
  
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  DOI: 10.3390/ijms231911814
  
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CASK loss of function differentially regulates neuronal maturation and synaptic function in human induced cortical excitatory neurons

1
1. scibot 19 Oct 2022
  
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  DOI: 10.1016/j.isci.2022.105187
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9574418/
Sep 2022
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De novo sphingolipid biosynthesis necessitates detoxification in cancer cells

1
1. scibot 29 Sep 2022
  
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  Plasmid_52961
  
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Zinc-finger antiviral protein-mediated inhibition of porcine epidemic diarrhea virus growth is antagonized by the coronaviral nucleocapsid protein

1
1. scibot 24 Sep 2022
  
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  RRID:Addgene_52961
  
  DOI: 10.3389/fmicb.2022.975632
  
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Meteorin links the bone marrow hypoxic state to hematopoietic stem/progenitor cell mobilization

1
1. scibot 22 Sep 2022
  
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CRISPR-Cas9 screen in human embryonic stem cells to identify genes required for neural differentiation

1
1. scibot 18 Sep 2022
  
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  plasmid_52961
  
  DOI: 10.1016/j.xpro.2022.101682
  
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Targeting of MCL-1 in breast cancer-associated fibroblasts reverses their myofibroblastic phenotype and pro-invasive properties

1
1. scibot 16 Sep 2022
  
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  plasmid_52961
  
  DOI: 10.1038/s41419-022-05214-9
  
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NCOA4-mediated ferritinophagy is a pancreatic cancer dependency via maintenance of iron bioavailability for iron-sulfur cluster proteins

1
1. scibot 10 Sep 2022
  
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  RRID:Addgene_52961
  
  DOI: 10.1158/2159-8290.CD-22-0043
  
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faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com

Sirtuin 6 protects against hepatic fibrogenesis by suppressing the YAP and TAZ function

1
1. scibot 09 Sep 2022
  
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  RRID:Addgene_52961
  
  DOI: 10.1096/fj.202200522R
  
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S1-END-seq reveals DNA secondary structures in human cells

1
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Membrane-Tethered Mucin 1 Is Stimulated by Interferon and Virus Infection in Multiple Cell Types and Inhibits Influenza A Virus Infection in Human Airway Epithelium

1
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  RRID:Addgene_52961
  
  DOI: 10.1128/mbio.01055-22
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9426523/
Aug 2022
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RBM45 is an m6A-binding protein that affects neuronal differentiation and the splicing of a subset of mRNAs

1
1. scibot 31 Aug 2022
  
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  Plasmid #52961
  
  DOI: 10.1016/j.celrep.2022.111293
  
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Induction of tumor cell autosis by myxoma virus-infected CAR-T and TCR-T cells to overcome primary and acquired resistance

1
1. scibot 27 Aug 2022
  
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  AddgeneCat#52961
  
  DOI: 10.1016/j.ccell.2022.08.001
  
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52.53.155.43 52.53.155.43

cd-21-1671-html.html

1
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  RRID:Addgene_52961
  
  DOI: 10.1158/2159-8290.cd-21-1671
  
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52.53.155.43/5e67ddaf80a7b90ec85c4b24452e48b76eabacbf/cd-21-1671-html.html
onlinelibrary.wiley.com onlinelibrary.wiley.com

BNIP-2 Activation of Cellular Contractility Inactivates YAP for H9c2 Cardiomyoblast Differentiation

1
1. scibot 24 Aug 2022
  
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  Addgene_52961
  
  DOI: 10.1002/advs.202202834
  
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onlinelibrary.wiley.com/doi/10.1002/advs.202202834
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Glycosphingolipids are mediators of cancer plasticity through independent signaling pathways

1
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  RRID:Addgene_52961
  
  DOI: 10.1016/j.celrep.2022.111181
  
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The redox cycling of STAT2 maintains innate immune homeostasis

1
1. scibot 17 Aug 2022
  
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  RRID:addgene-52961
  
  DOI: 10.1016/j.celrep.2022.111215
  
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Relationship of microsatellite instability to mismatch repair deficiency in malignant tumors of dogs

1
1. scibot 13 Aug 2022
  
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  RRID: Addgene 52961
  
  DOI: 10.1111/jvim.16454
  
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Discovery of compounds that reactivate p53 mutants in vitro and in vivo

1
1. scibot 12 Aug 2022
  
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Attenuation of SARS‐CoV‐2 replication and associated inflammation by concomitant targeting of viral and host cap 2'‐O‐ribose methyltransferases

1
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  RRID:Addgene_52961
  
  DOI: 10.15252/embj.2022111608
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9350232/
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Prominin1 and Notch Regulate Ciliary Length and Dynamics in Multiciliated Cells of the Airway Epithelium.

2
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  RRID:Addgene_52961
  
  DOI: 10.1016/j.isci.2022.104751
  
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  DOI: 10.1016/j.isci.2022.104751
  
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Regulation of alternative polyadenylation by the C2H2-zinc-finger protein Sp1

1
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  plasmid_52961
  
  DOI: 10.1016/j.molcel.2022.06.031
  
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Jul 2022
52.53.155.43 52.53.155.43

can-21-4313-html.html

1
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  Addgene 52961
  
  DOI: 10.1158/0008-5472.CAN-21-4313
  
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52.53.155.43/cccf0ba471fe636f8ee073caf3b8f7a0d9b2bd8e/can-21-4313-html.html
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FAM69C, a kinase critical for synaptic function and memory, is defective in neurodegenerative dementia

1
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  AddgeneCat# 52961
  
  DOI: 10.1016/j.celrep.2022.111101
  
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Development of STEAP1 targeting chimeric antigen receptor for adoptive cell therapy against cancer

1
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  RRID:Addgene_52961
  
  DOI: 10.1016/j.omto.2022.06.007
  
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52.53.155.43 52.53.155.43

157644.1-20220517111248-covered-e0fd13ba177f913fd3156f593ead4cfd-html.html

1
1. scibot 01 Jul 2022
  
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  RRID:Addgene_52961
  
  DOI: 10.1172/JCI157644
  
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Jun 2022
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Integrating multi-omics data reveals function and therapeutic potential of deubiquitinating enzymes

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Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence

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Lenalidomide bypasses CD28 co-stimulation to reinstate PD-1 immunotherapy by activating Notch signaling

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Targeting EP2 receptor with multifaceted mechanisms for high-risk neuroblastoma

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Vitamin D Receptor activation attenuates Hippo pathway effectors and cell survival in metastatic neuroblastoma

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BCL-2 isoform β promotes angiogenesis by TRiC-mediated upregulation of VEGF-A in lymphoma

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LXRβ Activation Inhibits the Proliferation of Small-cell Lung Cancer Cells by Depleting Cellular Cholesterol

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  RRID:Addgene_52961
  
  DOI: 10.21873/anticanres.15774
  
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Metabolic-scale gene activation screens identify SLCO2B1 as a heme transporter that enhances cellular iron availability

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Oncofusion-driven de novo enhancer assembly promotes malignancy in Ewing sarcoma via aberrant expression of the stereociliary protein LOXHD1

1
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Undercarboxylated, but not Carboxylated, Osteocalcin suppresses TNF-α induced inflammatory signaling pathway in Myoblast

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  DOI: 10.1210/jendso/bvac084
  
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Cryo-sensitive aggregation triggers NLRP3 inflammasome assembly in cryopyrin-associated periodic syndrome

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RNF31 inhibition sensitizes tumors to bystander killing by innate and adaptive immune cells

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Deubiquitinase OTUD3 regulates metabolism homeostasis in response to nutritional stresses

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HIF1α/HIF2α induces glioma cell dedifferentiation into cancer stem cells through Sox2 under hypoxic conditions

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The SETDB1–TRIM28 complex suppresses antitumor immunity

1
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  DOI: 10.1158/2326-6066.CIR-21-0754
  
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HER2 G776S mutation promotes oncogenic potential in colorectal cancer cells when accompanied by loss of APC function

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  DOI: 10.1038/s41598-022-13189-y
  
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Intrinsic antiviral immunity of barrier cells revealed by an iPSC-derived blood-brain barrier cellular model

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LL-37 transports immunoreactive cGAMP to activate STING signaling and enhance interferon-mediated host antiviral immunity

1
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  RRID:Addgene_52961
  
  DOI: 10.1016/j.celrep.2022.110880
  
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Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson’s disease

1
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May 2022
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Endocytic trafficking of GAS6–AXL complexes is associated with sustained AKT activation

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DDX41 is required for cGAS-STING activation against DNA virus infection

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HIV-1 exploits the Fanconi anemia pathway for viral DNA integration

1
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OGG1 Inhibition Triggers Synthetic Lethality and Enhances The Effect of PARP Inhibitor Olaparib in BRCA1-Deficient TNBC Cells

1
1. scibot 26 May 2022
  
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  plasmid_52961
  
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C/EBPδ-induced epigenetic changes control the dynamic gene transcription of S100a8 and S100a9

1
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  RRID:Addgene_52961
  
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Human NLRP1 is a sensor of pathogenic coronavirus 3CL proteases in lung epithelial cells

1
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Melanoma-secreted Amyloid Beta Suppresses Neuroinflammation and Promotes Brain Metastasis

1
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  RRID:Addgene_52961
  
  DOI: 10.1158/2159-8290.CD-21-1006
  
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aacrjournals.org/cancerdiscovery/article/12/5/1314/694563/Melanoma-Secreted-Amyloid-Beta-Suppresses
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Lymph node colonization induces tumor-immune tolerance to promote distant metastasis

1
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  plasmid_52961
  
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The lactate-NAD+ axis activates cancer-associated fibroblasts by downregulating p62

1
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  AddgeneCat# 52961
  
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The immune checkpoint B7-H3 (CD276) regulates adipocyte progenitor metabolism and obesity development

1
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  RRID:Addgene_52961
  
  DOI: 10.1126/sciadv.abm7012
  
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The immune checkpoint B7-H3 (CD276) regulates adipocyte progenitor metabolism and obesity development

1
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  RRID:Addgene_52961
  
  DOI: 10.1126/sciadv.abm7012
  
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Transmembrane serine protease 2 (TMPRSS2) proteolytically activates the epithelial sodium channel (ENaC) by cleaving the channel’s γ-subunit

2
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  RRID: Addgene 52961
  
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A myosin chaperone, UNC-45A, is a novel regulator of intestinal epithelial barrier integrity and repair

1
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  RRID:Addgene_52961
  
  DOI: 10.1096/fj.202200154R
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9044500/
Apr 2022
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Functional genetic screen identifies ITPR3/calcium/RELB axis as a driver of colorectal cancer metastatic liver colonization

1
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  DOI: 10.1016/j.devcel.2022.04.010
  
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Identifying a confused cell identity for esophageal squamous cell carcinoma

1
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  RRID:Addgene_52961
  
  DOI: 10.1038/s41392-022-00946-8
  
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Establishing transgenic murine esophageal organoids

1
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  DOI: 10.1016/j.xpro.2022.101317
  
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CDK2 Inhibition Enhances Antitumor Immunity by Increasing IFN Response to Endogenous Retroviruses

1
1. scibot 22 Apr 2022
  
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  plasmid_52961
  
  DOI: 10.1158/2326-6066.CIR-21-0806
  
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aacrjournals.org/cancerimmunolres/article/10/4/525/689540/CDK2-Inhibition-Enhances-Antitumor-Immunity-by
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In vitro and in vivo assay of the ER lipid scramblase TMEM41B

1
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  Addgene Cat# 52961
  
  DOI: 10.1016/j.xpro.2022.101333
  
  Resource: RRID:Addgene_52961
  
  Curator: @sophiastull
  
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sciencedirect.com/science/article/pii/S2666166722002131
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Multilayered omics reveal sex- and depot-dependent adipose progenitor cell heterogeneity

2
1. scibot 21 Apr 2022
  
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  AddgeneCat# 52961
  
  DOI: 10.1016/j.cmet.2022.03.012
  
  Resource: RRID:Addgene_52961
  
  Curator: @sophiastull
  
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  RRID:Addgene_52961
2. scibot 21 Apr 2022
  
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  Addgene_52961
  
  DOI: 10.1016/j.cmet.2022.03.012
  
  Resource: RRID:Addgene_52961
  
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sciencedirect.com/science/article/pii/S1550413122001267
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Mitochondrial dynamics regulate genome stability via control of caspase-dependent DNA damage

1
1. scibot 21 Apr 2022
  
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  RRID:Addgene_52961
  
  DOI: 10.1016/j.devcel.2022.03.019
  
  Resource: RRID:Addgene_52961
  
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sciencedirect.com/science/article/pii/S1534580722002295
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Rapid establishment of human colonic organoid knockout lines

1
1. scibot 14 Apr 2022
  
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  plasmid_52961
  
  DOI: 10.1016/j.xpro.2022.101308
  
  Resource: RRID:Addgene_52961
  
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sciencedirect.com/science/article/pii/S2666166722001885
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CHMP2A regulates tumor sensitivity to natural killer cell-mediated cytotoxicity

1
1. scibot 12 Apr 2022
  
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  Addgene_52961
  
  DOI: 10.1038/s41467-022-29469-0
  
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nature.com/articles/s41467-022-29469-0
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Virally programmed extracellular vesicles sensitize cancer cells to oncolytic virus and small molecule therapy

1
1. scibot 12 Apr 2022
  
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  RRID:Addgene_52961
  
  DOI: 10.1038/s41467-022-29526-8
  
  Resource: RRID:Addgene_52961
  
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nature.com/articles/s41467-022-29526-8
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Altered BAF occupancy and transcription factor dynamics in PBAF-deficient melanoma

1
1. scibot 07 Apr 2022
  
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  AddgeneCat# 52961
  
  DOI: 10.1016/j.celrep.2022.110637
  
  Resource: RRID:Addgene_52961
  
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sciencedirect.com/science/article/pii/S2211124722003898
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Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis

1
1. scibot 07 Apr 2022
  
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  RRID:Addgene_52961
  
  DOI: 10.1016/j.molcel.2022.03.016
  
  Resource: RRID:Addgene_52961
  
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sciencedirect.com/science/article/pii/S1097276522002544
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Generation of a CHIP isogenic human iPSC-derived cortical neuron model for functional proteomics

1
1. scibot 07 Apr 2022
  
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  RRID:Addgene_52961
  
  DOI: 10.1016/j.xpro.2022.101247
  
  Resource: RRID:Addgene_52961
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8980993/

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