1,483 Matching Annotations
  1. Oct 2020
  2. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    A Marine Alkaloid, Ascomylactam A, Suppresses Lung Tumorigenesis via Inducing Cell Cycle G1/S Arrest through ROS/Akt/Rb Pathway
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    pubmed.ncbi.nlm.nih.gov/32992455/
  3. Sep 2020
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    Reducing NADPH Synthesis Counteracts Diabetic Nephropathy through Restoration of AMPK Activity in Type 1 Diabetic Rats
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    sciencedirect.com/science/article/pii/S2211124720311967
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    Divergent Roles of PI3K Isoforms in PTEN-Deficient Glioblastomas
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    pubmed.ncbi.nlm.nih.gov/32997991/
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    BPS Publications
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.14980
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    Rheb1-Independent Activation of mTORC1 in Mammary Tumors Occurs through Activating Mutations in mTOR
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    sciencedirect.com/science/article/pii/S2211124720305209
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    A Live-Cell Screen for Altered Erk Dynamics Reveals Principles of Proliferative Control
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    sciencedirect.com/science/article/pii/S2405471220300752
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    Secreted Phospholipase PLA2G2D Contributes to Metabolic Health by Mobilizing ω3 Polyunsaturated Fatty Acids in WAT
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    GLP-1 Receptor Signaling in Astrocytes Regulates Fatty Acid Oxidation, Mitochondrial Integrity, and Function
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    An Acetylation Switch of the NLRP3 Inflammasome Regulates Aging-Associated Chronic Inflammation and Insulin Resistance
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    ncbi.nlm.nih.gov/pmc/articles/PMC7104778/
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    11q Deletion or ALK Activity Curbs DLG2 Expression to Maintain an Undifferentiated State in Neuroblastoma
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    The Kinase Activity of Drosophila BubR1 Is Required for Insulin Signaling-Dependent Stem Cell Maintenance
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    Entosis and apical cell extrusion constitute a tumor-suppressive mechanism downstream of MatriptaseThe double face of Matriptase
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    Tau Reduction Prevents Key Features of Autism in Mouse Models
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    Leukemogenic Chromatin Alterations Promote AML Leukemia Stem Cells via a KDM4C-ALKBH5-AXL Signaling Axis
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    Macropinocytosis Renders a Subset of Pancreatic Tumor Cells Resistant to mTOR Inhibition
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    Methylglyoxal Scavengers Resensitize KRAS-Mutated Colorectal Tumors to Cetuximab
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    ADORA1 Inhibition Promotes Tumor Immune Evasion by Regulating the ATF3-PD-L1 Axis
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    Tumor Microenvironment-Derived NRG1 Promotes Antiandrogen Resistance in Prostate Cancer
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    Adipocyte-Derived Versican and Macrophage-Derived Biglycan Control Adipose Tissue Inflammation in Obesity
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    Functional Analysis of KIT Gene Structural Mutations Causing the Porcine Dominant White Phenotype Using Genome Edited Mouse Models
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    ncbi.nlm.nih.gov/pmc/articles/PMC7063667/
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    UBE3A-mediated p18/LAMTOR1 ubiquitination and degradation regulate mTORC1 activity and synaptic plasticity
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    Glioblastoma Cell Resistance to EGFR and MET Inhibition Can Be Overcome via Blockade of FGFR-SPRY2 Bypass Signaling
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    Runx2+ Niche Cells Maintain Incisor Mesenchymal Tissue Homeostasis through IGF Signaling
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    Secreted Pyruvate Kinase M2 Promotes Lung Cancer Metastasis through Activating the Integrin Beta1/FAK Signaling Pathway
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    Targeting the Tie2–α v β 3 integrin axis with bi-specific reagents for the inhibition of angiogenesis
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    Consumption of a palatable diet rich in simple sugars during development impairs memory of different degrees of emotionality and changes hippocampal plasticity according to the age of the rats
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    Antidiabetic activity in vitro and in vivo of BDB, protein tyrosine phosphatase 1B selective inhibitor from Rhodonela conferviodes
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    Failed Apoptosis Enhances Melanoma Cancer Cell Aggressiveness
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    Vessel-derived angiocrine IGF-1 promotes Meckel's cartilage proliferation to drive jaw growth during embryogenesis
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    Glycolysis-Independent Glucose Metabolism Distinguishes TE from ICM Fate during Mammalian Embryogenesis
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    Knocking Out Non-muscle Myosin II in Retinal Ganglion Cells Promotes Long-Distance Optic Nerve Regeneration
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    Inhibition of MEK1/2 Forestalls the Onset of Acquired Resistance to Entrectinib in Multiple Models of NTRK1-Driven Cancer
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    Predictive and Pharmacodynamic Biomarkers of Response to the Phosphatidylinositol 3-Kinase Inhibitor Taselisib in Breast Cancer Preclinical Models
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    Opposing p53 and mTOR/AKT promote an in vivo switch from apoptosis to senescence upon telomere shortening in zebrafish
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    H1N1 Influenza Virus Cross-Activates Gli1 to Disrupt the Intercellular Junctions of Alveolar Epithelial Cells
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    Neurofibromin Is an Estrogen Receptor-α Transcriptional Co-repressor in Breast Cancer
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    Activation of metabotropic glutamate receptor 4 regulates proliferation and neural differentiation in neural stem/progenitor cells of the rat subventricular zone and increases phosphatase and tensin homolog protein expression
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    Defining and Targeting Adaptations to Oncogenic KRASG12C Inhibition Using Quantitative Temporal Proteomics
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    TNFAIP3 Interacting Protein 3 Overexpression Suppresses Nonalcoholic Steatohepatitis by Blocking TAK1 Activation
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    Reelin activates the small GTPase TC10 and VAMP7 to promote neurite outgrowth and regeneration of dorsal root ganglia (DRG) neurons
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    Periostin Promotes Colorectal Tumorigenesis through Integrin-FAK-Src Pathway-Mediated YAP/TAZ Activation
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    Proximal Tubule mTORC1 Is a Central Player in the Pathophysiology of Diabetic Nephropathy and Its Correction by SGLT2 Inhibitors
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  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genetic inactivation of mTORC1 or mTORC2 in neurons reveals distinct functions in glutamatergic synaptic transmission
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    Gut hormone GIP induces inflammation and insulin resistance in the hypothalamus
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    Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids
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    Genome-wide kinetic properties of transcriptional bursting in mouse embryonic stem cells
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  53. elifesciences.org elifesciences.org
    HNF1A is a novel oncogene that regulates human pancreatic cancer stem cell properties
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    PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells
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    Pyruvate Kinase M2 Promotes the Activation of Dendritic Cells by Enhancing IL-12p35 Expression
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    Disc1 Carrier Mice Exhibit Alterations in Neural pIGF-1Rβ and Related Kinase Expression
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    ncbi.nlm.nih.gov/pmc/articles/PMC7214624/
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    Aster‐C coordinates with COP I vesicles to regulate lysosomal trafficking and activation of mTORC1
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    embopress.org/doi/abs/10.15252/embr.201949898
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    Looking for a Better Characterization of Triple-Negative Breast Cancer by Means of Circulating Tumor Cells
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    Low-density lipoprotein receptor-related protein 1 deficiency in cardiomyocytes reduces susceptibility to insulin resistance and obesity
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    Phenotypic Screen with TSC-Deficient Neurons Reveals Heat-Shock Machinery as a Druggable Pathway for mTORC1 and Reduced Cilia
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  61. www.cell.com www.cell.com
    Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies
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    Gab1 mediates PDGF signaling and is essential to oligodendrocyte differentiation and CNS myelination
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    ncbi.nlm.nih.gov/pmc/articles/PMC6984811/
  63. stke.sciencemag.org stke.sciencemag.org
    Blocking EGFR palmitoylation suppresses PI3K signaling and mutant KRAS lung tumorigenesis
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    IGF-1 Signalling Regulates Mitochondria Dynamics and Turnover through a Conserved GSK-3β–Nrf2–BNIP3 Pathway
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  65. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    IKKε and TBK1 in diffuse large B‐cell lymphoma: A possible mechanism of action of an IKKε/TBK1 inhibitor to repress NF‐κB and IL‐10 signalling
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    High expression of miR-135b predicts malignant transformation and poor prognosis of gastric cancer
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  67. mcr.aacrjournals.org mcr.aacrjournals.org
    Dual Regulation of Histone Methylation by mTOR Complexes Controls Glioblastoma Tumor Cell Growth via EZH2 and SAM
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  68. journals.physiology.org journals.physiology.org
    Lactational metformin exposure programs offspring white adipose tissue glucose homeostasis and resilience to metabolic stress in a sex-dependent manner | American Journal of Physiology-Endocrinology and Metabolism
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    journals.physiology.org/doi/full/10.1152/ajpendo.00473.2019
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    Fibroblast-Derived STC-1 Modulates Tumor-Associated Macrophages and Lung Adenocarcinoma Development
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    Intermittent fasting promotes adult hippocampal neuronal differentiation by activating GSK‐3β in 3xTg‐AD mice
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    Biallelic Mutations in TSC2 Lead to Abnormalities Associated with Cortical Tubers in Human iPSC-Derived Neurons
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  72. Mar 2020
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  74. Jan 2020
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    Synthetic Essentiality of Metabolic Regulator PDHK1 in PTEN-Deficient Cells and Cancers
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    Altered Central Nutrient Sensing in Male Mice Lacking Insulin Receptors in Glut4-expressing Neurons
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    Mesothelial Cell HIF1α Expression Is Metabolically Downregulated by Metformin to Prevent Oncogenic Tumor-Stromal Crosstalk
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    An mTORC1-to-CDK1 Switch Maintains Autophagy Suppression during Mitosis
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    Angiotensinogen in hepatocytes contributes to Western diet-induced liver steatosis
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  80. dev.biologists.org dev.biologists.org
    Nutrient restriction causes reversible G2 arrest in Xenopus neural progenitors
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    Discovery of Small-Molecule Selective mTORC1 Inhibitors via Direct Inhibition of Glucose Transporters
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    TRIM32/USP11 Balances ARID1A Stability and the Oncogenic/Tumor-Suppressive Status of Squamous Cell Carcinoma
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    Upregulation of GLT-1 via PI3K/Akt Pathway Contributes to Neuroprotection Induced by Dexmedetomidine
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    Identification of a Paracrine Signaling Mechanism Linking CD34high Progenitors to the Regulation of Visceral Fat Expansion and Remodeling
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    EGFR-Pak Signaling Selectively Regulates Glutamine Deprivation-Induced Macropinocytosis
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    Keratinocyte growth factor reduces injury and leads to early recovery from cyclophosphamide bladder injury
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    Co-chaperones TIMP2 and AHA1 Competitively Regulate Extracellular HSP90:Client MMP2 Activity and Matrix Proteolysis
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    eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma
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  89. elifesciences.org elifesciences.org
    Extracellular Pgk1 enhances neurite outgrowth of motoneurons through Nogo66/NgR-independent targeting of NogoA
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