3,973 Matching Annotations
  1. Mar 2025
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A positive feedback loop between SMAD3 and PINK1 in regulation of mitophagy
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    pmc.ncbi.nlm.nih.gov/articles/PMC11894195/
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Trans-Golgi network tethering factors regulate TBK1 trafficking and promote the STING-IFN-I pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC11914254/
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Ubiquitination of gasdermin D N-terminal domain directs its membrane translocation and pore formation during pyroptosis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11914233/
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Suppression of the LKB1-AMPK-SLC7A11-GSH signaling pathway sensitizes NSCLC to albumin-bound paclitaxel via oxidative stress
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    pmc.ncbi.nlm.nih.gov/articles/PMC11915006/
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    LncRNA APTR amplification serves as a potential glioma biomarker and promotes glioma progression via miR-6734-5p/ TCF7/LEF1 axis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11914771/
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Crip2 affects vascular development by fine-tuning endothelial cell aggregation and proliferation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11904032/
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Next Generation Aqueous Two‐Phase System for Gentle, Effective, and Timely Extracellular Vesicle Isolation and Transcriptomic Analysis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11923243/
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Tumor Cell‐Expressed Herpesvirus Entry Mediator Regulates Proliferation and Adaptive Immunity in Ovarian Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11921469/
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting platinum-resistant ovarian cancer by disrupting histone and RAD51 lactylation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11898288/
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Enhanced therapeutic efficacy of anti-PD-1 blockade by targeting LAMP2A inhibits lysosomal degradation of STING and TBK1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11898276/
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The costimulatory domain influences CD19 CAR-T cell resistance development in B-cell malignancies
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    pmc.ncbi.nlm.nih.gov/articles/PMC11908201/
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A comprehensive map of missense trafficking variants in rhodopsin and their response to pharmacologic correction
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    pmc.ncbi.nlm.nih.gov/articles/PMC11908143/
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Succinate dehydrogenase activity supports de novo purine synthesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11888382/
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Epigenetic deprogramming by disruption of CIZ1-RNA nuclear assemblies in early-stage breast cancers
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    pmc.ncbi.nlm.nih.gov/articles/PMC11895699/
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    POT, an optogenetics-based endogenous protein degradation system
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    pmc.ncbi.nlm.nih.gov/articles/PMC11920400/
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Crohn’s Disease-associated variant in laccase domain containing 1 (LACC1) modulates T cell gene expression, metabolism and T cell function
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    pmc.ncbi.nlm.nih.gov/articles/PMC11910630/
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Guanine nucleotide biosynthesis blockade impairs MLL complex formation and sensitizes leukemias to menin inhibition
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    pmc.ncbi.nlm.nih.gov/articles/PMC11920272/
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A CPC-shelterin-BTR axis regulates mitotic telomere deprotection
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    pmc.ncbi.nlm.nih.gov/articles/PMC11914695/
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    USP7 V517F mutation as a mechanism of inhibitor resistance
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    pmc.ncbi.nlm.nih.gov/articles/PMC11909274/
  21. www.cell.com www.cell.com
    Small-molecule RNA therapeutics to target prostate cancer
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    cell.com/cancer-cell/abstract/S1535-6108(25)00079-0
  22. www.sciencedirect.com www.sciencedirect.com
    Spatial control of m6A deposition on enhancer and promoter RNAs through co-acetylation of METTL3 and H3K27 on chromatin
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    sciencedirect.com/science/article/pii/S1097276525001479
  23. www.sciencedirect.com www.sciencedirect.com
    Pyruvate metabolism enzyme DLAT promotes tumorigenesis by suppressing leucine catabolism
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    sciencedirect.com/science/article/pii/S155041312500066X
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A microglia clonal inflammatory disorder in Alzheimer’s disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC11908784/
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Overlapping and distinct functions of SPT6, PNUTS, and PCF11 in regulating transcription termination
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    pmc.ncbi.nlm.nih.gov/articles/PMC11915507/
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Recurrent breakpoints in the BRD4 locus reduce toxicity associated with gene amplification
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    pmc.ncbi.nlm.nih.gov/articles/PMC12008804/
  27. www.sciencedirect.com www.sciencedirect.com
    Protocol for the simultaneous activation and lentiviral transduction of primary human T cells with artificial T cell receptors
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    sciencedirect.com/science/article/pii/S2666166725000917
  28. www.sciencedirect.com www.sciencedirect.com
    Glutamine binds HSC70 to transduce signals inhibiting IFN-β-mediated immunogenic cell death
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    sciencedirect.com/science/article/pii/S1534580725001170
  29. www.sciencedirect.com www.sciencedirect.com
    YAP1 is a key regulator of EWS::FLI1-dependent malignant transformation upon IGF-1-mediated reprogramming of bone mesenchymal stem cells
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    sciencedirect.com/science/article/pii/S2211124725001524
  30. www.sciencedirect.com www.sciencedirect.com
    Simultaneous CRISPR screening and spatial transcriptomics reveal intracellular, intercellular, and functional transcriptional circuits
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    sciencedirect.com/science/article/pii/S0092867425001977
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The TCF4 Gene Regulates Apoptosis of Corneal Endothelial Cells in Fuchs Endothelial Corneal Dystrophy
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    pmc.ncbi.nlm.nih.gov/articles/PMC11895853/
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Protein phosphatase EYA1 regulates the dephosphorylation and turnover of BCL2L12 to promote glioma development
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    pmc.ncbi.nlm.nih.gov/articles/PMC11781168/
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Association of Selected STAT Inhibitors with Prolactin-Induced Protein (PIP) in Breast Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11855718/
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ATF3-SLC7A7 Axis Regulates mTORC1 Signaling to Suppress Lipogenesis and Tumorigenesis in Hepatocellular Carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC11854064/
  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Combinational Inhibition of MEK and AKT Synergistically Induces Melanoma Stem Cell Apoptosis and Blocks NRAS Tumor Growth
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    pmc.ncbi.nlm.nih.gov/articles/PMC11852824/
  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Sodium valproate enhances efficacy of NKG2D CAR-T cells against glioblastoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC11772361/
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Histone Demethylase LSD1/ZNF217/CoREST Complex is a Major Restriction Factor of Epstein-Barr Virus Lytic Reactivation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11774438/
  38. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Rac1 overexpression promotes Treg-derived cytokines to mediate choroidal neovascularization in wet age-related macular degeneration
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    pmc.ncbi.nlm.nih.gov/articles/PMC11884777/
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    γ-secretase facilitates retromer-mediated retrograde transport
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    pmc.ncbi.nlm.nih.gov/articles/PMC11883284/
  40. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Glutathione peroxidase 4 (GPX4) and obesity interact to impact tumor progression and treatment response in triple negative breast cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11863593/
  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A benchmark comparison of CRISPRn guide-RNA design algorithms and generation of small single and dual-targeting libraries to boost screening efficiency
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    pmc.ncbi.nlm.nih.gov/articles/PMC11863645/
  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Development and characterization of a double-fluorescent HIV-1 reporter cellular model to tackle the Rev-dependent export pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC11878058/
  43. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Norovirus co-opts NINJ1 for selective protein secretion
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    pmc.ncbi.nlm.nih.gov/articles/PMC11870086/
  44. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Local soft niches in mechanically heterogeneous primary tumors promote brain metastasis via mechanotransduction-mediated HDAC3 activity
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    pmc.ncbi.nlm.nih.gov/articles/PMC11864190/
  45. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CHIP protects lysosomes from CLN4 mutant-induced membrane damages
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    pmc.ncbi.nlm.nih.gov/articles/PMC11870535/
  46. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Synergistic RAS-MAPK and AKT Activation in MYC-Driven Tumors via Adjacent PVT1 Rearrangements
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    pmc.ncbi.nlm.nih.gov/articles/PMC11870553/
  47. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Optical Pooled Screening for the Discovery of Regulators of the Alternative Lengthening of Telomeres Pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC11844499/
  48. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pyrimethamine and a potent analogue WCDD115 inhibit NRF2 by suppressing DHFR and one-carbon metabolism
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    pmc.ncbi.nlm.nih.gov/articles/PMC11870417/
  49. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    EndoMAP.v1, a Structural Protein Complex Landscape of Human Endosomes
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    pmc.ncbi.nlm.nih.gov/articles/PMC11839024/
  50. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A novel alpha-synuclein K58N missense variant in a patient with Parkinson’s disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC11844588/
  51. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Higher throughput assays for understanding the pathogenicity of variants of unknown significance (VUS) in the RPE65 gene
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    pmc.ncbi.nlm.nih.gov/articles/PMC11838478/
  52. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Haplotype rather than single causal variants effects contribute to regulatory gene expression associations in human myeloid cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11838257/
  53. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Molecular determinants of RNase MRP specificity and function
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    pmc.ncbi.nlm.nih.gov/articles/PMC11838342/
  54. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-scale spatial mapping of the Hodgkin lymphoma microenvironment identifies tumor cell survival factors
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    pmc.ncbi.nlm.nih.gov/articles/PMC11785141/
  55. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Signal peptide-independent secretion of keratin-19 by pancreatic cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11785074/
  56. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Harnessing Extracellular Vesicles for Stabilized and Functional IL-10 Delivery in Macrophage Immunomodulation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11761701/
  57. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CellFIE: Integrating Pathway Discovery With Pooled Profiling of Perturbations Uncovers Pathways of Huntington’s Disease, Including Genetic Modifiers of Neuronal Development and Morphology
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    pmc.ncbi.nlm.nih.gov/articles/PMC11870572/
  58. www.biorxiv.org www.biorxiv.org
    Cardiolipin deficiency disrupts CoQ-complex III interface in steatohepatitis
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    biorxiv.org/content/10.1101/2024.10.10.617517v3
  59. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Multiplex, multimodal mapping of variant effects in secreted proteins
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    pmc.ncbi.nlm.nih.gov/articles/PMC11838247/
  60. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Functional characterization of all CDKN2A missense variants and comparison to in silico models of pathogenicity
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    pmc.ncbi.nlm.nih.gov/articles/PMC10793438/
  61. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Trans-synaptic molecular context of NMDA receptor nanodomains
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    pmc.ncbi.nlm.nih.gov/articles/PMC10769418/
  62. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Inhibition of triglyceride metabolism‐associated enhancers alters lipid deposition during adipocyte differentiation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11774232/
  63. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CRM1 regulates androgen receptor stability and impacts DNA repair pathways in prostate cancer, independent of the androgen receptor
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    pmc.ncbi.nlm.nih.gov/articles/PMC11774231/
  64. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Deletion of Xist repeat B disrupts cell cycle and asymmetric cell division through Usp9x hyperactivation in mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC11880805/
  65. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    c-JUN: a chromatin repressor that limits mesoderm differentiation in human pluripotent stem cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11760979/
  66. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Harnessing transcriptional regulation of alternative end-joining to predict cancer treatment
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    pmc.ncbi.nlm.nih.gov/articles/PMC11886861/
  67. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Deciphering the interplay between SETD2 mediated H3K36me3 and RNA N6-methyladenosine in clear cell renal cell carcinoma (ccRCC)
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    pmc.ncbi.nlm.nih.gov/articles/PMC11776469/
  68. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    High CDC20 levels increase sensitivity of cancer cells to MPS1 inhibitors
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    pmc.ncbi.nlm.nih.gov/articles/PMC11850905/
  69. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The proximity-based protein interactome and regulatory logics of the transcription factor p65 NF-κB/RELA
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    pmc.ncbi.nlm.nih.gov/articles/PMC11850942/
  70. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Circulating tumor cell plasticity determines breast cancer therapy resistance via neuregulin 1–HER3 signaling
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    pmc.ncbi.nlm.nih.gov/articles/PMC11779641/
  71. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Nematode serine protease inhibitor SPI-I8 negatively regulates host NF-κB signalling by hijacking MKRN1-mediated polyubiquitination of RACK1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11876351/
  72. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Distinct outcomes from targeted perturbations of the multi-subunit SCFSkp2 E3 ubiquitin ligase in blocking Trp53/Rb1-null prostate tumorigenesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11846996/
  73. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TDP-43 nuclear retention is antagonized by hypo-phosphorylation of its C-terminus in the cytoplasm
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    pmc.ncbi.nlm.nih.gov/articles/PMC11775348/
  74. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Impaired MC3T3-E1 osteoblast differentiation triggered by oncogenic HRAS is rescued by the farnesyltransferase inhibitor Tipifarnib
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    pmc.ncbi.nlm.nih.gov/articles/PMC11861272/
  75. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A study on the production of extracellular vesicles derived from novel immortalized human placental mesenchymal stromal cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11775310/
  76. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Proteomic profiling identifies upregulation of aurora kinases causing resistance to taxane-type chemotherapy in triple negative breast cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11762698/
  77. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SKI complex loss renders 9p21.3-deleted or MSI-H cancers dependent on PELO
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    pmc.ncbi.nlm.nih.gov/articles/PMC11864980/
  78. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Structure-function relationship of ASH1L and histone H3K36 and H3K4 methylation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11883000/
  79. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ACSS2 drives senescence-associated secretory phenotype by limiting purine biosynthesis through PAICS acetylation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11871226/
  80. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Bone morphogenetic protein (BMP) signaling determines neuroblastoma cell fate and sensitivity to retinoic acid
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    pmc.ncbi.nlm.nih.gov/articles/PMC11871043/
  81. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Screening the human druggable genome identifies ABHD17B as an anti-fibrotic target in hepatic stellate cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11873113/
  82. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    EZH2 serves as a viable therapeutic target for myeloma-induced osteolytic bone destruction
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    pmc.ncbi.nlm.nih.gov/articles/PMC11782520/
  83. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A compendium of Amplification-Related Gain Of Sensitivity genes in human cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11772776/
  84. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SLC25A38 is required for mitochondrial pyridoxal 5’-phosphate (PLP) accumulation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11760969/
  85. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Gut dysbiosis conveys psychological stress to activate LRP5/β-catenin pathway promoting cancer stemness
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    pmc.ncbi.nlm.nih.gov/articles/PMC11880501/
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    Activation of the imprinted Prader-Willi syndrome locus by CRISPR-based epigenome editing
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