2,193 Matching Annotations
  1. Dec 2020
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    An RNA Repair Operon Regulated by Damaged tRNAs
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    sciencedirect.com/science/article/pii/S2211124720315163
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    AKAP6 orchestrates the nuclear envelope microtubule-organizing center by linking golgi and nucleus via AKAP9
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    ncbi.nlm.nih.gov/pmc/articles/PMC7725499/
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    Nuclear cGAS Functions Non-canonically to Enhance Antiviral Immunity via Recruiting Methyltransferase Prmt5
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    sciencedirect.com/science/article/pii/S2211124720314790
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    Hyperactive CDK2 Activity in Basal-like Breast Cancer Imposes a Genome Integrity Liability that Can Be Exploited by Targeting DNA Polymerase ε
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    cell.com/molecular-cell/fulltext/S1097-2765(20)30723-1
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    BPS Publications
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15060
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    Human CST complex protects stalled replication forks by directly blocking MRE11 degradation of nascent‐strand DNA
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    embopress.org/doi/abs/10.15252/embj.2019103654
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    TRIM11 Prevents and Reverses Protein Aggregation and Rescues a Mouse Model of Parkinson’s Disease
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    sciencedirect.com/science/article/pii/S2211124720314078
  9. Nov 2020
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    ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B
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    sciencedirect.com/science/article/pii/S1097276520307383
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    Essentiality of CENP-A Depends on Its Binding Mode to HJURP
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    sciencedirect.com/science/article/pii/S2211124720313772
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    BUBR1 Pseudokinase Domain Promotes Kinetochore PP2A-B56 Recruitment, Spindle Checkpoint Silencing, and Chromosome Alignment
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    sciencedirect.com/science/article/pii/S2211124720313863
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    An Aphid-Secreted Salivary Protease Activates Plant Defense in Phloem
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    cell.com/current-biology/abstract/S0960-9822(20)31351-8
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    Formation of the CenH3-Deficient Holocentromere in Lepidoptera Avoids Active Chromatin
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    cell.com/current-biology/abstract/S0960-9822(20)31448-2
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    A Systematic Protein Turnover Map for Decoding Protein Degradation
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    The Proteomic Landscape of Centromeric Chromatin Reveals an Essential Role for the Ctf19CCAN Complex in Meiotic Kinetochore Assembly
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    sciencedirect.com/science/article/pii/S0960982220315293
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    Atg43 tethers isolation membranes to mitochondria to promote starvation-induced mitophagy in fission yeast
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    ncbi.nlm.nih.gov/pmc/articles/PMC7609059/
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    Auxin-Regulated Reversible Inhibition of TMK1 Signaling by MAKR2 Modulates the Dynamics of Root Gravitropism
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    GDF6-CD99 Signaling Regulates Src and Ewing Sarcoma Growth
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    Type-IInterferon-Inducible SERTAD3 Inhibits Influenza A Virus Replication by Blocking the Assembly of Viral RNA Polymerase Complex
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    Defining Essential Enhancers for Pluripotent Stem Cells Using a Features-Oriented CRISPR-Cas9 Screen
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    Fat Body p53 Regulates Systemic Insulin Signaling and Autophagy under Nutrient Stress via Drosophila Upd2 Repression
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    ncbi.nlm.nih.gov/pmc/articles/PMC9036415/
  23. Oct 2020
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    The Obesity-Susceptibility Gene TMEM18 Promotes Adipogenesis through Activation of PPARG
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    sciencedirect.com/science/article/pii/S2211124720312845
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    Functional Diversification of SRSF Protein Kinase to Control Ubiquitin-Dependent Neurodevelopmental Signaling
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    sciencedirect.com/science/article/pii/S1534580720307577
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    Gli3 utilizes Hand2 to synergistically regulate tissue-specific transcriptional networks
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    elifesciences.org/articles/56450
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    TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control
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    ncbi.nlm.nih.gov/pmc/articles/PMC7532188/
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    MC4R Signaling in Dorsal Raphe Nucleus Controls Feeding, Anxiety, and Depression
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    Identification of Fibroblast Activation Protein as an Osteogenic Suppressor and Anti-osteoporosis Drug Target
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    TRPV4 activity regulates nuclear Ca2+ and transcriptional functions of β‐catenin in a renal epithelial cell model
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    onlinelibrary.wiley.com/doi/10.1002/jcp.30096
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    Eater cooperates with Multiplexin to drive the formation of hematopoietic compartments
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    MED19 Regulates Adipogenesis and Maintenance of White Adipose Tissue Mass by Mediating PPARγ-Dependent Gene Expression
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    Temporal Proteomic Analysis of Herpes Simplex Virus 1 Infection Reveals Cell-Surface Remodeling via pUL56-Mediated GOPC Degradation
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  35. www.cell.com www.cell.com
    Phase Separation of Disease-Associated SHP2 Mutants Underlies MAPK Hyperactivation
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    cell.com/cell/fulltext/S0092-8674(20)31143-0
  36. Sep 2020
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    C-Terminal Motifs of the MTW1 Complex Cooperatively Stabilize Outer Kinetochore Assembly in Budding Yeast
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    Nuclear Import of the HIV-1 Core Precedes Reverse Transcription and Uncoating
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    Salmonella Typhoid Toxin PltB Subunit and Its Non-typhoidal Salmonella Ortholog Confer Differential Host Adaptation and Virulence
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    sciencedirect.com/science/article/pii/S1931312820302328
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    UBE3A-mediated p18/LAMTOR1 ubiquitination and degradation regulate mTORC1 activity and synaptic plasticity
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    elifesciences.org/articles/37993
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    High-performance CRISPR-Cas12a genome editing for combinatorial genetic screening
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    nature.com/articles/s41467-020-17209-1
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    FRET kinase sensor development reveals SnRK2/OST1 activation by ABA but not by MeJA and high CO2 during stomatal closure
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    ncbi.nlm.nih.gov/pmc/articles/PMC7289597/
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    Bisphosphoglycerate Mutase Deficiency Protects against Cerebral Malaria and Severe Malaria-Induced Anemia
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    Piezo1/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1-ß-catenin
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    ncbi.nlm.nih.gov/pmc/articles/PMC7112954/
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    TGF-β-Induced Phosphorylation of Usp9X Stabilizes Ankyrin-G and Regulates Dendritic Spine Development and Maintenance
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    Aire-dependent genes undergo Clp1-mediated 3’UTR shortening associated with higher transcript stability in the thymus
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    ncbi.nlm.nih.gov/pmc/articles/PMC7205469/
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    METTL3 and N6-Methyladenosine Promote Homologous Recombination-Mediated Repair of DSBs by Modulating DNA-RNA Hybrid Accumulation
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    Binding of the Treslin-MTBP Complex to Specific Regions of the Human Genome Promotes the Initiation of DNA Replication
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    pubmed.ncbi.nlm.nih.gov/32966791/
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    Regulation of S100A8 Stability by RNF5 in Intestinal Epithelial Cells Determines Intestinal Inflammation and Severity of Colitis
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    cell.com/cell-reports/abstract/S2211-1247(18)31344-5
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    The COMET toolkit for composing customizable genetic programs in mammalian cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC7005830/
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    The Interaction of the Tumor Suppressor FAM46C with p62 and FNDC3 Proteins Integrates Protein and Secretory Homeostasis
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    A WW Tandem-Mediated Dimerization Mode of SAV1 Essential for Hippo Signaling
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    An Optimized Immunoprecipitation Protocol for Assessing Protein-RNA Interactions In Vitro
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    Listeria Phages Induce Cas9 Degradation to Protect Lysogenic Genomes
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    Conserved Tao kinase activity regulates dendritic arborization, cytoskeletal dynamics and sensory function in Drosophila
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    ncbi.nlm.nih.gov/pmc/articles/PMC7046460/
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    The peroxisome counteracts oxidative stresses by suppressing catalase import via Pex14 phosphorylation
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    ncbi.nlm.nih.gov/pmc/articles/PMC7498260/
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    A Plug-and-Latch Mechanism for Gating the Mechanosensitive Piezo Channel
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    sciencedirect.com/science/article/pii/S0896627320301094
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    Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2
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    cell.com/cell/fulltext/S0092-8674(20)30338-X
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    A Genetic Toggle for Chemical Control of Individual Plk1 Substrates
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    CATP-8/P5A ATPase Regulates ER Processing of the DMA-1 Receptor for Dendritic Branching
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    Molecular mechanisms underlying altered neurobehavioural development of female offspring of mothers with polycystic ovary syndrome: FOS-mediated regulation of neurotrophins in placenta
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    BRAG2a mediates mGluR-dependent AMPA receptor internalization at excitatory postsynapses through the interaction with PSD-95 and endophilin 3
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    Site-Specific Photo-Crosslinking Proteomics Reveal Regulation of IFITM3 Trafficking and Turnover by VCP/p97 ATPase
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    The integrity of cochlear hair cells is established and maintained through the localization of Dia1 at apical junctional complexes and stereocilia
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    Structure of the TSC2 GAP Domain: Mechanistic Insight into Catalysis and Pathogenic Mutations
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    APOL1 C-Terminal Variants May Trigger Kidney Disease through Interference with APOL3 Control of Actomyosin
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    The Protein Arginine Methyltransferase PRMT8 and Substrate G3BP1 Control Rac1-PAK1 Signaling and Actin Cytoskeleton for Dendritic Spine Maturation
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    Identification of a PGXPP degron motif in dishevelled and structural basis for its binding to the E3 ligase KLHL12
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    ncbi.nlm.nih.gov/pmc/articles/PMC7333892/
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    The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation
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    Identification of ALPPL2 as a Naive Pluripotent State-Specific Surface Protein Essential for Human Naive Pluripotency Regulation
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    Ascl2-Dependent Cell Dedifferentiation Drives Regeneration of Ablated Intestinal Stem Cells
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    Organismal benefits of transcription speed control at gene boundaries
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    embopress.org/doi/abs/10.15252/embr.201949315
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    ZAKα Recognizes Stalled Ribosomes through Partially Redundant Sensor Domains
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    An Acetylation Switch of the NLRP3 Inflammasome Regulates Aging-Associated Chronic Inflammation and Insulin Resistance
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    Antagonistic control of Caenorhabditis elegans germline stem cell proliferation and differentiation by PUF proteins FBF-1 and FBF-2
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    Differential Cellular Response to Translocated Toxic Effectors and Physical Penetration by the Type VI Secretion System
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    Cdk4 and Cdk6 Couple the Cell-Cycle Machinery to Cell Growth via mTORC1
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    Dissecting the Roles of Mitochondrial Complex I Intermediate Assembly Complex Factors in the Biogenesis of Complex I
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    Loss of Human TGS1 Hypermethylase Promotes Increased Telomerase RNA and Telomere Elongation
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    cell.com/cell-reports/abstract/S2211-1247(20)30013-9
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    Endogenous Cyclin D1 Promotes the Rate of Onset and Magnitude of Mitogenic Signaling via Akt1 Ser473 Phosphorylation
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    L ARP7 Is a BRCA1 Ubiquitinase Substrate and Regulates Genome Stability and Tumorigenesis
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    Hyperinsulinemia Drives Epithelial Tumorigenesis by Abrogating Cell Competition
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    Cdk1 Controls Global Epigenetic Landscape in Embryonic Stem Cells
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    Ingestion of Food Particles Regulates the Mechanosensing Misshapen-Yorkie Pathway in Drosophila Intestinal Growth
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    pmc.ncbi.nlm.nih.gov/articles/PMC7480018/
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    Structural modeling, mutation analysis, and in vitro expression of usherin, a major protein in inherited retinal degeneration and hearing loss
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    sciencedirect.com/science/article/pii/S2001037020302889
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    Targeting Endogenous K-RAS for Degradation through the Affinity-Directed Protein Missile System
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    Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray Syndrome
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    elifesciences.org/articles/38430
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    mtDNA Activates cGAS Signaling and Suppresses the YAP-Mediated Endothelial Cell Proliferation Program to Promote Inflammatory Injury
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    Tuning Transcription Factor Availability through Acetylation-Mediated Genomic Redistribution
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    The Autophagy-Initiating Kinase ULK1 Controls RIPK1-Mediated Cell Death
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