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  1. May 2024
    1. protein degradation during endosomal trafficking. Herein, using custom made fluorescent probes to assess the endosomal activity of cathepsin B (CTSB) and protein degradation, we found that certain cancer cells with hyperacidified endosomes grant a spatiotemporal window where CTSB activity surpass protein digestion

      This is a strange argument. I thought cathepsins were precisely major enzymes involved in protein degradation.