backtracking algorithm

The cortical surface for each participant was reconstructed from the R1 image by the following steps

available from the AIBS (33) (human.brain-map.org)

This parcellation template was then transformed to the native space of each participant’s image

Between-site reliability and tolerability of all MRI procedures were satisfactorily assessed by a pilot study of five healthy volunteers each scanned for ∼25 min at each site (31). The between-site bias was less than 3% and the between-site coefficient of variation was less than 8% for both longitudinal relaxation rate (R1) and MT parameters (31).

Internal Replication.

SPM8

3T whole-body MRI systems (Magnetom TIM Trio; VB17 software version; Siemens Healthcare):

MPM sequence

We used a backtracking algorithm (55) to parcellate 66 regions defined by sulcogyral criteria in the Desikan–Killiany atlas (56) into 308 contiguous parcels of approximately equal area (500 mm2) across both hemispheres in standard space (SI Appendix, Fig. S2A).

FreeSurfer v5.3.0

sample of 297 healthy young people sampled from primary healthcare registers, stratified by age, and balanced for sex in the adolescent age range 14–24 y old, with ∼60 participants in each of five age-defined strata: 14–15 y old inclusive, 16–17 y old, 18–19 y old, 20–21 y old, and 22–24 y old

that adolescent consolidation of these connectome hubs was associated with a specific gene expression profile, enriched for neuronal and oligodendroglial function, and enriched for risk of schizophrenia, a neurodevelopmental disorder with its highest incidence in young adults

(ii) that adolescent cortical shrinkage/myelination (also known as consolidation) was concentrated anatomically on association cortex and topologically on the most strongly connected regions (hubs) of the human brain anatomical network

(i) that adolescent cortical shrinkage was coupled to intracortical myelination

Accurate autocorrelation modeling substantially improvesfMRI reliability