nuclear pore complex.
Nuclear pore complex or NPC. There is a size exclusion. <60kDa to pass through unassisted.
nuclear pore complex.
Nuclear pore complex or NPC. There is a size exclusion. <60kDa to pass through unassisted.
The SRP is a G-protein and exchanges its bound GDP for a GTP upon binding to a protein’s signal sequence.
As soon as this sequence is translated, the SRP binds it. Elongation is temporarily arrested. SRP-ribosome complex binds to the SRP receptor on the ER membrane. Translation now continues into the lumen of the ER. The SPR and its receptor are recycled.
a stop-transfer sequence (a hydrophobic domain within the polypeptide chain) traps the protein in the fatty acid interior