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  1. Sep 2024
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The von Willebrand factor Tyr2561 allele is a gain-of-function variant and a risk factor for early myocardial infarction
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    1. krisBussey97 23 Sep 2024

      Functional study methods:

      WAVE DNA fragment analysis to screen for variant

      VWF collagen binding activity

      cone and plate analysis (CPA)

      Microfluidics

      static VWF-platelet receptor binding assay

      protein expression in cultured HEK293 cell clones

      Near and far-UV circular dichroism spectra

      microfluidics VWF-platele receptor binding VWF collagen binding activity
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    ncbi.nlm.nih.gov/pmc/articles/PMC6347094/