Hypothesis

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Sep 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

PAINS in the Assay: Chemical Mechanisms of Assay Interference and Promiscuous Enzymatic Inhibition Observed during a Sulfhydryl-Scavenging HTS

1
1. zhentg 19 Sep 2021
  
  in Public
  
  this paper described some hit compounds that interfere with the assay components. some compounds react with thiol, and their SAR is reported.
  
  PAINS covalent warhead
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covalent warhead

PAINS

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zhentg

URL

ncbi.nlm.nih.gov/pmc/articles/PMC4360378/
Nov 2020
www.scripps.edu www.scripps.edu

The Cravatt Lab

1
1. zhentg 13 Nov 2020
  
  in Public
  
  Journal of the American Chemical Society. 2018, 140, 8069-8073.
  
  covalent warhead
  
  covalent warhead
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covalent warhead

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zhentg

URL

scripps.edu/cravatt/refs.html