efficiently mitigated by dexamethasone which does not influence BiTE®-induced T-cell activation and redirected lysis

Upon synapse formation, T cells not only release perforin and granzyme B but also release large amounts of cytokines, namely interleukin (IL)-6, IL-10, and interferon (IFN)-γ

10–15 of these interactions lead to the formation of a cytolytic synapse much like a pMHC-TCR interaction-based immunologic synapse between an antigen-presenting cell and a T cell [15]