Because of the very close spatial proximity of radiosensitive gastrointestinal structures and spatial instability during repeated fractions (especially in the case of the small intestine), the dose 35 Gy in five fractions was most frequently prescribed, and the median biological equivalent dose (BED10Gy) was 60 Gy (in the range of 48–112 Gy).

The most frequent prescription regimens were 24 Gy in 3 fractions (n = 52, 33%) and 30 Gy in 5 fractions

For HSRT, most common schedules were 24–27 Gy in 3 fractions and 30–35 Gy in 5 fractions with a reported similar 12-month local control of about 85–95%

Schedules 3 × 9 Gy and 5 × 6 Gy corresponding to lower BED10 Gy of 51.3 Gy and 48 Gy respectively, were more often applied on post-operative cavity and smaller lesions

The total dose of prescription was 25 or 40 Gy in 5 fractions volumetrically such that the entire prescription dose was applied at least 99% of the PTV and delivered over a 7- to 14-day period