Aortic dissection typically presents acutely with sudden, severe tearing chest or back pain, often described as lancinating in quality. [5-6] Approximately 50% of patients with thoracic aortic aneurysm may progress to dissection without timely intervention. [5] In contrast, thoracic aortic aneurysm is usually asymptomatic and discovered incidentally during physical examination or imaging for other indications. [5]
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- Mar 2026
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accessmedicine.mhmedical.com accessmedicine.mhmedical.com
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- CT angiography is the imaging modality of choice for differentiating these conditions in the emergency setting, with very high sensitivity and specificity for acute aortic syndromes
- Recent evidence suggests that inflammatory biomarkers may aid differentiation. The neutrophil-to-lymphocyte ratio (NLR) shows high diagnostic accuracy for distinguishing dissection from controls (AUC 0.933), while the fibrinogen-to-d-dimer ratio best differentiates dissection from aneurysm (AUC 0.898, sensitivity 77%, specificity 84%). [10] D-dimer levels below 500 ng/mL make acute aortic syndrome unlikely in low-risk patients
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- Apr 2021
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academic.oup.com academic.oup.com
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high neutrophil to lymphocyte ratio
Neutrophil to lymphocyte ratio as a cost-effective biomarker of COVID-19 severity https://10.1016/j.ajem.2021.01.006
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