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  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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    1. karim2001khoury 19 Feb 2026
      Functional Genomic Landscape of Acute Myeloid Leukemia

      [Paper-level Aggregated] PMCID: PMC6280667

      Evidence Type(s): Functional, Prognostic

      Justification: Functional: The text discusses the correlation of mutations in splicesome components, including serine/arginine rich 2 (ZRSR2), with novel sensitivity to several drugs, indicating a functional role of these mutations in drug response. Prognostic: The mention of mutations in TP53 and ASXL1 as causing a broad pattern of drug resistance suggests that these mutations are associated with poor prognostic features in AML cases.

      Gene→Variant (gene-first): ZRSR2(8233):serine/arginine

      Genes: ZRSR2(8233)

      Variants: serine/arginine

      CIViC paper-level aggregated PMC6280667
    2. karim2001khoury 19 Feb 2026
      Mutation of several genes, most notably TP53 or ASXL1 transcriptional regulator 1 (ASXL1), were shown to cause a broad pattern of drug resistance. Interestingly, a few drugs trended more sensitive to TP53 mutant cases, s

      [Paragraph-level] PMCID: PMC6280667 Section: RESULTS PassageIndex: 9

      Evidence Type(s): Predictive

      Justification: Predictive: The passage discusses the correlation of mutations, including those in splicing components like ZRSR2, with sensitivity to various drugs, indicating a relationship between the variant and treatment response.

      Gene→Variant (gene-first): 8233:serine/arginine

      Genes: 8233

      Variants: serine/arginine

      CIViC paragraph-level PMC6280667 Predictive
    3. karim2001khoury 19 Feb 2026
      Mutation of several genes, most notably TP53 or ASXL1 transcriptional regulator 1 (ASXL1), were shown to cause a broad pattern of drug resistance. Interestingly, a few drugs trended more sensitive to TP53 mutant cases, s

      [Paragraph-level] PMCID: PMC6280667 Section: RESULTS PassageIndex: 9

      Evidence Type(s): Predictive

      Justification: Predictive: The passage discusses the correlation of mutations, including those in splicing components like ZRSR2, with sensitivity to various drugs, indicating a relationship between the variant and treatment response.

      Gene→Variant (gene-first): 8233:serine/arginine

      Genes: 8233

      Variants: serine/arginine

      CIViC paragraph-level PMC6280667 Predictive
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    pmc.ncbi.nlm.nih.gov/articles/PMC6280667/pdf/nihms-1504008.pdf