On 2016 Dec 02, Stephen Strum commented:

This is a landmark publication and should be required reading of all those caring for patients with cancer that involves bone mets. In my medical oncology practice I rarely see attention paid to bone integrity and what is called the the vicious cycle of bone resorption & tumor cell proliferation (VC). The implications of how we assess patients at diagnosis and during the course of their care as it relates to VC and the associated increase in cytokines is of immense prognostic and even diagnostic value. I continue to see men with prostate cancer who never have any lab assessment that relates to bone resorption markers (BRMs). This paper beautifully portrays the importance of bone integrity & the underlying mechanisms of action.

On 2016 Dec 02, Stephen Strum commented:

This is a landmark publication and should be required reading of all those caring for patients with cancer that involves bone mets. In my medical oncology practice I rarely see attention paid to bone integrity and what is called the the vicious cycle of bone resorption & tumor cell proliferation (VC). The implications of how we assess patients at diagnosis and during the course of their care as it relates to VC and the associated increase in cytokines is of immense prognostic and even diagnostic value. I continue to see men with prostate cancer who never have any lab assessment that relates to bone resorption markers (BRMs). This paper beautifully portrays the importance of bone integrity & the underlying mechanisms of action.