- Jul 2018
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europepmc.org europepmc.org
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On 2015 Mar 27, Daniel Haft commented:
This landmark paper stopped short of determining the biologically relevant substrates of VanH and VanA. For the next step, see Handwerger, et al. (PMID:1522072), which clarified that D-ala-D-ala is replaced by D-Ala-D-lactate at the terminus of the peptidoglycan precursor molecule in vancomycin-resistant Enterococcus faecalis. VanH is now described as a D-lactate dehydrogenase (EC 1.1.1.28) and VanA as a D-alanine--(R)-lactate ligase (EC 6.1.2.1).
This comment, imported by Hypothesis from PubMed Commons, is licensed under CC BY.
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- Feb 2018
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europepmc.org europepmc.org
-
On 2015 Mar 27, Daniel Haft commented:
This landmark paper stopped short of determining the biologically relevant substrates of VanH and VanA. For the next step, see Handwerger, et al. (PMID:1522072), which clarified that D-ala-D-ala is replaced by D-Ala-D-lactate at the terminus of the peptidoglycan precursor molecule in vancomycin-resistant Enterococcus faecalis. VanH is now described as a D-lactate dehydrogenase (EC 1.1.1.28) and VanA as a D-alanine--(R)-lactate ligase (EC 6.1.2.1).
This comment, imported by Hypothesis from PubMed Commons, is licensed under CC BY.
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