On 2013 Jun 14, Dita Gratzinger commented:

The authors present a comprehensive and up to date review of an entity that must not be missed due to potentially severe clinical consequences, but is at present diagnosed using a constellation of individually fairly nonspecific criteria. Of note from the perspective of the surgical pathologist or hematopathologist is the fact that while hemophagocytosis itself is one of the 8 criteria that can be used in combination with at least 4 others to diagnose HLH, it is neither required nor very specific for the diagnosis.

On 2013 Jun 14, Dita Gratzinger commented:

The authors present a comprehensive and up to date review of an entity that must not be missed due to potentially severe clinical consequences, but is at present diagnosed using a constellation of individually fairly nonspecific criteria. Of note from the perspective of the surgical pathologist or hematopathologist is the fact that while hemophagocytosis itself is one of the 8 criteria that can be used in combination with at least 4 others to diagnose HLH, it is neither required nor very specific for the diagnosis.