- Jul 2018
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europepmc.org europepmc.org
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On 2014 Mar 19, Arthur Edelstein commented:
In Figure 3, the peak DAPI signal (proportional to the amount of DNA present in the cell) increases from ~7500 (before CMR) to ~10000 (after CMR). The gamma-H2AX peak signal (proportional to double-stranded breaks) increases from ~2200 (before CMR) to ~2900 (after CMR). Given that the DAPI signal and the gamma-H2AX signal increase by approximately the same ratio, it looks to me as if the proportion of DNA with double-stranded breaks is unaffected by CMR. Can you rule this out?
This comment, imported by Hypothesis from PubMed Commons, is licensed under CC BY.
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- Feb 2018
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europepmc.org europepmc.org
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On 2014 Mar 19, Arthur Edelstein commented:
In Figure 3, the peak DAPI signal (proportional to the amount of DNA present in the cell) increases from ~7500 (before CMR) to ~10000 (after CMR). The gamma-H2AX peak signal (proportional to double-stranded breaks) increases from ~2200 (before CMR) to ~2900 (after CMR). Given that the DAPI signal and the gamma-H2AX signal increase by approximately the same ratio, it looks to me as if the proportion of DNA with double-stranded breaks is unaffected by CMR. Can you rule this out?
This comment, imported by Hypothesis from PubMed Commons, is licensed under CC BY.
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