On 2015 Feb 07, Jayaprakash Sahoo commented:

Current existing literature supports the association of serum testosterone with decreased adiposity and estradiol with increased adiposity in men.Finkelstein et al in their original article have introduced a new paradigm of estrogen deficiency contributing to increases in body fat in men. However, the conclusions of this study are not supported by some plausible pathophysiology.

The sex steroids (total) are not the only determinants of the fat mass. Alterations in fat mass in study subjects could be contributed by concomitant changes in GH-IGF-1, thyroid, cortisol axes and free sex steroid levels.Local conversion of androgen to estradiol at pituitary level is required for adequate production of GH in a normal adult male. Aromatase inhibitors may lead to adult GH deficiency resulting increased fat mass in them. Additionally, probable GnRH analogue induced hypothyroidism and estradiol induced thyroxine binding globulin changes can also contribute to fat mass alterations by disturbing the thyroid axis. Alteration of free cortisol due to estradiol induced change in cortisol binding globulin levels may be another significant contributor. Hence, a similar study incorporating all hormonal determinants of fat mass is required for clearing uncertainty in the pathophysiology.

On 2015 Feb 07, Jayaprakash Sahoo commented:

Current existing literature supports the association of serum testosterone with decreased adiposity and estradiol with increased adiposity in men.Finkelstein et al in their original article have introduced a new paradigm of estrogen deficiency contributing to increases in body fat in men. However, the conclusions of this study are not supported by some plausible pathophysiology.

The sex steroids (total) are not the only determinants of the fat mass. Alterations in fat mass in study subjects could be contributed by concomitant changes in GH-IGF-1, thyroid, cortisol axes and free sex steroid levels.Local conversion of androgen to estradiol at pituitary level is required for adequate production of GH in a normal adult male. Aromatase inhibitors may lead to adult GH deficiency resulting increased fat mass in them. Additionally, probable GnRH analogue induced hypothyroidism and estradiol induced thyroxine binding globulin changes can also contribute to fat mass alterations by disturbing the thyroid axis. Alteration of free cortisol due to estradiol induced change in cortisol binding globulin levels may be another significant contributor. Hence, a similar study incorporating all hormonal determinants of fat mass is required for clearing uncertainty in the pathophysiology.