On 2013 Oct 28, Leslie Vosshall commented:

Feng Zhang and co-workers present a further optimization of the CRISPR-Cas9 system that that minimizes off-target cleavage. This technique keeps getting more compelling as a genome-editing tool because unlike TALENs and ZFNs, CRISPR-Cas9 can be implemented cheaply and easily in any laboratory.

On 2013 Oct 28, Leslie Vosshall commented:

Feng Zhang and co-workers present a further optimization of the CRISPR-Cas9 system that that minimizes off-target cleavage. This technique keeps getting more compelling as a genome-editing tool because unlike TALENs and ZFNs, CRISPR-Cas9 can be implemented cheaply and easily in any laboratory.