3 Matching Annotations
  1. Jul 2018
    1. On 2014 Jun 20, James Q Zheng commented:

      Thank you for your comment and it is a good point. However, in the discussion, 3rd paragraph, we explicitly discussed the possible involvement of GSK3alpha. Quoted here:

      It should be noted that these studies do not preclude a similar role for the GSK3b homologue, GSK3a, in dendritic development and maintenance. The kinase domains of both GSK3a and GSK3b are highly similar, and there are numerous contexts where both have been demonstrated to be at least partially functionally redundant (39,40).


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    2. On 2014 Jun 19, Jim Woodgett commented:

      Disappointing that the authors did not assess (or even mention) the possible role of GSK-3alpha in these processes, since it is highly redundant with GSK-3beta, has tightly overlapping substrate specificity, similar ubiquitous expression and is equivalently regulated by PI3K and Wnt. For example, does GSK-3alpha also bind Gephryn?


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  2. Feb 2018
    1. On 2014 Jun 19, Jim Woodgett commented:

      Disappointing that the authors did not assess (or even mention) the possible role of GSK-3alpha in these processes, since it is highly redundant with GSK-3beta, has tightly overlapping substrate specificity, similar ubiquitous expression and is equivalently regulated by PI3K and Wnt. For example, does GSK-3alpha also bind Gephryn?


      This comment, imported by Hypothesis from PubMed Commons, is licensed under CC BY.