On 2014 Apr 08, Steve Herman commented:

This abstract, and the authors' press releases, fail to adequately clarify the fact that the hazard ratios shown in the abstract are "adjusted", and do not represent the real risks to real offspring in the population. Some of the "adjustments" are staggering. For example, the actual population risks that were found in this study can be correctly summarized as follows:

Compared with offspring born to fathers 20 to 24 years old, offspring of fathers 45 years and older were 1.5 times more likely to have autism, .7 times less likely to have ADHD, 1.3 times more likely to have a psychotic disorder, 1.5 times more likely to have bipolar disorder, .9 times less likely to have suicidal behavior, .8 times less likely to have a substance abuse problem, .7 times less likely to have failing grades in school, .9 times less likely to have low educational attainment, .8 times less likely to have a low IQ; and 1.5 times more likely to have some higher education.

Please see http://ow.ly/v6ehS for more information.

On 2014 Apr 08, Steve Herman commented:

This abstract, and the authors' press releases, fail to adequately clarify the fact that the hazard ratios shown in the abstract are "adjusted", and do not represent the real risks to real offspring in the population. Some of the "adjustments" are staggering. For example, the actual population risks that were found in this study can be correctly summarized as follows:

Compared with offspring born to fathers 20 to 24 years old, offspring of fathers 45 years and older were 1.5 times more likely to have autism, .7 times less likely to have ADHD, 1.3 times more likely to have a psychotic disorder, 1.5 times more likely to have bipolar disorder, .9 times less likely to have suicidal behavior, .8 times less likely to have a substance abuse problem, .7 times less likely to have failing grades in school, .9 times less likely to have low educational attainment, .8 times less likely to have a low IQ; and 1.5 times more likely to have some higher education.

Please see http://ow.ly/v6ehS for more information.