On 2014 Jun 19, Sacchetti Maria Luisa commented:

This study demonstrate a high prevalence of the nerve dysfunction and a significant correlation with the severity of SDB, in acute stroke patients. Due to the recording technique limitations, the Authors do not classify patients' SDB as central or obstructive. As cases affected by previous peripheral neuropathy or previous OSA were excluded, what might have caused the deficit? Hypoglossal nerve function - and more in general upper airways patency- is regulated by serotonin (5HT). Several studies have demonstrated that altered central networks, particularly serotoninergic, can contribute to OSA Brown RE, 2012 as well as to central sleep apnea Buchanan GF, 2010. Moreover, Sunderram et al.Sunderram J, 2000 observed that a selective serotonin reuptake inhibitor (SSRI), paroxetine hydrochloride,may activate motor neurons in the hypoglossal nucleus and increase genioglossal electromyographic (EMG) activity. Therefore we can hypothesize that the hypoglossal nerve dysfunction observed in the study is -at least in part- the direct consequence of stroke on the serotoninergic network. The incidence of depression after stroke<PMID: 18728805 >, together with effectiveness of its treatment independently to the clinical relevance depressive symptoms Mead GE, 2012, partially support this hypothesis.

On 2014 Jun 19, Sacchetti Maria Luisa commented:

This study demonstrate a high prevalence of the nerve dysfunction and a significant correlation with the severity of SDB, in acute stroke patients. Due to the recording technique limitations, the Authors do not classify patients' SDB as central or obstructive. As cases affected by previous peripheral neuropathy or previous OSA were excluded, what might have caused the deficit? Hypoglossal nerve function - and more in general upper airways patency- is regulated by serotonin (5HT). Several studies have demonstrated that altered central networks, particularly serotoninergic, can contribute to OSA Brown RE, 2012 as well as to central sleep apnea Buchanan GF, 2010. Moreover, Sunderram et al.Sunderram J, 2000 observed that a selective serotonin reuptake inhibitor (SSRI), paroxetine hydrochloride,may activate motor neurons in the hypoglossal nucleus and increase genioglossal electromyographic (EMG) activity. Therefore we can hypothesize that the hypoglossal nerve dysfunction observed in the study is -at least in part- the direct consequence of stroke on the serotoninergic network. The incidence of depression after stroke<PMID: 18728805 >, together with effectiveness of its treatment independently to the clinical relevance depressive symptoms Mead GE, 2012, partially support this hypothesis.