2 Matching Annotations
  1. Jul 2018
    1. On 2014 Apr 04, Dale D O Martin commented:

      It should be noted that N-myristoylation of proteins can only occur on N-terminal Glycines, not internal glycines as they have predicted here and in other papers. That is why it's called N-myristoytlation. The only time that myristoylation can occur internally is following proteolysis of the protein that leads to an N-terminal Glycine on the C-terminal cleavage product. So far, this has only been shown to occur following caspase cleavage at Aspartate residues.

      The authors also don't include what prediction program they used nor do they reference any papers on myristoylation.

      I have commented on papers that include some of the same authors and this journal previously and I have brought it to their attention.


      This comment, imported by Hypothesis from PubMed Commons, is licensed under CC BY.

  2. Feb 2018
    1. On 2014 Apr 04, Dale D O Martin commented:

      It should be noted that N-myristoylation of proteins can only occur on N-terminal Glycines, not internal glycines as they have predicted here and in other papers. That is why it's called N-myristoytlation. The only time that myristoylation can occur internally is following proteolysis of the protein that leads to an N-terminal Glycine on the C-terminal cleavage product. So far, this has only been shown to occur following caspase cleavage at Aspartate residues.

      The authors also don't include what prediction program they used nor do they reference any papers on myristoylation.

      I have commented on papers that include some of the same authors and this journal previously and I have brought it to their attention.


      This comment, imported by Hypothesis from PubMed Commons, is licensed under CC BY.