On 2014 Aug 19, Nikolai Slavov commented:

The classical work of Goldbeter and Koshland, (1981) described how a cycle of competing enzymes, such as a kinase and a phosphatase, can significantly amplify a signal. This work of Dasgupta et al. makes two very significant contributions to the Goldbeter-Koshland mechanism: (i) it generalizes these classical ideas beyond Michaelis-Menten kinetics to arbitrarily complicated enzyme mechanisms; (ii) it demonstrates how the noise of low copy-number fluctuations can be amplified by Goldbeter-Koshland kinetics and points to an elegantly simple solution, enzyme bifunctionality. It is a must read.

On 2014 Aug 19, Nikolai Slavov commented:

The classical work of Goldbeter and Koshland, (1981) described how a cycle of competing enzymes, such as a kinase and a phosphatase, can significantly amplify a signal. This work of Dasgupta et al. makes two very significant contributions to the Goldbeter-Koshland mechanism: (i) it generalizes these classical ideas beyond Michaelis-Menten kinetics to arbitrarily complicated enzyme mechanisms; (ii) it demonstrates how the noise of low copy-number fluctuations can be amplified by Goldbeter-Koshland kinetics and points to an elegantly simple solution, enzyme bifunctionality. It is a must read.