On 2016 Mar 01, Jeffrey S Mogil commented:

In fact, stress is well known to produce both hypersensitivity to pain (see Imbe et al., Front. Biosci. 11:2179-2192, 2006) or inhibition of pain (see Butler & Finn, Prog. Neurobiol. 88:184-202, 2009), depending on the parameters of the stress. In our study, stress produced stress-induced analgesia. This is not a confound; it's the entire finding.

On 2016 Feb 22, Alireza Gharib commented:

Dear Editor I enjoyed studding your paper. However, I have a question. As an accepted fact “higher levels of stress induces pain”; yet, I suppose the results in this paper showed an inconsistent fact in support of other related literature “reduced pain response after stress exposure”. Maybe you just wanted to rule out stress as an intervening factor that may cause bias. I will be grateful if you could explain more. Best

On 2016 Feb 22, Alireza Gharib commented:

Dear Editor I enjoyed studding your paper. However, I have a question. As an accepted fact “higher levels of stress induces pain”; yet, I suppose the results in this paper showed an inconsistent fact in support of other related literature “reduced pain response after stress exposure”. Maybe you just wanted to rule out stress as an intervening factor that may cause bias. I will be grateful if you could explain more. Best

On 2016 Mar 01, Jeffrey S Mogil commented:

In fact, stress is well known to produce both hypersensitivity to pain (see Imbe et al., Front. Biosci. 11:2179-2192, 2006) or inhibition of pain (see Butler & Finn, Prog. Neurobiol. 88:184-202, 2009), depending on the parameters of the stress. In our study, stress produced stress-induced analgesia. This is not a confound; it's the entire finding.