On 2015 Feb 14, Martine Crasnier-Mednansky commented:

Data are fully supported by previous studies by Kao KC, 2004 aimed at the determination of Transcription Factor Activities (TFAs) and gene expression profiles, particularly after a transition from glucose to acetate. Thus the level of CRP-cAMP was shown to peak within the first hour of transition and gradually reduce after an hour. The gene expression profile of pckA indicated a similar time scale, pckA being down-regulated within the first hour (after 5 minutes of the transition) and up-regulated gradually after an hour. This 'Cyclic AMP Responsive Switching' is particularly interesting as it bears consequences for analyzing the drastic downshift from glucose to acetate.

On 2015 Feb 14, Martine Crasnier-Mednansky commented:

Data are fully supported by previous studies by Kao KC, 2004 aimed at the determination of Transcription Factor Activities (TFAs) and gene expression profiles, particularly after a transition from glucose to acetate. Thus the level of CRP-cAMP was shown to peak within the first hour of transition and gradually reduce after an hour. The gene expression profile of pckA indicated a similar time scale, pckA being down-regulated within the first hour (after 5 minutes of the transition) and up-regulated gradually after an hour. This 'Cyclic AMP Responsive Switching' is particularly interesting as it bears consequences for analyzing the drastic downshift from glucose to acetate.