On 2014 May 24, John B Furness commented:

Thanks for your comment. These cells have multiple receptors for luminal nutrients(e.g. Furness, Nature gastroenterology 2013). I imagine that different nutrient receptors may be coupled to the selective release of hormones, perhaps through selective receptor - second messenger - Ca release - vesicular store microdomains.

On 2014 May 22, Art Beyder commented:

very cool. i wonder then how do the cells know which organelles to release?

On 2014 May 22, Art Beyder commented:

very cool. i wonder then how do the cells know which organelles to release?