On 2014 Jul 28, Anthony Dear commented:
An interesting paper. What contribution do you think weight loss observed in the WD+MK animal group made to reduction in cardiac fibrosis?
On 2014 Jul 14, Christopher Haggerty commented:
Ok, interesting. Thank you for the response.
On 2014 Jul 03, Brian Bostick commented:
I would also refer you to take a look at another paper from our group on DPP-4 inhibition for prevention of obesity induced renal injury (Nistala 2014 Endocrinology). http://www.ncbi.nlm.nih.gov/pubmed/24712875. This study had telemetry for blood pressure which interestingly was not clearly affected by DPP4 inhibition in either control or Western diet fed mice, however there was a trend towards increase. We are still looking into the HR effect.
On 2014 Jul 03, Brian Bostick commented:
No, there were no differences in heart rate between the groups during MRI scans. However, we can't really comment on whether that has any significance because mice are under isoflurane anesthesia and our protocol attempts to control for HR during MRI scans to eliminate HR variation affects.
On 2014 Jun 26, Christopher Haggerty commented:
There appears to be some uncertainty regarding the effects of DPP-4 on heart rate- Were there any differences in heart rate during the MR scans between your study groups?
On 2014 Jun 26, Christopher Haggerty commented:
There appears to be some uncertainty regarding the effects of DPP-4 on heart rate- Were there any differences in heart rate during the MR scans between your study groups?
On 2014 Jul 03, Brian Bostick commented:
No, there were no differences in heart rate between the groups during MRI scans. However, we can't really comment on whether that has any significance because mice are under isoflurane anesthesia and our protocol attempts to control for HR during MRI scans to eliminate HR variation affects.
On 2014 Jul 03, Brian Bostick commented:
I would also refer you to take a look at another paper from our group on DPP-4 inhibition for prevention of obesity induced renal injury (Nistala 2014 Endocrinology). http://www.ncbi.nlm.nih.gov/pubmed/24712875. This study had telemetry for blood pressure which interestingly was not clearly affected by DPP4 inhibition in either control or Western diet fed mice, however there was a trend towards increase. We are still looking into the HR effect.
On 2014 Jul 14, Christopher Haggerty commented:
Ok, interesting. Thank you for the response.
On 2014 Jul 28, Anthony Dear commented:
An interesting paper. What contribution do you think weight loss observed in the WD+MK animal group made to reduction in cardiac fibrosis?